• Journal of Ginseng Research
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• 제22권1호
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• pp.60-65
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• 1998

The effect of Korean red-ginseng extract on the proliferation and cellular activity of mouse B and T lymphocytes was examined in vitro. Both water and ethanol extract from red-ginseng increased the growth of normal B and T lymphocytes 1.5∼2.5-folds. Saponin and polysaccharide fractions from ginseng extract also stimulated the proliferation of normal lymphocytes much higher than several well-known immunostimulators. B and T lymphoma cell lines responded to the ginseng extract and fractions by growth, too, while non-lymphoid cell lines did not. Immunoglobulin production of unprimed B-lymphocytes was little affected by the ginseng extract and fractions, though the ethanol extract slightly enhanced Ini, production of B-lymphocytes. When cytolytic activity of T lymphocytes against tumor tells was induced in vitro, both of the saponin and polysaccharide fractions and the ginseng ethanol extract increased the cellular activity of cytotoxic T lymphocytes 4-5-folds, while the ginseng water extract did not. Especially, the saponin fraction exhibited 10-times higher stimulatory effect on the cytolytlc activity of cytotoxic T cells than the ethanol extract and the pclysaccharide fraction did. These results suggest that Korean red-ginseng contain potent immunomodulating components to stimulate the proliferation of B and T lymphocytes and the cellular activity of cytotoxic T lymphocytes.

• Archives of Pharmacal Research
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• 제8권4호
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• pp.257-260
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• 1985

Based on spectral and chemical evidences two glycosides isolated from Korean red ginseng are characterized as isomaltol-.alpha.-D-glucopyranoside. These compounds are not found in Korean white ginseng.

• 한국응용과학기술학회지
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• 제37권1호
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• pp.38-48
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• 2020

중국산과 국내산 홍삼 농축액의 혼합비율에 따는 원산지 판별 가능성을 검토하기 위해 전자코를 이용하여 향기 패턴을 분석하였다. 중국산 홍삼 농축액과 국내산 홍삼 농축액의 원산지 판별이 가능하였고 중국산 홍삼농축액의 혼합비율이 증가할수록 검출되어지는 향기 성분의 패턴은 감소하는 경향을 나타내었다. Frequency pattern, derivative pattern을 Vapor print^TM 으로 도형화 하여 비교한 결과 서로 다른 패턴을 보여주어 중국산 홍삼 농축액 첨가비율에 따른 차이는 물론 원산지의 차이도 뚜렷하게 나타났다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2004년도 춘계 총회 및 학술대회
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• pp.36-38
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• 2004

• 한국식품영양학회지
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• 제22권2호
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• pp.199-204
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• 2009

For the purpose of developing a safe & hygienic manufacturing method to acquire low levels of benzo(a)pyrene in black and red ginseng products, this study investigated the effects of steam- and dry-processing temperatures on benzo(a)pyrene production in ginseng. By the red ginseng with a fix dry-process temperature of $50^{\circ}C$ and setting the steam-process temperature between $80{\sim}120^{\circ}C$, an extremely small amount(0.1 ppb) of benzo(a)pyrene was produced, indicating there was no relationship between the steam-temperature and benzo(a)pyrene production. On the other hand, when the red and black ginseng were steamed at the fixed temperature of $100^{\circ}C$ and dried at various temperatures between $50{\sim}120^{\circ}C$, the amount of benzo(a)pyrene produced was closely connected with the dry-temperature, and increased with higher drying temperatures. Upon repeating the steam and dry process nine times, in which the steam-temperature was set at $100^{\circ}C$ and the dry-temperature at $50^{\circ}C$, higher amount of benzo(a)pyrene were produced in red and black ginseng, respectively, with increasing steam- and dry-processing time. However, the level of benzo(a)pyrene still remained extremely small(below 0.12 ppb), showing a maximum amount in the black ginseng that was steamed and dried nine times. This suggests that the fine root of ginseng may be carbonized by increasing the number of times it is steam- and dry-processed. From the above results, this study determined that the optimum temperatures for manufacturing red and black ginseng products with safe levels of benzo(a)pyrene would be a temperature between 80 and $120^{\circ}C$ for steaming and a temperature less than $50^{\circ}C$ for drying.

• Journal of Ginseng Research
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• 제17권2호
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• pp.145-147
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• 1993

The amounts of ginseng acidic polysaccharide (GAP) in red ginseng (Panax ginseng) were higher than those of wild and cultured Panax quinquefolius, Panax notoginseng as well as white ginseng (Panax ginseng). In white ginseng, there is no difference in the GAP amount among root ages or sizes. Also, the GAP amount of red ginseng body was similar to that of ginseng rhizome, but was higher than that of leaf and epidermis.

