• 한국조경학회지
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• 제32권6호
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• pp.82-94
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• 2005

This study was undertaken to measure and analyze the thermal environment characteristics of the grey permeable cement concrete pavement(GPCCP), the permeable cement concrete brick pavement(PCCBP) compared with impermeable cement concrete pavement(ICCP) and bare soil(BS) under the summer outdoor environment. Following is a summary of major results. 1) The peak surface temperature was greatest in the GPCCP$(54.2^{\circ}C)$ followed by ICCP$(47.2^{\circ}C)$ rut August 2, 2002, the hottest day$(35.3^{\circ}C\;of\;highest\;temperature)$ during the experiment; peak temperature in the ICCP and BS were $45.5^{\circ}C)$ and $45.3^{\circ}C)$ respectively. 2) Analysis of heat budget of the pavements has revealed that the heat environment was worse in the GPCCP than that in the ICCP and that this was mainly due to a low albedo in the former(0.2) relative to that of the latter(0.4). 3) Analysis of heat budget of the pavements has revealed that the heat environment was worse in the GPCCP than that in the PCCBP, BS and that this was mainly due to a decreased latent heat resulting from a time dependent decreasing impact of rainfall. 4) It is necessary to make cool pavements to further studies on light-colored surface materials for attaining high albdo and construction methods which can enhance the latent heat through the continuous evaporation from pavements surface. 5) Vertical arrangement of pavement layers has not been considered in the present study, which has been focuses on the heat characteristics of the surface layer materials. Accordingly, future studies will have to be empasized on pavement methods including the vertical arrangement of the pavement layers.

• Journal of Microbiology and Biotechnology
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• 제26권7호
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• pp.1198-1205
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• 2016

Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heat-killed W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.

• 한국항행학회논문지
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• 제2권2호
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• pp.132-142
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• 1998

스케줄링 문제는 응용 영역에 따라 각기 다른 작업과 차원을 가지며, 이들간에 여러 가지 제약 조건이 존재한다. 이러한 문제에 인공지능 기법을 이용하여 문제를 효율적으로 해결할 수 있다. 그러나, 동적으로 변하는 상황에서 모든 제약조건을 만족하는 최적해를 구할 수 없는 경우, 부분적으로 만족하는 해를 구하기 위해 제약 조건들은 수정 또는 추가되어야 하며, 때로는 고려 대상에서 제외되어야 한다. 부분적으로 만족하는 해를 구하기 위해, 수정되어야 할 적절한 제약 조건을 스케줄링 시스템이 자동으로 선택하기에는 많은 문제가 있다. 이러한 문제를 해결하기 위해, 본 논문에서는 부분적으로 만족하는 해를 구해야 하는 경우, 제약 조건 완화를 위해 사용자와 상호 작용하며 사용자의 의견을 제약 조건에 반영하는 지능형 사용자 인터페이스(Intelligent User Interface)의 모델을 설계하고 구현하였다. 김포공항의 운항 스케줄 데이터를 사용한 실험에서 제약 조건을 모두 적용하여 이를 만족하는 해를 구하지 못한 경우, 사용자의 의견이 반영된 제약 조건완화를 통해 검색 도메인의 증가와 제약 조건을 부분적으로 만족하는 해를 구할 수 있었다.

• Journal of Information Display
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• 제9권4호
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• pp.21-29
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• 2008

We studied both the wavelength and intensity dependent photo-responses (photofield-effect) in amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs). During the a-IGZO TFT illumination with the wavelength range from $460\sim660$ nm (visible range), the off-state drain current $(I_{DS_off})$ only slightly increased while a large increase was observed for the wavelength below 400 nm. The observed results are consistent with the optical gap of $\sim$3.05eV extracted from the absorption measurement. The a-IGZO TFT properties under monochromatic illumination ($\lambda$=420nm) with different intensity was also investigated and $I_{DS_off}$ was found to increase with the light intensity. Throughout the study, the field-effect mobility $(\mu_{eff})$ is almost unchanged. But due to photo-generated charge trapping, a negative threshold voltage $(V_{th})$ shift is observed. The mathematical analysis of the photofield-effect suggests that a highly efficient UV photocurrent conversion process in TFT off-region takes place. Finally, a-IGZO mid-gap density-of-states (DOS) was extracted and is more than an order of magnitude lower than reported value for hydrogenated amorphous silicon (a-Si:H), which can explain a good switching properties observed for a-IGZO TFTs.

