• Title/Summary/Keyword: LIM domain

Search Result 595, Processing Time 0.032 seconds

The Effect of Companion Animals Presence and Absence on Quality of Life and Emotions of Adults in their 20s (반려동물 유·무와 종류에 따른 20대 성인의 삶의 질과 정서에 미치는 영향)

  • Han, Ji-Won;Bae, Won-Sik;Lee, Keon-Cheol;Sung, Ji-Ho;Yoon, Ji-Young;Jeong, Ho-Yeon;Lee, Jae-Min;Lim, Ji-Hoon
    • Journal of The Korean Society of Integrative Medicine
    • /
    • v.10 no.1
    • /
    • pp.137-147
    • /
    • 2022
  • Purpose : The purpose of this study is to investigate how the existence of companion animals and the type of companion animals affect the quality of life and emotional stability of adults in their 20s. Methods : The subjects of this study were adults in their twenties living in Busan who could understand the method of this study. The survey method was conducted with a questionnaire, consisting of 4 questions on general characteristics, 26 questions on quality of life, and 20 questions on emotional stability for a total of 50 questions. An independent t-test and one-way ANOVA were used to verify the difference in quality of life and emotional stability according to general characteristics. Results : As a result of analyzing the difference in the quality of life of the study subjects, the case of having a companion animal scored statistically significantly higher in the satisfaction of the physical domain, psychological domain, living environment domain, overall quality of life domain, and social domain. In addition, there was a statistically significant difference in the case of companion animals according to the type of companion animal. However, there was no statistical significance in the analysis of differences in emotional stability of study subjects according to the presence or absence of companion animals. Conclusion : This study was conducted with 400 adults in their twenties to determine the effects of the presence and absence and type of companion animals on the quality of life and emotional stability of adults in their twenties. As a result, the group with companion animals showed higher satisfaction scores than the group without companion animals in terms of quality of life. This suggests that raising companion animals for adults in their 20s has a positive effect on improving their quality of life. Therefore, it can be recommended for the physical, psychological, and social health of adults in their 20s.

TIR-catalyzed Small Molecules: Structure and Function in Plant Immunity (TIR 촉매반응에 의해 생성된 소분자들의 식물면역반응에서의 역할)

  • Seong-Hyeon Bae;Sang-Hyun Park;Ye-Rim Cha;Dawon Jeon;Gah-Hyun Lim
    • Journal of Life Science
    • /
    • v.34 no.9
    • /
    • pp.666-672
    • /
    • 2024
  • Plants recognize pathogens through intracellular receptors that trigger defense signaling. Nucleotide-binding leucine-rich repeat (NLR) proteins within a cell specifically recognize pathogenic molecules (effectors), leading to signal transduction that ultimately triggers the cell death pathway, thereby inducing effector-triggered immunity in plants. NLR proteins are broadly categorized into two types based on their N-terminal domains: coiled-coil domain NLRs (CNLs) and toll/interleukin-1 receptor (TIR) domain NLRs (TNLs) are defined by their unique N-terminal domains. The TIR domain, which is responsible for activates nicotinamide adenine dinucleoside hydrolases (NADases), is crucial for the degradation of the NAD+ cofactor. TNL-dependent immune signaling involves lipase-like proteins known as Enhanced Disease Susceptibility 1 (EDS1) and its partners Phytoalexin Deficient 4 (PAD4) and Senescence-Associated Gene 101 (SAG101). This immune system also requires helper NLR subfamilies, such as activated disease resistance 1 (ADR1) and N requirement gene 1 (NRG1). The catalytic activity of TIR domain proteins generates various small molecules reported to activate plant's immune responses. These small molecules bind to specific sites on EDS1-PAD4 and EDS1-SAG101, inducing structural changes in the EP domain, and subsequently enabling interaction with ADR1 or NRG1. Here, we will discuss the characteristics of these small molecules and describe their relationships with protein complexes based on their structural and biochemical characteristics. We will also discuss how these small molecules can activate immune pathways.

