• Title/Summary/Keyword: Lee Sam

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Neuroprotecticve Effect of Sophora Subprostrata on Transient Global Ischemia in Gerbil (광두근(廣豆根)의 Gerbil 전뇌(全腦)허혈에 대한 신경손상방어효능 연구)

  • Min, Hong-Kyu;Kang, Ho-Chang;Lee, Hyun-Sam;Kim, Sun-Yeou;Sohn, Young-Joo;Jung, Hyuk-Sang;Sohn, Nak-Won;Kim, Yoon-Bum
    • The Korea Journal of Herbology
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    • v.23 no.3
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    • pp.1-9
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    • 2008
  • Objectives : This research was performed to investigate protective effect of Sophora Subprostrata against transient global ischemic damage after 5-min two vessel occlusion. Methods : Gerbils were divided into three groups: Normal group, 5-min two vessel occlusion (2VO) group, Sophora Subprostrata administrated group after 2VO. The CCAs were occluded by microclip for 5min. Sophora Subprostrata was administrated orally(12mg/ml) for 7 days after 2VO. The histological and immunohistochemistrical analysis was performed at 72 hours and 7 days after the surgery each. For histological analysis, the brain tissue was stained with 1% cresyl violet solution and Immunohistochemistry for BAX and Bcl-2 was carried out to examine effect of Sophora Subprostrata on ischemic brain tissue. Results : The results showed that (1) Sophora Subprostrata has the protective effect against ischemia in CA1 area of the gerbil hippocampus 7 days after 5-minute occlusion, (2) the treatment of Sophora Subprostrata inhibits the expression of Bax relatively after 2VO-induced ischemia. That protective effect of the Sophora Subprostrata seems to be performed by regulating the proportion of Bax and Bcl-2 protein, (3) in hypoxia/reperfusion model using PC12 cell, the Sophora Subprostrata extract has the protective effect against ischemia in the dose of $2{\mu}/m{\ell}$ and $20{\mu}/m{\ell}$.This study suggests that Sophora Subprostrata has neuroprotective effect against neuronal damage following cerebral ischemia in vivo with a widely used experimental model of cerebral ischemia in Mongolian gerbils and that Sophora Subprostrata regulates the proportion of Bax and Bcl-2 protein following ischemia. And, Sophora Subprostrata extract has protective effects also on a hypoxia/reperfusion cell culture model using PC12 cell. Conclusions : Sophora Subprostrata has protective effects against ischemic brain damage at the early stage of ischemia.

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Accuracy of CT image in measuring the mandible for implant : Effect of mandibular position and gantry angle (임플랜트를 위한 하악골 측정시 전산화단?사진상의 정확도에 관한 연구 : 하악 위치와 gantry각이 미치는 영향)

  • Choi Soon-Chul;Choi Hang-Moon;Park Rae-Jeong;Lee Sam-Sun;Park Tae-Won;You Dong-Soo
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.28 no.1
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    • pp.225-234
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    • 1998
  • We used five adult dog mandibles embedded in resin block and six different cross-sectional planes for each mandible were choosen. According to the angle of mandibular occulsal plane to vertical plane(mandibular angle) and gantry angle of CT machine, we classified 4 experimental groups and 1 control group. The control group images were taken at the mandibular angel 0° and gantry angle 0°. The experimental images were taken at the mandibular angle 15° and gantry angle 0°(group 1); 30° and 0°(group 2); 15° and 15°(group 3) ;30° and 30°(group 4), respectively. Using the reformatted cross-sectional images, the distance from the mandibular canal to the alveolar crest and the distance from the mandibular canal to the buccal cortex and to the lingual cortex was measured and compared. The obtained results were as follows: 1. The distance from the mandibular canal to the alveolar crest of group 1 and 2 was larger than control group, but the distance of group 3 and 4 was smaller. The distance from the mandibular canal to the buccal cortex and to the lingual cortex of all experimental groups was smaller than control group. 2. The distance from the mandibular canal to the alveolar crest showed the largest difference from control group in all experimental groups, especially in group 2 and 4(p<0.05). 3. In the distance from the mandibular canal to the alveolar crest, the number of deviation value under 1 mm was 20 in group 3 and was 11 in group 2 and 4, respectively. 4. The deviation value of the distance from the mandibular canal to the buccal cortex and to the lingual cortex was under 1 mm in most cases.

