• Journal of The Korean Dental Society of Anesthesiology
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• v.14 no.2
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• pp.101-106
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• 2014

Background: Remifentanil, an ultra-short-acting mu-opioid receptor agonist, is unique from other opioids because of its esterase-based metabolism, minimal accumulation, and very rapid onset and offset of clinical action. Remifentanil can prevent the inflammatory response and can suppress inducible nitric oxide synthase expression in a septic mouse model. However, the effects of remifentanil on human keratinocyte and autophagy have yet to be fully elucidated during hypoxia-reoxygenation. Here we investigated whether remifentanil confers protective effect against hypoxia-reoxygenation in human keratinocyte and, if so, whether autophagy mediates this effect. Methods: The human keratinocytes were cultured under 1% oxygen tension. The cells were gassed with 94% $N_2$, and 5% $CO_2$ and incubated for 24 h at $37^{\circ}C$. To determine whether the administration of affects human keratinocytes hypoxia-reoxygenation injury, cells were then exposed to various concentrations of remifentanil (0.01, 0.1, 0.5 and 1 ng/ml) for 2 h. After remifentanil treatment, to simulate reoxygenation and recovery, the cells were reoxygenated for 12 h at $37^{\circ}C$. Control group did not receive remifentanil treatment. Normoxia group did not receive hypoxia and remifentanil treatment for 36 h. 3-MA group was treated 3-methyladenine (3-MA) for 1h before remifentanil treatment. Cell viability was measured using a quantitative colorimetric assay with MTT, showing the mitochondrial activity of living cells. Cells were stained with fluorescence and analyzed with Western blot analysis to find out any relations with activation of autophagy. Results: Prominent accumulation of autophagic specific staining MDC was observed around the nuclei in RPT group HaCaT cells. Similarly, AO staining, red fluorescent spots appeared in RPT group HaCaT cells, while the Normoxia, control and 3-MA groups showed mainly green cytoplasmic fluorescence. We here examined activation of autophagy related protein under H/R-induced cells by Western blotting analysis. Atg5, Beclin-1, LC3-II (microtubule-associated protein 1 light chain 3 form II) and p62 was elevated in RPT group cells. But they were decreased when autophagy was suppressed by 3-MA (Fig. 5). Conclusions: Although the findings of this study are limited to an in vitro interpretation, we suggest that remifentanil may have a beneficial effect in the recovery of wound from hypoxia-reoxygenation injury.

• Journal of the Korean Society of School Health
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• v.9 no.1
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• pp.99-108
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• 1996

The purpose of the survey was to identify the degree and the relationship of sexual knowledge, sexual attitude and need of sex education. This information will provide useful data for a more systematic. desirable, and practical sex education. The data was collected from 300 first grade schoolchildren (150 boys and 150 girls) of two Junior high school in K city. The data was gathered by questionnaire from Nov.21 to 28, 1995. The questionnaire was modified by authors using the questionnaire developed by Lief & Reed. Data was analyzed by using the statistical computer package, SAS to manipulate the data along with percentages, means, standard deviation, t-test, $X^2$-test, GLM, and Pearson correlation coeffiency. The results in this study were summarized as follows: 1. Sexual knowledge. - The mean score of sexual knowledges showed no significant differences between boys and girls(p<0.6180), but in the areas of biological differences(boys; $11.57{\pm}2.43$, girls; $10.93{\pm}2.41$, p<0.0242), and pregnancy physiology(boys; $9.28{\pm}1.87$, girls; $10.04{\pm}2.42$, p<0.0026) showed significant difference between boys and girls. 2. Sexual attitudes. - The mean score of sexual attitudes showed no significant difference between boys and girls (p<0.8286), but in the areas of masturbation (boys : $6.69{\pm}2.22$, girls : $5.65{\pm}1.88$, p<0.0001), and premarital intercourse (boys : $5,42{\pm}1.35$, girls : $6.00{\pm}1.33$, p<0.0002) showed significant difference between boys and girls 3. Need of sex education. - The majority of the subjects wanted to learn about sexual delinquency and it's prevention(57.7%), form a friendship with the other sex(56.3%), physical differences of the other sex(52.0%), psychological differences and the charateriatics of the other sex (50.3%) and meaning of love(50.3%). 4. The relationships between sexual knowledges and sexual attitudes. - Those who had higher sexual knowledges showed more positive attitudes towards sex, and showed statistical significance(r=0.2074, p<0.0003). 5. The relationships between general charateristics and sexual knowledge. - Better students(by self-perception of school performance) had higher knowledge scores about sex. 6. The relationships between general charateristics and sexual attitudes. - Those who wanted to learn more about sex, and better students had higher attitude scores about sex. - Those who were in high standard of living had higher attitude scores about sex as well. Suggestions based on above study are as follows' 1. The planned sex education showed be performed to the schoolchildren establish responsible attitudes about sex. 2. Systematic sex education through formal school education according to age is recommended. 3. Further studies should be done to measure the effect of sex education based on the needs of the schoolchildren.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.208-216
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• 2019

