• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.7
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• pp.915-922
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• 2004

A stent is small tube-like structure expanded into stenotic arteries to restore blood flow. The stent expansion behaviors define the effectiveness of the surgical operation. In this paper, finite-element method was employed to analyze expansion behaviors and fatigue life of a typical diamond-shaped balloon-expandable stent. Beyond safety considerations, this type of analysis provides mechanical properties that are often difficult to obtain by experiments. Mechanical properties of the stent expansion pressure, radial recoil, longitudinal recoil and foreshortening were simulated using commercial FEM code, ANSYS and fatigue life were estimated using NISAII ENDURE. The FEM results showed that the pressures necessary to expand the stent up to a diameter of 3mm, 4mm and 5mm were 0.75MPa, 0.82MPa and 0.97MPa. The fatigue lifes according to expansion diameter were 114${\times}$10$^{7}$cycles, 714${\times}$$^{6}$cycles and 163${\times}$10$^{6}$cycles. As a result, a finite element model used in this study can simulate expansion behaviors of stents and should be useful to design new stents or analyze actual stents.

• Journal of Korean Society of Rural Planning
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• v.10 no.3 s.24
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• pp.41-51
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• 2004

This study aims to develop a potential evaluation method for urban spatial expansion using remote sensing (RS) and geographic information system (GIS). A multi-criteria evaluation method with several criteria and their weighting values was introduced to evaluate the score and quantification of the potential surface around the existing cities. The six criteria with one geographic factor, slope, and five accessibility factors, time distance from center of the city, national road, interchange of expressway, a big city, and station, were defined for the potential. RS techniques were applied for classification of the actual urban expansion maps between two periods, and GIS functions were used for score of accessibility criteria with a distance decay function from geographic, road and several point maps, which was developed in this study. The new methodology was applied to a test area, Suwon, between 1986 and 1996. In order to optimize the six weighting values, this study made new findings to search the optimal combination of the weighting values from new methodology, weighted scenario method for intensity order (WSM), combined with intensity order and AHP method, including a trial and error method for sensitivity analysis to make the intensity order. The optimal combination of the weighting values by the new method generated the optimal potential surface, considering spatial trend of urban expansion in the test area.

• Molecules and Cells
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• v.38 no.10
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• pp.918-924
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• 2015

During T cell activation, mitochondrial content increases to meet the high energy demand of rapid cell proliferation. With this increase, the level of reactive oxygen species (ROS) also increases and causes the rapid apoptotic death of activated cells, thereby facilitating T cell homeostasis. Nicotinamide (NAM) has previously been shown to enhance mitochondria quality and extend the replicative life span of human fibroblasts. In this study, we examined the effect of NAM on $CD8^+$ T cell activation. NAM treatment attenuated the increase of mitochondrial content and ROS in T cells activated by CD3/CD28 antibodies. This was accompanied by an accelerated and higher-level clonal expansion resulting from attenuated apoptotic death but not increased division of the activated cells. Attenuation of ROS-triggered pro-apoptotic events and upregulation of Bcl-2 expression appeared to be involved. Although cells activated in the presence of NAM exhibited compromised cytokine gene expression, our results suggest a means to augment the size of T cell expansion during activation without consuming their limited replicative potential.

• International Journal of Highway Engineering
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• v.20 no.3
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• pp.65-73
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• 2018

PURPOSES : In this study, the propriety of expansion joint spacing of airport concrete pavement was examined by using weather and material characteristics. METHODS : A finite element model for simulating airport concrete pavement was developed and blowup occurrence due to temperature increase was analyzed. The critical temperature causing the expansion of concrete slab and blow up at the expansion joint was calculated according to the initial vertical displacement at the joint. The amount of expansion that can occur in the concrete slab for 20 years of design life was calculated by summing the expansion and contraction by temperature, alkali-silica reaction, and drying shrinkage. The effective expansion of pavement section between adjacent expansion joints was calculated by subtracting the effective width of expansion joint from the summation of the expansion of the pavement section. The temperature change causing the effective expansion of pavement section was also calculated. The effective expansion equivalent temperature change was compared to the critical temperature, which causes the blowup, according to expansion joint spacing to verify the propriety of expansion joint applied to the airport concrete pavement. RESULTS : When an initial vertical displacement of the expansion joint was 3mm or less, the blowup never occurred for 300m of joint spacing which is used in Korean airports currently. But, there was a risk of blow-up when an initial vertical displacement of the expansion joint was 5mm or more due to the weather or material characteristics. CONCLUSIONS : It was confirmed that the intial vertical displacement at the expansion joint could be managed below 3mm from the previous research results. Accordingly it was concluded that the 300m of current expansion joint spacing of Korean airports could be used without blowup by controling the alkali-silica reaction below its allowable limit.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.8
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• pp.1615-1622
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• 2002

The purpose of this study is comparing cold expansion method with interference fit. Cold expansion method and interference fit of fastener hole is using in the aerospace industry. These treatment lead to an improvement of fatigue life to the compressive residual stresses developed on the hole surface. But Research is nothing to about difference effect of between cold expansion method and interference fit. So, this paper, it is shown that Comparing cold expansion method with interference fit using the finite element method. It is further shown that residual stress distribution according to plate thickness and clamping force.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.419-424
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• 2001

The purpose of this study is comparing cold expansion method with interference fit. Cold expansion method and interference fit of fastener hole is using in the aerospace industry. These treatment lead to an improvement of fatigue life to the compressive residual stresses developed on the hole surface. But Research is nothing to about difference effect of between cold expansion method and interference fit. So In this paper, It is shown that Comparing cold expansion method with interference fit. and It is further shown that residual stress distribution according to plate thickness.

