• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.80-80
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• 2010

Graphene has attracted tremendous attention for the last a few years due to it fascinating electrical, mechanical, and chemical properties. Up to now, several methods have been developed exclusively to prepare graphene, which include micromechanical cleavage, polycrystalline Ni employing chemical vapor deposition technique, solvent thermal reaction, thermal desorption of Si from SiC substrates, chemical routes via graphite intercalation compounds or graphite oxide. In particular, polycrystalline Ni foil and conventional chemical vapor deposition system have been widely used for synthesis of large-area graphene. [1-3] In this study, synthesis of mono-layer graphene on a Ni foil, the mixing ratio of hydrocarbon ($CH_4$) gas to hydrogen gas, microwave power, and growth time were systemically optimized. It is possible to synthesize a graphene at relatively lower temperature ($500^{\circ}C$) than those (${\sim}1000^{\circ}C$) of previous results. Also, we could control the number of graphene according to the growth conditions. The structural features such as surface morphology, crystallinity and number of layer were investigated by scanning electron microscopy (SEM) and atomic force microscopy (AFM), transmission electron microscopy (TEM) and resonant Raman spectroscopy with 514 nm excitation wavelength. We believe that our approach for the synthesis of mono-layer graphene may be potentially useful for the development of many electronic devices.

• Journal of Veterinary Science
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• 제22권5호
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• pp.47.1-47.10
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• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 1997년도 제12회 동계학술발표회 논문집
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• pp.159-176
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• 1997

This paper deals with demand surveys for big science and technology research facilities and equipments to advance national S'||'&'||'T research infrastructure. We perform surveys thrice based on applied Delphi method on the future demand of big S'||'&'||'T research facilities and equipments among Korean scientists and engineers. We employ the concept of big S'||'&'||'T research facilities and equipments as follows: \circled1 The operating size of it is equivalent to that of an institute or research center, and/or \circled2 The users in various disciplines are many, and/or \circled3 The application areas or spill-over effects are large, and/or \circled4 The scale and scope of research objects is equivalent to that of mega science area such as earth.oceanography.space, and/or \circled5 The expenses for installing and operating it are to be supported by government, and/or \circled5 The facilities are expected as necessary for international joint research, and/or \circled7 It is necessary for promoting creative basic science and developing creative technology. We ask the respondents to answer the following questionnaire: - How to prioritize the equipments according to the degree of importance\ulcorner $\square$ Promotion of basic science and mega science, the development of the technologies to enhance the public welfare, the competitiveness of industrial technologies, the job creation for the S'||'&'||'T personnel, and international cooperation. - Who should be in charge of acquisition and operation of the equipments\ulcorner $\square$ Industry, Government Research Institutes, Academy, ERC and SRC. - When shall we acquire the equipment\ulcorner $\square$ Within 2000, 2002, 2007, 2012, and 2017. - How shall we acquire the equipments\ulcorner $\square$ International Joint Development, Domestic Development, Acquisition from Overseas, - How much will the equipment generate spill-over effects to national competitiveness\ulcorner $\square$ Promotion of basic science, contribution to the economy, supply of S'||'&'||'T personnel, and international cooperation. We suggest the following equipments as prioritized candidates after consulting the officers from MOST, MOE, MIC, MOEN and experts from KBSI and STEPI:(table omitted) where, #1, Korea Advanced Liquid Metal Reactor, #2. 800 MHz Superconduction Fourier-Transform Nuclear Magnetic Resonance Spectrometer, #3. Ion Accelerator, #4. Seismic Test Facility, #5. Transonic Wind Tunnel, #6. Radio Telescope for Very Long Baseline Interferometer, #7. 3000t Universal(or Large Structure) Testing Machine, #8. Compost Facility or Plasma Pyrolysis Facility.

• Archives of Plastic Surgery
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• 제36권4호
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• pp.512-515
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• 2009

Purpose: Neurofibromatosis(NF) is an autosomal - dominant systemic disease. Up to fifty percent of patients with NF are reported to have concomitant vascular abnormalities. In the resection of a larger NF, the risk of uncontrolled hemorrhage is much higher due to the difficulty of hemostasis of large vessels within the tumor. We ligated the base of the giant NF with a simple loop - shaped ligation before removal of the giant NF in both buttocks. And then we could successfully reduce the amount of hemorrhage during the operation. Methods: A 46 - year - old female patient presented for giant masses of both gluteal area, which has been growing slowly for the last ten years. Each mass was about $30{\times}20cm$ in size. After designing the elliptical resection margin, we tightened the tumor base by using continuous loop - shaped suture ligation(weaving the thread up and down in a loop - shaped pattern, leaving a space of 2 cm between each loop) with a straight needle and prolene 2 - 0. After skin incision, we proceeded the dissection toward the central and inferior side of the mass obliquely while we avoided breaking large vascular sinuses. We resected the tumor in a wedged - shape. Subcutaneous tissue was sutured layer by layer and skin was closed by vertical mattress and interrupted suture. The loop - shaped ligation of the base was removed and compressive dressing was done with gauzes and elastic bandages. Results: Postoperative complications such as infection, hemorrhage, hematoma, and dehiscense did not occur. Perioperatively the patient was sufficiently transfused with five units of blood and two units of fresh frozen plasma. During the subsequent 1 year follow - up, the functional and cosmetic result was excellent. Conclusion: A continuous loop - shaped suture ligation procedure along the base of the giant NF effectively reduced the amount of hemorrhage during the operation, made dissection and ligation of vessels easily and quickly, and shorten the operating time and postoperative recovery time.

