• Integrative Medicine Research
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• v.3 no.4
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• pp.204-210
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• 2014

The aim of this review was to understand the effects of ${\beta}$-adrenergic stimulation on oxidative stress, structural remodeling, and functional alterations in the heart and cerebral artery. Diverse stimuli activate the sympathetic nervous system, leading to increased levels of catecholamines. Long-term overstimulation of the ${\beta}$-adrenergic receptor (${\beta}AR$) in response to catecholamines causes cardiovascular diseases, including cardiac hypertrophy, stroke, coronary artery disease, and heartfailure. Although catecholamines have identical sites of action in the heart and cerebral artery, the structural and functional modifications differentially activate intracellular signaling cascades. ${\beta}AR$-stimulation can increase oxidative stress in the heart and cerebral artery, but has also been shown to induce different cytoskeletal and functional modifications by modulating various components of the ${\beta}AR$ signal transduction pathways. Stimulation of ${\beta}AR$ leads to cardiac dysfunction due to an overload of intracellular $Ca^{2+}$ in cardiomyocytes. However, this stimulation induces vascular dysfunction through disruption of actin cytoskeleton in vascular smooth muscle cells. Many studies have shown that excessive concentrations of catecholamines during stressful conditions can produce coronary spasms or arrhythmias by inducing $Ca^{2+}$-handling abnormalities and impairing energy production in mitochondria, In this article, we highlight the different fates caused by excessive oxidative stress and disruptions in the cytoskeletal proteome network in the heart and the cerebral artery in responsed to prolonged ${\beta}AR$-stimulation.

• Safety and Health at Work
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• v.13 no.3
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• pp.343-349
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• 2022

Background: In the United States, the dairy product manufacturing industry has consistently had higher rates of work-related nonfatal injuries and illnesses compared to the national average for industries in all sectors. The selection and implementation of appropriate safety performance indicators are important aspect of reducing risk within safety management systems. This study examined the leading safety indicators implemented in the dairy product-manufacturing sector (NAICS 3115) and their perceived effectiveness in reducing work-related injuries. Methods: Perceptions were collected from individuals with safety responsibilities in the dairy product manufacturing facilities. OSHA Incident Rate (OIR) and Days away, restricted and transferred (DART) rates from 2013 to 2018 were analyzed. Results: The perceived most effective leading were safety observations, stop work authority, near miss reporting, safety audits, preventative maintenance, safety inspections, safety training attendance, and job hazard analysis/safety analysis, respectively. The 6-year trend analysis showed that those implementing all eight top indicators had a slightly lower rates than those that did not implement all eight. Production focused mentality, poor training, and lack of management commitment were perceived as the leading causes of injuries in this industry. Conclusion: Collecting leading indicators with the unique interest to meet the regulatory requirements and to document the management system without the actual goal of using them as input to improve the system most probably will not lead to an effective reduction of negative safety outcomes. For leading indicators to be effective, they should be properly selected, executed, periodically evaluated and actions are taken when necessary.

• Safety and Health at Work
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• v.13 no.4
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• pp.394-400
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• 2022

Background: Impacts of exposure are generally monitored and recorded after injuries or illness occur. Yet, absence of conventional after-the-effect impacts (i.e., lagging indicators), tend to focus on physical health and injuries, and fail to inform if workers are not exposed to safety and health hazards. In contrast to lagging indicators, leading indicators are proactive, preventive, and predictive indexes that offer insights how effective safety and health. The present study is to validate an extended Voluntary Protection Programs (VPP) that consists of six leading indicators. Methods: Questionnaires were distributed to 13 organizations (response rate = 93.1%, 1,439 responses) in Taiwan. Cronbach α, multiple linear regression and canonical correlation were used to test the reliability of the extended Voluntary Protection Programs (VPP) which consists of six leading indicators (safe climate, transformational leadership, organizational justice, organizational support, hazard prevention and control, and training). Criteria-related validation strategy was applied to examine relationships of six leading indicators with six criteria (perceived health, burnout, depression, job satisfaction, job performance, and life satisfaction). Results: The results showed that the Cronbach's α of six leading indicators ranged from 0.87 to 0.92. The canonical correlation analysis indicated a positive correlation between the six leading indicators and criteria (1st canonical function: correlation = 0.647, square correlation = 0.419, p < 0.001). Conclusions: The present study validates the extended VPP framework that focuses on promoting safety and physical and mental health. Results further provides applications of the extended VPP framework to promote workers' safety and health.

• Molecules and Cells
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• v.45 no.10
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• pp.692-694
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• 2022

• Molecules and Cells
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• v.47 no.1
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• pp.100002.1-100002.3
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• 2024

• Journal of the Korean Society of Combustion
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• v.18 no.1
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• pp.13-20
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• 2013

Leading edge statistics are obtained by direct numerical simulation(DNS) of freely propagating incompressible and stagnating compressible turbulent premixed flames. Conditional averages of velocities in terms of reaction progress variable, c, and local flame surface density, ${\sum}^{\prime}_f$, are defined and compared through the flame brush. It holds asymptotically that $<u>_f=<S_d>_f$ and $<u>_u-<u>_b=D_t/L_w$ with the characteristic length scale of $\bar{c}$ variation, $L_w$. It also holds that $<u>_b=<u>_f$ for a freely propagating flame under no mean strain rate. The turbulent burning velocity, $S_T$, is determined by the conditional statistics at the leading edge under large activation energy.

