• 대한영상의학회지
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• 제85권2호
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• pp.482-483
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• 2024

• 생물정신의학
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• 제18권1호
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• pp.36-45
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• 2011

Objectives : Though a proportion of Alzheimer's disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders' characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods : Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG, same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results : After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions : This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.

• Ocean and Polar Research
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• 제40권1호
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• pp.49-58
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• 2018

This study aimed to analyze the causality of hairtail prices among import and domestic distribution channels using a Vector Error Correction Model(VECM). The results are as follows. First, since the ADF unit-root test suggests that each of the price variables, apart from retail price, has a unit root, the price variables should be 1st-differenced to secure the stability of the prices. Next, through the Johansen co-integration test, it was discovered that there are long-term relationships among the price variables. On the basis of the co-integration test, VECM analysis shows that the producer price has a long-run balance with the import and wholesale prices. In particular, when the prices deviate from the balance, the producer price dynamically adjusts to return to the long-term relationship among prices. It also indicates that the producer price has an impact on the import, wholesale, and retail prices in the short-term, and the import price has an influence on the producer and wholesale prices. In addition, the impulse response analysis demonstrates that the impulse of import and producer prices has a lasting impact on each of the prices.

• 생물정신의학
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• 제8권2호
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• pp.226-232
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• 2001

The pharmacotherapy of depression has reduced morbidity and improved outcome for many depressive patients. A wide range of classical and new antidepressants are available for their treatment. However, 30-40% of all patients do not respond sufficiently to the initial treatment and present adverse effects. Pharmacogenetics studies the genetic basis of an individual's ability to respond to pharmacotherapy. Recently, some reports on serotonin transporter gene polymorphisms and their influence on the response to antidepressive therapy provide an interesting diagnostic tool in assessing the chances of response to antidepressants. We also investigated the relationship between serotonin transprter polymorphisms(5-HTTLPR) and the long-term effect of the antidepressant treatment. 128 depressive patients were enrolled into 2nd year study. The therapeutic response of each subset was not different at 8th, 16th week, but the subset with homozygote(l/l) of long variant showed a better therapeutic response to antidepressant than the heterozygote(l/s) of long and short variant, which showed a better therapeutic response than the subset with homozygote (s/s) of short variant at 1st year and 2nd year after the antidepressant treatment. This result shows that the serotonin transporter polymorphisms may be related to the long-term effect of antidepressant treatment. The potential for pharmacogenomics, the use of genetic information to guide pharmacotherapy and improve outcome by providing individualized treatment decisions, has gained increasing attention. pharmacogenomics will contribute to individualize drug choice by using genotype to predict positive clinical outcomes, adverse reactions, and levels of drug metabolism. Personalized medicine, the use of marker-assisted diagnosis and targeted therapies derived from an individual molecular profile, will impact the antidepressant therapy and this approach will replace the traditional trial-and-error practice of medicine.

• 생약학회지
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• 제29권1호
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• pp.48-55
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• 1998

The effects of Bezoar Bovis on immune responses of ICR Mice were studied. In the present study, the Jerne hemolytic plaque assay (PFC) was used to evaluate the humoral immune response to sheep red blood cells, and macrophage regulatory function was measured by quantitating the production of molecules secreted by macrophages. Bezoar Bovis was given in single daily p.o doses for short term (1, 2 days) or long term (7, 14 days). PFC response for taken 3 days after short term exposure to Bezoar Bovis was increased. The production of nitirc oxide in macrophages was also stimulated. In contrast, long term exposure to Bezoar Bovis resulted in inhibitory effect of Bezoar Bovis on nitirc oxide, $TNF-{\alpha}$and IL-6 production in macrophages. These findings suggest that treatment with Bezoar Bovis may result in differential immunological effect depending on treatment schedule.

• Fisheries and Aquatic Sciences
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• 제2권2호
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• pp.199-209
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• 1999

Before investigating the long-term variations in macrobenthic communities sampled in the Chokchon macrotidal flat in Inchon, Korea, from 1989 to 1996, we need to understand how environmental factors in the area vary. As potential governing agents of tidal flat communities, abiotic factors such as mean sea level, seawater, air temperature, and precipitation were considered. Data for these factors were collected at equal intervals from 1976 or 1980 to 1996, and were analyzed using a decomposition method. In this analysis, all the above variables showed strong seasonal nature, and yielded a significant trend and cyclical variation. Positive trends were seen in the seawater and air temperatures, and based upon this relationship, it was found that the biological sampling period of our program has been carried out during warmer periods in succession. This paper puts forth some hypotheses concerning the response of tidal flat macrobenthos communities to the changing environment including mild winters in succession.

• 대한가정학회지
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• 제40권6호
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• pp.197-211
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• 2002

This study constructed a family life education program designed to help divorced parents. The purpose of this research was to develop long term education program for post-divorce adjustment. This program is consisted of 6 sessions aiming for understanding the grief process for adults and the six station of divorce, the recovery through forgiveness, children's response to divorce and coping strategy, the opened mind of parent-child relation, enhancing the self-esteem, the healthy single parent. We expect this program to be helpful in helping divorced parents'post-divorce adjustment, improving parent-child relation and helping future life of divorced parents.

