• Animal cells and systems
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• v.16 no.1
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• pp.11-19
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• 2012

A major concern regarding the collection and storage of biodiversity information is the inefficiency of conventional taxonomic approaches in dealing with a large number of species. This inefficiency has increased the demand for automated, rapid, and reliable molecular identification systems and large-scale biological databases. DNA-based taxonomic approaches are now arguably a necessity in biodiversity studies. In particular, DNA barcoding using short DNA sequences provides an effective molecular tool for species identification. We constructed a large-scale database system that holds a collection of 5531 barcode sequences from 2429 Korean species. The Korea Barcode of Life database (KBOL, http://koreabarcode.org) is a web-based database system that is used for compiling a high volume of DNA barcode data and identifying unknown biological specimens. With the KBOL system, users can not only link DNA barcodes and biological information but can also undertake conservation activities, including environmental management, monitoring, and detecting significant organisms.

• Journal of Korean Medical classics
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• v.25 no.1
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• pp.1-16
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• 2012

"Yixuerumen" is a comprehensive medical text published in the Ming-dynasty by Li Chan(李梴). In this text, Sanghan(傷寒, cold damage) is categorized among external contraction(外感) with much emphasis. The subject of this study is the verse "The Principal and secondary aspects must first be decided." and its annotations in the in the Sanghan chapter of "Yixuerumen". The complex theoretical structure of this verse was firstly analyzed, together with the historical background of how and why Li Chan adopted this concept. The Pyo-Bon concept is the contrast between phenomena(標) and its underlying source of motivation(本). The methodology for this study was to compare and analyze this main verse with contents on Sanghan and Un-gi(運氣) within the text, while reviewing historical theories explaining the physiology and pathology of the human body in terms of the Pyo-bon(標本) concept. As a result, we discovered that the Pyo-bon(標本) concept used in the aforementioned verse of "Yixuerumen" matches the Three Eum Three Yang(三陰三陽)-標本中氣(pyo-bon-jung gi)-gi transformation(氣化) theory of Un-gi(運氣). Li Chan created the connecting link in understanding the Three Eum Three Yang diagnosis system through the viscera/bowels theory(臟腑論) by adopting the Three Eum Three Yang(三陰三陽)-標本中氣(pyo-bon-jung gi)-gi transformation(氣化) theory from Un-gi. Li's work lead to several changes in the field of Sanghan. First, Li understood the disease pattern of Sanghan by using the accumulated knowledge of the viscera/bowel theory during the Jin-Yuan dynasty, and developed a medical perspective that observes the disease pattern based on the body's essence gi(精氣). Second, he set the category of the Sanghan-Three Eum Three Yang disease pattern, establishing a separate guideline. Third, by adding knowledge of herbs to the accumulated knowledge of the viscera/bowel theory, the process of diagnosis and herbal application were made explicable. On the other hand, in the process of interpreting the 三陰三陽 diagnosis system with viscera/bowels theory, theoretical inconsistencies appeared, of which Li tried to mend by several means. The results of the research on "Yixuerumen(醫學入門) the Sanghan chapter(傷寒篇)" calls for further studies, as it has effected both "Dongeuibogam(東醫寶鑑) the Sanghan part(寒門)" and "Dongeuisoosebowon(東醫壽世保元)" as well.

• Korean Journal of Weed Science
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• v.16 no.3
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• pp.194-199
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• 1996

