• Coupled systems mechanics
• /
• v.11 no.6
• /
• pp.557-586
• /
• 2022

In spite of extensive testing of the individual shear wall and the coupling beam (CB), numerical and experimental researches on the seismic behavior of CSW are insufficient. As far as we know, no previous research has investigated the affectations of position of CB regarding to the slab level (SL). So, the investigation aims to enhance an overarching framework to examine the consequence of connection positions between CB and SL. And, three cases have been created. One is composed of the floor slab (FS) at the top of the CB (FSTCB); the second is created with the FS within the panel depth (FSWCB), and the third is employed with the FS at the bottom of the CB (FSLCB). And, FEA is used to demonstrate the consequences of various CB positions with regard to the SL. Furthermore, the main measurements of structure response that have been investigated are deformation, shear, and moment in a coupled beam. Additionally, wall elements are used to simulate CB. In addition, ABAQUS software was used to figure out the strain distribution, shear stress for four stories to further understand the implications of slab position cases on the coupled beam rigidity. Overall, the findings show that the position of the rigid linkage among the CB and the FS can affect the behavior of the structures under seismic loads. For all structural heights (4, 8, 12 stories), the straining actions in FSWCB and FSLCB were less than those in FSTCB. And, the increases in displacement time history response for FSWCB are around 16.1-81.8%, 31.4-34.7%, and 17.5% of FSTCB.

• Molecules and Cells
• /
• v.46 no.9
• /
• pp.558-572
• /
• 2023

Chronic obstructive pulmonary disease (COPD) will be the third leading cause of death worldwide by 2030. One of its components, emphysema, has been defined as a lung disease that irreversibly damages the lungs' alveoli. Treatment is currently unavailable for emphysema symptoms and complete cure of the disease. Hyaluronan (HA) and proteoglycan link protein 1 (HAPLN1), an HA-binding protein linking HA in the extracellular matrix to stabilize the proteoglycan structure, forms a bulky hydrogel-like aggregate. Studies on the biological role of the full-length HAPLN1, a simple structure-stabilizing protein, are limited. Here, we demonstrated for the first time that treating human alveolar epithelial type 2 cells with recombinant human HAPLN1 (rhHAPLN1) increased TGF-β receptor 1 (TGF-β RI) protein levels, but not TGF-β RII, in a CD44-dependent manner with concurrent enhancement of the phosphorylated Smad3 (p-Smad3), but not p-Smad2, upon TGF-β1 stimulation. Furthermore, rhHAPLN1 significantly increased sirtuins levels (i.e., SIRT1/2/6) without TGF-β1 and inhibited acetylated p300 levels that were increased by TGF-β1. rhHAPLN1 is crucial in regulating cellular senescence, including p53, p21, and p16, and inflammation markers such as p-NF-κB and Nrf2. Both senile emphysema mouse model induced via intraperitoneal rhHAPLN1 injections and porcine pancreatic elastase (PPE)-induced COPD mouse model generated via rhHAPLN1-containing aerosols inhalations showed a significantly potent efficacy in reducing alveolar spaces enlargement. Preclinical trials are underway to investigate the effects of inhaled rhHAPLN1-containing aerosols on several COPD animal models.

• Journal of Korean Dental Hygiene Science
• /
• v.1 no.2
• /
• pp.21-39
• /
• 2018

The purpose of this study was to examine the learning competencies of students at a college from September 1 to November 30, 2017, in an effort to provide some information on how to foster learning competencies in college years, which lay the foundation for work and social lives. 1. The learning competencies of the subjects consisted of academic vision, student identity, cognitive regulation, emotional regulation, learning management and creating learning environments. Out of five points, they scored the highest in academic vision and student identity with 3.34, followed by learning management with 3.20, creating learning environments with 3.18, emotional regulation with 3.16 and cognitive regulation with 3.14. 2. There were statistically significant differences in academic vision according to age, the area of major, the academic credential of their fathers, commuting time, military service experience and career plans. 3. There were statistically significant differences in student identity and cognitive regulation according to gender, age, the area of major, the academic credential of their fathers, commuting time, military service experience and career plans. 4. There were statistically significant differences in emotional regulation according to age, the area of major, the academic credential of their fathers, commuting time, career plans and daily mean study hours. 5. There were statistically significant differences in learning management according to gender, age, the area of major, grade point average, the academic credential of their fathers, career plans and daily mean study hours. 6. There were statistically significant differences in creating learning environments according to gender, age, the area of major, the academic credential of fathers, commuting time, career plans and daily mean study hours. As they were poorest at the cognitive regulation area among the areas of learning competencies, self-directed learning programs that deal with how to study, learning process, how to take notes and arrange them, how to link different pieces of acquired knowledge and how to map out study plans should be developed to give support to students.

