• Food Science and Preservation
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• v.24 no.4
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• pp.524-528
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• 2017

Ricinus communis, belongs to the family Euphorbiaceae, has been known as medicinal plants for treatment of inflammation, tumors, antidiabetic, hepatoprotective and laxative. Compared to many pharmacological studies, the effect of R. communis extract on regulating adipogenesis as therapeutic drug for treating obesity has not been reported. R. communis extract (RCE) was investigated to determine its effects on the adipogenesis by monitoring the status of $Wnt/{\beta}-catenin$ signaling and factors involving the differentiation of adipocytes. The differentiation of 3T3-L1 cells monitored by Oil Red O staining was inhibited in concentration dependent manner by RCE. The luciferase activity of HEK 293-TOP cells containing pTOPFlash with Tcf4 response element-luciferase gene was increased approximately 2-folds by the treatment of RCE at concentrations of $100{\mu}g/mL$ compared to the control. Activation of the $Wnt/{\beta}-catenin$ pathway by RCE was further confirmed by immunocytochemical analysis which shows an increment of nuclear localization of ${\beta}-catenin$. In addition, safety of RCE was verified through performing neural stem cell morphology assay. Among the identified flavonoids in RCE, isoquercitrin was the most abundant. Therefore, these results indicate that the adipocyte differentiation was significantly reduced by isoquercitrin in R. communis. In this study, RCE suppresses the adipogenesis of 3T3-L1 cells via the activation of $Wnt/{\beta}-catenin$ signaling.

• Journal of Digital Contents Society
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• v.19 no.7
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• pp.1263-1270
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• 2018

We investigated the e-learning platforms for higher education in developing countries. First, we introduced e-learning environmental factors such as ICT technology as well as ASEAN Cyber University (ACU) project for developing countries. And then, we presented Cambodian case as an example of e-learning platform for developing countries. We analyzed the national education policy and ICT environment as well as the demands and obstacles of e-learning in Cambodia. We derived e-learning strategies and plans based on the analysis results, and finally proposed e-learning platform C-MOOC Net. In order to verify the proposed scheme, we developed prototype of C-MOOC Net system which is implemented based on open software. As a result, we have met the requirement of networking the C-MOOC hub, supporting localization of local language and personalization of favorite courses respectively.

• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.299-304
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• 2006

The aim of this study was to investigate the effect of deformable liposomes with sodium cholate on the skin permeation and skin deposition of arbutin, a hydrophilic skin-whitening agent. Various compositions of liposomes were prepared by the extrusion method. Particle size distribution and entrapment efficiency were determined by the laser light scattering and the gel permeation chromatography, respectively. The in vitro rat skin permeation and deposition of arbutin in various skin layers were investigated using the Keshary-Chien diffusion cells at $37^{\circ}C$. The average particle size of the deformable liposomes ranged from 217.4 to 117.4 nm, depending on the composition. The entrapment efficiency was dependent on surfactant concentration and loading dose of arbutin. The permeation rate of 5% arbutin in deformable liposomes was $8.91({\pm}1.33){\mu}g/cm^2/h$, and was not significantly different from 5% arbutin aqueous solution $[9.82({\m}0.86){\mu}g/cm^2/h]$. The deposition of arbutin was $43.34({\pm}12.13)$ and $16.99({\pm}7.83){\mu}g/cm^2$ in stratum corneum layer and epidermis/dermis layer, respectively, after 12 h of permeation study. These results are consistent with several earlier studies for the localization effect of liposomal formulations in stratum corneum, and demonstrated the feasibility of the deformable liposomes as a promising carrier for the skin deposition of hydrophilic skin-whitening compounds.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.6
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• pp.1-7
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• 2008

FlexRay is a new standard of network communication system which provides a high speed serial communication, time triggered bus and fault tolerant communication between electronic devices for future automotive applications. FlexRay communication controller (CC) is the core of the FlexRay protocol specification. In this paper, we first design the FlexRay CC protocol specification and function parts using SDL (Specification and Description Language). Then, the system is re-designed using Verilog HDL based on the SDL source. The FlexRay CC system was synthesized using Samsung $0.35\;{\mu}m$ technology. It is shown that the designed system can operate in the frequency range above 80 MHz. In addition, to show the validity of the designed FlexRay system the FlexRay system is combined with sound source localization system in Robot applications. The combined system is implemented using ALTERA Excalibur ARM EPXA4F672C3. It is shown that the implemented system operates successfully.