Seed size and days required to reach specific growth stages were determined for Echinochloa crus-galli (L.) P. Beauv. varieties which are major grass species found in Korean paddy field and the results were compared with E. frumentacea (Roxb.) Link. In addition, responses of the Echinochloa species on preemergence herbicides (molinate, esprocarb, and mefenacet) were investigated with respect to time of application. One thousand seed weight of E. crus-galli var. oryzicola was about 3 times heavier than that of var. praticola, but was not significantly different that of E. frumentacea. Days requited to reach the 2.5 leaf-stage (LS) were 11, 13, and 14 days after seeding for E. frumentacea, E. crus-galli var. oryzicola, and E. crus-galli var. praticola, respectively. E. crus-galli var. praticola was more sensitive to molinate, esprocarb and mefenacet than var. oryzicola and the sensitivity of both the varieties decreased as the time of application LS was delayed. However, there was no great difference in the response for E. frumentacea when applied between 1.5 and 3.0 LS. In thiocarbamate hebicides esprocarb was more active to Echinochloa species than molinate and the higher the active ingredient of the herbicides, the greater was the activity to Echinochloa species. Differential susceptibility of Echinochloa species to the herbicides was not related to the seed size, but to the early growth stages at the time of herbicide application which were affected by the seed size.

• Korean Institute of Interior Design Journal
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• v.16 no.6
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• pp.152-160
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• 2007

The purpose of this study is to compare conditions of Korean Restaurants in Hong Kong with those of Thai ones, which have already succeeded in globalization, by investigating and analyzing the characteristics of the two parties in Hong Kong, a world-wide international city. For these purposes, we selected 10 Korean restaurants & 10 Thai restaurants in Hong Kong, and visited the selected restaurants during the period from 2007.7.9 to 2007.7.14, to examine indoor spaces and food-related elements were recorded in detail, photographed and analyzed. The results of study is as follows ; we have first found that Korean restaurants did not show any humane properties linked to restaurant concepts and indoor space, did link Korean images through their trade names, and showed decorative culture based on traditional house and dietary-life cultural properties based on traditional Korean Bansang table setting at large. On the other hand, 4 (22.5%) out of the entire cases in Thai restaurants showed religious characteristics with strong Buddhist colors revealed, and all cases showed traditional Thai food cultures, from which we could find out dietary-life cultural properties. Second, whereas there were one case of Korean restaurants in which tradition was main and modernity was assistant, five cases in which tradition and modernity were paralleled in value, and two cases in which modernity was main and tradition was assistant, Thai restaurants had one case where tradition was main and modernity was associative, four cases in which tradition and modernity were paralleled in value, and four cases where modernity was main and tradition was assistant. This means that the Thai restaurants did not insist only on tradition, but showed efforts to transmit luxurious and refined Thai images to people from the world. Third, whereas Korean restaurants had to do with all kinds of menu, were equipped with brazierson their tables uniformly, and showed any differences because they did not use different tableware in accordance with foods, Thai restaurants divided the dinner into the hors d'oeuvre, the main, and the dessert or systemized menu structure by categories in accordance with cooking styles, and tableware selection in accordance with menus, table setting, food materials, and food styling using flowers were consistently expressed.

• Journal of Science and Technology Studies
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• v.16 no.2
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• pp.65-98
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• 2016

Living Lab is being introduced and applied as an innovation model driven by social entities (residents, users, etc.) and as an innovation place based on local and field. This study analyzed three living lab cases of Bukchon IoT living lab, Seong-Daegol energy transition living lab, and Daejeon Geonneoyu project, which were designated as 'Living Lab' to solve local problems. We analyzed the local problem, the problem solving goal, the role of each participant and the subject, the living lab promotion system, the significance in each case. In addition, the types and characteristics of living labs were elucidated and future development plans were discussed. The result is as follow. First, each case has a tendency to link science technology and ICT with local problem solving though there is a difference between the technologies used. Second, local residents played a leading role in the whole living lab process from problem identification to technical experimentation, diffusion and application. Third, the role of the intermediaries commonly played an important role in the operation of the living lab. Last but not least, each case has different types of living lab. Bukchon IoT living lab being operated as a project by the government / municipality to create a living lab activity-base or to support actors' activities. On the other hand, the Seong-Daegol energy transition living lab and Daejeon Geonneoyu project were conducted by the civil society itself to define problems and explore technologies in order to solve local problems.