• Advanced Industrial SCIence
• /
• v.3 no.1
• /
• pp.37-50
• /
• 2024

This study explored the link between reproductive health knowledge, attitudes, and self-efficacy in young women from Uganda's Luwero district. A survey was conducted on 82 women in the Luwero region from May to July 2016, and the predictive power of knowledge and attitudes toward self-efficacy was evaluated through multiple linear regression analysis. Results showed positive correlations among these factors, with knowledge and attitude predicting self-efficacy. Specifically, understanding healthy puberty habits and valuing women's roles positively influenced self-efficacy for healthy behaviors. These findings emphasize the need to target these aspects in reproductive health education programs, crucial for addressing adolescent pregnancy and related issues in Uganda's rural areas.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.22 no.6
• /
• pp.1210-1230
• /
• 1997

In this paper, we suggest an architecture of DS/CDMA tranceiver composed of one pilot channel used as reference and multiple traffic channels. The pilot channel-an unmodulated PN code-is used as the reference signal for synchronization of PN code and data demondulation. The coherent demodulation architecture is also exploited for the reverse link as well as for the forward link. Here are the characteristics of the suggested DS/CDMA system. First, we suggest an interlaced quadrature spreading(IQS) method. In this method, the PN coe for I-phase 1st channel is used for Q-phase 2nd channels and the PN code for Q-phase 1st channel is used for I-phase 2nd channel, and so on-which is quite different from the eisting spreading schemes of DS/CDMA systems, such as IS-95 digital CDMA cellular or W-CDMA for PCS. By doing IQS spreading, we can drastically reduce the zero crossing rate of the RF signals. Second, we introduce an adaptive threshold setting for the synchronization of PN code, an initial acquistion method that uses a single PN code generator and reduces the acquistion time by a half compared the existing ones, and exploit the state machines to reduce the reacquistion time Third, various kinds of functions, such as automatic frequency control(AFC), automatic level control(ALC), bit-error-rate(BER) estimator, and spectral shaping for reducing the adjacent channel interference, are introduced to improve the system performance. Fourth, we designed and implemented the DS/CDMA MODEM to be used for variable transmission rate applications-from 16Kbps to 1.024Mbps. We developed and confirmed the DS/CDMA MODEM architecture through mathematical analysis and various kind of simulations. The ASIC design was done using VHDL coding and synthesis. To cope with several different kinds of applications, we developed transmitter and receiver ASICs separately. While a single transmitter or receiver ASC contains three channels (one for the pilot and the others for the traffic channels), by combining several transmitter ASICs, we can expand the number of channels up to 64. The ASICs are now under use for implementing a line-of-sight (LOS) radio equipment.

• Journal of the Korean Society for Marine Environment & Energy
• /
• v.16 no.1
• /
• pp.17-24
• /
• 2013

In order to have market competitiveness in local and global areas, Domestic Marine Leisure Industry business, which is a latecomer in the Marine Leisure industry, should retain a strong market adaptability by reducing time and cost that are required for work of planning, designing, and preparation for product development. To meet above requirements, it is essential that integrated system control extensive marine leisure industry. After ensuring integrated information by figuring out the systematic link between related-industries, the core of this research is to secure information classifications that are not just in the flow of simple serial order, but in that of integration and object-oriented information classifications. For this end, we examine other similar cases in industries using real information system applied to industrial production and Product Lifecycle Management (PLM), Product Data Management (PDM), Digital Manufacturing (DM) and applying the same methodology to review practical application in order to construct the information system, and Work Breakdown Structure (WBS), compared with the case studies. Through this basic task for the marine leisure industry classification system configuration (Work Breakdown Structure, WBS) and utilizing information of driving real companies of marine leisure industry, a unique area of MLWBS (Marine Leisure Work Breakdown Structure, MLWBS) is configured. This Marine Leisure Work Breakdown Structure can be used in various areas of applications like products, design information, engineering, production, purchasing, sales, marketing, AS, utilizing various forms of customer support.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.17 no.10
• /
• pp.2273-2280
• /
• 2013

This article introduces the next-generation air surveillance system and investigates how to design of front-end low noise amplifier of the ground station receiver. In consideration of the international standard documentation and the performance of existing products, the study conducts the link budget on the entire system so that it can be competitive in terms of receive sensitivity or reliability. To obtain a proper low noise amplifier, standards of design are decided so that such factors as gain, gain flatness, and reflective loss can be optimal. In its design, the bias circuit appropriate for the characteristics of low power, low noise, or high gain was built, and according to the results of the simulation conducted after the optimal design, its gain was 16.24dB, noise factor was 0.36dB, input-output reflective loss was -18dB and -28dB each, and frequency stability was 1.11. According to the results measured after the design, its gain was 17dB, noise factor was 0.51dB, gain flatness was 0.23dB, and input-output reflective loss was -18.28dB and -24.50dB each, so the results gained were suitable for building the overall system.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.19 no.4
• /
• pp.118-129
• /
• 2016

