• 대한물리의학회지
• /
• 제14권4호
• /
• pp.143-152
• /
• 2019

PURPOSE: This examined the effects of a sling exercise based on music on the cognition, physical performance of patients with dementia. METHODS: Thirty subjects with dementia volunteered to participate in this study. All subjects were allocated randomly to either the experimental group or control group, with 15 subjects in each group. All subjects underwent the exercise program for an average of 60 minutes per day for 16 weeks. The experimental group performed sling exercise based on music, and the control group performed the general exercise program. Assessments were made using the Korean version of mini-mental state examination (MMSE-K), 10 m walk test (10MWT), Tinetti mobility test (TMT), and Katz's Index of Independence in activity daily living (KIIADL) to detect changes in the cognitive level and physical performance before and after the 16-week training period. A paired t-test was conducted to compare the within-group change before and after the intervention. An independent t-test was performed to compare the between-group difference. The statistical significance level was set to α=.05 for all variables. RESULTS: The experimental group showed significant within-group changes in the MMSE-K, 10MWT, TMT, and KIIADL (p<.05). The control group showed a significant change in only the KIIADL (p<.05). A significant difference was observed between the experimental group and the control group regarding the change in MMSE-K and KIIADL after the interventions (p<.05). CONCLUSION: A music-based sling exercise program effectively improves cognition, physical performance, and ADL in patients with dementia. Further studies with a wider range of subjects and scientific equipment will be needed to strengthen the results of this study.

• 정신신체의학
• /
• 제24권2호
• /
• pp.227-235
• /
• 2016

연구목적 본 연구의 목적은 자가면역 갑상선장애 환자에서 인지결함의 발생 빈도를 알아보고, 이에 영향 미치는 변인을 규명하며, 특히 갑상선 자가항체와의 연관성을 알아보기 위함이다. 방 법 여성 자가면역 갑상선장애 환자 65명을 대상으로 구조적 면담을 통해서 인구학적 정보를 얻었으며, 한국판 Mini-Mental State Examination(Korean Version of the Mini-Mental State Examination, MMSE-K)와 한국판 Montreal Cognitive Assessment(Korean Version of the Montreal Cognitive Assessment, MoCA-K)를 사용해서 인지기능을 평가하였고, 한국판 Depression Rating Scale(Korean Version of the Hamilton Depression Rating Scale, K-HDRS)를 사용해서 우울증을 평가하였다. 결 과 1) MMSE-K 총점 24점 이하는 7.69%, MoCA-K 총점 22점 이하는 10.77%였다. 인지기능 저하의 빈도는 antimicrosomal 항체 양성군(N=38, 58.46%)과 음성군(N=27) 간에 유의한 차이가 없었다. 2) Antimicrosomal 항체 양성군과 음성군의 변인별 차이를 비교한 결과, 음성군보다 양성군에서 antithyroglobulin 항체 수치, antimicrosomal 항체 수치, TSH 농도는 유의하게 높았고, free T4는 유의하게 낮았다(각각 p<0.05). 3) 자가면역 갑상선장애 환자의 인지기능과 여러 변인의 연관성을 분석한 결과, MMSE-K 검사와 MoCA-K 검사의 총점은 연령, 결혼상태, antithyroglobulin 항체 수치, K-HDRS 총점과 각각 유의한 상관관계가 있었다(각각 p<0.05). 4) 회귀분석 결과, 연령, 교육수준, 갑상선 자가항체, 갑상선기능, 우울증은 자가면역 갑상선장애 환자의 인지기능에 영향을 미치지 않았다. 결 론 본 연구의 결과는 자가면역 갑상선장애 환자의 인지기능과 갑상선 자가항체의 연관성을 지지할 수 없었다.