• Nutrition Research and Practice
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• v.13 no.1
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• pp.58-63
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• 2019

BACKGROUND/OBJECTIVES: Telomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by hTERT and c-MYC, maintains telomeric DNA sequences. Especially, telomerase is active in cancer and stem cells to maintain telomere length for replicative immortality. Recently we reported that walnut phenolic extract (WPE) can reduce cell viability in a colon cancer stem cell (CSC) model. We, therefore, investigated the effect of WPE on telomere maintenance in the same model. MATERIALS AND METHODS: $CD133^+CD44^+$ cells from HCT116, a human colon cancer cell line, were sorted by Fluorescence-activated cell sorting (FACS) and treated with WPE at the concentrations of 0, 10, 20, and $40{\mu}g/mL$ for 6 days. Telomere lengths were assessed by quantitative real-time PCR (qRT-PCR) using telomere specific primers and DNA extracted from the cells, which was further adjusted with single-copy gene and reference DNA ($ddC_t$). Telomerase activity was also measured by qRT-PCR after incubating the PCR mixture with cell protein extracts, which was adjusted with reference DNA ($dC_t$). Transcriptions of hTERT and c-MYC were determined using conventional RT-PCR. RESULTS: Telomere length of WPE-treated cells was significantly decreased in a dose-dependent manner ($5.16{\pm}0.13$ at $0{\mu}g/mL$, $4.79{\pm}0.12$ at $10{\mu}g/mL$, $3.24{\pm}0.08$ at $20{\mu}g/mL$ and $3.99{\pm}0.09$ at $40{\mu}g/mL$; P = 0.0276). Telomerase activities concurrently decreased with telomere length ($1.47{\pm}0.04$, $1.09{\pm}0.01$, $0.76{\pm}0.08$, and $0.88{\pm}0.06$; P = 0.0067). There was a positive correlation between telomere length and telomerase activity (r = 0.9090; P < 0.0001). Transcriptions of both hTERT and c-MYC were also significantly decreased in the same manner. CONCLUSION: In the present cell culture model, WPE reduced telomere maintenance, which may provide a mechanistic link to the effect of walnuts on the viability of colon CSCs.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.6
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• pp.121-132
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• 2018

Weather is an important factor affecting roadway transportation in many aspects such as traffic flow, driver 's driving patterns, and crashes. This study focuses on the relationship between weather and road surface condition and develops a model to estimate the road surface condition using machine learning. A road surface sensor was attached to the probe vehicle to collect road surface condition classified into three categories as 'dry', 'moist' and 'wet'. Road geometry information (curvature, gradient), traffic information (link speed), weather information (rainfall, humidity, temperature, wind speed) are utilized as variables to estimate the road surface condition. A variety of machine learning algorithms examined for predicting the road surface condition, and a two - stage classification model based on 'Random forest' which has the highest accuracy was constructed. 14 days of data were used to train the model and 2 days of data were used to test the accuracy of the model. As a result, a road surface state prediction model with 81.74% accuracy was constructed. The result of this study shows the possibility of estimating the road surface condition using the existing weather and traffic information without installing new equipment or sensors.

• Korean Journal of Radiology
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• v.24 no.10
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• pp.974-982
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• 2023

