• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.446-451
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• 2010

We investigated whether oral administration with capsicum extract (Capsicum annuum var. cheongyang) would affect the immune system by examining the immune cells of Peyer's patch (PP), a gut associated lymphoid tissue, ex vivo. The mice were orally administrated with capsicum extract (100 mg/kg/day), capsaicin (10 mg/Kg), and the vehicle for four consecutive days, and PPs were isolated from intestines 2 days later. When the PP cells were cultured in the presence of Concanavalin A for 72 hr, the levels of cytokines, including IL-2 and IFN-${\gamma]$, were dramatically increased, while the levels of IL-4 remained unchanged compared with the control. Data from the FACS analysis of PP cells indicated that capsicum extract significantly increased the number of CD3+ and CD4+ T cells as well as CD 19+ B cells compared with the control but not CD11b+ cells. Furthermore, the percentages of IL-2+ /CD4+ cells and IFN-${\gamma}+$/CD4+ were greatly increased. These data suggested that oraladministration with capsicum extract might activate the CD4+ T cells leading to cytokine production as well as CD19+ B cells in Peyer's patches. As such, capsicum extract might have potential as an immune modulating agent.

• Journal of Korean Society for Quality Management
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• v.48 no.1
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• pp.125-147
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• 2020

Purpose: This study would measure the users'perceived overall quality level of A automobile Company, which has leading market power in the domestic automobile market and analyze the causal relationships in the quality value process Model to quality capability, customer value and loyalty based on that. Especially, this study would analyze the relative impacts of the users'perceived risks appearing in the quality value process model of the formation of Quality Factors(QF), Customer Value(CV), and Customer Loyalty(CL) and analyze the moderating effect of the causal relationships among the components. Methods: For an analysis of causal relationships connected to QF, CV, and CL of the customers who purchased Auto manufacturer A's automobile users, 179 users who used within 3 years were utilized as samples for the analysis. As for QF, based on the Garvin(1988), the QF of automobiles were redesigned. For a structural equation analysis of the entire research model, the PLS(S(Partial Least Square) model was utilized. Results: As a result of an analysis, R2 of CV and CL was 0.652 for CV and 0.664 for CL, which was a very stable Goodness of fit. As a result of an analysis of the hypotheses of QF and CV, automobile performance, conformance, aesthetics, serviceability, and durability. In addition, it turned out that the perceived risk had a moderating effect on convenience, service availability, and perceived quality. Conclusion: This study found that the perceived quality risk appearing among automobile users had negative effects on the quality value process model to QF, CV and CL. In contrast, there were factors not affecting the users'quality value process in spite of the perceived risk. These factors can suggest important managerial implications in that they can be utilized as Auto manufacturer A's market-dominant strengths.

• Journal of Korean Medicine for Obesity Research
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• v.15 no.2
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• pp.104-110
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• 2015

Objectives: The herb of Agastache rugosa (AR) is a traditional herbal medicine used for colds, vomiting and furuncles. However, there are few reports to investigate the inhibitory effects of AR on obesity. In this study, the effects of AR on high fat diet (HFD)-induced obesity and its mechanism of actions were investigated in experimental animals. Methods: The mice were fed HFD for 4 weeks to induce obesity. After randomly divided into normal fat diet, HFD and AR groups, 200 mg/kg of AR was administrated for 4 weeks with continuous HFD feeding while vehicle was orally treated to HFD group. Food intake and body weight were recorded weekly. Results: Increased body weight by HFD was improved by AR treatment. AR administration inhibited an increase of visceral fat weight as well as adipocyte hypertrophy. Hepatic steatosis was ameliorated in AR-treated mice. In addition, treatment of AR attenuated the expression of adipogenic transcription factor, peroxisome proliferator-activated receptor (PPAR)-gamma in the epididymal adipose tissue. Also the increased serum leptin level by HFD was maintained in AR group, leading to inhibition of food intake. Conclusions: AR treatment showed inhibitory effects on HFD-induced obesity by inhibition of PPAR-gamma and reduction of food intake. AR could be an alternative treatment for obesity.

