Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Immunomodulatory Effects of Orally Administrated Capsicum Extract on Peyer's Patches

고추 추출물의 경구 투여에 의한 피어스판 면역세포 활성화 작용

  • Park, Min-Young (Laboratory of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Laboratory of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Jin, Mi-Rim (Laboratory of Pathology, College of Oriental Medicine, Daejeon University)
  • 박민영 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 진미림 (대전대학교 한의과대학 병리학교실)
  • Received : 2010.05.25
  • Accepted : 2010.06.14
  • Published : 2010.06.25
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Abstract

We investigated whether oral administration with capsicum extract (Capsicum annuum var. cheongyang) would affect the immune system by examining the immune cells of Peyer's patch (PP), a gut associated lymphoid tissue, ex vivo. The mice were orally administrated with capsicum extract (100 mg/kg/day), capsaicin (10 mg/Kg), and the vehicle for four consecutive days, and PPs were isolated from intestines 2 days later. When the PP cells were cultured in the presence of Concanavalin A for 72 hr, the levels of cytokines, including IL-2 and IFN-${\gamma]$, were dramatically increased, while the levels of IL-4 remained unchanged compared with the control. Data from the FACS analysis of PP cells indicated that capsicum extract significantly increased the number of CD3+ and CD4+ T cells as well as CD 19+ B cells compared with the control but not CD11b+ cells. Furthermore, the percentages of IL-2+ /CD4+ cells and IFN-${\gamma}+$/CD4+ were greatly increased. These data suggested that oraladministration with capsicum extract might activate the CD4+ T cells leading to cytokine production as well as CD19+ B cells in Peyer's patches. As such, capsicum extract might have potential as an immune modulating agent.

Keywords

References

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