• 대한수의학회지
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• 제57권2호
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• pp.97-104
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• 2017

Solanum lycopersicum, commonly known as tomato, is widely used in raw, cooked, or liquid forms because it contains nutritional compounds that are beneficial for human health, including carotenoids, lycopene, ascorbic acid, vitamins, and minerals. The tomato is perhaps the most widely studied fruit, especially with respect to its cardioprotective effects. In this study, we aimed to identify the anti-inflammatory mechanisms by which the tomato elicits its anti-inflammatory properties. We treated murine macrophage RAW 264.7 cells with a tomato ethanol extract and performed various biochemical assays including nitric oxide inhibition, cell viability, RNA extraction, expression of pro-inflammatory mediators and cytokines, and immunoblotting, as well we assessed cell survival rates. Our results have shown for the first time that a tomato ethanol extract treatment can suppress nitric oxide production in a dose-dependent manner without cytotoxicity. Moreover, it inhibits the expression of pro-inflammatory mediators and cytokines and elicits its anti-inflammatory effects via the nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$) and mitogen-activated protein kinase (MAPK) pathways. In addition, administration of tomato syrup potently rescued mice from septic shock induced by lipopolysaccharide injection. Collectively, our results elucidate details regarding the anti-inflammatory mechanisms of tomato.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.101-101
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• 2018

Resveratrol is a polyphenolic compound, which is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. Although several studies have demonstrated that resveratrol possesses anti-cancer activity against various types of human cancer, the molecular mechanisms of resveratrol-mediated overcome drug resistance potential are unclear. In this study, we determined whether resveratrol attenuates drug resistance responses in 5-fluorouracil-resistant colon cancer (SNUC5/5-FUR) cells. Treatment with resveratrol significantly enhanced apoptosis in a concentration-dependent manner, which was associated with the modulation of anti- and/or pro-apoptotic protein expression, activation of caspases and activation of AMP-activated protein kinase. Resveratrol treatment also increased the induction of autophagy through up-regulation of autophagy-related genes such as Microtubule-associated protein 1A/1B-light chain 3, P62 and beclin-1. However, blocking of autophagy by bafilomycin A1 reduced apoptotic cell death, suggesting that resveratrol-induced autophagy functions as a cell death mechanism in SNUC5/5-FU cells. Although the further studies are needed, these findings suggest that resveratrol may have therapeutic potential to overcome drug resistance in colon cancer patients.

• 한국항만경제학회지
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• 제34권1호
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• pp.99-110
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• 2018

본 연구는 해운기업의 주요 비용요인 벙커 가격과 환율의 불확실성으로 인한 재무적 리스크를 수치화하는 방법론을 2010년 1월 1일부터 2018년 1월 31일까지의 일별자료를 대상으로 적용한다. 기하브라운 운동 (Geometric Brownian Motion 이하 GBM)과 이를 확장한 조건부 이분산성(heteroskedasticity) 및 점프 확산 프로세스(jump diffusion process)에 의존하는 모형으로부터 추정한 현금 흐름 리스크 추정치는 다음 세 가지 학술적 기여로 요약할 수 있다. 첫째, 운임수익률과 같은 단일 변수에 의존한 리스크 분석을 벙커가격과 환율 수익률 변동성과 같이 복합요인으로부터 발생하는 영향으로 분석을 확장하였다. 둘째, 개별기업 수준에서 벙커가격과 환율 리크스 관리의 필요성을 민감도 분석을 통해 현금흐름수준으로 제시하였다. 마지막으로 분석결과가 제시하는 리스크 규모를 근거로 해운기업은 리스크 관리를 위한 수단으로 무엇이 적절한가를 고민해야 할 필요성이 있음을 제기한다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제17권4호
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• pp.483-491
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• 2017