• Journal of the Ergonomics Society of Korea
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• v.28 no.3
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• pp.63-71
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• 2009

A car navigation system as an in-vehicle route guidance information (RGI) offers a state-of-the-art technological solution to driver navigation in an unfamiliar area. However, the RGI is provided by some pre-determined options in terms of the interface between a driver and a car navigation system. Drivers occasionally pass the target intersection owing to non- or late- recognizing it. This paper is examined the position of driver's turn signal operation and intersection recognition approaching at the target intersection which is difficult to identify, as a fundamental research on developing the additional RGI connecting with the turn signal control. The field experiment was conducted to measure distances of the turn signal operation and the intersection recognition from the target intersection according to left turns, right turns, and landmarks at adjacent intersection. And glance behavior to the car navigation display was evaluated by using an eye camera. The results of the field study indicate that, most case of driving, drivers operate the turn signal until 40m to 50m before coming to the target intersection. The driving simulator experiment was performed to examine the effectiveness of providing the additional RGI when drivers did not operate the turn signal approaching at the target intersection based on the results of the field study. To provide the additional RGI is effective for the intersection identification and recognition, and expected to improve the traffic safety and the comfort for drivers.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.46 no.3
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• pp.183-190
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• 2020

Objectives: The purpose of this retrospective epidemiological study was to determine the etiology and pattern of maxillofacial injuries in a pediatric population. Materials and Methods: Data for pediatric maxillofacial trauma patients aged 12 years and younger who were registered at the Department of Pediatric and Preventive Dentistry, Dr. R. Ahmed Dental College and Hospital, Kolkata, India, were reviewed and examined. Patients who were treated between October 2016 and September 2018 were analyzed according to age, sex, cause of injury, frequency and site of facial fractures, and soft tissue injuries. The chi-square tests were carried out for statistical analyses with a significance level of 5%. Results: Of 232 patients with a mean age of 6.77±3.25 years, there were 134 males (57.8%) and 98 females (42.2%). The overall male to female ratio was 1.39:1. The most common causes of injuries were falls (56.5%) and motor vehicle accidents (16.8%). Incidence of falls decreased significantly with age (P<0.001). Dentoalveolar injuries (61.6%) and soft tissue injuries (57.3%) were more common than facial fractures (42.7%). Mandibular fractures (82.8%) were the most common facial fractures, and perioral or lip injuries were the most prevalent injuries in our patient population. There was a positive association between facial fractures and soft tissue injury (P<0.01) (odds ratio 0.26; confidence interval 0.15-0.46). Conclusion: Falls were the leading cause of maxillofacial trauma in our sample of children, and the most common site of fractures was the mandible.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.2
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• pp.126-136
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• 2020

Recently, unmanned aerial vehicles (UAV, Drone) are highly regarded for their potential in the agricultural field, and research and development are actively conducted for various purposes. Therefore, in this study, to present a framework for tracking research trends in UAV use in the agricultural field, we secured a keyword search strategy and analyzed social network, a methodology used to analyze recent research trends or technological trends as an analysis model applied. This study consists of three stages. As a first step in data acquisition, search terms and search formulas were developed for experts in accordance with the Keyword Search Strategy. Data collection was conducted based on completed search terms and search expressions. As a second step, frequency analysis was conducted by country, academic field, and journal based on the number of thesis presentations. Finally, social network analysis was performed. The analysis used the open source programming language 'Python'. Thanks to the efficiency and convenience of unmanned aerial vehicles, this field is growing rapidly and China and the United States are leading global research. Korea ranked 18th, and bold investment in this field is needed to advance agriculture. The results of this study's analysis could be used as important information in government policy making.

• Preventive Nutrition and Food Science
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• v.17 no.2
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• pp.101-108
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• 2012