• Molecules and Cells
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• v.38 no.10
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• pp.866-875
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• 2015

COPI vesicles are essential to the retrograde transport of proteins in the early secretory pathway. The COPI coatomer complex consists of seven subunits, termed ${\alpha}-$, ${\beta}-$, ${\beta}^{\prime}-$, ${\gamma}-$, ${\delta}-$, ${\varepsilon}-$, and ${\zeta}$-COP, in yeast and mammals. Plant genomes have homologs of these subunits, but the essentiality of their cellular functions has hampered the functional characterization of the subunit genes in plants. Here we have employed virus-induced gene silencing (VIGS) and dexamethasone (DEX)-inducible RNAi of the COPI subunit genes to study the in vivo functions of the COPI coatomer complex in plants. The ${\beta}^{\prime}-$, ${\gamma}-$, and ${\delta}$-COP subunits localized to the Golgi as GFP-fusion proteins and interacted with each other in the Golgi. Silencing of ${\beta}^{\prime}-$, ${\gamma}-$, and ${\delta}$-COP by VIGS resulted in growth arrest and acute plant death in Nicotiana benthamiana, with the affected leaf cells exhibiting morphological markers of programmed cell death. Depletion of the COPI subunits resulted in disruption of the Golgi structure and accumulation of autolysosome-like structures in earlier stages of gene silencing. In tobacco BY-2 cells, DEX-inducible RNAi of ${\beta}^{\prime}$-COP caused aberrant cell plate formation during cytokinesis. Collectively, these results suggest that COPI vesicles are essential to plant growth and survival by maintaining the Golgi apparatus and modulating cell plate formation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.7C
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• pp.677-684
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• 2002

Today's Internet does not have efficient traffic engineering mechanism to support QoS for the explosive increasing internet traffic such as various multimedia traffic. This functional shortage degrades prominently the quality of service, and makes it difficult to provide multi-media service and real-time service. Various technologies are under developed to solve these problems. IETF (Internet Engineering Task Force) developed the MPLS (Multi-Protocol Label Switching) technology that provides a good capabilities of traffic engineering and is independent layer 2 protocol, so MPLS is expected to be used in the Internet backbone network$\^$[1][2]/. The faults occurring in high-speed network such as MPLS, may cause massive data loss and degrade quality of service. So fast network restoration function is essential requirement. Because MPLS is independent to layer 2 protocol, the fault detection and reporting mechanism for restoration should also be independent to layer 2 protocol. In this paper, we present the experimental results of the MPLS OAM function for the performance monitoring and fault detection 'll'&'ll' notification, localization in MPLS network, based on the OPNET network simulator

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.10a
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• pp.493-496
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• 2011

Currently in the development of community wireless technology is gaining interest in location-based services and as a result, the importance of the location information is a growing trend. To calculate the location information is being suggested several ways, among them Trilateration is representative. Trilateration is three beacon nodes, the distance between the location in which you want to calculate with information. Beacon from a node to know where to get information when the distance between the obstacle and the distance error caused by the surrounding environment, which leads to the exact location can not be obtained. Currently due to distance error, location information has a variety of algorithms to reduce the error. However, a systematic analysis of these algorithms is not progress. This paper analyzes the location-aware technologies, and the error the distance of the location information to reduce errors in the various aspects of the algorithm for the systematic and empirical comparison was evaluated through the analysis.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.295-298
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• 2010

There are three types of survey research system, telephone surveys, online surveys, interviews and so on. Currently most of the survey data have been verified by hand-collecting state in korea. Semi-automated research systems, some companies are using imported from abroad. This paper is the study on the design and implementation of linked research system for global standardization. The system is optimized through customizing for local conditions, as well as professionals for telephone surveys, online surveys, interviews even a normal user can enter the questionnaire easily and quickly. The result data is passed to the customer quickly and accurately. In particular, this system is based on automatic data input and collected provides best efficient analysis and statistics. Office programs and advanced statistical program SPSS is compatible with the maximum benefits for proposed system. Additionally, to achieve the import substitution effect through localization and to propose a global standard the proposed system is designed and implemented.

• Journal of the military operations research society of Korea
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• v.33 no.1
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• pp.135-155
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• 2007

A performance specification states requirements in terms of the required results, such as performance, environment and interchangeability, but without stating the methods for achieving the required results, such as material and process. therefore the performance specification is applied to attain economic efficiency and high reliability by using the advanced commercial Technology for the weapon systems and The development of performance specification and conversion into performance specification have been activated in the advanced nations. The Ministry of National Defence of Korea has regulated the specification to make performance type in developing specification and prepared performance specification guide. but the result of the development of and conversion into performance specification is very unsatisfactory, To efficiently develop and convert into performance specification, this study gives the way of market research, the creation of the performance specification from development of weapon system and part localization, the process and method for conversion of detail specification into performance specification, the use of hybrid type of performance and detail specification.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.3
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• pp.381-386
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• 2008

Virtual 3D audio methods that create 3D sound effects are researched highly for multimedia devices using 2 speakers or headphone. The most typical method to create 3D effects is a technology through use of head related transfer function (HRTF) which contains the information that sound arrives from a sound source to the ears of the listener. But it can decline some 3D effects by cone of confusion between front and back directions due to the non-individual HRTF depending on each listener. In this paper, we propose a new method to use psychoacoustic theory that creates realistic 3D audio. In order to improve 3D sound, we calculate the excitation energy of each symmetric HRTF and extract the ratio of energy of each bark range. Informal listening tests show that the proposed method improves the front-bach sound localization characteristics much better than the conventional methods.