• 생명과학회지
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• 제23권5호
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• pp.710-720
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• 2013

방사선 치료는 가장 일반적으로 사용되고 있는 항암치료로, 암 환자의 수 증가와 동반하여 방사선 활용도는 더욱 증가하고 있다. 방사선치료에 대한 환자들의 심리적 거부감과 산화적 스트레스, 저산소증, DNA 손상을 포함하여, 치료 후 나타나는 간 섬유화는 방사선 치료의 가장 큰 문제점으로 대두되고 있다. 간암의 경우 대부분의 환자들이 섬유화를 동반하고 있어서, 방사선에 의해 암세포가 제거된다 하더라도, 기존에 남아있는 손상 부위에서의 섬유화와 방사선 조사에 의한 정상조직의 섬유화는 간경변 유발 확률을 높이고 있다. 간 섬유화는 여러 간질환에서 흔히 관찰되는 증상으로, 간 섬유화 진행 기작의 규명은 만성질환으로의 진행을 억제할 수 있는 치료책 개발로 연계될 수 있지만, 아직까지 명확히 규명되지 않음에 따라, 섬유화를 억제할 수 있는 효과적인 방법이 없는 실정이다. 최근 간 섬유화 생성 및 진행에 대한 헤지호그의 역할이 밝혀지면서, 간암 및 만성질환으로의 진행을 이해하기 위한 연구대상으로 대두되고 있다. 헤지호그는 손상된 간에서 발현되어 보수과정에 기여하게 된다. 헤지호그의 발현은 간 손상 정도에 비례하여 발현되어, 간 줄기세포 및 간 성상세포의 증식을 조절한다. 또한, TGF-${\beta}1$와, EMT를 유도하고 근섬유화세포의 활성을 조절하여, 간 섬유화 진행에 중심적 역할을 한다. 방사선이 조사된 생쥐의 간에서도 헤지호그의 발현증가가 관찰되었고, 이에 따른 간 줄기세포의 증식 및 EMT 유도, 콜라겐의 축적이 관찰되었다. 또한, 방사선이 조사된 암컷 생쥐의 간에서 헤지호그의 차별적 증가는 줄기세포 및 섬유화 증대로 연결되었고, 이는 방사선 민감성에 대한 성별차이를 설명할 수 있는 생물학적 근거가 될 수 있다. 그러나, 방사선에 의해 유도된 간 섬유화에 대한 연구결과들이 헤지호그를 비롯하여, 표면적인 결과보고만 있을 뿐, 섬유화 진행에 대한 구체적 기작을 밝히지 못하고 있다. 여러 간 질환진행에서 규명된 헤지호그 작용에 대한 지식을 방사선에 의해 유도된 간 섬유화를 이해하기 위한 기초자료로 활용하고, 사람에서의 방사선 부작용과 유사한 동물모델의 정립 및 헤지호그 역할을 직접적으로 규명할 수 있는 추가적 연구을 통해서, 간 섬유화 형성 기작을 이해할 수 있는 연구결과가 기대된다.

• 대한한방내과학회지
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• 제45권3호
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• pp.519-531
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• 2024

Objectives: This case study reports the effectiveness of Korean medical treatment in a patient with cyclic vomiting syndrome. Methods: A 29-year-old female Korean patient with cyclic vomiting syndrome received acupuncture, electroacupuncture, herbal medicine, and moxibustion for 2 weeks in hospital. Changes in symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS), Visual Analog Scale (VAS), Index for Nausea, Vomiting, and Retching (INVR), Nausea Severity Scale (NSS), Nepean Dyspepsia Index-Korean version (NDI-K), quality of life using the Functional Dyspepsia Related Quality of Life questionnaire (FD-QoL), and gastric motility using electrogastrography (EGG). Results: Post-treatment, the patient showed high satisfaction and improvement in symptoms of nausea and vomiting. The following changes were observed in scores: GSRS: 23 to 19; VAS of nausea: 88 to 95; VAS of dyspepsia: 95 to 12; INVR: 13 to 1; NSS: 17 to 5; NDI-K: 107 to 78; and FD-QoL 84 to 27. We also found positive results in Channel 3 of EGG parameters, implying the improvement of gastric motility disorder. Conclusion: Korean medical treatment can be a therapeutic option for cyclic vomiting syndrome.