Interruption or prolonged reduction and subsequent restoration of blood flow into the kidney triggers the generation of a burst of reactive oxygen species (ROS), leading to injury in the tubular epithelial cells. In this study, we determined whether methanol extract of goat's-beard (Aruncus dioicus) (extract) could prevent this ischemia/reperfusion injury. When in vitro radical scavenging activity of the extract was measured using a DPPH radical quenching assay, the extract displayed slightly lower activity than ascorbic acid. One hour after administration of the extract (400 mg/kg) by intraperitoneal injection in rats, renal ischemia/reperfusion injury was generated by clamping the left renal artery for forty minutes, followed by 24 hr restoration of blood circulation. Prior to clamping the left renal artery, the right renal artery was removed. Compared with the vehicle-treated group, pretreatment with the extract significantly reduced the tubular epithelial cell injury by 37% in the outer medulla region, and consequently reduced serum creatinine concentration by 39%. Reduction in the cell injury was mediated by attenuation of Bax/Bcl-2 ratio, inhibition of caspase-3 activation from procaspase-3, and subsequent reduction in the number of apoptotic cells. Thus, goat's-beard (Aruncus dioicus) might be developed as a prophylactic agent to prevent acute kidney injury.

• International Journal of Highway Engineering
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• v.9 no.4
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• pp.21-32
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• 2007

The linear traffic model(Vertical queueing model) that is adopted widely in traffic flow estimation assumes that all vehicles have the identical motion before joining a queue at the stop-line. Thus, a queue is supposed to form vertically not horizontally. Due to the simplicity of this model, the departure time of the leading vehicle is assumed to coincide with the start of effective green time. Thus, the delay estimates given by the Vertical queueing model is not always realistic. This paper explores a microscopic traffic model(a Kinematic Car-following model at Signalised intersections: a KCS traffic model) based on the one dimensional Kinematic equations in physics. A comparative evaluation in delay and sensitivity of delay difference between the KCS traffic model and the previously known Vertical queueing model is presented. The results show that the delay estimate in the Vertical queueing model is always greater than or equal to the KCS traffic model; however, the sensitivity of delay in the KCS traffic model is greater than the Vertical queueing model.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.34 no.6
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• pp.426-432
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• 2021

Injection molding is used in many industrial fields such as home appliances, vehicle parts, and electronic device parts because various resins can be molded, leading to mass production of complex shapes. Generally, the empirical prediction method is used to set the initial processing conditions of injection molding. However, this approach requires a lot of cost and its presented solution is not accurate. In this paper, injection molding was simulated through the Moldflow^TM in order to manufacture the spacer for gas insulated switch. Through the simulation, the flow of the resin with respect to the diameter of the inlet was analyzed. It was found that the process was possible at a higher resin temperature as the diameter of the inlet increased. In addition, through thermal analysis during injection of the resin, it was confirmed that a stagnation phenomenon occurred at the insert portion during injection molding, and the temperature of the resin was higher than that of the mold. As in this paper, if the spacer is manufactured by optimizing the injection hole and the temperature of the injection process based on simulation, it is expected that the spacer can be manufactured with high productivity.

• Advances in aircraft and spacecraft science
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• v.6 no.2
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• pp.117-144
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• 2019

High Altitude and Long Endurance (HALE) aircraft are capable of providing intelligence, surveillance and reconnaissance (ISR) capabilities over vast geographic areas when equipped with advanced sensor packages. As their use becomes more widespread, the demand for additional range, endurance and payload capability will increase and designers are exploring non-conventional configurations to meet the increasing demands. One such configuration is the joined-wing concept. A joined-wing aircraft is one that typically connects a front and aft wings in a diamond shaped planform. One such example is the Boeing SensorCraft configuration. While the joined-wing configuration offers potential benefits regarding aerodynamic efficiency, structural weight, and sensing capabilities, structural design requires careful consideration of elastic buckling resulting from the aft wing supporting, in compression, part of the forward wing structural loading. It has been shown already that this is a nonlinear phenomenon, involving geometric nonlinearities and follower forces that tend to flatten the entire configuration, leading to structural overload due to the loss of the aft wing's ability to support the forward wing load. Severe gusts are likely to be the critical design condition, with flight control system interaction in the form of Gust Load Alleviation (GLA) playing a key role in minimizing the structural loads. The University of Victoria Center for Aerospace Research (UVic-CfAR) has built a 3-meter span scaled and flexible wing UAV based on the Boeing SensorCraft design. The goal is to validate the nonlinear structural behavior in flight. The main objective of this research work is to perform Ground Vibration Tests (GVT) to characterize the dynamic properties of the scaled flight vehicle. Results from the experimental tests are used to characterize the modal dynamics of the aircraft, and to validate the numerical models. The GVT results are an important step towards a safe flight test program.