• The Korean Journal of Physiology and Pharmacology
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• 제15권3호
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• pp.179-187
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• 2011

Regulation of B cell receptor (BCR)-induced $Ca^{2+}$ signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature WEHI-231 cells to ${\alpha}$-IgM antibody (0.5~48 hr), the initial transient decrease in BCR-induced $[Ca^{2+}]_i$ was followed by spontaneous recovery to control level within 24 hr. The recovery of $Ca^{2+}$ signaling in WEHI-231 cells was not due to restoration of internalized receptor but instead to an increase in the levels of $PLC{\gamma}2$ and $IP_3R-3$. CD40 co-stimulation of WEHI-231 cells prevented BCR-induced cell cycle arrest and apoptosis, and it strongly inhibited the recovery of BCR-induced $Ca^{2+}$ signaling. CD40 co-stimulation also enhanced BCR internalization and reduced expression of $PLC{\gamma}2$ and $IP_3R-3$. Pre-treatment of WEHI-231 cells with the antioxidant N-acetyl-L-cysteine (NAC) strongly inhibited CD40-mediated prevention of the recovery of $Ca^{2+}$ signaling. In contrast to immature WEHI-231 cells, identical long-term ${\alpha}$-IgM pre-stimulation of mature Bal-17 cells abolished the increase in BCR-induced $[Ca^{2+}]_i$, regardless of CD40 co-stimulation. These results suggest that CD40-mediated signaling prevents antigen-induced cell cycle arrest and apoptosis of immature B cells through inhibition of sustained BCR-induced $Ca^{2+}$ signaling.

• 무역학회지
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• 제48권3호
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• pp.151-176
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• 2023

본 연구는 지역 유통업자의 역할 성과를 자극-유기체-반응(SOR) 모델을 활용하여 비판적으로 검토하며, 시장 경쟁이 유기체(O) 및 반응(R) 요소에 미치는 조절적 영향을 고려한다. 종합적인 접근을 채택한 SOR 모델은 분배, 절차 및 상호 작용 불공정성을 포함한 외부 자극이 지각된 불공정성과 같은 내부 심리적 과정과 상호작용하여 수입업체의 장기 지향성을 형성하는 방식을 분석하는 포괄적인 프레임워크를 제시한다. 연구 수행을 위해 선행연구 검토를 바탕으로 설문지를 구성하였으며 한국 수출입기업을 대상으로 설문을 배포해 총 121부의 유효 표본을 획득하였다. 획득된 표본은 smart pls 3.0을 사용하여 가설을 검정하였다. 분석 결과, 경쟁적인 시장 역동성이 불공정성 인식과 유통업자의 장기 지향성 사이의 관계를 조절하는 것이 나타남으로써 시장 경쟁의 중추적인 역할을 확인하였다. 본 연구는 SOR 모형을 적용함으로써 수출입과 연계된 유통물류 분야의 이론적 지평을 넓혔으며, 외부 자극, 내부 심리적 과정 및 시장 경쟁 간의 상호작용에 대한 종합적인 이해를 제공했다는 점에서 의의를 지닌다.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.8-16
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• 2018

본 논문의 목적은 고속철도 콘크리트 궤도 및 노반 측정 데이터(노반압력, 진동가속도, 탄성변위 등)를 이용하여 토공노반의 장기거동을 분석하고 궤도 노반의 장기성능을 평가하고자 하는데 있다. 최근 고속철도 궤도 형식이 콘크리트 슬래브로 채택되고 있다. 그러나 콘크리트 궤도는 노반 침하에 취약하다. 자갈궤도의 경우 노반이 침하되어도 유지보수로 원상복구가 용이하다. 반면에 콘크리트 궤도의 경우 노반의 과도한 침하가 발생하면 도상 및 침목에 균열이 지속적으로 발생되고 사용성이 크게 저하된다. 이와 같은 이유로 부분보수만으로 원상복구가 어렵다. 본 논문에서는 운영 중 콘크리트 궤도에 대하여 건설 초부터 매설된 센서의 측정 데이터를 개통 후 약 3년까지 모니터링하여 장기성능평가를 수행하였다. 성능평가 방법은 열차별 궤도 토공노반 및 장기 궤도 노반 성능평가, 장기침하에 따른 궤도 노반 성능 영향 분석 및 장기 침하 영향인자 분석 등이다. 열차별 궤도 노반 성능평가에서는 KTX-산천중련의 노반응답이 가장 컸다. 장기 궤도 노반 성능평가 결과는 측정항목이 기준치이내로 측정되었다. 장기침하에 따른 궤도 노반 성능영향 평가는 TCL처짐은 침하와 깊은 연관이 있는 것으로 분석되었다. 장기침하의 외부영향인자 분석을 통해 함수비와 지하수위의 영향성을 확인하였다. 이와같은 방법을 통해 궤도상 토공노반의 안정성을 확보할 수 있을 것으로 사료된다.