The interdigitated germanium (Ge) meta-lsemiconductor-metal (MSM) photodetectors (PDs) with and without an $SiO_2$ anti-reflection (AR) layer was fabricated, and the effect of $SiO_2$ AR layer on their optoelectronic response properties were investigated in detail. The lowest reflectance of 15.6% at the wavelength of 1550 nm was obtained with a $SiO_2$ AR layer with a thickness of 260 nm, which was in a good agreement with theoretically calculated film thickness for minimizing the reflection of Ge surface. The Ge MSM PD with 260 nm-thick $SiO_2$ AR layer exhibited enhanced device performance with the maximum values of responsivity of 0.65 A/W, the quantum efficiency of 52.2%, and the detectivity of $2.49{\times}10^9cm\;Hz^{0.5}W^{-1}$ under the light illumination with a wavelength of 1550 nm. Moreover, time-dependent switching analysis of Ge MSM PD with 260 nm- thick $SiO_2$ AR layer showed highest on/off ratio with excellent stability and reproducibility. All this investigation implies that 260 nm-thick $SiO_2$ AR layer, which is effective in the reduction in the reflection of Ge surface, has a great potential for Ge based optoelectronic devices.

• Advances in Traditional Medicine
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• 제6권4호
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• pp.274-285
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• 2006

Allium sativum (Family Amaryllidaceae or Liliaceae) is used worldwide for various clinical uses like hypertension, cholesterol lowering effect, antiplatelets and fibrinolytic activity etc. Due to these common house hold uses of Allium sativum, as a herbal supplements, and failure of patients to inform their physician of the over-the-counter supplements they consume leads to drugnutrient interactions with components in herbal supplements. Today these types of interactions between a herbal supplement and clinically prescribed drugs are an increasing concern. In vitro studies indicated that garlic constituents modulated various CYP (cytochrome P450) enzymes. CYP 3A4 is abundantly present in human liver and small intestine and contributes to the metabolism of more than 50% of commonly used drugs including nifedipine, cyclosporine, erythromycin, midazolam, alprazolam, and triazolam. Extracts from fresh and aged garlic inhibited CYP 3A4 in human liver microsomes. The in vivo effects of garlic constituents are found to be species depended and the dosing regimen of garlic constituents appeared to influence the modulation of various CYP isoforms. Studies have indicated that the inhibition of various CYPs by organosulfur compounds from garlic was related to their structure also. Studies using in vitro, in vivo, animal and human models have indicated that various garlic constituents can be the substrates, inhibitors and or inducers of various CYP enzymes. The modulation of CYP enzyme activity and expression are dependent on the type and chemical structure of garlic constituents, dose regime, animal species and tissue, and source of garlic thus this review throws light on the possible herb drug interaction with the use of garlic.

• 한국수소및신에너지학회논문집
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• 제18권4호
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• pp.452-457
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• 2007

Titanium foil and mesh(anodized tubular $TiO_2$ electrode, ATTE) were anodized in a bath at $5^{\circ}C$ with 20V external bias applied, then annealed at different temperatures($450^{\circ}C{\sim}850^{\circ}C$) to obtain tubular $TiO_2$ on the Ti substrate. The prepared sample was used to investigate rate of hydrogen production as well as Cr(VI) reduction. The ATTEs annealed at relatively lower temperatures showed higher activity than those at relatively higher temperatures. In particular, the Cr(VI) reduction was pH-dependent. To improve photocatalytic Cr(VI) reduction with the ATTEs, two configurations, fixing foil type and rotating mesh type, were also compared. As a result, the rotating mesh type was much more effective for Cr(VI) reaction than the former due to the more efficient use of the light. In the rotating type reactor, as the rotating speed increased, the rate of the Cr(VI) reduction was getting faster.