• Journal of Korean Biological Nursing Science
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• v.22 no.3
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• pp.157-171
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• 2020

Purpose: The purpose of this study was to analyze the characteristics and effects of the forest therapy programs for adult patients. Methods: Six databases (PubMed, Cochrane library, CiNii, PsychoInFO, AGRICOL, EMBASE) and six domestic databases were systematically searched with language restrictions of Korean, English, and Japanese. The systematic review was based on the Preferred Reporting Items Systematic Reviews and Meta-Analysis (PRISMA) flow diagram. Results: Twenty five studies met the inclusion criteria. A systematic review identified adult patients classified as 1) disease of the circulatory system, 2) mental and behavioral disorders, 3) malignant neoplasms, 4) etc. (diabetes mellitus, chronic pain). This integrative review showed a positive effect of the forest therapy program for adult patients on physiological indices such as blood pressure, heart rate, heart rate variability, level of stress hormone, and natural killer cells as well as social·psychological indices such as the Profile of Mood States (POMS), anxiety, depression, and quality of life. Conclusion: The results of this study could be useful key principles in developing and applying the forest therapy programs in nursing intervention. Further research should be conducted to develop the forest therapy programs suitable for each patient group and measure its effectiveness.

• Genomics & Informatics
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• v.7 no.4
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• pp.181-186
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• 2009

Myotonic dystrophy type 1 (DM1), which is a dominantly inherited neurodegenerative disorder, results from a CTG trinucleotide repeat expansion in the 3'-untranslated region (3'-UTR) of the myotonic dystrophy protein kinase (DMPK) gene. Retention of mutant DMPK (mDMPK) transcripts in the nuclei of affected cells has been known to be the main cause of pathogenesis of the disease. Thus, reducing the RNA toxicity through elimination of the mutant RNA has been suggested as one therapeutic strategy against DM1. In this study, we suggested RNA replacement with a trans -splicing ribozyme as an alternate genetic therapeutic approach for amelioration of DM1. To this end, we identified the regions of mDMPK 3'-UTR RNA that were accessible to ribozymes by using an RNA mapping strategy based on a trans-splicing ribozyme library. We found that particularly accessible sites were present not only upstream but also downstream of the expanded repeat sequence. Repair or replacement of the mDMPK transcript with the specific ribozyme will be useful for DM1 treatment through reduction of toxic mutant transcripts and simultaneously restore wild-type DMPK or release nucleus-entrapped mDMPK transcripts to the cytoplasm.

• Journal of the Society of Naval Architects of Korea
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• v.47 no.5
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• pp.719-724
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• 2010

Thousands of passengers and crews are onboard a cruise ship and there are many cabins and large public spaces such as atria and theaters. Therefore it is easy to cause a huge loss of life and damage to property when accidents happen at sea. To improve the safety of passenger ships, in October 2007, IMO proposed MSC.1/Circ.1238 on guidelines for evacuation analysis and recommended its use. However, this guideline is difficult to apply because ship designers need to get many pieces of information from CAD drawings such as width and length of stairs and corridors and manually calculate the evacuation time. In this paper, for practical application of the guidelines, an evacuation time calculation program is developed using AutoCAD .NET API library and C Sharp language.

• Journal of Korean Clinical Nursing Research
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• v.17 no.2
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• pp.163-175
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• 2011

Purpose: This study was to analyze the characteristics and effect size of intervention studies applied to cancer-related fatigue in Korea. Methods: For meta-analysis, a total of 963 studies were retrieved from search engines. And 19 studies with a total of 721 participants published from 1990 to 2010 were selected upon their satisfaction with the inclusion criteria. Two authors independently extracted data from the selected studies and assessed the methodological quality. The data was analyzed by the RevMan 5.0 program of Cochrane library. Results: Intervention studies included 4 studies on foot-reflexo-massage (21.1%), comprehensive program (21.1%), and exercise (21.1%), respectively, 3 for hand-reflexo-massage (15.8%), and 4 for others. The effect size of the intervention studies shown higher effect size in order of exercise (d=-1.80), and foot & hand-reflexo-massage (d=-0.55). Conclusion: This study suggest that exercise can reduce the intensity of cancer-related fatigue, even though the number of intervention studies and randomized controlled trials were very few. There is limited evidence that reflexo-massage is effective in reducing cancer-related fatigue.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.29 no.5
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• pp.985-996
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• 2019

This paper analyzes the source code of FIPS-OpenSSL cryptographic module approved as FIPS cryptographic module in USA and shows how the selftest requirements are implemented as software cryptographic library with respect to pre-operational test and conditional tests. Even though FIPS-OpenSSL follows FIPS 140-2 standard, lots of security requirements are similar between FIPS 140-2 and Korean cryptographic module validation standards. Therefore, analysis from this paper contributes to help Korean cryptographic module vendors develop correct and secure selftest functions on their own cryptographic modules, which results in reducing the test period.

