• 대한방사선치료학회지
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• 제15권1호
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• pp.35-40
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• 2003

I. 목적 방사선 치료에서 인접한 두 target을 가진 두경부 환자의 target간의 이동시, 육안으로 판별하여 수동으로 couch를 이동하는 방식에서 나타날 수 있는 오차를 확인하기 위하여, couch의 좌표값을 분석하고 target간의 이동에 대한 재현성의 정확성을 평가하고자 한다. II. 대상 및 방법 방사선 치료에 있어서 치료하고자 하는 인접한 두 target간의 이동시 operator에 의한 수동이동에서 나타날 수 있는 이동오차를 확인하기 위하여, couch의 좌표값(vertical, longitudinal, lateral 세 방향)을 이용, 수동으로 위치잡이시 이동거리에 대한 정확도를 평가하기 위해 치료장비( CL 2100C, Varian, USA) 의 console monitor에 나타난 좌표값을 기록하였다. 매 치료마다 vertical, longitudinal, lateral 세 방향에서 기록된 좌표의 이동거리를 구한 후에, 이를 RTP(Pinnacle, ADAC, USA)에 의한 target간의 거리와 비교하여 오차값을 구하였다. 동일환자를 10회에 걸쳐 실제 set-up시의 좌표이동의 평균값과 오차정도, 그리고 표준편차를 구하였다. III. 결과 환자의 skin mark를 육안으로 확인하며 수동으로 couch를 이동하는 방식에서 두 target간 이동의 평균 표준편차가 각 방향에서 vertical 1.4mm, longitudinal 0.9mm, lateral 2.2mm로 나타났고, 직선상의 이동오차는 평균 약 3.6mm, 최대 5.1mm의 오차가 나타났다. Lateral 방향에서 오차정도가 가장 커서 최대 5mm까지 오차가 발생하였으며, 각 방향에서 오차평균값은 vertical 1mm, longitudinal 0.7mm, lateral 2.7mm이고 이중에서 가장 오차가 큰 lateral방향의 오차평균값을 크게 넘어서는 경우는 전체의 $30\%$정도로 나타났다. IV. 결론 Couch를 수동으로 이동하여 target간을 이동시, 평균 약 3.6mm정도의 오차가 발생하였다. 3D conformal therapy나 IMRT처럼 높은 정밀도를 요구하는 치료의 경우에는 인접한 target간의 정확한 이동을 요구하므로, couch의 실제 좌표의 오차를 확인하는 일이 중요하다. 따라서 couch의 좌표확인을 이용한 치료의 재현성과 정확성 평가를 더욱 발전시켜 응용한다면 양질의 방사선 치료를 실시할 수 있을 것이라 사료된다.

• 한국의학물리학회지:의학물리
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• 제25권4호
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• pp.288-297
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• 2014

Dynamic conformal arc therapy (DCAT) and flattening-filter-free (FFF) beams are commonly adopted for efficient conformal dose delivery in stereotactic body radiation therapy (SBRT). Off-axis geometry (OAG) may be necessary to obtain full gantry rotation without collision, which has been shown to be beneficial for peripheral targets using flattened beams. In this study dose distributions in OAG using FFF were evaluated and the effect of mechanical rotation induced uncertainty was investigated. For the lateral target, OAG evaluation, sphere targets (2, 4, and 6 cm diameter) were placed at three locations (central axis, 3 cm off-axis, and 6 cm off-axis) in a representative patient CT set. For each target, DCAT plans under the same objective were obtained for 6X, 6FFF, 10X, and 10FFF. The parameters used to evaluate the quality of the plans were homogeneity index (HI), conformality indices (CI), and beam on time (BOT). Next, the mechanical rotation induced uncertainty was evaluated using five SBRT patient plans that were randomly selected from a group of patients with laterally located tumors. For each of the five cases, a plan was generated using OAG and CAG with the same prescription and coverage. Each was replanned to account for one degree collimator/couch rotation errors during delivery. Prescription isodose coverage, CI, and lung dose were evaluated. HI and CI values for the lateral target, OAG evaluation were similar for flattened and unflattened beams; however, 6FFF provided slightly better values than 10FFF in OAG. For all plans the HI and CI were acceptable with the maximum difference between flattened and unflattend beams being 0.1. FFF beams showed better conformality than flattened beams for low doses and small targets. Variation due to rotational error for isodose coverage, CI, and lung dose was generally smaller for CAG compared to OAG, with some of these comparisons reaching statistical significance. However, the variations in dose distributions for either treatment technique were small and may not be clinically significant. FFF beams showed acceptable dose distributions in OAG. Although 10FFF provides more dramatic BOT reduction, it generally provides less favorable dosimetric indices compared to 6FFF in OAG. Mechanical uncertainty in collimator and couch rotation had an increased effect for OAG compared to CAG; however, the variations in dose distributions for either treatment technique were minimal.