• 대한의료기공학회지
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• 제18권1호
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• pp.1-26
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• 2018

The objective of this study is to verify the effects of Moosim-Gi-Gong Doinbeop on low back pain targeting low back pain patients hospitalized in Korean medicine hospitals. For the study, 44 adult female and male patients hospitalized with low back pain at M Korean Medicine Hospital and H Korean Medicine Hospital located in Gimpo, Gyeonggi Province were recruited. The subjects had a temperature difference between left and right 湧泉(KI1) of over 0.5℃ through infrared thermographic imaging, and 23 of them were classified in the control group for retrospective analysis based on the test records. Infrared thermographic imaging, X-ray pelvic AP view - standing position, a sit-and-reach test and a VAS survey were employed for detection, and IBM SPSS Statistics 24 for the statistical process. The results were rounded down to three decimal places as in an average±standard deviation, and the significance level was 0.05 to be evaluated significant if p<0.05. The result of the study is as follows: 1. In the comparison between before and after conducting Moosim-Gi-Gong Doinbeop, the meaningful difference was shown in the experimental group in all indicators. But Indicators except for the temperature difference between right and left 湧泉(KI1)(difference between before and after) and In displaced pelvic correction indicators on the X-ray showed a significant difference in the control group. 2. As for the variation widths of the experimental group and the control group, the former showed significant temperature differences between 印堂(EX-HN3) and 關元(CV4) and right and left 湧泉(KI1); difference variations of anteflexion; and changes in PI and In displacement on the X-ray. 3. As for changes in the experimental group according to demographic characteristics, gender, age and degree of obesity did not show significant differences in all indicators. However, those who experienced back pain for more than six months in the experimental group showed the biggest body temperature differences between 印堂(EX-HN3) and 關元(CV4), while other indicators had no significant difference. As a result, patients who received Korean medicine treatment showed relieved back pain and improvement in pelvic correction and sports activity; however, those who got Moosim-Gi-Gong Doinbeop together showed more clearer improvement effects in pelvic correction and sports activity.

• 대한수의학회지
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• 제8권1호
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• pp.45-53
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• 1968

1. The albumin, ${\beta}-globurin$ and ${\gamma}-globurin$ fractions of non-vaccinated bovine serum (Control) int declined, and a total protein and ${\alpha}-globurin$ level are advanced on the reversible rather than of vaccinated immumized bovine serum. (Table 5.) 2. Some few exists the to bring about changed in the individuals and sexual in a vaccinated bovine serum, however, Male serum globurin fractions are higher than Female globurin fractions percentage. (Table 1 and 3.) 3. Albumin fractions are Age-ablly variable, so that, younger's are rather lower than adult's such reported as in the another litratures. 4. In the monthly analysis of immunized bovine serum the first week to at dulation for third weeks were slowly advanced as variablly in serum-protein fractions of ater by the Black-leg No. 2 vaccination, then, albumin fractions were illustated as maximum ratio (42.73 3.49%) and increased much as 14.9% more than non-vaccinates, and ${\alpha}-globurin$ fractions indicated the minimum ratio(15.11 2.35%) at for 4th month after vaccination decrease much as about 7.71 % rather non-vaccinated normal bovine serum. (Table 4. and Fig 3.) Next, continuous advanced the ${\beta}-globurin$ fractions at first month as primary crisis in a diagram, and indicated the maximum ratio at 8th months as the second crieir on the its diagram of after vaccinati on, however, few changed in non-vaccinated bovine serum. (Figs 4.) Especially, ${\gamma}-globurin$ fractions are advanced the maximum ratio as 41. 45% 4.48% anp advanced to be widely range much as about 22.55% more than control serum at 5th months of after the vaccination. That is one of the most considerable evalution in Black-leg No. 2 vaccination to Korean calevs as great presence of the maximum immune antibodies at for 5th month after the vaccination. (Table 4. and Fig 4.) 5. In the relationship between vaccinated rabbit and Korean calves, serum protein fraractions were to be changed within the 3 weeks, so that albumin fractions of vaccinated immune bovine serum are increased as directly ratio, while vaccinated rabbit immunized serum showed the decrease as to reciprocal ratio. Although, conclude that ${\gamma}-globurin$ fractions are increased gradually by and large on the vaccinated immune bovine serum(B. P. S.) and vaccinated immune rabbit serum(R. P. S.) together. (Table 6).

