Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Senotherapeutics: Different approaches of discovery and development

  • Jee Hyeon Yoon (Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Seoul National University) ;
  • Ho Jae Han (Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Seoul National University)
  • Published : 2024.01.31
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Abstract

Keywords

Acknowledgement

This research was supported by the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2021R1A5A1033157).

References

  1. Gems, D. (2022). The hyperfunction theory: An emerging paradigm for the biology of aging. Ageing Res. Rev. 74, Article 101557.
  2. Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., and Li, J. (2022). Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct. Target Ther. 7, Article 391.
  3. Landry, D.A., Yakubovich, E., Cook, D.P., Fasih, S., Upham, J., and Vanderhyden, B.C. (2022). Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci. Adv. 8, eabq1475.
  4. Nambiar, A., Kellogg, D., 3rd, Justice, J., Goros, M., Gelfond, J., Pascual, R., Hashmi, S., Masternak, M., Prata, L., LeBrasseur, N., et al. (2023). Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine, 90, Article 104481.
  5. Pereira, B.I., Devine, O.P., Vukmanovic-Stejic, M., Chambers, E.S., Subramanian, P., Patel, N., Virasami, A., Sebire, N.J., Kinsler, V., Valdovinos, A., et al. (2019). Senescent cells evade immune clearance via HLA-E-mediated NK and CD8(+) T cell inhibition. Nat. Commun. 10, 2387.
  6. Ryu, W., Park, C.W., Kim, J., Lee, H., and Chung, H. (2023). The Bcl-2/Bcl-xL inhibitor ABT-263 attenuates retinal degeneration by selectively inducing apoptosis in senescent retinal pigment epithelial cells. Mol. Cells, 46, 420-429. https://doi.org/10.14348/molcells.2023.2188
  7. Shi, D., Liu, W., Gao, Y., Li, X., Huang, Y., Li, X., James, T.D., Guo, Y., and Li, J. (2023). Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging, 3, 297-312. https://doi.org/10.1038/s43587-023-00360-x
  8. Wang, L., Wang, B., Gasek, N.S., Zhou, Y., Cohn, R.L., Martin, D.E., Zuo, W., Flynn, W.F., Guo, C., Jellison, E.R., et al. (2022). Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 34, 186.
  9. Wong, F., Omori, S., Donghia, N.M., Zheng, E.J., and Collins, J.J. (2023). Discovering small-molecule senolytics with deep neural networks. Nat. Aging, 3, 734-750. https://doi.org/10.1038/s43587-023-00415-z
  10. Yang, D., Sun, B., Li, S., Wei, W., Liu, X., Cui, X., Zhang, X., Liu, N., Yan, L., Deng, Y., et al. (2023). NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates. Sci. Transl. Med. 15, eadd1951.