• 한국군사과학기술학회지
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• 제16권3호
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• pp.398-404
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• 2013

The simulation of the ballistic trajectory of penetrator into the spaced multi-layer RC targets is very important to predict the hitting condition in subsequent target. Because of perturbation by lateral load of penetrator caused by asymmetric hitting position between penetrator and steel bar reinforcement, penetrator rotates and deviates from the straight path. Therefore, penetration capability of penetrator is decreased in the subsequent targets. This paper presents the result of the penetration of steel-bar-reinforced concrete target by using the explicit finite element code LS-DYNA. A series of computations is performed and compared to experimental data and the computed results are in good agreement with the experimental results over a wide range of velocities. And then we conduct the simulation according to various RC target hitting condition and impact velocities.

• 대한정형도수물리치료학회지
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• 제14권1호
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• pp.24-30
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• 2008

Purpose : The patients who have Supraspinatus tendinitis, Lateral epicondylitis, Achilles tendinitis are our targets, so we want to know their opinions in order to take Sono-graphic tests and to study utility value of Sono-graphic. Object and Methods : The case of 30 patients with Tendinitis results, we classified with three categories, Supraspinatus tendinitis, Lateral epicondylitis and Achilles tendinitis. Case by case, before medical treatment, we executed the inspections which are Sound side and Affected side. After 4 weeks of medical treatment, we executed the inspection which is Sono-graphic. Objectively comparing with Sono-graphic, we measured VAS(Visual Analog Scale) before and after physical therapy. Results : We could learn that VAS (Visual Analog Scale) and Sono-graphic wore decreased about changing the lesion area of each disease. For example, Supraspinatus tendinitis is from case 1 and case 2, Lateral epicondylitis is from case 8, case 9 and case 10, Achilles tendinitis is from case 16, case 17 and case 18. Conclusion : About organization of complicated anatomy, we could learn general ideas about Supraspinatus tendinitis, Lateral epicondylitis, Achilles tendinitis. And finally the results which appeared between the decrements of VAS and Sono-graphic are similar.

• The Journal of Korean Physical Therapy
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• 제34권2호
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• pp.57-62
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• 2022

Purpose: The purpose of this study was to determine the effects of bilateral visual feedback training with visual targets on the postural balance and fall efficacy of stroke patients with hemiparesis. Methods: A total of 24 stroke patients with hemiparesis were randomly assigned to either a bilateral visual feedback training (BVFT, n=8) group, unilateral visual feedback training (UVFT, n=8) group, or a control group (n=8). The BVFT and UVFT groups performed weight-bearing training on the bilateral (less-affected and affected side) or unilateral side (affected side) with visual feedback using visual targets. The control group performed squat training without visual feedback using visual targets. The training program was conducted in the form of 3 sets a day, 3 times a week, for 4 weeks. The participants were evaluated using the Berg balance scale (BBS), lateral reaching test (LRT), timed up and go test (TUG), and the activities-specific balance confidence scale (ABC). Results: In the intra-group comparison after the intervention, the BVFT group showed a significant difference in the BBS, TUG, affected and less-affected side LRT, and ABC (p<0.05). The UVFT group showed a significant difference in the BBS and ABC (p<0.05). In the inter-group comparison after the intervention, the BVFT group showed significant improvements in their BBS, affected side LRT, and TUG, when compared to the control group (p<0.05). Conclusion: These findings show that bilateral visual feedback training with visual targets during bilateral weight-bearing exercises can improve the postural balance function in stroke patients.

• BMB Reports
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• 제50권11호
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• pp.535-536
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• 2017

A novel approach has been used to identify functional interactions relevant to human disease. Using high-throughput human-yeast genetic interaction screens, a first draft of disease interactome was obtained. This was achieved by first searching for candidate human disease genes that confer toxicity in yeast, and second, identifying modulators of toxicity. This study found potentially disease-relevant interactions by analyzing the network of functional interactions and focusing on genes implicated in amyotrophic lateral sclerosis (ALS), for example. In the subsequent proof-of-concept study focused on ALS, similar functional relationships between a specific kinase and ALS-associated genes were observed in mammalian cells and zebrafish, supporting findings in human-yeast genetic interaction screens. Results of combined analyses highlighted MAP2K5 kinase as a potential therapeutic target in ALS.

