• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.3
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• pp.185-199
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• 2003

Objectives : The purpose of this clinical report was to estimate the efficacy of Lizhongtang plus Baidusan(理中湯合敗毒散) on allergic rhinitis. Methods : We prescribed Lizhongtang plus Baidusan(理中湯合敗毒散) for 15 patients who visited Kabsan oriental clinic with allergic rhinitis. We inquired into distribution of age, case history period, improvement of symptoms, etc. We used the statistical methods of student t-test in order to analysis of the different of symptom before and after treatment(p 〈0.05). Results : 1. The distribution of sex & age was as follows; Total patient were women. 10-19 years 2 cases, , 30-39 years 5 cases, 40-49 years 6 cases and 50-59 years 2 cases. 2. The case of history period was as follows; under a year 1 case, 1-3 years 3 cases, 3-5 years 2 cases, 5-10 years 4 cases and over 10 years 5 cases. 3. The amount of herbal medicine they took as follows: 1 je(劑) 1 case, 2 je(劑) 7 cases, 3 je(劑) 5 cases and 4 je(劑) 2 cases. 4. The frequency of acupuncture and moxibustion was as follows; under 5 times 1 case, 6-10 times 10 cases, 11-15 times 3 cases, over 16 times 1 case. 5. The nasal symptoms except the nasal mucosa color(pale) were improved significantly after treatment(p 〈0.05). 6 The general symptoms except menstruation pain were improved significantly after treatment(p 〈0.05). 7. The curative influence of rhinitis by Lizhongtang plus Baidusan(理中湯合敗毒散) was as follows excellent 2 cases. good 11 cases, ineffectiveness 2 cases. Conclusion: If we administer Lizhongtang plus Baidusan(理中湯合敗毒散) to allergic rhinitis patients with cold in the Zhong Jiao of deficiency type (中焦虛寒), it improves not only allergic symptoms such as the watery rhinorrhea, turbinate swelling, sneeze, nasal obstruction, etc but also coldness of the limbs(手足冷症), dyspepsia, dysmenorrhea, etc. Therefore, we consider that administration of Lizhongtang plus Baidusan(理中湯合敗毒散) to allergic rhinitis patients with cold in the Zhong Jiao of deficiency type (中焦虛寒) improves in quality of life, as removes inconvenience of life and stress.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.2
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• pp.72-80
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• 2004

Background and Objectives: Recently the incidence of allergic rhinitis has increased but treatment in most cases has only dealt with the symptoms. Medicine has been developed that shows fewer side effects. However, some side effects and the psychological stress over taking medicine have remained. There have been no studies so far performed on the effect of Lizhongtang plus Baidusan Extract. This study aimed to find out the therapeutic effects of its exclusive use in rats with Allergic Rhinitis. Materials and Methods : Thirty Sprague-Dawley rats were divided into three groups: the control group, the cetirizine HCI group and the sample group. To induce allergic rhinitis in the control group, the cetirizine HCI group and the sample group, rats were sensitized intraperitoneally with 0.1$\%$ ovalumin solution 3 times at an interval of I week. Then intranasal sensitization was performed by diffusing 0.1$\%$ ovalumin solution 3 times at an interval of 2 days. After that time, rats of the cetirizine HCI group were orally administered with cetirizine HCI. Rats of the sample group were treated with Lizhongtang plus Baidusan Ex. for 28 days. We observed changes in nasal mucosa and submucosa. Also we found changes in the segment of neutrophil and lympocyte in Leukocyte. We used the statistical methods of ANOVA test(p 〈0.05). Results: The loss of the cilium and the secretion of mucus in the treated group was rare when compared to control group. Effects of Lizhongtang plus Baidusan Ex. on the liver function were also studied in rats. Treatment of Lizhongtang plus Baidusan Ex. did not affect AST and ALT. The segment of neutrophil was significantly increased in the treated group when compared with the control group and the cetirizine HCI group(p 〈0.05). The segment of lympocyte was significantly decreased in the treated group when compared with the control group and the cetirizine HCI group(p 〈0.05). Conclusion: This study shows that Lizhongtang plus Baidusan Ex. decreases the inflammatory response in rats with Allergic Rhinitis.