• Journal of Advanced Marine Engineering and Technology
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• 제40권9호
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• pp.768-773
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• 2016

엔진 밸브 시트와 페이스는 엔진 성능에 영향을 미치므로 내마모성, 내열성 및 내식성이 요구된다. 이러한 특성을 갖는 표면층을 형성하기 위해 일반적으로 PTA 프로세스를 사용하고 있지만 넓은 열 영향부와 높은 모재 희석 등과 같은 문제가 발생한다. 이러한 단점을 개선한 레이저 클래딩은 희석률이 낮고 열 영향 및 열 변형을 최소화하므로 더욱 우수한 클래드 층을 형성할 수 있다. 하지만 레이저 빔의 특성상 넓은 면적을 클래딩 할 경우, 1 패스 클래드 층의 중첩이 불가피하다. 중첩률 기준을 빔 사이즈와 클래드 층 폭으로 나누어 멀티패스 클래드 층을 형성한 결과, 기준에 관계없이 중첩률이 증가할수록 클래드 층의 폭이 감소하고 높이가 증가하였다. 하지만 빔 사이즈 기준 중첩률 조건으로 형성된 멀티패스 클래드 층이 다른 기준보다 모재 희석이 감소하여 더욱 높은 경도 값을 나타내었다. 결론적으로, 중첩률 기준을 클래드 층 폭으로 할 경우, 클래드 층 형상에 영향을 주는 공정변수가 변할 때 마다 폭의 길이가 달라지기 때문에 빔 사이즈를 중심으로 중첩률을 정의하였다.

• 한국융합학회논문지
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• 제10권3호
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• pp.39-47
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• 2019

본 논문에서는 실시간으로 보행자를 추적할 때 배경 제거를 이용하여 변형된 HOG(Histogram of Oriented Gradients) 특징 추출을 제안하였다. 기존의 HOG 특징 추출은 연산량이 많아 추적 속도가 느린 문제가 있다. 배경 제거를 통해 연산량 감소와 추적률을 향상시키기 위해 연구하였다. 불필요한 영역에서의 특징 추출을 감소시키기 위해 HSV 색공간에서 S 채널과 V 채널을 이용하여 영역 제거를 진행하였다. 영상의 평균 S 채널과 V 채널로 배경 제거 후 입력 영상이 전체적으로 어두워 객체 추적에 실패하는 경우가 있다. 이러한 경우를 방지하기 위해 히스토그램 평활화를 하였다. 제거된 영역에서 추출되는 HOG 특징이 감소되고, 객체에서는 명확한 HOG 특징이 추출되어 객체 추적 속도와 추적률이 향상되었다. 본 실험에서는 다수의 보행자나 한명의 보행자가 존재하는 영상, 배경이 복잡한 영상, 흔들림이 심한 영상을 가지고 실험하였다. 제안하는 방법은 기존의 HOG-SVM 방법과 비교하여 처리 속도는 약 41.84% 향상되었으며 오 추적률은 약 52.29% 감소되어 개선된 추적률을 보였다.

• 한국산학기술학회논문지
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• 제9권4호
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• pp.878-885
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• 2008

최근에 많은 수요와 각광을 받고 있는 디스플레이 장치에서 CRT는 곡면이며 무겁고 큰 부피 때문에 LCD, PDP, OLED와 같은 평판디스플레이(FPD)로 대체되고 있다. FPD는 $0.6\sim0.8mm$ 두께의 대면적 글래스에 여러 공정을 거친 후에 최종 제품 규격으로 절단하여 제작하기 때문에 글래스의 면적이 크면 클수록 FPD의 생산성이 높다는 밀접한 관계를 갖는다. 따라서 FPD 제조 업계에서는 글래스 면적을 증가시키기 위하여 노력하고 있으며, 예를 들면, 현재 8세대 LCD인 경우 약 $2,200mm\times2,600mm$의 면적을 가진다. 이러한 글래스를 이송하는 대표적인 장치로서 공기부상 컨베어시스템은 압축공기를 이용해서 FPD용 대면적 글래스 등을 약 $0.3\sim0.5mm$ 정도 부상시켜 비접촉으로 이송할 수 있는 장치이다. 이 때 글래스와 다공질판 표면 사이의 공기 유동이 모델링되고 해석되며, 이것으로부터 글래스의 공기부양 조건이 예측될 수 있다. 글래스를 이송시 전기공급 중단에 의하여 압축공기가 공급되지 않아 부상판과 접촉이 발생하였을 때, 자기윤활 특성을 가진 다공질판 위의 글래스는 1mm 홀을 많이 가진 사각덕트 부상판 위의 글래스와 조사, 비교된다.