• Molecules and Cells
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• 제41권9호
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• pp.818-829
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• 2018

Significant research efforts are ongoing to elucidate the complex molecular mechanisms underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential therapeutic targets for treatment. The ALS research field has evolved with recent discoveries of numerous genetic mutations in ALS patients, many of which are in genes encoding RNA binding proteins (RBPs), including TDP-43, FUS, ATXN2, TAF15, EWSR1, hnRNPA1, hnRNPA2/B1, MATR3 and TIA1. Accumulating evidence from studies on these ALS-linked RBPs suggests that dysregulation of RNA metabolism, cytoplasmic mislocalization of RBPs, dysfunction in stress granule dynamics of RBPs and increased propensity of mutant RBPs to aggregate may lead to ALS pathogenesis. Here, we review current knowledge of the biological function of these RBPs and the contributions of ALS-linked mutations to disease pathogenesis.

• 한국정보통신학회논문지
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• 제13권12호
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• pp.2753-2758
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• 2009

해군에서는 수중 표적을 효과적으로 탐색하기 위한 소나운용전술을 개발하기 위해 노력하고 있다. 효율적인 소나운용전술 개발을 위해서는 먼저 다양한 소나운영전술에 대한 효과도를 분석할 수 있는 시뮬레이션 시스템이 필요하다. 시뮬레이션 시스템은 해양환경 정보, 자함 정보, 소나 정보, 그리고 수중표적의 정보를 매개변수로 입력받아 소나운용전술에 대한 시뮬레이션을 수행하며, 시뮬레이션의 진행에 따른 다양한 정보를 제공할 수 있어야 한다. 본 연구에서는 다양한 환경에서 수중표적에 대한 함정의 최적 탐색 전략을 평가할 수 있는 탐색효과도 분석용 시뮬레이션 시스템을 설계 개발하였다. 시뮬레이션 시스템은 소나방정식 및 탐지확률곡선을 이용할 수 있도록 개발되었으며, 표적의 실제적인 행동패턴을 고려하여 여러 가지 형태의 기동 패턴을 시스템에 묘사하였다. 개발된 시스템은 앞으로 수중표적에 대한 효율적인 소나운용전술을 개발하고 발전시키는데 유용하게 사용될 수 있을 것으로 판단된다.

• Smart Structures and Systems
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• 제20권5호
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• pp.563-572
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• 2017

The safety of structures is closely associated with the structural out-of-plane behavior. In particular, long and slender beam structures have been increasingly used in the design and construction. Therefore, an evaluation of the lateral and torsional behavior of a structure is important for the safety of the structure during construction as well as under service conditions. The current contact measurement method using displacement meters cannot measure independent movements directly and also requires caution when installing the displacement meters. Therefore, in this study, a vision-based system was used to measure the in-plane and out-of-plane displacements of a structure. The image processing algorithm was based on reference objects, including multiple targets in Lab color space. The captured targets were synchronized using a load indicator connected wirelessly to a data logger system in the server. A laboratory beam test was carried out to compare the displacements and rotation obtained from the proposed vision-based measurement system with those from the current measurement method using string potentiometers. The test results showed that the proposed vision-based measurement system could be applied successfully and easily to evaluating both the in-plane and out-of-plane movements of a beam including twisting rotation.

• 한국전문물리치료학회지
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• 제13권4호
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• pp.23-29
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• 2006

The purpose of the present study was to examine gaze effects on spatial and kinematic characteristics during a pointing task. Subjects were asked to watch and point to an aimed target (2 mm in diameter) displayed on a vertically mounted board. Four gaze conditions were developed as combinations of "seeing-aiming" in terms of the eye movements: Focal-Focal (F-F), Focal-Fixing (F-X), Fixing-Focal (X-F), and Fixing-Fixing (X-X). Both the home target and an aimed target were presented for 1 second and then were disappeared in F-F and X-F. In X-F and X-X, only an aimed target disappeared after 1 second. Subjects were asked to point (with index finger tip) to an aimed target accurately as soon as the aimed target was removed. A significant main effect of gaze was found (p<.01) for normalized movement time. Peripheral retina targets had significantly larger absolute error compared to central retina targets on the x (medio-lateral) and z (superior-inferior) axes (p<.01). A significant undershooting to peripheral retina targets on the x axis was found (p<.01). F-F and X-F had larger peak velocities compared to F-X and X-X (p<.01). F-F and X-F were characterized by more time spent in the deceleration phase compared to F-X and X-X (p<.01). The present study demonstrates that central vision utilizes a form of on-line visual processing to reach to an object, and thus increases spatial accuracy. However, peripheral vision utilizes a relatively off-line visual processing with a dependency on proprioceptive information.