A Study on the Derivation of Powder factor for Tunnel Blast Design Based on Blastability Evaluation (현지 암반의 발파특성 평가를 통한 발파 설계인자 도출에 관한 연구)

  • Lim Kyung-Ho;Kim Joon-Youp;Lim Dae-Kyu;Shin Young-Chul
    • Explosives and Blasting
    • /
    • v.23 no.3
    • /
    • pp.75-82
    • /
    • 2005
  • Many blasting engineers develope their own approach to define how to blast different rockmass properties. The problem is that most of these approaches haven't been formalized in any systematic manner and they depend mainly on casual observation of local conditions by an experienced blaster. In this paper blastability index developed by Lilly is adopted to induce powder factor for blast design considering local conditions. With this approach blastability scheme can be considered joint properties as well as rockmass represented local conditions. This approach is also expected to supplement the shortcomings of existing blast design approaches.

Expression of Ajuba, a Novel LIM Protein, is Regulated by Endorlasmic Reticulum Stress (소포체 스트레스가 Ajuba 발현유도)

  • Park, Sang-Mi;Kwon, Ki-Sang;Yun, Eun-Young;Goo, Tae-Won;Kwon, O-Yu
    • Journal of Life Science
    • /
    • v.17 no.7 s.87
    • /
    • pp.1023-1025
    • /
    • 2007
  • Ajuba is a number of proteins containing cytosolic LIM domain. Its function may provide a new pathway whereby cell-cell adhesive events are transmitted to the nucleus to regulate cell proliferation and differentiation decisions. Here, Ajuba gene expression was investigated its molecular properties associated with endoplasmic reticulum (ER) stresses (tunicamycin, DTT, A23187 and BFA) which induced remarkable ex-pression of Ajuba mRNA. The mRNA half life of Ajuba was also determined, its half life of Ajuba mRNA in FRTL-5 cells was approximately 2 hr after the initial translation. Although the obvious bioligical function of Ajuba is not clear, on the base of the results, Ajuba gene expression is deeply associated with ER stresses.

A Validation Study of Retrospective Pre-post Testin the Affective Domain in Science Learning:for Scientifically Gifted Elementary Students (과학학습의 정의적 영역에서 사전-사후 통합 검사 설계의 타당화 연구: 과학영재를 대상으로)

  • Lim, Chae-Seong;Park, Hyoung-Min
    • Journal of Korean Elementary Science Education
    • /
    • v.36 no.3
    • /
    • pp.219-226
    • /
    • 2017
  • In this study, the reliability and validity of the retrospective pre-post test were analyzed in order to solve the problem of traditional pre-post test including response shift bias. Samples of the study were 162 elementary school students who are studying at the S university gifted education center in Seoul. Before completion of the field trip, we conducted pre test of science-related attitudes. After completion of the field trip, respondents were asked to compare their responses of pre and post science-related attitudes to quantitatively analyze the commonalities and differences of the two tests. To find out more characteristics, qualitative data such as daily records and interview were also gathered and analyzed. The major results of the study are as follows. First, for the paired t-test, there was no statistically significant difference between separate pre-test scores and retrospective pre-test. There was a very high correlation between the separate pre-test scores and the retrospective pre-test. Second, there were significant differences in all seven sub-factors of science-related attitudes between the retrospective pre-test and the post-test. Third, the separate pre-test scores showed a slightly higher tendency than the retrospective pre-test scores. This suggests that the response shift bias appears when it is performed the separate pre-test in affective domain. As a result of the interview, it was found that the evaluation standards of separate pre-test did not match with those of post-test. Forth, internal consistency reliability of the retrospective pre-test was higher than that of the separate pre-test. However, there were significant differences in six factors of science-related attitudes excluding the 'social implications of science' between the separate pre-test and the post-test. Based on these results, the retrospective pre-post test design provides simplicity and convenience to both respondents and investigators, as it is done with one test. The retrospective pre-post test design can be regarded as a valid design for the self-report measurement of affective domain on a single experimental group.

Analyses of Elementary School Students' Scientific Creativity in Cognitive Domain by Applying a Brain-Based Evolutionary Approach to Science Instruction (인지적 영역 중심의 뇌기반 진화적 접근법을 적용한 초등 과학 수업에서 학생들의 과학 창의성 분석)

  • Ok, Chanmi;Lim, Chae-Seong;Kim, Sung-Ha;Hong, Juneuy
    • Journal of Korean Elementary Science Education
    • /
    • v.35 no.4
    • /
    • pp.469-478
    • /
    • 2016
  • A brain-based evolutionary approach developed by reflecting the brain functions and authentic science is consisted of Affective, Behavioral, and Cognitive domains, and within each domain the processes of Diversifying, Evaluating, and Furthering are proceeded (ABC-DEF). Two core components of creativity of originality and usefulness are inherent in each step. So, this study analyzed scientific creativity with the originality and usefulness components in cognitive domain, which is composed of diversifying the meanings inherent in the results of observations or experiments (C-D), evaluating the meanings (C-E), and furthering (C-F) in learning of 'World of Plants' unit which includes two topics of 'Plants on Land' and 'Plants in Water and Special Environment'. A total of 20 fourth grade students at Y elementary school in Gyeonggi province participated in the study. The main results of this study are as follows. First, the scientific creativity in step C-D (Diversifying stage) was assessed according to the scientific creativity assessment formula. The scores of scientific creativity were quite different with topics and showed different pattern in the originality and usefulness components. Second, when the students compare and evaluate the values of each meaning (C-E stage), they weighed more on usefulness than originality, such as "because it is useful" or "because it solve many everyday problems". Third, the overall scores of scientific creativity in step C-F (Furthering stage), as compared with those of step C-D, were low and showed decrease in the average scores of originality from 9.8 to 7.5 points, whereas increase in the average scores of usefulness from 5.4 to 6.1 points. In conclusion, these results showed that, even though the levels were not so high, the students, as scientists, can exhibit the scientific creativity in the processes of diversifying, comparing and evaluating, and applying the meanings about the results obtained by observations or experiments. The specific and various strategies to help students express their potential scientific creativity more effectively need to be developed.

Multi-view Image Generation using Grid-mesh based Image Domain Warping and Occlusion Region Information (차폐영역 정보와 그리드 메쉬 기반의 영상 워핑을 이용한 다시점 영상 생성)

  • Lim, Jong-Myeong;Um, Gi-Mun;Shin, Hong-Chang;Lee, Gwangsoon;Hur, Namho;Yoo, Jisang
    • Journal of Broadcast Engineering
    • /
    • v.18 no.6
    • /
    • pp.859-871
    • /
    • 2013
  • In this paper, we propose an algorithm that generates multi-view images by grid-mesh based image domain warping using occlusion mask and various image features obtained from the stereoscopic images. In the proposed algorithm, we first extract image saliency map, line segments and disparity saliency map from stereo images and then get them through a process that improves the quality of extracted features. This process is accomplished in two steps. In the first step, reliability of disparity saliency map on object boundary regions is enhanced by using occlusion information. And in the second step, we enhance the quality of image features in terms of temporal consistency by using temporal consistency information for stereo images. With these enhanced features, multi-view images are generated by grid-mesh based image domain warping technique. Experimental results show that the proposed algorithm performs better than existing algorithms in terms of visual quality.

The Concept of 'Wisdom' and Its Perception According to a Survey of Science Teachers ('지혜'의 개념과 과학교사들의 '지혜'에 대한 인식)

  • Lim, Insook;Song, Jinwoong
    • Journal of The Korean Association For Science Education
    • /
    • v.37 no.4
    • /
    • pp.731-745
    • /
    • 2017
  • This study is a part of our research project that considers 'Science as Wisdom (SaW)' as a new approach to science education. We presented a review of previous studies on wisdom from relevant areas as philosophy, psychology and education, and drew a few educational meanings. We also conducted a survey of science teachers' perception of wisdom to obtain implications for a follow-up study. The survey was conducted on pre-service science teachers, in-service science teachers, and teachers of other subjects. The results of this study are as follows: First, all three groups of participants perceive 'practical' domain of wisdom as most important while 'interpersonal' domain was perceived as least important. Second, all three groups of participants perceive that 'to catch what the most important problem is,' is the most important among 20 elements of wisdom. Third, when participants were asked about the 'wise people around them', the interpersonal domain followed as the second most frequent response after the 'practical' domain, which was in contrast to our first finding above. Fourth, about 80% of all participants answered that wisdom can be cultivated through school education. Finally, answers to the question asking the scientific concepts related to wisdom were categorized into four types as follows: (1) the wisdom required to understand and apply scientific knowledge, (2) the wisdom included in the meaning of scientific knowledge, (3) the wisdom needed to discover scientific knowledge, (4) the wisdom that can be developed through scientific activities.