• Journal of Advanced Marine Engineering and Technology
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• v.26 no.3
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• pp.307-312
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• 2002

A study on the exhaust emissions of marine diesel engine with various fuel injection timing is performed experimentally .In this paper, fuel injection timing is changed from BTDC $14^{\circ}$ to $20^{\circ}$ by $2^{\circ}$ intervals, the experiments are performed at engine speed 1800rpm and from load 0% to 100% by 25% intervals, and main measured parameters are fuel consumption rate, Soot, NOx, HC and CO emissions etc. The obtained conclusions are as follows (1) Specific fuel consumption is indicated the least value at BTDC $18^{\circ}$ of fuel injection timing and it is increased in case of leading the injection timing. (2) Soot emission is decreased in case of leading fuel injection timing and it is increased in the form of convex downwards with increasing the load. (3) NOx emission is increased in case of leading fuel injection timing and it is increased in the form of straight line nearly with increasing the load. (4) HC and CO emissions are decreased in case of leading fuel injection timing and they are changed in the form of convex downwards with increasing the load.

• Journal of The Korean Astronomical Society
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• v.47 no.3
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• pp.105-113
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• 2014

We apply differential affine velocity estimator (DAVE) to the Solar Dynamics Observatory (SDO)/Helioseismic and Magnetic Imager (HMI) 12-min line-of-sight magnetograms, and separately calculate the injected magnetic helicity for the leading and the following polarities of nine emerging bipolar active regions (ARs). Comparing magnetic helicity flux of the leading polarity with the following polarity, we find that six ARs studied in this paper have the following polarity that injected more magnetic helicity flux than that of the leading polarity. We also measure the mean area of each polarity in all the nine ARs, and find that the compact polarity tend to possess more magnetic helicity flux than the fragmented one. Our results confirm the previous studies on asymmetry of magnetic helicity that emerging bipolar ARs have a polarity preference in injecting magnetic helicity. Based on the changes of unsigned magnetic flux, we divide the emergence process into two evolutionary stages: (1) an increasing stage before the peak flux and (2) a constant or decreasing stage after the peak flux. Obvious changes on magnetic helicity flux can be seen during transition from one stage to another. Seven ARs have one or both polarity that changed the sign of magnetic helicity flux. Additionally, the prevailing polarity of the two ARs, which injects more magnetic helicity, changes form the following polarity to the leading one.

• International Journal of Contents
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• v.8 no.1
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• pp.95-99
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• 2012

Interior design companies in Seoul, Korea, senior level designers-designers shared leadership model has not been implemented by the design management. The whole interior design companies are worked each by a leadership team consisting of senior level designers, contractors and designers, being accountable for company, workers, and budgets. The results for workers' opinion in leadership positions were evaluated. All 154 leading workers of all professional teams were anonymously interviewed with a questionnaire containing 45 items regarding their satisfaction with this new shared leadership model. The response rate was 96.2%. After all, the leading workers were satisfied with the shared leadership model both in their own designing practice and in general. Non-design workers were comprehensively more in favor of quite a few aspects of shared leadership than senior level designers, but even the latter reported to be generally satisfied. However, both professional teams estimated leading positions to be only modestly attractive. The consequences yield some evidence that the transform from traditional leadership models to the senior level designers -designers shared leadership model may have advantages in the management of interior design companies. Furthermore, there is a need for greater clarity about precisely what we mean by shared leadership and also a deeper exploration of potential challenges arising from shared leadership models if we are to try to come to terms with their practice.

• Journal of Power Electronics
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• v.16 no.5
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• pp.1833-1842
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• 2016

In grid-connected converter control, grid voltage feedforward is usually introduced to suppress the influence of grid voltage distortion on the converter's grid-side AC current. However, owing to the time-delay in control systems, the suppression effect of the grid voltage distortion is seriously affected. In this paper, the positive effects of the grid voltage feedforward control are analyzed in detail, and the time-delay caused by the low-pass filter (LPF) in the voltage filtering circuits and digital control are summarized. In order to reduce the time-delay effect on the performance of the feedforward control, a voltage feedforward control strategy with time-delay compensation is proposed, in which, a leading correction of the feedforward voltage is used. The optimal leading step used in this strategy is derived from analyzing the phase-frequency characteristics of a LPF and the implementation of digital control. By using the optimal leading step, the delay in the feedforward path can be further counteracted so that the performance of the feedforward control in terms of suppressing the influence of grid voltage distortion on the converter output current can be improved. The validity of the proposed method is verified through simulation and experiment results.