• Journal of Ginseng Research
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• 제14권1호
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• pp.36-43
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• 1990

The quality of raw, red and white ginseng and the contents of some minerals were examined using 6-year-old ginseng roots produced in different shades, thatch and polyethylene net (P..E.). The yield of first and second grade ginseng roots was higher in the thatch shade than in the P.E. shade. The smaller sizes of ginseng routs were probably due to loss of ginseng yield called by alternaria blight in the third and fourth years, and lower quality was dale to more rusty roots in the P.E. shading. For red ginseng. rates of heaven and earth grades were higher in the P.E. than thatch shade. producing red ginseng with less inside cavity Production of white ginseng was higher in the thatch shade than in the P.E. shade. showing a higher yield, better piece grade, lower inside crack and better quality index in the thatch. The contents of some minerals such as K, Ca, Mg and Mn of fine ginseng roots differed between the two shades, some of which had a significant correlation with the quality indices of white ginseng. Keywords Thatch shade, polyethylene shade, alternaria blight, rulsty root, quality of ginseng.

• Journal of Biosystems Engineering
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• 제29권4호
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• pp.329-334
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• 2004

This study was conducted to investigate the characteristics of transmittance spectrum of Korean red ginseng using VIS/NIR spectroscopy. The results of this study were as follows; Light intensity affected the characteristics of the spectrum. For over 40% light intensity, the first and second peaks appeared at 700nm and 1,100nm, respectively. For the 20% light intensity, the first and second peaks appeared at 800nm and 1,100nm, respectively. Thus, the typical color characteristics of halogen lamp were similar to each other if over 40% of maximum light intensity power, otherwise it was not. Transmittance spectrum showed different characteristics at different portions of red ginseng. Normal red ginseng showed strong intensity at the first peak around 700nmbecause of reddish internal tissue. However, an internal white core red ginseng showed weak peak-intensity due to whitish internal tissue. There was no significant difference in the second peak at 800nm for the different internal qualities. Third peak at 900nm showed somewhat difference by internal qualities but it was difficult to find significant trend. To separate the differences of the internal qualities, intensity differences between peaks were used. It was possible to classify normal red ginseng by the differences of "peak 1 -peak 2" and "peak 1 - peak 3". In addition, shift of the first and the third peaks in the spectrum could separate normal red ginseng from others.ginseng from others.

• Journal of Ginseng Research
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• 제43권4호
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• pp.666-675
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• 2019

Background: Korean Red Ginseng (KRG) has been widely used as an herbal medicine to normalize and strengthen body functions. Although many researchers have focused on the biological effects of KRG, more studies on the action mechanism of red ginseng are still needed. Previously, we investigated the proteomic changes of the rat spleen while searching for molecular signatures and the action mechanism of KRG. The proteomic analysis revealed that differentially expressed proteins (DEPs) were involved in the increased immune response and phagocytosis. The aim of this study was to evaluate the biological activities of KRG, especially the immune-enhancing response of KRG. Methods: Rats were divided into 4 groups: 0 (control group), 500, 1000, and 2000 mg/kg administration of KRG powder for 6 weeks, respectively. Isobaric tags for relative and absolute quantitation was performed with Q-Exactive LC-MS/MS to compare associated proteins between the groups. The putative DEPs were identified by a current UniProt rat protein database search and by the Gene Ontology annotations. Results: The DEPs appear to increase the innate and acquired immunity as well as immune cell movement. These results suggest that KRG can stimulate immune responses. This analysis refined our targets of interest to include the potential functions of KRG. Furthermore, we validated the potential molecular targets of the functions, representatively LCN2, CRAMP, and HLA-DQB1, by Western blotting. Conclusion: These results may provide molecular signature candidates to elucidate the mechanisms of the immune response by KRG. Here, we demonstrate a strategy of tissue proteomics for the discovery of the molecular function of KRG.

• Journal of Ginseng Research
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• 제34권4호
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• pp.264-273
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• 2010

While ginseng is reported to have a wide array of applications, there is growing evidence for its indications in diabetes and vascular disease. A clear connection, however, has not been established between ginseng's composition, dose and its targeted efficacy in humans. We therefore developed and initiated the Korean Red Ginseng Clinical Testing Program for diabetes and vascular function which is an efficacy and safety-based clinical screening model for ginseng. The most efficacious sources, ginsenoside profiles, doses, and modes of administration were examined in sequential, acute, followed by long term, randomized-controlled trials to investigate the efficacy and safety profiles. This review discusses the current state of the clinical research of Korean red ginseng program conducted in Toronto, paving the way for the use of clinically selected ginseng and its ginsenoside fractions in the management of diabetes and vascular diseases.