• Clinical and Experimental Reproductive Medicine
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• 제43권4호
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• pp.193-198
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• 2016

Objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect. G6PD plays a key role in the pentose phosphate pathway, which is a major source of nicotinamide adenine dinucleotide phosphate (NADPH). NADPH provides the reducing equivalents for oxidation-reduction reductions involved in protecting against the toxicity of reactive oxygen species such as $H_2O_2$. We hypothesized that G6PD deficiency may reduce the amount of NADPH in sperms, thereby inhibiting the detoxification of $H_2O_2$, which could potentially affect their motility and viability, resulting in an increased susceptibility to infertility. Methods: Semen samples were obtained from four males with G6PD deficiency and eight healthy males as a control. In both groups, motile sperms were isolated from the seminal fluid and incubated with 0, 10, 20, 40, 60, 80, and $120{\mu}M$ concentrations of $H_2O_2$. After 1 hour incubation at $37^{\circ}C$, sperms were evaluated for motility and viability. Results: Incubation of sperms with 10 and $20{\mu}M\;H_2O_2$ led to very little decrease in motility and viability, but motility decreased notably in both groups in 40, 60, and $80{\mu}M\;H_2O_2$, and viability decreased in both groups in 40, 60, 80, and $120{\mu}M\;H_2O_2$. However, no statistically significant differences were found between the G6PD-deficient group and controls. Conclusion: G6PD deficiency does not increase the susceptibility of sperm to oxidative stress induced by $H_2O_2$, and the reducing equivalents necessary for protection against $H_2O_2$ are most likely produced by other pathways. Therefore, G6PD deficiency cannot be considered as major risk factor for male infertility.

• Journal of Preventive Medicine and Public Health
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• 제37권3호
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• pp.238-245
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• 2004

Objectives : This study was conducted to examine the smoking behaviors and the relationship between smoking and other health behaviors among medical students. Methods : A self-administrated questionnaire was administered to a sample of 1,775 students from four medical schools between April and May 2003. Due to the small number of female smokers, the characteristics of smoking behaviors were analyzed only for males. Results : A total of 1,367 students (920 males and 447 females) completed the questionnaires, with an overall response rate of 77.7%. The smoking rates for males and females were 31.5, and 2.2%, respectively. Among the male smokers, 70.7% smoked daily, and 39.0% smoked one pack or more per day. Male students on medical course were more likely to smoke daily, and one pack or more per day, than those on premedical course. Male daily smokers desired to quit smoking less than occasional smokers, and 65.0% of male daily smokers were not ready to quit compared with 37.8% of the occasional smokers. Among the male daily smokers, 29.6% were severely nicotine dependent. The most common reason for not to quit smoking among male smokers was 'no alternative stress coping method' (44.4%), followed by 'lack of will power' (25.4%), and 'no need to quit' (19.4%). Compared with male non-smokers, male smokers were more likely to drink alcohol more often and in larger amounts, take coffee more often, eat breakfast less regularly, and be overweight or obese. Conclusions : The results of this study suggest that many male medical students were serious smokers, especially those on medical course. It is necessary to install a smoking prevention program for pre-medical students, provide effective smoking cessation methods for smokers, teach positive stress coping methods, and make the school environment suitable for coping with stress.

• The Korean Journal of Pain
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• 제30권3호
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• pp.176-182
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• 2017

Background: Current evidence suggests that intravenous magnesium sulfate might be effective for reducing migraine pain. In a recent pilot study, we showed that intravenous caffeine citrate could reduce the severity of migraine headache. The objective of this study is to investigate the efficacy of intravenous caffeine citrate vs. magnesium sulfate for management of acute migraine headache. Methods: We conducted a prospective quasi-experimental study from January until May 2016 in two educational medical centers of Shahid Beheshti University of Medical Sciences (Shoahadaye Tajrish Hospital and Imam Hossein Hospital), Tehran, Iran. The study included patients who were referred to the emergency department and met the migraine diagnosis criteria of the International Headache Society. Patients were allocated into 2 groups receiving either 60 mg intravenous caffeine or 2 g intravenous magnesium sulfate. The pain scores, based on the visual analog scale, were recorded on admission, as well as one and two hours after receiving the drug. A Chi-Square test and student t-test were used for analysis of baseline characteristics. A Mann-Whitney U test and Wilcoxon singed rank test were used to analyze differences in the visual analogue scale (VAS) score between and within the groups respectively. Results: In total, 70 patients (35 patients in each group) with the mean age of $33.1{\pm}11.3years$ were included (64.3% female). For the Caffeine citrate group, the median pain score decreased from 9.0 (2.0) to 5.0 (4.0) after one hour and to 3.0 (4.0) after two hours. For the magnesium sulfate group, the pain score decreased from 8.0 (2.0) to 2.0 (2.0) after one hour and to 0.0 (1.0) after two hours. Both intravenous caffeine citrate and intravenous magnesium sulfate reduced pain scores significantly but the magnesium sulfate group showed more improvement than the Caffeine citrate group after one hour (P < 0.001) and after two hours (P < 0.001). Conclusions: It is likely that both intravenous caffeine and intravenous magnesium sulfate can reduce the severity of migraine headache. Moreover, intravenous magnesium sulfate at a dose of 2 g might be superior to intravenous caffeine citrate 60 mg for the short term management of migraine headache in emergency departments.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1104-1113
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• 2020