Rural houses are losing their original shape as they mimic the spatial composition of urban houses. Therefore, the purpose of this study was to extract the design elements needed for rural housing by applying Christopher Alexander's "A PATTERN LANGUAGE" to Standard Rural-House Design (SRHD). The scope and method of research was to compare and analyze the standard designs (SD) produced and distributed by the 'Korea Rural Community Corporation' from 2009 to 2014. The research result is summarized as follows. 1) The housing layout in the SD ignored the site conditions of various rural areas. 2) Most of the houses were not actively planned, considering that they contain various activities of rural life. 3) There was no room for children and the kitchen was planned to integrate the interior into a flexible space in the form of L.D.K. 4) There was no space plan that could be used as both a leasable annex and office space for the farming community. 5) Many small area plans were made because of the SD plan for couples only in 2014. Although the rural environment and living patterns were ignored in the SD, the diverse pattern language provided by the pattern language was developed as a SD element for rural houses, which is the most suitable housing plan for the farmers' livelihood pattern.

• Therapeutic Science for Rehabilitation
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• v.8 no.1
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• pp.7-25
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• 2019

Objective: The purpose of this study was to perform a systematic literature review focusing on international studies to identify various factors affecting the quality of life(QOL) of dementia patients admitted to long-term care facilities. Methods: From January 2000 to July 2018, the articles published in foreign journals were searched through CINAHL and MEDLINE databases. The main search terms were'dementia or Alzheimer's'. 'quality of life', 'long-term care', 'care home', 'nursing home', 'care institution', 'residential care', 'small- scale setting'. The first 1706 articles were searched, but 10 studies were selected using the selection and exclusion criteria. Results: Analysis of ten cross-sectional studies showed that factors such as physical functioning status, ability to perform activities of daily living, and cognition showed a positive correlation with QOL. Depression and anxiety, severity of dementia, and neuropsychiatric symptoms were found to be negatively correlated with QOL. In addition, two longitudinal studies have confirmed that factors affecting QOL are affected by individual functional status and social environmental factors rather than the size and form of care facilities. Conclusion: This study summarized 10 papers and analyzed them through a systematic review of literature. We found that factors such as individual characteristics and social environment determine QOL of patients with dementia. In this study, various intervention methods to improve QOL of patients with dementia should be developed and used in long-term care facilities by identifying the factors affecting QOL of dementia patients and using them.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.2
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• pp.15-25
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• 2018

Objective : The purpose of this study was to examine the differences between motor functions and executive functions according to the timing of children with attention deficit hyperactivity disorder (ADHD). Methods : The subjects were 32 children with ADHD aged between 6 and 12 living Busan. To assess the timing, Long Form Assessment (LFA) of Interactive Metronome (IM) was used. Bruininks-Oseretsky of Motor Proficiency, Second Edition (BOT-2) were also used to assess motor functions. STROOP Color and Word Test and Children's Color Trails Test were used to evaluate executive functions. Mann-Whitney U tests were used to determine the differences between the executive functions and the motor functions according to the timing. Results : Comparing the inter-group motor functions according to the timing, there was a statistically significant difference in the Fine manual control and Fine motor precision in BOT-2 (p<.05). Comparing the inter-group executive functions according to the timing, there was not statistically significant difference (p>.05). Conclusion : Among the deficits in ADHD children, we could see the differences between motor function and executive function according to timing function. This study would be meaningful in that the results could be a basic data for study on the timing of children of ADHD in the future.

• The Korean Journal of Archival Studies
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• no.33
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• pp.39-84
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• 2012

Maul is a rural community with common culture and self-government system and generally consists of tens of houses living together in Korea. Maul is different from a village in the West. Maul archive is a community archive of a maul. It is not only the space to record the life of residents, history and culture of a maul but also the space to realize democracy by the participation of maul residents and to satisfy the cultural life of current residents. Nowadays, it is very important to establish maul archives to connect mauls and to communicate with the outside world, to reinforce the orignal form in maul culture and revive the alienated maul culture. To establish the maul archives, it is necessary to draw the recognition and continuous interest of the central and local government and scientifical study of scholars. The first step to found maul archives is to organize a committee. Then the committee will benchmark the preceding practices, collect, record and manage the maul archives. The maul archives is recommended to be housed in an existent traditional house with some remodeling for spaces of display and education, preservation and management. I believe that the maul archive is culturally meaningful for the resident. They will enjoy and develop their lives better, connected to outside world. The co-operation of the scholar, the resident, and the government will foster the maul archive to a success.