• 대한치과마취과학회지
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• 제14권1호
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• pp.29-39
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• 2014

Background: Dental phobia or anxiety of patients is the serious impediment to appropriate and effective dental treatment. Sedative technique helps to mitigate patients' fear and anxiety thus make them more cooperative and familiar to dental practices. With increasing attention to sedative dentistry in dentists, educational requirements and technical qualification also become stricter but actual survey on recent sedative dentistry has not been reported yet. Especially there is insufficient study reporting the survey of sedative dentistry subjected to Korean adults. In this paper, we conducted a survey study on the actual condition and practice related to sedation with a questionnaire to dentists in South Korea. Methods: The survey was done for members of The Korean Dental Society of Anesthesiology (KDSA), who had great interest in sedation and for whom survey-by-mail was convenient. 472 members of The KDSA having dental license and solid address and contact information were subjected to the survey by sending them survey questions about their sedative techniques and knowledge. In order to increase the response rate, small gifts were presented to those who accurately responded to the survey questions and text messages and phone calls were made to encourage their participation. We collected their responses over two months and examined the returned surveys. Statistical analysis was performed using IBM SPSS Statistics 21 for each question. Results: Out of 472 dentists, 181 responded (38.4% response rate). 63.0% (114 dentists; 77 male and 37 female) of respondents had experience on sedative technique and their average age was $39.8{\pm}7.6$ year. 74 of them were private practitioners, 17 of them were professors (14.9%), 11 of them were dentists-in-service (9.6%), 11 of them were residents (specialist training) (9.6%) and 1 of them was military doctors (0.9%). There were 89 dentists (78.1%) who were specialists or receiving trainings to be specialist, most of whom were pediatric dentists (55, 48.2%) and oral surgeon (31, 27.2%). The most popular route for drug medications was orderly oral, inhalational, intravenous medication. Combination of oral and inhalational medications or single use of intravenous medication was the most common. The most preferred sedative drug was pocral in oral sedation and midazolam in intravenous sedation. 48.2% of practitioners responded that they experienced side effects and emergency situations. Airway obstruction was the most frequent. Conclusions: Results from the survey show that the protocol and system for sedative dentistry have been improved compared to the past. Nevertheless, quality of emergency protocol, monitoring devices and preparation of sedative drugs was still insufficient to achieve safe sedative procedure. This study acquires novelty since actual survey on recent sedative dentistry for adult patients has not been reported yet.

• 한국산학기술학회논문지
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• 제17권9호
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• pp.57-67
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• 2016

본 연구는 제 4기, 제 5기 국민건강영양조사 자료를 이용하여 18세 이상 성인 23577 명을 남성 전체와 여성 전체, 65세 이상 남성과 65세 미만 남성, 폐경 전 여성과 폐경 후 여성으로 나누어 비타민 D의 수준에 따라 헤모글로빈과 페리틴 농도의 변화가 어떤 차이를 보이는지 알아보고자 하였다. 각 조사 대상 군을 비타민 D의 수준에 따라 5분 위수로 나누어 각 군 별 헤모글로빈과 페리틴 농도의 변화를 복합표본설계방법에 따라 일반선형모형을 사용하여 분석하였고 분석 결과 여성 전체 군(p<0.001)과 폐경 전 여성 군(p<0.001)에서 비타민 D 수준에 따라 헤모글로빈 농도의 차이가 통계적으로 유의하였고 폐경 후 여성 군과 남성 전체 및 65세 이상 남성, 65세 미만 남성 군에서는 통계적으로 유의하지 않았다. 페리틴 농도는 여성 전체 군(p<0.001)과 폐경 전 여성 군(p<0.001)과 남성 전체 군(p<0.05), 65세 미만 남성 군(p<0.05))에서 통계적으로 유의한 차이를 나타냈으나 남성에서 비타민 D가 높은 그룹이 페리틴이 낮았던 반면 여성에서는 비타민 D가 높은 그룹이 페리틴 농도가 더 높았고, 폐경 후 여성 군과 65세 이상 군에서 통계적으로 유의하지 않았다. 따라서 비타민 D는 폐경 전 여성에서 헤모글로빈 농도에 영향을 줄 가능성이 있고 폐경 전 여성과 65세 미만 남성의 체내 철 조절에 관여할 가능성이 있다.