Objective: To assess the regional ventilation in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) using xenon-ventilation dual-energy CT (DECT), and to compare it to that in patients with COPD. Materials and Methods: Twenty-one patients with ACOS and 46 patients with COPD underwent xenon-ventilation DECT. The ventilation abnormalities were visually determined to be 1) peripheral wedge/diffuse defect, 2) diffuse heterogeneous defect, 3) lobar/segmental/subsegmental defect, and 4) no defect on xenon-ventilation maps. Emphysema index (EI), airway wall thickness (Pi10), and mean ventilation values in the whole lung, peripheral lung, and central lung areas were quantified and compared between the two groups using the Student's t test. Results: Most patients with ACOS showed the peripheral wedge/diffuse defect (n = 14, 66.7%), whereas patients with COPD commonly showed the diffuse heterogeneous defect and lobar/segmental/subsegmental defect (n = 21, 45.7% and n = 20, 43.5%, respectively). The prevalence of ventilation defect patterns showed significant intergroup differences (p < 0.001). The quantified ventilation values in the peripheral lung areas were significantly lower in patients with ACOS than in patients with COPD (p = 0.045). The quantified Pi10 was significantly higher in patients with ACOS than in patients with COPD (p = 0.041); however, EI was not significantly different between the two groups. Conclusion: The ventilation abnormalities on the visual and quantitative assessments of xenon-ventilation DECT differed between patients with ACOS and patients with COPD. Xenon-ventilation DECT may demonstrate the different physiologic changes of pulmonary ventilation in patients with ACOS and COPD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제11권1호
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• pp.79-90
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• 2000

연구 목적：본 연구는 요인분석을 통하여 한국 청소년의 비행행동 유형을 분류하고, 청소년 비행행동을 조기에 평가하기 위한 측정도구 개발을 위한 연구이다. 방 법：서울 및 지방의 소아·청소년 정신과 외래 방문청소년 4명, 소년원, 분류심사원의 재소청소년 4명과, 중 ${\cdot}$ 고교에 재학중인 학생청소년 4명, 총 12명을 대상으로 실시한 개인면담 내용과 관련문헌 고찰을 근거로 총 31개 문항으로 구성된 예비도구를 작성하였다. 다음 단계로 본 예비도구에 대한 신뢰도와 타당도를 검증하였는데 도구의 타당도 검증은 전문가집단에 의한 내용타당도와 요인분석을 통한 구성타당도를 검증하였으며, 신뢰도 검증은 검사-재검사 신뢰도, 내적 일관성 정도 및 각 문항과 요인과의 상관계수를 조사하였다. 이상의 검증과정을 통하여 31개 문항이 모두 청소년 비행행동 평가를 위한 최종 도구로 확정되었다. 마지막으로 실제 상황에서의 최종도구의 변별력 정도를 확인하기 위하여 학생청소년군과 비행청소년군총 2,177명을 대상으로 본 도구를 이용한 설문조사를 실시한 후 t 검정을 하였다. 결 과：1) 최종확정된 도구는 총 31개 문항 3개 요인으로 구성되어 있으며 이들 요인들의 총설명변량은 52.2%였다. 또한 31개 문항들은 모두 각 요인에 .40이상의 유의한 적재량을 보였다. 2) 3개요인 중 요인 I 은 반사회적 비행행동으로 명명하였고 총 17개문항으로 구성되어 있으며, 요인 II는 공격적 비행행동으로 총 8개문항, 그리고 요인 III은 정신병질적 비행행동으로 총 6개 문항으로 구성되어 있다. 3) 본 도구의 총 31개 문항의 신뢰도는 Cronbach Coefficient Alpha값이 .952였으며, 각 요인별 신뢰도 는 요인 Ⅰ이 .950, 요인 II가 .866, 그리고 요인 III이 .721이었다. 4) 본 도구의 변별력을 확인하기 위하여 학생청소년군과 비행청소년군을 대상으로 실시한 요인별 차이검정 결과 요인 Ⅰ, 요인 II, 요인 III 및 전체 문항 모두에서 학생청소년군과 비행청소년군간에 유의한 차이가 있었다. 결 론：1) 본 연구를 통해 개발된 도구를 다른 대상자에게 반복 적용하여 연구함으로써 계속적인 신뢰도와 타당도 검증이 필요하다. 2) 이상적인 도구평가기준은 신뢰도와 타당도 뿐만 아니라 단순성, 효율성, 객관성 등까지도 고려되어져야 한다는 관점에서 볼 때, 본 도구는 지속적인 수정 보완 작업이 필요하며 이 과정을 통하여 보다 완전한 도구가 될 수 있으리라 추론된다. 3) 본 도구를 적용하여 한국청소년의 비행행동 유형이 어떤 것인지를 파악하고 이와 관련된 치료적 접근, 비행가능 청소년에 대한 사전 평가 척도까지도 연구 개발할 수 있다고 본다.