• Journal of Korean Academy of Oral Health
• /
• 제41권2호
• /
• pp.96-101
• /
• 2017

Objectives: The aim of this study was to investigate the relationship between cognitive function and occlusal status in elderly individuals. Methods: A total of 162 individuals aged 65 years and older, who attended the senior citizen center in Daegu city, were included after consent for participation in the study was obtained. The Korean version of the Mini-Mental State Examination (MMSE-K) was used to evaluate the level of cognitive function. Occlusal status was determined using the T-scan $III^{(R)}$ system. All collected data were analyzed by ${\chi}^2$ test, t-test, one way ANOVA, and linear regression analysis using SPSS version 23.0 for Windows. Results: There was a significant relationship between the cognitive function and the use of dentures. Individuals with posterior occlusal status had higher MMSE-K scores than those with anterior occlusal status. There was a positive correlation between the cognitive function and posterior occlusal force. Conclusions: These results suggest that occlusal status was associated with cognitive function in the elderly individuals. Active national policies to improve occlusal condition in the elderly population are needed.

• 대한한방내과학회지
• /
• 제38권2호
• /
• pp.217-225
• /
• 2017

Objectives: This case study evaluated the effectiveness of Chengsimyeonja-tang-gamibang (Gamicheongsim-tang and Cheongsimsunhwal-tang) in a patient with a pontine hemorrhage and quadriparesis, dysarthria, and dysphagia. Methods: A patient diagnosed with a pontine hemorrhage was treated with Chengsimyeonja-tang-gamibang (Gamicheongsim-tang and Cheongsimsunhwal-tang) acupuncture, and moxibustion. The manual muscle test (MMT), modified Barthel index (MBI), National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Mini Mental State Examination-Korea (MMSE-K), and Articulatory Functional Ability of Achievement Scale were administered. Results: Improvements in the MMT, MBI, NIHSS, mRS, and K-MMSE were observed after the treatment. The MMT grade increased from Rt. 3/3- and Lt. 3/3- pretreatment to Rt. 4/4 and Lt. 4+/4+ post-treatment. The MBI increased from 10 to 50 post-treatment. The NIHSS decreased from 24 to 6 post-treatment, and the mRS fell from 5 to 4 post-treatment. Finally, the MMSE-K increased from 0 to 24 post-treatment. The Articulatory Functional Ability of Achievement Scale also improved. Conclusion: This study shows that Chengsimyeonja-tang-gamibang can be used to treat the symptoms of patients with a pontine hemorrhage.

• 약학회지
• /
• 제37권5호
• /
• pp.442-452
• /
• 1993

Previous experimental and clinical investigations suggest a possible role of new nootropic drug, oxiracetam, in improving cognitive performances in patients affected by organic brain syndrome. In this study, the cognitive and behavioral effects of oxiracetam treatment in patients with clinical symptoms of organic brain syndrome were evaluated. Sixty-six patients were enrolled and assigned to either oxiracetam or placebo, according to a randomized, double-blind design between two patient-groups. Either oxiracetam or placebo was orally given bid for 8 weeks ; daily dose of oxiracetam was 1600mg. All the patients, enrolled in this study, were diagnosed as having mild to moderate cognitive dysfunction as defined by a baseline Mini Mental State ExaminationKorean version (MMSE-K) score between 14 and 25. The patients under-went, at baseline, 4 weeks and 8 weeks after, routine laboratory study (CBC, SMA12, U/A, EKG) and the following neuropsychological tests ; MMSE-K, modified Korean Wechsler Intelligence Scale(MKWIS), Nurses' Observation Scale for Geriatric patients(NOSGER). Fifteen patients of whom were dropped out or excluded from the analysis because of poor compliance or violation of the protocol. Fiftyone patients (aged 54~78 years, male 25, female 26) were analyzed (vascular dementia, 30 ; senile dementia of Alzheimer type, 9 ; mixed type, 5 ; other cause, 7). Statistical analysis of the data demonstrated that the two groups were comparable at baseline. At the end of each study period the oxiracetam group scored significantly better on the majority of the tests evaluating cognitive function, psychometricity and the improvement rating scale of subjective symptoms than placebo group, in which worsening trends or no changes were seen on the whole. No side effects were noted during oxiracetam treatment. The present study, showing positive clinical findings after oxiracetam therapy, confirmed that this drug can be useful pharmacological treatment in organic brain syndrome.