• 화약ㆍ발파
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• 제35권1호
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• pp.43-52
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• 2017

우리나라는 산지와 구릉지가 전 국토 면적의 70% 이상을 정하고 있어 국토 확장, 고속도로 건설, 지하철공사 등의 대형 토목사업과 도심지 아파트 신축과 재개발, 고층건물 신축 등 부지공사 과정에서 암반굴착이 불가피한 경우가 많다. 이러한 대 소형 공사 시 ~ 차질을 받는 경우가 많다. 이에 따라 소음과 지반진동을 감소시키는 발파방법의 적용이 필요하다. 이러한 경우에 적합한 발파방법으로 지금까지 미진동발파, 기계식 굴착공법(할암, Breaker 등), 유사 발파 공법(플라즈마, 겔파쇄 등)이 있다. 본 연구에서는 기존의 미진동 발파에서 사용되고 있는 New KINECKER-I의 순폭성과 배합비 등을 개선하여 경제성 및 시공성을 높인 New KINECKER-II의 특징과 성능을 알아보고 발파진동 추정식을 산출하여 표준 발파패턴 및 시공 방법을 제시하여 사용자의 제품 사용편의를 제공하고자 한다. 또한 연결캡을 사용하여 하나의 뇌관으로 공내 모든 폭약이 순폭됨을 확인하였다.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2016년도 추계학술대회 논문집
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• pp.199-199
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• 2016

Commercially pure titanium (cp-Ti) and Ti alloys (typically Ti-6Al-4V) display excellent corrosion resistance and biocompatibility. Although the chemical composition and topography are considered important, the mechanical properties of the material and the loading conditions in the host have, conventionally. Ti and its alloys are not bioactive. Therefore, they do not chemically bond to the bone, whereas they physically bond with bone tissue. The electrochemical deposition process provides an effective surface for biocompatibility because large surface area can be served to cell proliferation. Electrochemical deposition method is an attractive technique for the deposition of hydroxyapatite (HAp). However, the adhesions of these coatings to the Ti surface needs to be improved for clinical used. Plasma electrolyte oxidation (PEO) enables control in the chemical com position, porous structure, and thickness of the $TiO_2$ layer on Ti surface. In addition, previous studies h ave concluded that the presence of $Ca^{+2}$ and ${PO_4}^{3-}$ ion coating on porous $TiO_2$ surface induced adhesion strength between HAp and Ti surface during electrochemical deposition. Silicon (Si) in particular has been found to be essential for normal bone and cartilage growth and development. Zinc (Zn) plays very important roles in bone formation and immune system regulation, and is also the most abundant trace element in bone. The objective of this work was to study electrochemical characteristcs of Zn and Si coating on Ti-6Al-4V by PEO treatment. The coating process involves two steps: 1) formation of porous $TiO_2$ on Ti-6Al-4V at high potential. A pulsed DC power supply was employed. 2) Electrochemical tests were carried out using potentiodynamic and AC impedance methoeds. The morphology, the chemical composition, and the micro-structure an alysis of the sample were examined using FE-SEM, EDS, and XRD. The enhancements of the HAp forming ability arise from $Si/Zn-TiO_2$ surface, which has formed the reduction of the Si/Zn ions. The promising results successfully demonstrate the immense potential of $Si/Zn-TiO_2$ coatings in dental and biomaterials applications.

• 대한장애인치과학회지
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• 제4권2호
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• pp.73-76
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• 2008

만 1세의 남아가 입에서 피가 계속 난다는 주소로 본과에 내원하였으며 지혈을 위해 봉합술을 시행하였다. 수일 후 다시 출혈 양상이 관찰되어 혈액종양과 협진 의뢰 및 임상 병리검사를 시행하여 경증의 혈우병 A 로 진단하였고 FFP를 투여하여 최종 지혈을 얻었다. 경증의 혈우병은 치과 외상을 통해 처음 발견되는 경우가 종종 있기 때문에 출혈이 지속되거나 수일 후 재발되는 경우에는 혈액 관련 전문가에게 의뢰하고 병리 검사를 시행하는 것이 바람직하다.