• Toxicological Research
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• 제22권3호
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• pp.301-306
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• 2006

Microcystin-LR(MC-LR), a cyanobacterial toxin produced by Microcystis aeruginosa, causes severe hepatotoxicity. Here we investigated the morphologic changes of rat hepatocyte spheroid induced by exposure of MC-LR($10^{-6}M$) in vitro. In addition, to determine the effects of such toxin in the process of hepatocyte spheroid formation, primarily isolated hepatocytes were incubated with MC-LR and the process of spheroid formation was observed. In both hepatocyte spheroid and suspension culture systems, the morphologic changes caused by MC-LR were noticible at 5 min post exposure and were characterized by the loss of microvilli, cytoplasmic vacuolation, the accumulation of lipid droplets, and blob formation. Especially, the size and numbers of blob on the cell surface were increased as the incubation time prolonged and the appearance of electron dense bodies were observed in the cytoplasm of hepatocyte at 20 min post exposure. Furthermore, bile canaliculi-like structures in the hepatocyte spheroids were slightly widened and the process of spheroids formation was inhibited in the isolated hepatocytes incubated with MC-LR. These results indicate that morphologic changes in. the hepatocyte membrane and organelles seem to be typical events in showing the MC-LR induced hepatotoxic effects and the spheroid culture method might be a useful experimental tool to evaluate hepatoxicity since it reflects the in vivo status of hepatocytes.

• 한국통신학회논문지
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• 제33권5B호
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• pp.310-317
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• 2008

LR-WPAN(Low Rate Wireless Personal Area Network)에서 데이터 충돌은 재전송의 원인이 되며 이로 인한 에너지 소비는 전체 네트워크의 수명을 감소시킨다. 또한 LR-WPAN은 상대적으로 적은 backoff 재시도 횟수를 가지고 있기 때문에 충돌에 대해 민감하다. 본 논문에서 제안하는 LCS(Limited Contention Scheme)는 전체 노드를 일정한 수의 그룹으로 나누어 데이터를 전송하는 방식으로써 경쟁을 하는 노드의 수를 줄여 데이터의 충돌 발생 확률과 재전송을 감소시킨다. 그 결과 데이터의 처리율과 전체 네트워크의 수명은 증가하게 된다. 향후 LR-WPAN의 설계 시 LCS를 이용한다면 배터리의 수명은 늘어나게 되어 저전력 소모를 필요로 하는 응용분야에 유용하게 사용될 수 있을 것이다.

• 대한전자공학회논문지TC
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• 제46권5호
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• pp.88-94
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• 2009

본 논문에서는 다중 안테나 시스템에서 신호 수신을 위한 lattice reduction (LR) 기반 복호기의 복잡도를 줄이기 위한 방법을 제안한다. ML (Maximum Likelihood) 방식이 복호 성능은 우수하지만 안테나와 성상 점의 개수에 따라 지수적으로 복잡도가 증가하는데 반해 LR 기반의 복호기는 상대적으로 적은 복잡도로 동일한 다이버시티 성능을 보이는 것으로 알려져 있다. 그러나 LR 과정도 채널 행렬의 열 벡터 교환 과정을 포함한 반복 연산에 의해서 복잡도가 높고 하드웨어 구현이 어려운 점이 있다. LR 과정은 채널 행렬이 주어지는 경우 유일하게 결정되기 때문에 이 과정을 offline으로 미리 수행하여 Look-Up Table(LUT)에 저장하는 방식으로 계산량을 줄일 수 있다. 본 논문에서는 LR 기반 수신기에서 LUT 를 효율적으로 구성하는 방법을 제시하고 성능을 비교한다. 제안된 방식을 적용할 경우 기존의 LR 방식에 비하여 적은 연산량으로 유사한 수신 성능을 보임을 모의실험을 통하여 보인다.

• 한국항행학회논문지
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• 제18권5호
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• pp.476-482
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• 2014

최근 다양한 센서를 활용하는 응용분야의 증가로, 가변전송률을 지원하는 무선 통신 시스템의 필요성이 증가하고 있다. 이를 위해 2.45 GHz 주파수 대역을 사용하는 IEEE 802.15.4 LR-WPAN 시스템이 보편적으로 활용되고 있으나, LR-WPAN 시스템은 250 kbps의 단일 전송률만을 지원하고 있어 다양한 센서 네트워크 시스템에 응용되기에는 한계가 존재한다. 따라서, 본 논문에서는 31.25 kbps, 62.5 kbps, 125 kbps의 가변 전송률을 지원할 수 있는 프리앰블 구조를 정의하고, 주파수 오프셋에 강인한 이중 상관알고리즘을 기반으로 저복잡도 특성을 갖는 시간 동기부의 하드웨어 구조를 설계하였다. 제안된 시간 동기부는 18.36 K의 logic slices 및 4개의 DSP48s로 합성되었으며, 기존의 구조 대비 각각 79.1%와 99.4%의 감소를 보였다.