• Journal of Preventive Medicine and Public Health
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• 제32권4호
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• pp.443-451
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• 1999

Objective: To examine the relationship between hypertension prevalence and the four commonest anthropometric measurements for obesity(body mass index(BMI), wasit-hip ratio(WHR), waist circumference(WC) and body fat in Korean adults. Methods: We studied the cross-sectional association of the anthropometric indices and blood pressure in 1,197 individuals(who were participants in the population-based cohort study). Hypertension was defined as blood pressure $\geq160/95\;mmHg$ or current use of antihypertensive medication. Informations on life-style factors were obtained from personal interview. Results: There were close associations between BMI, WHR and WC with blood pressure in both men and women. After age adjustment, BMI and WC showed significantly positive correlation with systolic and diastolic blood pressure levels in both men and women. Odds ratio(ORs) of being hypertensive were estimated comparing the highest to the lowest quantile, adjusting for age, smoking status, alcohol intake levels, education attainment. The simultaneously adjusted ORs of being hypertensive, comparing the highest vs the lowest categories, was for BMI 2.0(95% confidence interval(CI)=0.9-3.2) in men and 3.2 (95% CI=1.7-6.1) in women, for WC 2.1(95% CI=1.0-4.4) in men and 3.1 (95% CI=1.6-5.9) in women, for fat(%) 4.2(95% CI=1.9-9.5) in men and 2.1(95% CI=1.2-3.6) in women. Conclusion: In addition to measures of overall obesity(BMI) as well as central obesity(WHR, WC), body fat(%) was independently associated with prevalence of hypertension. Among obesity indices, body fat was the most predictor variable in hypertensive state in male and BMI was in female.

• 한국임상수의학회지
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• 제8권2호
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• pp.127-142
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• 1991

This study was carried out to investigate fatty liver in Korean black goats. Adult female goats were divided into 3 test groups(A, B and C). Group A and B of goats each received 3 test consecutive daily doses of DL-ethionine at 75mg/kg and 150mg/kg body weight, respectively. Group C of goats was given 3 consecutive doses of the compound every 48 hours at 150mg/kg body weight. The clinical symptoms, hematological values, serum chemical values and histopathological study of the liver were investigated in the test animals. The results obtained are as follows ; 1. Fatty liver were observed in every test animal. 2. Some clinical symptoms( anorexia, depression) were appeared from 1st day to 7th day after administration of the compound in every test animal. In addition to these symptoms, diarrhea and salivation were generally observed in test animals which were given the compound at 150mg/kg body weight. The degree of these symptoms was dose dependent. 3. There was no significant variations in total WBC counts and fibrinogen values in the blood of test goats. The PCV values were significantly increased on 5th day of dosing in group A and B of goats. 4. The total lipid value was not changed but the concentration of NEFA was significantly increased on 3rd day of dosing with the compound and returned to normal value after 10 days hereafter. The value of triglycerides was significantly increased on 1st day and returned to normal value on 3rd day of dosing. The value of cholesterol was significantly decreased on 3rd day and returned to normal value on 10th day after treatment. 5. Total protein level was decreased on 10th day of dosing in the groups of B and C, and billirubin level was significantly increased on 7th day of dosing in every test group and returned to normal level after 13th day of administration. 6. The activity of GGT in serum was not changed while the activities of SDH and AST were significantly increased in every test goat and those values were returned to normal after 10~13th day of trestment. 7 The 35K-protein fraction in serum was not detected by SDS-polyacrylamide gel electrophoresis, but this protein fraction was detected by the same method after treating the 21st and 22nd fraction which were obtained by column chromatography with Sephadex G-100. 8. The affected liver was congested and swollen on 3rd day, and yellowish brown in color and mottled appearance on 7th day of treatment. Histopathologically, fat droplets were common in the hepatocytes, this change was intensive on 7th day after treatment in group B and C. Hepatic cell necrosis was observed in some livers but this pathological change was disappeared and returned to normal after 13 days of treatment.