Objective: Recent studies have highlighted the active and potential role of perivascular adipose tissue (PVAT) in atherosclerosis and aneurysm progression, respectively. This study explored the link between PVAT attenuation and abdominal aortic aneurysm (AAA) progression using computed tomography angiography (CTA). Materials and Methods: This multicenter retrospective study analyzed patients with AAA who underwent CTA at baseline and follow-up between March 2015 and July 2022. The following parameters were obtained: maximum diameter and total volume of the AAA, presence or absence of intraluminal thrombus (ILT), maximum diameter and volume of the ILT, and PVAT attenuation of the aortic aneurysm at baseline CTA. PVAT attenuation was divided into high (> -73.4 Hounsfield units [HU]) and low (≤ -73.4 HU). Patients who had or did not have AAA progression during the follow-up, defined as an increase in the aneurysm volume > 10 mL from baseline, were identified. Kaplan-Meier and multivariable Cox regression analyses were used to investigate the association between PVAT attenuation and AAA progression. Results: Our study included 167 participants (148 males; median age: 70.0 years; interquartile range: 63.0-76.0 years), of which 145 (86.8%) were diagnosed with AAA accompanied by ILT. Over a median period of 11.3 months (range: 6.0-85.0 months), AAA progression was observed in 67 patients (40.1%). Multivariable Cox regression analysis indicated that high baseline PVAT attenuation (adjusted hazard ratio [aHR] = 2.23; 95% confidence interval [CI], 1.16-4.32; P = 0.017) was independently associated with AAA progression. This association was demonstrated within the patients of AAA with ILT subcohort, where a high baseline PVAT attenuation (aHR = 2.23; 95% CI, 1.08-4.60; P = 0.030) was consistently independently associated with AAA progression. Conclusion: Elevated PVAT attenuation is independently associated with AAA progression, including patients of AAA with ILT, suggesting the potential of PVAT attenuation as a predictive imaging marker for AAA expansion.

• Journal of Preventive Medicine and Public Health
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• v.5 no.1
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• pp.115-123
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• 1972

As a link of chain study program of school health, a survey was made up by the screening test with audiometry for hearing disturbance on 18,675 high school students who are mainly aged in 15-19 years from November 5.1969 to October 30. 1970. The results obtained were summerized as follows. According to our criteria as table 3, the rates of the profound, the severe and the moderate who required the appropriate hearing aids were 0.02%, 0.03% and 0.14% respectively:-the cumulative percentage was 0.197. When the marginal, 0.23% should be included the cumulative rate was 0.41%. But there was no-significance by sex and school classes. If we will make the special classes for them one class would be estimated out of 10,000 persons when a class is formed with about 15 persons. Otherwise when we examined that according to each ear of persons, the rates of the profound, the severe and the moderate were 0.17%, 0.22% and 0.33% respectively and their cumulative percentage wag 0.72. There was no significance also by sex and age. By the way, the rate of hearing disturbance in urban high school students tended to lower than rural. And the perceptive disturbance was higher than rural in rate. The conductive disturbance tended to oppose in comparison with the above.

• Journal of Chest Surgery
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• v.42 no.2
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• pp.157-164
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• 2009

Background: Various studies and experimental trials have been done to develop bioprosthetic devices to treat complex congenital heart disease due to the limited usage of homograft tissue. The purpose of the present study was to evaluate the effect of diamine bridges with using L-lysine, as compared with using ethanol. Material and Method: Porcine pericardium was fixed at 0.625% GA (commercial fixation). An interim step of ethanol (80%; 1 day at room temperature) or L-lysine (0.1 M; 2 days at $37^{\circ}C$) was followed by completion of the GA fixation (2 days at $4^{\circ}C$ and 7 days at room temperature). The tensile strength and thickness of the porcine percardium were measured, respectively. The treated pericardiums were implanted subcutaneously into three-week old Long-Evans rats for 8 weeks. The calcium content of the implants was assessed by atomic absorption spectroscopy and the histology. Result: Ethanol pretreatment ($13.6{\pm}10.0ug/mg$, p=0.008), L-lysine pretreatment ($15.3{\pm}1.0 ug/mg$, p=0.002), and both treatment ($16.1{\pm}11.1ug/mg$, p=0.012) significantly inhibited calcification, as compared with the controls $(51.2{\pm}8.5ug/mg)$. L-lysine pretreatment ($0.18{\pm}0.02mm,\;1.20{\pm}0.30kg$ f/5 mm) significantly increased the thickness and tensile strength, as compared with ethanol pretreatment ($0.13{\pm}0.03mm,\;0.85{\pm}0.36$ 1.0 kg f/5 mm) (p<0.01, p=0.035). Conclusion: The diamine bridges using L-lysine seemed to decrease the calcification of porcine pericardium fixed with glutaraldehyde, and this was comparable with Ethanol. Additionally, it seemed to enhance the thickness and tensile strength.