• 한국정보과학회논문지:정보통신
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• 제30권5호
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• pp.641-648
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• 2003

본 논문은 가변 패킷을 사용하는 일반적인 망에서 실시간 세션이 이종의 여러 스케줄러들을 통과할 때 네트워크가 보장하는 지연의 한계를 추출하는 범용 도구를 제안한다. 이 도구는 이질적인 각 스케줄러를 동질적인 서비스 곡선 서버로 특성화한다. 우리는 서비스 곡선 서버가 LR 서버보다 엄격히 큰 범주의 스케줄러들을 특성화할 수 있음을 보인다 즉, 모든 LR 서버는 서비스 곡선 서버로 특성화할 수 있고, 또한 RC-EDF와 SC 알고리즘조차도 서비스 곡선 서버로 정확히 특성화할 수 있음을 보인다. 이와 같이 서비스 곡선 서버는 LR 서버에 비해서 범용성 관점에서 큰 장점이 있으면서도 분석 결과가 정확하다. 우리는 LR 서버들로 분석할 수 있는 네트워크의 경우도 서비스 곡선 서버로 분석했을 때, 두 경우 모두 동일한 지연의 한계를 추출함을 수학적으로 증명한다.

• Journal of Acupuncture Research
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• 제24권2호
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• pp.125-140
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• 2007

Objectives: This study was performed to investigate the effects of acupuncture therapy(AT, AT-9), electro-acupuncture therapy(EAT) and low level laser acupuncture therapy(LAT) at LRJ on the focal ischemia-induced by intraluminal filament insertion in rats. Methods : In the present syudy, the focal ischemia was induced by Intraluminal filament insertion into left middle cerebral artery. The subjects were divided into five groups after focal brain ischemia. (n=15, in each group) : Control with no treatment, AT with acupuncture at $LR_3$, AT-9 with acupuncture at $LR_3$ and rotating 9 times in a clockwise direction, EAT with electro-acupuncture at $LR_3$ and LAT with invasive laser acupuncture at $LR_3$. Anti-apoptotic and neuroprotective effects of acupuncture were observed by mGluR5 mRNA, Bax mRNA, Bcl-2 mRNA, Cytochrome C protein, Cresyl violet-stain and Choline acetyltransferase (ChAT)-stain in the hippocampus. Results: 1. In LAT, mGluR5, Cresyl violet-stain and ChAT-stain were increased. 2. In LAT, Cytochrome C protein was decreased. 3. In AT-9, Bax, Cytochrome C protein and the Bax/Bcl-2 ratio were decreased. 4. In AT-9, Bcl-2, Cresyl violet-stain and ChAT-stain were increased. 5. In EAT, Bcl-2 and Cresyl violet-stain were increased. Conclusions: These results suggests that LAT and AT-9 show anti-apoptotic and neuro-protective effects and that LAT and AT-9 may be useful for managing stroke by focal brain ischemia.

• 상하수도학회지
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• 제30권5호
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• pp.579-586
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• 2016

In many countries in order to manage corrosion of water treatment process, it is currently using Langelier index (LI). However, management of the Larson's ratio (LR) to compare corrosion management and LI which can be generated by the water treatment process is required. In this study, in order to ensure data LR, factors associated with the actual corrosion resistance of water treatment plant was measured. Using the measured data, the model equation can be estimated alkalinity, and using the statutory water quality data, LR and alkalinity is estimated. At comparison of the measured value and estimated value of alkalinity, it appeared in $R^2$ = 0.629, using the statutory water quality data and estimated alkalinity model, LR and alkalinity (Whole water treatment plants : 472) is estimated. Concentration of estimated alkalinity is 0.5 mg/L to 107.5 mg/L (average : 23.2 mg/L), and LR is 0.1 to 10 (average : 1.3). At tendency to corrosion of investigated LR, "No metal tendency" (>0.5) is 39 water treatment plants, 8.26 %, and "corrosion metal tendency" is 433 water treatment plants, 91.74%.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6923-6928
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• 2015