• Journal of Nutrition and Health
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• 제20권2호
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• pp.90-103
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• 1987

A study was conducted to measure nitrogen intake and excretion in young korean women on their normal diet and leading normal activity level. Dietary survey by food record, fecal and urinary samples were collected for 3 days in 19 healthy female college students in Korea. On one of the 3 days, duplicate of one-day diet was collected from each subjects. Mean daily intakes of energy and protein were calculated from food recorded. Duplicate diet samples and pooled fecal samples were analyzed for N content. Pooled urine samples were analyzed for total N, urea N, and creatinine content. Apparent N absorption, apparent N balance and urea N/creatinine N were calculated to evaluate protein nutritional status. The results obtained are summarized as following ; 1) Accordingly to food record, mean daily intakes of energy, protein, carbohydrate and far were 1535.2 $\pm$53.78Kcal, 55.95$\pm$2.97g(total nitrogen 8.95$\pm$0.45g), 254.13$\pm$10.31g and 39.24$\pm$2.76 g, providing 14.6%, 66.2%, 19.2% of total energy respectively. 2) Nitrogen intake by chemical analysis was 7.16$\pm$0.31g/day (protein 44.75$\pm$1.94kg/day) providing 82.39$\pm$4.58% of nitrogen intake by food record. The difference of total nitrogen intake between food record and chemical analysis in diets was significant(p<0.05). 3) Mean daily fecal nitrogen excretion was 1.38$\pm$0.10g and then mean apparent digesbility of protein was 80.53$\pm$5.21%. 4) Mean daily urinary nitrogen excretion, urea N excretion and creatinine excretion were 6.03$\pm$0.30g, 4.52$\pm$0.22g, and 0.88$\pm$0.04g respectively. Urinary urea nitrogen was 75.2$\pm$1.38% of total urinary nitrogen excretion and urinary nitrogen was 85.4$\pm$3.56% of total nitrogen intake by chemical analysis. 5) Mean urea N/creatinine N ration was 14.01$\pm$0.77. 6) Mean nitrogen balance was -0.244$\pm$0.33g/day. From the above results, it is concluded that the subjects in this study seem to be in marginal protein nutritional status and therefore should increase dietary protein intake.

• 한국방사선학회논문지
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• 제14권3호
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• pp.337-343
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• 2020

비장종대를 일으킬 수 있는 질환에는 감염성질환, 간경화, 기타 간질환, 비정상혈구에 의한 혈류질환, 림프계질환, 면역성질환 등이 있다. 따라서, 정상적인 비장의 크기를 아는 것은 비장의 정상 여부와 비장종대의 진단에 도움을 주며, 추적검사에도 유용하게 이용될 수 있다. 초음파검사에서 최대길이 12cm 미만, 두께 5cm 미만이면 정상적인 크기라고 여겨지나 성별, 인종에 따라 다를 수 있다. 저자들은 우리나라 20대 학생들을 대상으로, 초음파 검사로 비장크기를 측정하여, 비장 크기의 정상범위를 제시하고, 신장과 체중에 따른 비종종대 기준의 상한치 조정이 필요한지 알아보고자 한다. 측정결과 남자 비장의 길이는 10.95±1.07 cm(8.9~13.9), 폭은 4.48±0.61 cm 이었으며, 여자 비장의 길이는 9.20±1.30 cm(6.8~12.0), 폭은 3.55±0.44 cm으로 남녀 간에 평균에 유의한 차이가 있었다(p<0.001). 신장의 크기가 증가할수록 비장의 길이는 증가하였으며(r=.57), 체중이 증가함에 따라서 비장의 길이가 증가하는 뚜렷한 양적 선형관계가 있었다(r=.63). 정상 성인에서 비장의 길이가 12cm를 초과한 남자는 5명, 여자는 2명 이었으며, 13cm를 초과한 경우는 남성 2명이었다.