Many epidemiological studies, relying on administrative air pollution monitoring data, have reported the association between particulate matter ($PM_{10}$) air pollution and human health. These monitoring data were collected at a limited number of fixed sites, whereas government-generated health data are aggregated at the area level. To link these two data types for assessing health effects, it is necessary to estimate area-level concentrations of $PM_{10}$. In this study, we estimated district (Gu)-level $PM_{10}$ concentrations using a previously developed pointwise exposure prediction model for $PM_{10}$ and three types of point locations in Seoul, Korea. These points included 16,230 centroids of the largest census output residential areas, 422 community service centers, and 610 centroids on the 1km grid. After creating three types of points, we predicted $PM_{10}$ annual average concentrations at all locations and calculated Gu averages of predicted $PM_{10}$ concentrations as representative Gu-estimates. Then, we compared estimates to each other and to measurements. Prediction-based Gu-level estimates showed higher correlations with measurement-based estimates as prediction locations became more population representative ($R^2=0.06-0.59$). Among the three estimates, grid-based estimates gave lowest correlations compared to the other two(0.35-0.47). This study provides an approach for estimating area-level air pollution concentrations and assesses air pollution health effects using national-scale administrative health data.

• IMMUNE NETWORK
• /
• v.1 no.2
• /
• pp.104-108
• /
• 2001

Aging is a senescence and defined as a normal physiologic and structural alterations in almost all organ systems with age. As Leonard Hayflick, one of the first gerontologists to propose a theory of biologic aging, indicated that a theory of aging or longevity satisfies the changes of above conditions to be universal, progressive, intrinsic and deleterious. Although a number of theories have been proposed, it is now clear that cell aging (cell senescence) is multifactorial. No single mechanism can account for the many varied manifestations of biological aging. Many theories have been proposed in attempt to understand and explain the process of aging. Aging is effected in individual by genetic factors, diet, social conditions, and the occurrence of age-related diseases as diabetes, hypertension, and arthritis. It involves an endogenous molecular program of cellular senescence as well as continuous exposure throughout life to adverse exogenous influences, leading to progressive infringement on the cell's survivability so called wear and tear. So we could say the basic mechanism of aging depends on the irreversible and universal processes at cellular and molecular level. The immediate cause of these changes is probably an interference in the function of cell's macromolecules-DNA, RNA, and cell proteins-and in the flow of information between these macromolecules. The crucial questions, unanswered at present, concerns what causes these changes in truth. Common theories of aging are able to classify as followings for the easy comprehension. 1. Biological, 1) molecular theories - a. error theory, b. programmed aging theory, c. somatic mutation theory, d. transcription theory, e. run-out-of program theory, 2) cellular theories - a. wear and tear theory, b. cross-link theory, c. clinker theory, d. free radical theory, e. waste product theory, 3) system level theory-a. immunologic/autoimmune theory, 4) others - a. telomere theory, b. rate of living theory, c. stress theory, etc. Prevention of aging is theoretically depending on the cause or theory of aging. However no single theory is available and no definite method of delaying the aging process is possible by this moment. The most popular action is anti-oxidant therapy using vitamin E and C, melatonin and DHEA, etc. Another proposal for the reverse of life-span is TCP-17 and IL-16 administration from the mouse bone marrow B cell line study for the immunoglobulin VDJ rearrangement with RAG-1 and RAG-2. Recently conclusional suggestion for the extending of maximum life-span thought to be the calory restriction.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.5
• /
• pp.1857-1863
• /
• 2015

Background: Alpha-methylacyl-CoA racemase(AMACR) is thought to play key roles in diagnosis and prognosis of prostate cancer. However, studies of associations between AMACR gene polymorphisms and prostate cancer risk reported inconsistent results. Therefore, we conducted the present meta-analysis to clarify the link between AMACR gene polymorphisms and prostate cancer risk. Materials and Methods: A literature search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of any association between AMACR polymorphisms and prostate cancer risk. Subgroup analyses by ethnicity, source of controls, quality control and sample size were also conducted. Results: Five studies covering 3,313 cases and 3,676 controls on five polymorphisms (D175G, M9V, S201L, K277E and Q239H) were included in this meta-analysis. Significant associations were detected between prostate cancer and D175G (dominant model: OR=0.89, 95%CI=0.80-0.99, P=0.04) and M9V (dominant model: OR=0.87, 95%CI=0.78-0.97, P=0.01) polymorphisms as well as that in subgroup analyses. We also observed significant decreased prostate cancer risk in the dominant model (OR=0.90, 95%CI=0.81-0.99, P=0.04) for the S201L polymorphism. However, K277E and Q239H polymorphisms did not appear to be related to prostate cancer risk. Conclusions: The current meta-analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. The S201L polymorphism might also be linked with prostate cancer risk to some extent. However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer.