• Title/Summary/Keyword: L-His

Search Result 422, Processing Time 0.031 seconds

Surgical Treatment of Double Outlet Right Ventricle with Dextrocardia and Situs Inversus{I.L.L}: (Report of A Case) (장기역위증 및 우심증을 동반한 양대혈관 우심실기시증 (I.L.L.) 1례 보고)

  • 김광호
    • Journal of Chest Surgery
    • /
    • v.12 no.4
    • /
    • pp.346-349
    • /
    • 1979
  • We have recently operated 6 year-old male patient who had double outlet right ventricle with dextrocardia, situs inversus, pulmonary stenosis and 2 ventricular septal defects. Rastelli operation was performed by internal baffling with Cooley woven Dacron and tunnel grafting with Hancock valved conduit between the right ventricle and the main pulmonary artery.His postoperative course was uneventful. He was discharged in good conditions on P.O.D. #33.

  • PDF

A Comparative Study on Louis L Kahn's Architectural Philosophy and Kabbalah based on Psychoanalysis (정신분석학에 의한 루이스 칸의 건축철학과 카발라와의 비교 연구)

  • Choi, Hyo-Sik
    • Journal of architectural history
    • /
    • v.18 no.2
    • /
    • pp.85-105
    • /
    • 2009
  • This study set out to compare and analyze the influences Kabbalah, which was Louis I. Kahn's faith as a Jew, on his architecture based on Freud's psychoanalysis that had many exchanges with modernism and contemporary architecture and theories. The specific goals of the study were to shed light to Kahn's presence in contemporary architecture anew and establish the methodology of using psychoanalysis in building new theories of architectural planning. When the theories of psychoanalysis were introduced for comparison and analysis purposes, Kahn tried to differentiate his buildings by placing a function or symbolic central space at the heart of a building even though he did adopt a characteristic of modernism architecture, which was placing a core at the centre of plan, for a while. Such a tendency of his was based on Jung's opinions rather than Freud's and affected by Ecole des Beaux-Art. The analysis results also indicate that he conceived "Served Space & Servant Space," "architecture of connection" and "silence and light" that made up the essence of his architectural theory from the relationships between Ayin-Sof, Kabbalah's absolute god, and Sefiroth. It's also very likely that his often use of triangles and circles in his architecture was affected by the Tree of Sefiroth diagram of Kabbalah. His tendency is well reflected in Salk Institute and Philips Exeter Academy Library, where he placed a laboratory or courtyard at the center where a core was supposed to be, created a corridor or courtyard space between those central spaces and the core, and connected them one another with to perceive the being of Ayin-Sof into an architectural space, which is well proven with Mikveh Israel Synagogue where he directly applied the Tree of Sefiroth diagram. The synagogue also contained a hollow column that served as an important concept in his late architecture. The hollow column was also the result of him applying the concept of Sefiroth of the place where Ayin-Sof Was reduced in Kabbalah.

  • PDF

Abducens Nerve Palsy after Lumbar Spinal Fusion Surgery with Inadvertent Dural Tearing

  • Cho, Dae-Chul;Jung, Eul-Soo;Chi, Yong-Chul
    • Journal of Korean Neurosurgical Society
    • /
    • v.46 no.6
    • /
    • pp.581-583
    • /
    • 2009
  • Abducens nerve palsy associated with spinal surgery is extremely rare. We report an extremely rare case of abducens nerve palsy after lumbar spinal fusion surgery with inadvertent dural tearing, which resolved spontaneously and completely. A 61-year-old previous healthy man presented with chronic lower back pain of 6 weeks duration and 2 weeks history of bilateral leg pain. He was diagnosed as having isthmic spondylolisthesis at L4-5 and L5-S1, and posterior lumbar interbody fusion was conducted on L4-5 and L5-S1. During the operation, inadvertent dural tearing occurred, which was repaired with a watertight dural closure. The patient recovered uneventfully from general anesthesia and his visual analogue pain scores decreased from 9 pre-op to 3 immediately after his operation. However, on day 2 he developed headache and nausea, which were severe when he was upright, but alleviated when supine. This led us to consider the possibility of cerebrospinal fluid leakage, and thus, he was restricted to bed. After an interval of bed rest, the severe headache disappeared, but four days after surgery he experienced diplopia during right gaze, which was caused by right-side palsy of the abducens nerve. Under conservative treatment, the diplopia gradually disappeared and was completely resolved at 5 weeks post-op.