• International Journal of Knowledge Content Development & Technology
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• v.11 no.4
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• pp.53-86
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• 2021

The International Research Cooperation Information Center has carried out a project to collect the DBs related to the international research cooperation information, and build an online service system. This study seeks to examine and understand the trends of international research cooperation by analyzing the data corresponding to the other international cooperation DBs such as symposium and seminar, which may be said to be the arena of cooperation by the international research cooperation related experts, among the international research cooperation information DBs collected by the International Research Cooperation Information Center. The other international cooperation DBs are divided into the international cooperation consortium, international cooperation symposium, international research cooperation seminar, international training program, international research cooperation workshop, and the international research cooperation equipment / facility. It seems that, based on the research results, it is necessary to hold international cooperation programs, seminars, and workshops, among others, with a focus on the themes to recover the trends of international cooperation as in the past, and recover from the pandemic situation. The results of this study may be utilized as the basic data for the researchers related to the international research cooperation, and furthermore, by analyzing various international research cooperation information DBs in a multi-faceted manner, the studies analyzing the research trends of international research cooperation by field, subject, and type may be conducted, and the facilitation of the international research cooperation in Korea is expected moving forward.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.87-93
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• 2013

In this research, a new methodology to perform building energy analysis using Industry Foundation Classes (IFC) standard has been studied. With the help of Archicad 14 modeling software, a 3D test model is generated and then exported to IFCXML format. A ruby code program retrieves the building information from the resulting IFCXML file using Nokogiri library. An INP file is created and gets ready for next energy analysis step. DOE 2.2 program analyzes the INP file and gives a detailed report of the energy cost of the building. Case study shows when using the IFC standard method, the Interoperability of the energy analysis is greatly improved. The main stream 3D building modeling software supports IFC standard. DOE 2.2 is able to read the INP file generated by IFC file. This means almost any 3D model created by main stream modeling software can be analyze in terms of energy cost Thus, IFC based energy analysis method has a promising future. With the development and application of IFC standard, designers can do more complex and easy-to-run energy analysis in a more efficient way.

• Molecules and Cells
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• v.24 no.2
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• pp.276-282
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• 2007

Protein phosphorylation is one of the major mechanisms by which eukaryotic cells transduce extracellular signals into intracellular responses. Calcium/calmodulin ($Ca^{2+}/CaM$)-dependent protein phosphorylation has been implicated in various cellular processes, yet little is known about $Ca^{2+}/CaM$-dependent protein kinases (CaMKs) in plants. From an Arabidopsis expression library screen using a horseradish peroxidase-conjugated soybean calmodulin isoform (SCaM-1) as a probe, we isolated a full-length cDNA clone that encodes AtCK (Arabidopsis thaliana calcium/calmodulin-dependent protein kinase). The predicted structure of AtCK contains a serine/threonine protein kinase catalytic domain followed by a putative calmodulin-binding domain and a putative $Ca^{2+}$-binding domain. Recombinant AtCK was expressed in E. coli and bound to calmodulin in a $Ca^{2+}$-dependent manner. The ability of CaM to bind to AtCK was confirmed by gel mobility shift and competition assays. AtCK exhibited its highest levels of autophosphorylation in the presence of 3 mM $Mn^{2+}$. The phosphorylation of myelin basic protein (MBP) by AtCK was enhanced when AtCK was under the control of calcium-bound CaM, as previously observed for other $Ca^{2+}/CaM$-dependent protein kinases. In contrast to maize and tobacco CCaMKs (calcium and $Ca^{2+}/CaM$-dependent protein kinase), increasing the concentration of calmodulin to more than $3{\mu}M$ suppressed the phosphorylation activity of AtCK. Taken together our results indicate that AtCK is a novel Arabidopsis $Ca^{2+}/CaM$-dependent protein kinase which is presumably involved in CaM-mediated signaling.

• Journal of Plant Biotechnology
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• v.41 no.2
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• pp.81-88
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• 2014

Salt cress (Thellungiella halophila or Thellungiella parvula), species closely related to Arabidopsis thaliana, represents an extremophile adapted to harsh saline environments. To isolate salt-tolerance genes from this species, we constructed a cDNA library from roots and leaves of salt cress plants treated with 200 mM NaCl. This cDNA library was subsequently shuttled into the destination binary vector [driven by the cauliflower mosaic virus (CaMV) 35S promoter] designed for plant transformation and expression via recombination- assisted cloning. In total, 305,400 pools of transgenic BASTA-resistant lines were generated in Arabidopsis using either T. halophila or T. parvula cDNA libraries. These were used for functional screening of genes involved in salt tolerance. Among these pools, 168,500 pools were used for primary screening to date from which 7,157 lines showed apparent salt tolerant-phenotypes in the initial screen. A secondary screen has now identified 165 salt tolerant transgenic lines using 1,551 (10.6%) lines that emerged in the first screen. The prevalent phenotype in these lines includes accelerated seed germination often accompanied by faster root growth compared to WT Arabidopsis under salt stress condition. In addition, other lines showed non-typical development of stems and flowers compared to WT Arabidopsis. Based on the close relationship of the tolerant species to the target species we suggest this approach as an appropriate method for the large-scale identification of salt tolerance genes from salt cress.

• Journal of the Korean Society for Library and Information Science
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• v.51 no.3
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• pp.45-64
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• 2017

The purpose of this study is to understand the direction of the community reading campaign in the U.S.A. known as 'One Book, One City' reflected in the books selected for this campaign for the past 20 years in terms of their classification numbers, subject headings, publication dates, and genres. Analyzed are the author and state lists of 'One Book, One City' Reading Promotions Projects available from the website of the LC (Library of Congress) Center for the Books, and bibliographic records of 735 books selected in only one 'One Book' program, accessed from LC OPAC. Major findings include continuing influences of the all-time favorite 'One Book' selections, including To Kill a Mockingbird and the extension of their span of life through The Big Read, preference for the recent publications, importance of P (Literatures and Languages) Class (530 titles, 72.1%) and PS(American Literatures) subclass (307 titles, 57.9%) in the LC Classification Scheme, distribution of books in 43 genres, including domestic fiction, historical fiction, and psychological fiction, etc., the use of 535 unique LC subject headings and much interests in "City and town life" (10 titles) and "World War, 1939-1945" (8 titles), and prominence of subject groups which begin with "African American..." and "Woman..." out of 96 groups of subject headings. It is found that the subjects and focus of the selected books expand from integration, understanding, integrity to human rights, environment, peace, etc. The limitations of this study is that the influence of the selected books and the changes in communities are not properly analyed.