• PNF and Movement
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• v.16 no.3
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• pp.485-493
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• 2018

Purpose: This study provides a treatment for central nervous system development in patients with chronic stroke by investigating changes in the upper limb function over time. The correlations among the activities, participation, and environmental factors of the international classification of functioning (ICF), disability and health are also examined. Methods: The subjects of this study are 18 patients with chronic stroke who were hospitalized and treated at 00 hospital in the Chungcheongbuk-do province. Their upper extremity functions are evaluated using the manual function test (MFT). The activities, participation, and environmental factors are evaluated using the ICF generic form. The correlations between the total scores of the affected and unaffected sides and the ICF items are analyzed using the Pearson correlation analysis. The significance level is p<0.05. Results: When the correlations between the activities and participation areas of ICF and the total score of the affected side of MFT were examined, significant correlations (p<0.05) were found in the following items: changing basic body position (D410), lifting and carrying objects (D430), moving around using equipment (D465), using transportation (D470), washing oneself (D510), caring for body parts (D520), and dressing (D540). When the correlations between the activities and participation areas of ICF and the total score of the unaffected side of MFT were examined, significant correlations (p<0.05) were found among writing (D170), speaking (D330), eating (D550), and drinking (D560). In addition, when the correlation between the environment area of ICF and the total score of the unaffected side of the MFT were examined, significant correlations (p<0.05) were found between products and technology for personal use in daily living (E115) and immediate family (E310). Conclusion: The MFT of patients with chronic stroke is closely correlated with the activities, participation, and environmental factors of ICF. This result suggests that ICF can be used as a useful tool to comprehensively evaluate the abilities of the patient, including the upper extremity function.

• Journal of The Korean Association For Science Education
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• v.39 no.1
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• pp.89-99
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• 2019

The purpose of this study is to investigate the effect of students' formation of evolutionary concept and learning on the development of digital teaching materials. The explanation of biological evolution, which explains the changes that living organisms undergo over a long period of time, can provide various contents for use in a book. The production and editing of images in digital textbooks would provide explanation of difficult concepts in a fun way. For this study, we designed instructional materials consisting of four class hours using iBooks Author, an electronic book authoring tool based on the 5E learning cycle model. In order to verify the effectiveness of the developed digital textbooks, we compared instructions by the general textbooks to those using digital textbooks. Both teaching through general textbook form and teaching using digital textbook materials had a significant effect on the formation of the concept of evolution, but interest in biological science and evolution increased significantly only in the group taught using digital textbooks. As a result of testing the instruction effect by the digital textbooks by classifying the students by type, the group that is familiar with smart devices was more active and interesting in class depending on digital literacy. The satisfaction of the developed digital textbooks also showed a positive score in the group with high digital literacy. The results of this study suggest that the development of digital textbooks in the unit of evolution can be an instructional material for easy and interesting approach to difficult concepts in the teaching of evolution.

• (The)Study of the Eastern Classic
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• no.72
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• pp.217-264
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• 2018

The purpose of this research is to understand the view on people(百姓) and Lee Won-ik(李元翼)'s view on politics, comparing with Seonjo(宣祖)'s view on them. They as political actors sufficiently cognized the condition of life of people had been very desperate. Seonjo had approached from politics to the life of people, while Lee from the life of people to politics. The former has the precariousness of transformation and instrumentalisation of the life of people. The latter has the possibility of the life of people to lead the politics. Lee's stance was on the latter aspect. He had tried to conceive the people as they are, in other words as reality, not as they should be, in other words as idea. He refrained the elucidation of people from confining it within dichotomy structure of ruling-ruled. He had tried to conceive the organic relationship between people and other existences within community. He did not give knowledge-centered question of what is the life of people, but gave situation-phenomenon-centered question of how people has been living. This approach eulciates Lee's focus on the problems of Gongyi(工役), military service(軍役), Labour service(?役), the reduction and exemption of the tax, and the appointment of provincial officer(守令). As for Lee Won-ik, the best form of life of people is to make people have mind to deserve to live, to economize their power(寬民力), to make them savor their life(樂民生), and to make their life easy(安民).

• (The)Study of the Eastern Classic
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• no.48
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• pp.289-310
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• 2012

The present study analyzes the content of "Suojaegi (The Account of the Suo Residence)," an essay written by the Joseon-dynasty scholar Jeong Yak-yong (丁若鏞, 1762-1836). The study identifies the work's characteristic features and significance, seeking to develop a methodology to use this essay to teach students how to write. In terms of its content, the author of "Suojaegi" asserts what it means to "protect one's self-integrity" as the word "Suo" means in the title of the residence where the author's brother Jeong Yak-hyeon(丁若鉉) lived. According to the author, his elder brother could keep on living in his house, without being sent to exile in the political turmoils, because he preserved his sense of self and adhered to his principles. The originality of the essay is attributed to the use of gi (記), a genre of writing in classical Chinese that can be translated as "record," or "account," to express his thoughts in a place of exile in the form of a dialogue with his own self. Lastly, this self-reflective essay can be served as a guide for teaching students to make their own pen names, and to write a letter of self-introduction.