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INFLUENCE OF CENTRAL PANORAMIC CURVE DEVIATION ON THE MANDIBULAR IMAGE RECONSTRUCTION IN THE IMPLANT CT (임플랜트전산화단층촬영시 CENTRAL PANORAMIC CURVE의 변화가 하악골의 영상 재구성에 미치는 영향)

  • Park Rae-Jeong;Lee Sam-Sun;Choi Soon-Chul;Park Tae-Won;You Dong-Soo
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.28 no.1
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    • pp.47-58
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    • 1998
  • The purpose of this study was to investigate an influence of the change of central panoramic curves on the image reconstruction in the dental implant CT. The author designed three experimental groups according to the location of central panoramic curve. In group A, central panoramic curve was determined as the curve connecting the center of roots from the first premolar to the first molar. In group B, central panoramic curve was determined as the line connecting the lingual cortical plate at the level of the mesial aspect of the first premolar with the buccal cortical plate at the level of the mesial aspect of the first molar. In Group C, central panoramic curve was determined as the line connecting the buccal cortical plate at the level of the mesial aspect of the first premolar with the lingual cortical plate at the level of the mesial aspect of the first molar. Twenty four reformatted CT images was acquired from four mandibles embedded in the resin block and twenty four contact radiographs of dog specimens were acquired. Each Image was processed under Adobe Photoshop program analysed by MSPA(mandible/maxilla shape pattern analysis) variables such as MXVD, MXHD, UHD, MHD, and LHD. The obtained results were as follows ; 1. The mean of MXVD variable was 19.9, 20.2, and 20.0 in group A, B, and C, respectively, which were smaller than actual value 20.5. But, there was no significant difference among 3 groups (p>0.05). 2. The mean of MXHD, UHD, MHD, and LHD variables in group A, B, and C was 11.9, 12.2, and 12.3; 9.3, 9.5, and 9.6; 10.0, 10.3, and 10.3; 9.2, 9.3, and 9.4 respectively which were equal to or greater than the actual value 11.8, 9.3, 10.0, and 9.2. But, there was no significant difference among 3 groups (p>0.05). 3. The number of noneffective observations with difference over or under 1 mm with comparison to the actual value was 24(20%), 58(48.3%), and 52(43.3%), respectively, in group A, B, and C. 4. In group A, the number of observations over 1 mm and under 1 mm was 9 and 15, respectively, but in group Band C, the number of observations over 1 mm was more than under 1 mm.

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The effects of digital image processing for noise reduction on observer performance (노이즈 감소 필터 사용이 판독능에 미치는 효과)

  • Jung, Young-Chul;Choi, Bo-Ram;Huh, Kyung-Hoi;Yi, Yon-Jin;Heo, Min-Suk;Lee, Sam-Sun;Choi, Soon-Chul
    • Imaging Science in Dentistry
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    • v.40 no.3
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    • pp.103-107
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    • 2010
  • Purpose : This study was performed to examine the effects of image filter on observer performance by counting the number of holes at each wedge step on a radiographic image. Materials and Methods : An aluminum step wedge with 11 steps ranged in thickness from 1.5 mm to 16.5 mm in 1.5 mm increments was fabricated for this study. Each step had 10 notched holes with 1.0 mm diameter on the bottom of the step wedge which were ranged in depths from 0.1 mm to 1.0 mm in 0.1 mm increments. Digital radiographic raw images of the aluminum step wedge were acquired by using CCD intraoral sensor. The images were processed using several types of noise reduction filters and kernel sizes. Three observers counted the number of holes which could be discriminated on each step. The data were analyzed by ANOVA. Results : The number of holes at each step was decreased as the thickness of step was increased. The number of holes at each step on the raw images was significantly higher than that on the processed images. The number of holes was different according to the types and kernel sizes of the image filters. Conclusions : The types and kernel sizes of image filters on observer performance were important, therefore, they should be standardized for commercial digital imaging systems.

A Study on the Students' Needs for the Improvement of Liberal Arts Curriculum : Focused on the Case of J University (교양교육과정 개선을 위한 학생 요구 분석: J대학 사례를 중심으로)

  • Lee, Jung-Yull;Kim, Sam-Sup
    • Journal of Digital Convergence
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    • v.17 no.12
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    • pp.545-554
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    • 2019
  • The purpose of this study is to analyze students' needs for improving the liberal arts curriculum at J University. In order to achieve such as this, 422 students from 11 departments of J University's two campuses looked at the core goals of 1 liberal arts education, 2 core competences that they think should be achieved in the liberal arts curriculum, 3 subject areas of the liberal arts curriculum they wish to open, 4 hopeful subjects, and 5 urgent tasks in reforming liberal arts education. The results are as follows. First, male students were most likely to point out the achievement of core competency as a key goal of liberal arts education. Second, the core competences to be achieved in the liberal arts curriculum were found to place importance on communication and interpersonal relations, character, self-care development and job creation skills. Third, there was a high percentage of people who wanted to open a curriculum in the field of arts and sports. Fourth, liberal arts courses that wish to be opened appeared in the order of women's studies or feminism, sports related subjects, philosophy, and psychology. The results of this study could be used as basic data for the revision of the J University liberal arts curriculum.