• 보건행정학회지
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• 제9권4호
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• pp.15-40
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• 1999

To assess the university health service organization(UHSO) and its school health programs a questionnaire survey for all of 186 four-year colleges in Korea was conducted from December 1. 1998 to March 31. 1999. The response rate was 91.9 percent(171 universities). The UHSO was established in 116 universities(67.8%L The most common name of UHSO. used in 61 universities(52.6%). was school health center. Only 45(38.8%) of the 116 universities surveyed had a committee to support and run the UHSO. The percentage of universities that had committee was higher in national universities and those with a large number of students. The average number of staff working in the UHSO was 3.5; 4.6 in national universities; and 7.1 in universities with more than 15.000 students. There were 43 universities(37.1%) which had a part-time physician and 104 universities (89. 7%) had full-time nurses. Only 4 universities(3.4%) had a independent facility for the UHSO while most of UHSO were housed in other building. The UHSO had an independent budget in 86 universities(74.1%). The average budget per university was 46.890.000 won: private universities had more budget with 59.170.000 won on average than national universities with 36.990.000 won. The average budget allocated per student was 4.362 won. A regular physical examination was performed in 72 universities(62.1%). The percentage of university that performed regular physical examination was higher in private universities than in national universities. Health counseling was performed in 113 universities(97.4%) and vaccinations in 87 universities(75.0%). Medical care services were performed in 87 universities(75.0%). and the private universities and those with over 10.000 students provided the student with more services. Environmental sanitation was executed in 73 universities(62.9%) and health education was conducted in 68 universities(58.6%)' The school health management activities were promoted in 104 universities(89.7%) out of 116 universities with UHSO. Only 12 universities(10.3%) published reports on the achievements and performance of the UHSO. Only 29 universities(25.0%) had a continuing education for employees of the UHSO.

• 수면정신생리
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• 제8권2호
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• pp.138-143
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• 2001

Sleepiness is associated with many different conditions and, as a neglected topic, it can be the cause of serious psychological and social disadvantages. In the aspect of learning, additional problems may arise from poor progress in school caused by the effect of sleepiness on concentration, memory, and other cognitive functions. Narcolepsy is by no means the most common cause of excessive sleepiness. Nonetheless, it is not a rarity, especially in young people. The non-specific nature of early features of narcolepsy, combined with very limited awareness that the condition can start in various ways, leads to many misinterpretations. Misinterpretation of narcolepsy symptoms is not confined to the medical profession. Teachers may well be critical of a student with narcolepsy because of their perception of narcolepsy symptoms as laziness, poor motivation, or difficult behavior and dull learning ability. Inappropriate reactions by parents, teachers, and peers, based on misinterpretation of narcolepsy symptoms or the patient's reactions to them, make a difficult situation worse. Especially in Korea, where schooling is focused on college entrance examinations, the problem is very serious and intensified by inappropriate or delayed diagnosis and treatment. Therefore, psychiatrists should be aware that narcolepsy in young adolescents is not rare and that they need to be familiar with its clinical features in both its classic and less obvious forms. Narcolepsy should be suspected if a adolescent's excessive sleepiness can not be explained in other ways. Therefore, we report on two patients who portray the tendency of dull learning ability and are mistaken as idle students. We diagnosed narcolepsy through polysomnography and multiple sleep latency testing. We treated the students with methylphenidate and pemolin. The students showed improvement in learning ability and were able to adapt better to school.