Background: Early detection of various kinds of cancers nowadays is needed including colorectal cancer due to the highly significant effects in improving cancer treatment. The aim of this study was to evaluate the potential value of adiponectin, visfatin and resistin as early biomarkers for colorectal cancer patients. Materials and Methods: Serum levels of adiponectin, visfatin and resistin were measured by a sandwich-enzyme-linked (ELISA) assay technique in 114 serum samples comprising 34 patients with colorectal cancer (CRC), 27 with colonic polyps (CP), 24 with inflammatory bowel disease (IBD) and 29 healthy controls. The diagnostic accuracy of each serum marker was evaluated using receiver-operating characteristic (ROC) curve analysis. Results: The mean concentration of adiponectin was significantly higher in CRC and CP groups than IBD and control groups (P-value <0.05). Also the mean concentration of serum resistin was significantly elevated in the IBD and control groups compared to CRC and CP groups (P-value = 0.014). However, no significant difference was noted in patients of the CRC and CP groups. On the other hand, the mean concentration of visfatin was significantly elevated in CRC and control groups compared to CP and IBD groups (P-value = 0.03). ROC analysis curves for the studied markers revealed that between CRC and IBD groups serum level of adiponectin had a sensitivity of 76.7% and a specificity of 76% at a cut off value of 3940, +LR being 3.2 and -LR 0.31 with AUC 0.852, while serum level of adiponectin between CP and IBD had a sensitivity of 77.8% and a specificity of 75% at a cut off value of 3300, with +LR=3.11 and -LR = 0.3 with AUC 0.852. On the other hand the serum level of visfatin between CRC and CP groups had a sensitivity of 65.5% and a specificity of 66.7 at a cut off value of 2.4, +LR being 1.67 and -LR 0.52 with AUC 0.698. Also the serum level of resistin had a sensitivity of 62.5% and a specificity of 70.3% at a cut off value of 24500, with +LR=2.1 and -LR = 0.53 with AUC 0.685 between control and other groups. On the other hand by comparing control vs CP groups resistin had a sensitivity of 81.8% and a specificity of 70.8% at a cut off value of 17700, with +LR=2.8 and -LR = 0.26 with AUC 0.763 while visfatin had a sensitivity of 68.2% and a specificity of 70.8% at a cut off value of 2.7, with +LR=2.34 and -LR = 0.0.45 with AUC 0.812. Conclusions: These findings support potential roles of adiponectin, visfatin and resistin in early detection of CRC and discrimination of different groups of CRC, CP or IBD patients from normal healthy individuals.

• Korean Journal of Acupuncture
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• 제23권1호
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• pp.1-14
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• 2006

Objectives : This research was performed to investigate the effect of invasive low level laser acupuncture therapy(LLLAT) at Yolgyol+yogu(LU7+LR5) on weight gain, food intake, food efficiency, lipid metabolism and liver function in hyperlipemia rats. Methods : Experimental groups were divided into high fat diet cup(Control group), high fat diet and 15 mW/5 min LLLAT at LU7+LR5(15 mW/5 min group), 15 mW/10 min LLLAT at LU7+LR5(15 mW/10 min group), 30 mW/5 min LLLAT at LU7+LRS(30 mW/5 min group), 30 mW/10 min LLLAT at LU7+LR5(30 mW/10 min group). LLLAT was treated at the 15,30mW-5,10min once a 2day during 5 weeks. Results : Body weight was decreased significantly in 30 mW/s min group and 30 mW/10 min group compared with control group. Food intake was decreased significantly in 15 mW/5 min group and 15 mW/10 min group compared with control group. Food efficiency was decreased significantly in 30 mW/10 min group compared with control group. In the lipid metabolism, total cholesterol, HDL-cholesterol and free fatty acid were increased significantly in 15 mW/5 min group and 30 mW/10 min group compared with control group. LDL-cholesterol was increased in 30 mW/10 min group and phospholipids was decreased significantly in all experimental group compared with control group. triglyceride was not showed significant result in all experimental group. In the liver function, AST was not showed significant result in all experimental group, ALT and ALP were increased significantly in 30 mW/10 min group, ALP was decreased in 30 mW/5 min group compared with control group. Conclusions : LLLAT at LU7 and LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.

• 대한화학회지
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• 제38권10호
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• pp.741-748
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• 1994

남조류의 독성물질인 microcystin을 HPLC로 분석하기 위해 지금까지는 ODS cartridge를 사용하였으나 본 연구에서는 CN cartridge를 사용하는 새로운 분석 방법을 시도하였다. CN cartridge는 0.5M 초산 용액으로 처리되었으며 Microcystins RR과 LR을 용리시키기 위해 30% Acetonitrile 용액이 사용되었다. CN cartridge를 이용하는 분석 방법이 기존의 ODS cartridge를 이용하는 방법보다 훨씬 더 정확한 정량을 할 수 있었다. 특히 Microcystin LR의 경우 피크 면적에서 현저한 차이를 보였다.