Myometrial relaxation of mice via expression of two pore domain acid sensitive K+ (TASK-2) channels

  • Kyeong, Kyu-Sang;Hong, Seung Hwa;Kim, Young Chul;Choi, Woong;Myung, Sun Chul;Lee, Moo Yeol;You, Ra Young;Kim, Chan Hyung;Kwon, So Yeon;Suzuki, Hikaru;Park, Yeon Jin;Jeong, Eun-Hwan;Kim, Hak Soon;Kim, Heon;Lim, Seung Woon;Xu, Wen-Xie;Lee, Sang Jin;Ji, Il Woon
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.20 no.5
    • /
    • pp.547-556
    • /
    • 2016
  • Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing $K^+$ channels (TASK-2) might be one of the candidates for the regulation of uterine circular smooth muscles in mice. In this study, we tried to show the mechanisms of relaxation via TASK-2 channels in marine myometrium. Isometric contraction measurements and patch clamp technique were used to verify TASK conductance in murine myometrium. Western blot and immunehistochemical study under confocal microscopy were used to investigate molecular identity of TASK channel. In this study, we showed that TEA and 4-AP insensitive non-inactivating outward $K^+$ current (NIOK) may be responsible for the quiescence of murine pregnant longitudinal myometrium. The characteristics of NIOK coincided with two-pore domain acid-sensing $K^+$ channels (TASK-2). NIOK in the presence of $K^+$ channel blockers was inhibited further by TASK inhibitors such as quinidine, bupivacaine, lidocaine, and extracellular acidosis. Furthermore, oxytocin and estrogen inhibited NIOK in pregnant myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed stronger inhibition of NIOK by quinidine and increased immunohistochemical expression of TASK-2. Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch-activated channels in the longitudinal myometrium of mouse. Activation of TASK-2 channels seems to play an essential role for relaxing uterus during pregnancy and it might be one of the alternatives for preventing preterm delivery.

A Comparison Study on the Speech Signal Parameters for Chinese Leaners' Korean Pronunciation Errors - Focused on Korean /ㄹ/ Sound (중국인 학습자의 한국어 발음 오류에 대한 음성 신호 파라미터들의 비교 연구 - 한국어의 /ㄹ/ 발음을 중심으로)

  • Lee, Kang-Hee;You, Kwang-Bock;Lim, Ha-Young
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
    • /
    • v.7 no.6
    • /
    • pp.239-246
    • /
    • 2017
  • This paper compares the speech signal parameters between Korean and Chinese for Korean pronunciation /ㄹ/, which is caused many errors by Chinese leaners. Allophones of /ㄹ/ in Korean is divided into lateral group and tap group. It has been investigated the reasons for these errors by studying the similarity and the differences between Korean /ㄹ/ pronunciation and its corresponding Chinese pronunciation. In this paper, for the purpose of comparison the speech signal parameters such as energy, waveform in time domain, spectrogram in frequency domain, pitch based on ACF, Formant frequencies are used. From the phonological perspective the speech signal parameters such as signal energy, a waveform in the time domain, a spectrogram in the frequency domain, the pitch (F0) based on autocorrelation function (ACF), Formant frequencies (f1, f2, f3, and f4) are measured and compared. The data, which are composed of the group of Korean words by through a philological investigation, are used and simulated in this paper. According to the simulation results of the energy and spectrogram, there are meaningful differences between Korean native speakers and Chinese leaners for Korean /ㄹ/ pronunciation. The simulation results also show some differences even other parameters. It could be expected that Chinese learners are able to reduce the errors considerably by exploiting the parameters used in this paper.