• 의학교육논단
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• 제20권1호
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• pp.44-50
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• 2018

The purpose of this study was to investigate factors associated with the critical thinking ability of nursing students at the individual and school levels. The study adopted a descriptive design and recruited 465 nursing students from four nursing schools from November 2014 to September 2015 through convenience sampling. The Clinical Critical Thinking Skill Test was used to measure critical thinking ability, and the data were analyzed with the SAS ver. 9.4 program (SAS Institute Inc., Cary, NC, USA) for descriptive statistics, t-test, analysis of variance, and multi-level model. The results showed that clinical practicum experience (${\beta}=-0.72$, p=0.025), taking critical thinking courses (${\beta}=0.63$, p=0.010), and taking simulation courses (${\beta}=0.56$, p=0.035) improved critical thinking ability in the individual level model. In the school level model, the interaction effect between the years of clinical practice done by the student and the presence of full-time clinical instructors was significant (${\beta}=1.29$, p=0.011). These results suggest that critical thinking ability improves with the more years of clinical practice individual nursing students have, and this improvement is greater with the presence of full-time clinical instructors in the school. Therefore, it is recommended that nursing students undergo critical thinking and simulation courses to develop their critical thinking ability, and dedicated clinical instructors in nursing schools should play a vital role.

• 한국컴퓨터정보학회논문지
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• 제27권2호
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• pp.91-98
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• 2022

본 연구의 목적은 COVID -19 상황에서 온라인 기초임상실습이 간호대학생의 비판적 사고성향, 자기결정성 동기 및 실습만족도에 미치는 효과를 파악하고자 시행되었다. 본 연구는 단일군 사전·사후설계이다. 연구 대상자는 G시에 소재한 간호학과 3학년을 대상으로 온라인 설문지를 이용하여 수집하였고 41명이 최종 참여하였다. 연구결과 비판적 사고성향(t=-2.60, p=.013)과 자기결정성동기(t=-2.84, p=.007)는 통계적으로 유의하게 상승했다. 이 결과는 온라인 기초임상실습이 비판적사고성향, 자기결정성 동기 향상에 효과가 있음을 의미한다. 최근 COVID-19 의료현장에서의 직접간호수행이 어려운 만큼 다양한 온라인 콘텐츠를 활용한다면 온라인 임상실습의 한계를 극복할 수 있을 것으로 기대된다.

• Clinical and Experimental Reproductive Medicine
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• 제30권3호
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• pp.233-240
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• 2003

연구목적: 본 연구에서는 정상 환자와 습관성 유산 질환 환자에서 유래된 융모막 조직 내에서의 면역억제유전자들의 발현 양상에 대해 알아보고자 하였다. 연구재료 및 방법: 임신 6주와 8주의 습관성 유산 질환 환자와 정상 환자로부터 융모막 조직을 채취하였다 (Normal N=6; RSA N=6). 면역조직화학적 분석을 통해서 조직을 관찰하고 세포가 살아있음을 확인한 후에, 역전사 중합효소연쇄반응을 통해서 면역억제유전자인 placenta protein 14 (PP14), indoleamine 2, 3-dioxygenase (IDO) 그리고 mucin1 (MUC1) 유전자의 발현 정도를 비교하였다. GAPDH 발현에 기준한 면역억제유전자 발현을 정량 분석하여 Student's t-test를 시행하였고, p<0.05를 유의성이 있는 것으로 판정하였다. 결 과: 습관성 유산 질환 환자의 경우, 임신 6주와 8주의 융모막 조직에서의 면역억제유전자 (PP14, IDO, MUC1) 발현이 현저하게 낮은 양상을 보이고 있었다. 습관성 유산과 면역억제유전자의 발현이 통계학적으로 유의성 있는 연관성을 가지고 있다는 것이 확인되었다. 결 론: 면역억제유전자 (PP14, IDO, MUC1)의 발현이 습관성 유산 질환 환자에서 특이적으로 낮게 나타나는 것으로 보아 습관성 유산 질환의 진단과 치료 연구 방안에 이 유전자들의 발현이 이용될 수 있을 것으로 사료된다.