Studies on the Nest site Selection and Characteristics of Habitat use of Long-tailed Tits Aegithalos caudatus in Korea (한국에서 번식하는 오목눈이의 둥지장소 선택과 서식지 이용 특성)

  • Baek, Chung-yeol;Lee, Jin-hee;No, Sun-ho;Jang, Kyung-Hee;Cho, Sam-rae
    • Korean Journal of Environment and Ecology
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    • v.30 no.5
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    • pp.829-836
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    • 2016
  • This study was carried out on Kongju National University and its neighboring area, Mt. Gyeryong national park and Mt. Worak national park in the breeding season of long-tailed tits Aegithalos caudaatus from 2008 to 2012. The result of the inquiry, the nests were found in 15 species of trees, and this result shows me it's not choosy about them. But after having classified them according to the features and analyzed them, long-tailed tits preferred evergreen needleleaf tree and deciduous broad-leaf tree and deciduous bush, especially evergreen needleleaf tree. The concealment rate of long-tailed tits' nests was $11.61{\pm}4.79%]\;4.38{\pm}2.19%$(n=29) in Kongju National University and it's neighboring area, $6.06{\pm}2.31%$(n=43) in Mt. Gyeryong national park and $4.38{\pm}2.19%$(n=32) in Mt. Worak national park. By regional groups, the concealment rates of neighboring nests were almost same, but there are no differences among the areas. The average of the color codes was $26.52{\pm}16.14$(n=32) that those of the nest subtract from those of surroundings of the nest. The nests were procryptic according to their surroundings, and if their nest in a tree were evergreen needleleaf trees, they were made of moss. while if the trees of nest in a tree were yellow because of fungus, made of dried moss, they were yellow, too.

1-Deoxynojirimycin Content and Blood Glucose-Lowering Effect of Silkworm (Bombyx mori) Extract Powder

  • Ryu, Kang-Sun;Lee, Heui-Sam;Kim, Kee-Young;Kim, Mi-Ja;Sung, Gyoo-Byung;Ji, Sang-Deok;Kang, Pil-Don
    • International Journal of Industrial Entomology and Biomaterials
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    • v.27 no.2
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    • pp.237-242
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    • 2013
  • We investigated the 1-deoxynojirimycin (1-DNJ) content of extracts from silkworm larvae at each developmental stage within three silkworm varieties. We also compared the content of the following polyhydroxylated alkaloids in the silkworm extracts: 1-DNJ, fagomine, and 1,4-dideoxy-1,4-imino-d-arabinitol (DAB). In addition, we evaluated the glucose-lowering effects of silkworm extract powder in db/db mice. The 1-DNJ content was the highest in Yeonnokjam $5^{th}$ instar $3^{rd}$ d larvae and Hansaengjam $5^{th}$ instar $3^{rd}$ d larvae, which contained 18.4 mg/100 g dry weight and 18.3 mg/100 g dry weight, respectively. The $5^{th}$ instar $3^{rd}$ d larvae exhibited a higher content of 1-DNJ than that of $5^{th}$ instar $5^{th}$ d larvae among all varieties. The glucose-lowering effects of silkworm extracts and Yeonnokjam powder were tested on db/db mice, and the blood glucose levels were found to decrease significantly in the YR70 group. Silkworm extracts (180 mg/kg, 90 mg/kg, 45 mg/kg, and 22.5 mg/kg) and acarbose (50 mg/kg) were administered orally for 4 wk. Changes in water intake were not statistically significant between control and silkworm extract-treated groups. Compared to the control group, blood glucose levels in the silkworm extract powder-treated group decreased in the 22.5 mg/kg/d group after being administered for 4 wk. This decrease was statistically significant. Furthermore, biochemical changes in the AST(Aspartate aminotransferase), ALT(Alanine aminotransferase), TCHO(Total Cholesterol), TG(Triglyceride), LDL(Low density lipoprotein), and HDL(High density lipoprotein) levels in blood were not observed. However, statistically significant decreases in blood GLU in the 22.5 mg/kg/d group compared to that of the control group occurred. In addition, the epididymal fat weight of the silkworm extract powder-treated group decreased significantly in both the 22.5 mg/kg/d group and 180 mg/kg/d group compared to that of the control group, but there were no statistically significant changes in perirenal fat weight. These results demonstrate that silkworm extracts inhibit changes in blood glucose levels in model diabetic mice.