An introductory research of application of Markov process to literary study

  • Park, Chae-Heung
    • Journal of Korean Society for Quality Management
    • /
    • v.28 no.4
    • /
    • pp.99-105
    • /
    • 2000
  • This paper attempts to apply Markove chain theory to literary works. the objective of this paper is to show the trend of authors and his works by way of Markovian Models. In this introductory research, it is useful to make simple criteria as virtue and evil, good and bad, justice and injustice, positive and negative, man and woman, etc. Markovian transition matrixes which are derived by M.L.E. and A.U.E are almost same. In case of Hamlet, we are able to know the author of Hamlet or his works are inconsistent and fickle.

  • PDF

Buyers' Payment of Price by Letters of Credit under CISG (국제물품매매협약상 매수인의 신용장에 의한 대금지급)

  • Heo, Hai-Kwan
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
    • /
    • v.41
    • /
    • pp.103-132
    • /
    • 2009
  • In international sales of goods, the buyer must pay the price for the goods as required by the contract and CISG, The buyer's this obligation includes taking such steps and complying with such formalities as may be required under the contract, which includes providing the seller with relevant letter of credit through the issuing bank. Where the parties have not stipulated the time limit within which the credit should be opened, but there is an agreed date or period for shipment, the time limit for the L/C opening should be calculated back from the agreed date of shipment or the first date of shipment, while, in addition, the buyer should open the L/C sufficiently earlier than the shipment date in order for the seller to be able to know the L/C's opening before beginning to ship the goods. The L/C provided the buyer should conform to the contract of sale. Therefore, for example, when an unconfirmed L/C is provided violating the agreement or the L/C opened states that, under a FOB contract, a "freght prepaid" bill of lading shall be presented as a required document of the L/C, the buyer has failed to perform his obligation. If the buyer fails to perform his obligations to provide the letter of credit, the seller may require the buyer to perform that obligation; may fix an additional period of time of reasonable length for performance of the obligation; or, the seller may declare the contract avoided, if the failure amounts to a fundamental breach of contract, or if the buyer does not, within the additional period of time fixed by the seller, perform the obligation; and the seller claim damages. However, when a relevant L/C has been issued for the seller, as a rule, he cannot ask directly for the buyer to pay the price before avail himself of the L/C first.

  • PDF

A Study for F.L. Wright's Space Pattern by Grid Planning -Focusing on Prairie and Usonian Houses- (그리드 프래닝에 의한 F.L 라이트의 공간패턴에 관한 연구 -프래리와 유소니언 주택을 중심으로-)

  • 전영미
    • Korean Institute of Interior Design Journal
    • /
    • no.17
    • /
    • pp.181-186
    • /
    • 1998
  • Grid serves as an auxiliary instrument that explains design logically and objectively when you designing an interior. But grid is unacceptable to the space which is produced by designer who wants to express a design subjectively. Because grid makes usual and standardized space without flexibility. Changing and developing a fundamental unit with modern touch is going to be a way compensate for the weakpoint Also versatile grid unit can support the designer's subjective intention. This study focuses on the limits of Wright's house which show interior space aestheically through grid planing. In this paper Wright's uniqe interior space pattern will be examined through the selection of some of his works specifically the Prairies and Usonians whose transforming is noticable as Wright house and analysis about formation process of grid planning characteristics and spaces is continued. With all this analysis I'm, going to look over Wright's philosophy and pattern that is usually intended by his grid planning.

  • PDF

Screening of New Antibiotics Inhibiting Bacterial Enoyl-Acyl Carrier Protein Reductase (Fabl) (세균의 지방산 생합성 효소 (Enoyl-Acyl Carrier Protein Reductase, FabI)를 저해하는 새로운 항균물질의 스크리닝)

  • 곽진환
    • YAKHAK HOEJI
    • /
    • v.46 no.1
    • /
    • pp.24-29
    • /
    • 2002
  • Enoyl-Acyl Carrier Protein Reductase (Fabl) of bacteria is hem as an important target for new antibacterial drugs and plays a determinant role in completing cycles of elongation in type-H fatty acid synthase system. In this study, a fabI gene from Staphylococcus aureus 6538p cloned in pET-l4b vector and FabI protein was over-produced in Escherichaia coli BL2l (DE3). $NH_2$-terminal His-tagged FabI protein was purified by nickel-nitrilotriacetic acid (Ni-NTA) metalaffinity chromatography Purified 6xHis-tagged FabI showed a catalytic activity on tram - 2 - octenoyl - N -acethlcysteamine by utilizing NADPH as a cofactor. For the discovery of new FabI inhibitors from chemical libraries, a target-oriented screening system using a 96-well plate was developed. About 10,000 chemical libraries from Korea Chemical Bank wore tested in this screening system, and 26 chemicals (0.25%) among them showed an inhibitory activity against FabI enzyme. This result showed that a new screening system can be used for the discovery of new FabI inhibitors.