• Journal of Animal Reproduction and Biotechnology
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• v.34 no.2
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• pp.86-92
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• 2019

The aim of this study was to investigate effects of hyaluronidase during IVM on oocyte maturation, oxidative stress status, expression of cumulus expansion-related (PTX, pentraxin; GJA1, gap junction protein alpha 1; PTGS2, prostaglandin-endoperoxide synthase 2) and fatty acid metabolism-related (FADS1, delta-6 desaturase; FADS2, delta-5 desaturase; PPARα, peroxisome proliferator-activated receptor-alpha) mRNA, and embryonic development of porcine oocytes. The cumulus-oocyte complexes (COCs) were incubated with 0.1 mg/mL hyaluronidase for 44 h. Cumulus expansion was measured at 22 h after maturation. At 44 h after maturation, nuclear maturation, intracellular glutathione (GSH) and reactive oxygen species (ROS) levels were measured. Gene expression in cumulus cells was analyzed using real time PCR. The cleavage rate and blastocyst formation were evaluated at Day 2 and 7 after insemination. In results, expansion of cumulus cells was suppressed by treatment of hyaluronidase at 22 h after maturation. Intracellular GSH level was reduced by hyaluronidase treatment (p < 0.05). On the other hand, hyaluronidase increased ROS levels in oocytes (p < 0.05). Only PTGS2 mRNA was enhanced in COCs by hyaluronidase (p < 0.05). Population of oocytes reached at metaphase II stage was higher in control group than hyaluronidase treated group (p < 0.05). Both of cleavage rate and blastocyst formation were higher in control group than hyaluronidase group (p < 0.05). Our present results showed that developmental competence of porcine oocytes could be reduce by hyaluronidase via inducing oxidative stress during maturation process and it might be associated with prostaglandin synthesis. Therefore, we suggest that suppression of cumulus expansion of COCs could induce oxidative stress and decrease nuclear maturation via reduction of GSH synthesis and it caused to decrease developmental competence of mammalian oocytes.

• Journal of Life Science
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• v.32 no.4
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• pp.318-324
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• 2022

PPARγ and C/EBPα are master adipogenic transcription factors (TFs) required for adipose tissue development. They control the induction of many adipocyte genes and the early phase of adipogenesis in the embryonic development of adipose tissue. Adipose tissue continues to expand after birth, which, as a late phase of adipogenesis, requires the lipogenesis of adipocytes. In particular, the liver and adipose tissues are major sites for de novo lipogenesis (DNL), where carbohydrates are primarily converted to fatty acids. Furthermore, fatty acids are esterified with glycerol-3-phosphate to produce triglyceride, a major source of lipid droplets in adipocytes. Hepatic DNL has been actively studied, but the DNL of adipocytes in vivo remains not fully understood. Thus, an understanding of lipogenesis and adipose expansion may provide therapeutic opportunities for obesity, type 2 diabetes, and metabolic diseases. In adipocytes, DNL gene expression is transcriptionally regulated by lipogenesis coactivators, as well as by lipogenic TFs such as ChREBP and SREBP1a. Recent in vivo studies have revealed new insights into the lipogenesis gene expression and adipose expansion. Future detailed molecular mechanism studies will determine how nutrients and metabolism regulate DNL and adipose expansion. This review will summarize recent updates of DNL in adipocytes and adipose expansion in terms of transcriptional regulation.

• Journal of Chest Surgery
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• v.28 no.1
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• pp.81-84
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• 1995

Re-expansion pulmonary edema following pneumothorax or hemothorax is clinically uncommon but occasionally life threatening. Clinical details are given of two patients.Ipsilateral pulmonary edema were developed after chest tube insertion due to spontaneous pneumothorax in case I and after evacuation of postoperative hemothorax in case II. The patients were treated with frequent bronchial toilet.The administration of colloid solution and diuretics was effective. The possible mechanisms underlying the edema are discussed.Both increased time of collapse and suction tended to correlate with reexpansion edema.The present two cases provided evidence for longstanding lung collapse and immediate application of suction.

• Korean Journal of Remote Sensing
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• v.33 no.5_3
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• pp.835-854
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• 2017

Government regulations and policies are important means of restraining the indiscreet expansion of urban areas. According to the standards from those means, it is clear that the fluctuation of forest green proportion encroached by the increase of urban space is obvious. In this study, we interpreted the changes of urban areas as well as the green ones owing to the urban expansion by the decades from 1996, with focusing on the cities of Seoul and Daegu highly developed in South Korea. The purpose of this study is to analyze the spatial expansion and morphological characteristics of urban land cover using not only satellite imageries (1996, 2006, 2016). but also the urban expansion intensity index (UEII) and GUIDOS program. Ultimately, this study is to compare the changes in the rate of forests due to urban expansions annually analyzed based on areas of forest elevation, slope, and the area of single forest patch. In Seoul, the expansion begun from urban space to suburban areas was comparatively rapid, which led the forest fragmentation and the gradual decline of the single patch. However, when it comes to DEM (Digital elevation model) and slope above a certain standard, by the development regulations, there was little decrease in area by anthropogenic developments. The city of Daegu has increased at a slow speed since 1996 in urban and suburban areas, whereas green forests have greatly increased through green forest conservation campaigns. In this way, as to the government policies and regulations, the quantitative and morphological expansion of cities owing to development could be controlled and forest spaces could be preserved as well. Therefore, regulations and policies by the government should be appropriately utilized for sustainable cities.