Control of Short-period and Solitary Waves Using Two-rowed Impermeable Rectangular Submerged Dike (2열 불투과성 사각형 잠제를 이용한 단주기파랑 및 고립파의 제어)

  • Lee, Kwang-Ho;Jung, Sung-Ho;Ha, Sun-Wook;Kim, Do-Sam
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.22 no.4
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    • pp.203-214
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    • 2010
  • This study numerically investigates the wave control of 2-rowed Impermeable Rectangular Submerged Dike(IRSD) with an object of how to control short-period and solitary waves simultaneously based on the Bragg resonance phenomenon that elevates the wave control performance. The boundary integral method using Green formula and the 3-D one-field Model for immiscible TWO-Phase flows (TWOPM-3D) by 3-D numerical wave flume have been used for the numerical predictions for short-period and solitary waves, respectively. These numerical models were verified through the comparisons with the previously published numerical results by other researchers. Through the parametric tests of numerical experiments for short-period waves, an optimum model of 2-rowed IRSD of a lowest transmission coefficient has been found. Furthermore, the performances of 3-D wave control for solitary waves were evaluated for the various free board, crown widths and gap distance between dikes, and have been compared with those of a single-rowed IRSD. Numerical results show that a 2-rowed IRSD with a less cross sectional area than 1-rowed one improves the wave attenuation performances when it is compared to that of single-rowed IRSD. Within the test frequency ranges of the numerical simulations conducted in this study, 2-rowed IRSD with an optimum gap distance shows an outstanding improvement of the wave attenuation up to 58% compared to that of single-rowed IRSD.

Periodic Mesh Generation for Composite Structures using Polyhedral Finite Elements (다면체 유한요소를 이용한 복합재 구조의 주기 격자망 생성)

  • Sohn, Dongwoo;Park, Jong Youn;Cho, Young-Sam;Lim, Jae Hyuk;Lee, Haengsoo
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.27 no.4
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    • pp.239-245
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    • 2014
  • Finite element modeling of composite structures may be cumbersome due to complex distributions of reinforcements. In this paper, an efficient scheme is proposed that can generate periodic meshes for the composite structures. Regular meshes with hexahedral finite elements are first prepared, and the elements are then trimmed to fit external surfaces of reinforcements in the composite structures. The trimmed hexahedral finite elements located at interfaces between the matrix and the reinforcements correspond to polyhedral finite elements, which allow an arbitrary number of nodes and faces in the elements. Because the trimming process is consistently conducted by means of consistent algorithms, the elements of the reinforcements are automatically compatible with those of the matrices. With the additional consideration of periodicity of reinforcements in a representative volume element(RVE), the proposed scheme provides periodic meshes in an efficient manner, which are compatible for each pair of periodic boundaries of the RVE. Therefore, periodic boundary conditions for the RVE are enforced straightforwardly. Numerical examples demonstrate the effectiveness of the proposed scheme for finite element modeling of complex composite structures.

DECIPHERING THE DOUBLE MEANINGS OF THE COWHERD STAR (견우성의 이중적 의미에 대한 해석)

  • Ahn, Sang-Hyeon;Kim, Dong-Bin;Lee, Yong-Sam;Song, Doo-Jong
    • Publications of The Korean Astronomical Society
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    • v.25 no.4
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    • pp.129-139
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    • 2010
  • The Cowherd Star and the Weaving Maid Star have been famous stars in East Asian countries. Nowadays Altair is defined to be the Cowherd Star in public materials including science books, mass media, public outreach programs, and movies played in public planetariums and science museums. However, in astronomical books and star-charts in history, the Cowherd Big Star (牽牛大星) has been known to be Dabih or $\beta$ Cap in the constellation Capricorn, and the asterism Cowherd consists of six stars including Dabih. Since the same title is given to the different objects simultaneously, considerable misunderstanding and confusion among the public have occurred. In this paper we consider this problem in two aspects. One aspect is which star has been defined to be the Cowherd Star in ancient literatures; the other is which stars were regarded as the Cowherd or the Cowherd Star in the historical records of occultation or conjunction in History of Koryo, Annals of the Choson Dynasty, and Daily Records of Royal Secretariat of the Choson Dynasty. As a result, we see that Altair has been regarded as the Cowherd Star in folklore and literature, but Dabih has been defined to be the Cowherd Big Star in astronomical works. An explanation proposed by previous researchers on the reason why such double meanings have been appeared is introduced. In the explanation, the fact that the Altair was defined as the Cowherd Star in ancient times had not been handed over properly, and the name of Cowherd was later put to the Dabih and its surrounding five stars to form one of 28 lunar lodges. Based upon these facts, we suggest the following ideas: (1) Altair should be introduced to be the Cowherd Star in public-friendly programs, and Dabih should be noticed to be the Cowherd Big Star in the field of history of astronomy. Dabih should be added as the astronomical Cowherd Big Star in academic books such as a dictionary of astronomical terminology. (2) The Korean pronunciation for Altair should be al-tear instead of al-tairu in accordance with the definition in the astronomical terminology dictionary compiled by the Korean Astronomical Society.