Interaction between Lactobacillus acidophilus and Kluyveromyces fragilis on the Metabolism of Amino Acids in Soymilk (Lactobacillus acidophilus와 Kluyveromyces fragilis의 혼합배양에 의한 두유의 젖산발효중 아미노산 대사의 상호작용)

  • 류인덕;박정길;유주현
    • Microbiology and Biotechnology Letters
    • /
    • v.16 no.4
    • /
    • pp.287-292
    • /
    • 1988
  • The interaction between Lactobacillus acidophilus and Kluyveromyces fragilis on the utilization of amino acids in soymilk was investigated. K. fragilis assimilated relatively well various amino acids such as Met., ILe., Phe., Leu., Thr., Lys., Val., Arg., Tyr., Ser., Asp., Ala. and Glu. that existed only in trace amounts in soymilk. K. fragilis did not utilized Gly., while hi accumulated His. L. acidophilus hydrolyzed soyprotein to liberate various amino acids. Among various amino acids, it utilized Met., ILe., Thr., Tyr., Ser., Val. and His. as growth factors and accumulated Leu., Phe., Lys., Arg., Glu., Asp. and Ala. among the essential amino acids required by K. fragilis and Gly. These results implied that K. fragilis grew on amino acids that existed only in trace amounts in soymilk, but it's growth was stimulated by amino acids such as Leu., Phe., Lys., Arg., Glu., Asp. and Ala. ac-cumulated by L. acidophilus.

  • PDF

Protein structure analysis : Pharmacophore study for new insecticide target AnCE using the substrate of ACE, HHL molecule (단백질의 구조연구 : ACE의 기질 HHL을 이용한 신규 살충제 표적 AnCE에 대한 약리단 연구)

  • Lee, Jung-Kyung;Kim, Kyeong-Yee
    • The Korean Journal of Pesticide Science
    • /
    • v.9 no.3
    • /
    • pp.191-198
    • /
    • 2005
  • Hippuryl-L-histidyl-L-leucine (Hip-L-His-L-Leu, HHL) is the known substrate of ACE, which used often in inhibition kinetic study to design new inhibitor. Here we use HHL molecule as a template to predict pharmacophore which can interact with residues in active site of AnCE, new potential insecticide target protein. To explain physicochemical properties related to molecular geometry and conformational change in reaction field as well as electron density of atoms associated to pharmacophores, geometry optimization, NMR chemical shifts and natural population analysis were performed by ab initio and DFT method. Calculated NMR chemical shifts showed good agreement with the experimental ones and obtained electron densities were used for analyzing pharmacophores of corresponding atoms. Finally, we could extract aye pharmacophores related to hydrophobic aliphatic and aromatic site, hydrogen bonding donor and acceptor site and Zn binding site from the HHL molecule.

NMR Studies on the Structure of Human Annexin I

  • Lee, Yeon-Hee;Han, Hee-yong;Oh, Jee-Young;Na, Doe-Sun;Lee, Bong-Jin
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 1997.04a
    • /
    • pp.86-86
    • /
    • 1997
  • Human annexin I is a member of annexin family of calcium dependent phospholipid binding proteins, which have been implicated in various physiological roles including phospholipase A$_2$ (PLA$_2$) inhibition, membrane fusion and calcium channel activity. In this work, the structure of N-terminally truncated human annexin I (Δ-annexin I) and its interactions with Ca$\^$2+/, ATP and cAMP were studied at atomic level by using $^1$H, $\^$15/N, $\^$l3/C NMR (nuclear magnetic resonance) spectroscopy. The effect of Ca$\^$2+/ binding on the structure of Δ-annexin I was investigated, and compared with that of Mg$\^$2+/ binding. The addition of Ca$\^$2+/ to Δ-annexin I caused some changes in the high field and low field regions of $^1$H NMR spectra. Whereas, upon addition of Mg$\^$2+/ to Δ-annexin I, almost no change could be observed. Also we found that the binding ratio of ATP to Δ-annexin I is 1. Because Δ-annexin I is a large protein with 35 kDa molecular weight, site-specific (carbonyl-$\^$l3/C, amide-$\^$15/N) labeling technique was used to determine the interaction sites of Δ-annexin I with Ca$\^$2+/ and ATP. Assignments of all the histidinyl carbonyl carbon resonances have been completed by using Δ-annexin I along with its specific 1,2-subdomain. The carbonyl carbon resonances originating from His52 and His246 of Δ-annexin I were significantly affected by Ca$\^$2+/ binding, and some Tyr and Phe resonances were also affected. The carbonyl carbon resonances originating from His52 is significantly affected by ATP binding, therefore His52 seems to be involved in the ATP binding site of Δ-annexin I.

  • PDF