• 재활치료과학
• /
• 제7권4호
• /
• pp.67-77
• /
• 2018

목적 : 본 연구는 수공예활동을 이용한 그룹 작업치료 중재프로그램이 뇌졸중 환자의 일상생활 수행능력과 삶의 질 향상에 미치는 효과를 알아보고자 한다. 연구방법 : 뇌졸중 환자 10명을 대상으로 진행하였으며, 두 집단 사전-사후 설계(Pretest-Posttest control group design)를 사용하였다. 실험은 사전검사 1회, 중재 10회, 사후 검사 1회로 총 12회기로 주 2회 6주간 실시하였다. 인지기능은 한국판 간이 정신상태검사 (Mini-Mental State Examinatin for Korean: MMSE-K)와 일상생활평가로 한글판 수정 바델 지수 (Korean Version of Modified Bathel Index: K-MBI)와 캐나다 작업수행 측정 (Canadian occupational performance measure: COPM)을 사용하였고, 삶의 질 평가는 한국판 세계 보건기구 삶의 질 간편형 척도(The World Health Organization Quality of life- BREF: WHOQOL-BREF)를 중재 전 후에 시행하였다. 기술통계와 비 모수 통계를 이용하여 결과분석을 하였다. 결과 : 실험군과 대조군의 사전 - 사후 결과를 비교한 결과 일상생활 활동 수행능력 부분에서 K-MBI의 점수 증진은 있었으나, 유의미한 차이는 없었다. COPM은 실험군에서만 수행도 전 후에 유의미한 차이가 있었으며, 실험군, 대조군 모두 만족도에 유의미한 차이가 있었다. WHOQOL-BREF에서 실험군에서 실험 전 후 및 집단 내에 유의미한 차이가 있었으며, 집단 간에도 유의미한 차이가 있었다. 결론 : 본 연구 결과를 통하여 뇌졸중 환자에게 수공예활동을 적용한 그룹 작업치료 중재프로그램이 작업수행능력과 삶의 질 증진에 효과가 있음을 확인 할 수 있었다.

• 동의생리병리학회지
• /
• 제25권1호
• /
• pp.144-148
• /
• 2011

The purpose of this case series was to investigate the effectiveness of Bojungikki-tang-gamibang for vascular dementia. The case subjects were nine patients who were diagnosed as vascular dementia by Mini-Mental State Examination-Korean (MMSE-K) and Hachinski's ischemic score. They were inpatients at the Kumi Oriental Medical Hospitalof Daegu Haany University from February in 2008 to Aprile in 2009. They were treated with Bojungikki-tang-gamibang. Results of before and after therapy were evaluated and scored using Korean-version Dementia Rating Scale (K-DRS). The results were analyzed using statistical methods, such as Wilcoxon signed rank test and Mann-Whitney U test. The study showed that the K-DRS score significantly increased after treatment (P<0.05). In summary, this cases report suggests that Bojungikki-tang-gamibang appears to be effective in the treatment of vascular dementia.

• Journal of Korean Biological Nursing Science
• /
• 제12권3호
• /
• pp.140-147
• /
• 2010

Purpose: The purpose of this study was to identify the effects of the cognitive training program on cognitive function, stress and depression in geriatric hospitals. Methods: The subjects of the experimental group were 17 elderly patients who attended the cognitive training program in Geriatric Hospitals and the subjects of the control group were 15 elderly patients who attended in geriatric hospitals. The persons in training group must take cognitive training program for 4 weeks by 3 times a week. The Mini-mental State Examination Korea version (MMSE-K), Geriatric depression Scaleshort form-Korea version (GDS-K) and Korean Computerized Neurobehavioral Test (KCNT) were utilized to determine cognitive function, stress and depression. The collected data were analyzed by descriptive statistics, t-test and ANOVA using SPSS/PC 12.0 program. Results: Cognitive function (t=-7.625, p=.000) in the elderly after receiving the cognitive training program was significantly more improved than before intervention. Also, Stress and depression (t=2.73, p=.004) was significantly more reduced than before the intervention. Conclusion: This cognitive training program was partially effective in improving cognitive function, neurobehavioral performance and reduce stress and depression. Therefore, it is recommended that this program be used in clinical practice as an effective nursing intervention in geriatric hospitals.

• Journal of Preventive Medicine and Public Health
• /
• 제37권2호
• /
• pp.174-181
• /
• 2004

Objective : To examine the association between dietary factors and cognitive impairment in older Korean women living in the community. Methods : Wave 2 data, from the Suwon Longitudinal Aging Study (SLAS), of 365 women aged 65 years or over, were used. The Korean version of the 30-point Mini-Mental State Examination (MMSE-K) was used to assess cognitive impairment (score$\geq$19). Dietary habits and frequencies of food group consumption were also examined. Results : A total of 67 women (18.4%) were found to be cognitively impaired. In bivariate analyses, nondietary factors, such as age, marital status, education, income, self-rated health, depression, emotional support, social activity, exercise, and dietary factors, such as self-rated nutritional status, frequency of beans and bean products and milk and dairy products consumption were associated with cognitive impairment. In the multivariate analysis, a higher frequency ($\geq$1 vs. <1 time/day) of beans and bean products (OR=0.48, 95% CI: 0.23-0.99) and milk and dairy products (OR=0.25, 95% CI: 0.10-0.61) consumption was inversely associated with cognitive impairment, after adjustment for non-dietary factors. Conclusion : These results suggest that dietary factors may play a significant role in cognitive impairment of older Korean women.

• 대한한방내과학회지
• /
• 제21권2호
• /
• pp.193-201
• /
• 2000

Objective : In western medicine, many medication therapies and non-medication therapies have been treated for dementia. But these methods did no more than symptomatic therapies, not basic treatment, which just can better subordinate symptoms. In fact, care or control became the very point of treatment of dementia. So, to try to find oriental medical treatments for Dementia, a clinical analysis was carried out for 84 patients who were diagnosed as Dementia through MMSE-K and treated in Dong-shin Oriental Medicine Kwangju Hospital and Karitaas Sanatorium from 10. Jan. 1998 to 20. May. 2000. Methods : Regardless of patterns of Dementia, the basic treatment(本治) is to supplement encephalon deficiency(腦髓不足). And the external treatment(標治) must be accompanied by through diagnosis according to symptoms(辨證). All patients were given Yukmi-jihwanghwan gami and acupuncture treatment. Results : Dementia of cerebral vascular type shows a high distribution(51 patients, 60.7%). Women also are distributed more widely(62명, 73.8%). In Age distribition, 70-79 years-32 patients(38.1%), over 80 years-21 patients(25%), 60-69 years-17 patients(20.2%), 50-59 years-13 patients(15.5%) and under 49 years-1 patient(1.2%). From this, Dementia occurs well over 60 years and the rate of occurrence of Dementia is high as people grow older. In past history of people with Dementia, hypertension is associated much(50 patients, 64.1%). Distribution of mental state by MMSE-K examination declined in orientaion, mathmatical faculty, memory faculty and composition faculty. In therapeutic effect by treatment duration, 14 patients(93.3%) out of 15 in sanatorium show a significant effect. And 52 patients(75.4%) out of 69 in the hospital show the same result. Especially, 11 patients with Alzheimer type in sanatorium showed an good effect when treated over 4 months. 40 patients(83.3%) with cerebral vascular type out of 48 in the hospital showed the stage of betterment. Conclusions : The basic treatment(本治) for Dementia is to supplement encephalon deficiency(腦髓不足). For promoting encephalon through supplementing kindney(補腎健腦), All patients were given Yukmi-jihwanghwan gami. And the external treatment(標治) through diagnosis according to symptoms(辨證) were be accompanied by. The result is quite effective. We consider there must be more research based on this study.