• Tunnel and Underground Space
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• v.13 no.5
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• pp.331-343
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• 2003

Though the Grouting has been in use for a long time, it is still regarded as an technique rather than engineering. The study of ground improvement by grouting is rare especially in jointed rock mass. In this study, biaxial compression tests were performed in the jointed rock mass models with .ough surfBce joints assembled with blocks before and after grouting. The load-deformation curves of the jointed rock masses showed a non-linear relationship before grouting but showed a relatively linear deformaion behavior after grouting. Improvement ratio (deformation modulus after grouting/deformation modulus before grouting) decreased with increasing joint spacing and lateral stress. Improvement ratio decreased exponentially with increasing deformation modulus of the rock mass model before grouting. Three-dimensional FDM analysis was performed to a highway tunnel case using experimental data of grouted rock. The convergence of the tunnel predicted after grouting by the numerical modelling coincided with those attained from the field measurement.

• Quality Improvement in Health Care
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• v.3 no.2
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• pp.52-59
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• 1997

Background : In many Nursing Delivery System, Nursing Department at D Hospital had used to traditional nursing practice model what is called functional activities based system. It has a lot of merit that carried out specialized and rapid works but tend to ignore indivisual professional responsibility and task-based work assignments. In addition this system showed high turnover rates due to heavy workload, timesum of handing over duties, lack of support from peers and interstaff communication. So we performed conversion of Nursing Delivery System to My Patients Nursing Care System for providing comprehensive nursing to patient and reducing turnover rates and increasing job satisfaction to nurse. Method : 1. 1st step(96.4.9): Detected the problem of Nursing delivery System and estabilished improving planning 2. 2nd step(96.4.26): Visited other hospital on job training 3. 3th step(96.4.29): Discussed to premonitoring problem after conversion Nursing Delivery System and prepared structure 4. 4th step(96.5.6): My Patients Nursing Care System practical application 5. 5th step(96.7.20): Held complementary meeting 6. 6th step(96. 7): The other ward application 7. 7th step(96. 10): Extended application to whole wards Results: 1. Workload: (1) reduction(55.6%) (2) addition(44.4%) 2. Strong points after conversion: (1) decreased timesum of handing overduties (35.2%) (2) increased responsibility(33%) (3) broaden nurse's outlook to duties(14.8%) 3. Shortcoming after conversion: (1) understanding difficulties except my patient(57.8%) (2) weak teamwork(23.3%) (3) intensive stress to low grade nurse(12.2%) 4. Effective complemental way: (1) manpower(76.7%) (2) conversion of though (8.9%) (3) education(14.4%) 5. Patient's satisfaction: (1) satisfaction(64%) (2) no effect(36%) 6. Physician and peer's satisfaction: (1) satisfaction(12.5%) (2) dissatisfaction(21.6%) (3) no interest(44.3%) 7. Nurse's satisfaction: (1) satisfaction(74.7%) (2) dissatisfaction(5.5%) (3) unknown(20.5%) 8. Want to continued: (1) want(76.4%) (2) try to any other system(18%) Conclusion : Even though Nursing Delivery System conversion still has many problem, we gained more merits than traditional nursing delivery system. So we suggest that My Patients Nursing Care System should be encouraged for comprehensive nursing care and satisfaction to nurses.

• Tunnel and Underground Space
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• v.22 no.2
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• pp.120-129
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• 2012

Recently, mining facilities have being installed in an underground space according to a social demand for environment-friendly mine development. The underground structures for mining facilities usually requires a large volume of space with width greater than height, and thus the stability assessment of the large-scale underground mine structure is an important issue. In this study, we analysed a factor of safety based on strength reduction method, and proposed a numerical design approach to determining the dimension of underground mine structures in combination with a strength reduction method and a multivariate regression analysis. Input design parameters considered in the present study were the stress ratio and shear strength of rock mass, and the width and cover depth of underground mine structures. The stabilities of underground mine structures were assessed in terms of factor of safety under different conditions of the above input parameters. It was calculated by the strength reduction method, and several kinds of fit functions were obtained through various multivariate regression analyses. Using a best-fit regression model, we proposed the charts which provide preliminary design information on the dimension of underground mine structures.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.4
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• pp.1-8
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• 1985

Stability analysis of the embankment as to water level varation is the most important problem in the safety of the slope because the stress of embankment inside varies as to drawdown of seepage line. Especially when the water level is rapidly drawdown, because the flow direction of the free surface changes the toe of embankment, the factor of safety comes to small, therefore the embankment is dangered. For the purpose of studing these phenomena, the experimental models are built with sand in the laboratory. In the experimental consideration, the falling seepage line and the shape of failure are measured. This paper intends to study the failure slip surface, the relationship between the factor of safety and drawdown velocity, and hydraulic gradient. The results of the experimental study are summarized as follows; 1. Owing to the drawdown of free surface, sliding failure occurred in the upstream fill, the height of failure is 5~10, 9~15, and 13~21(cm) in each model. 2. In consideration of the distribution of pore water pressure Table-5 shows each factor of safety. In the relationship between the drawdown velocity and the factor of factor it's velocity should be limited to 0.21~0.28 (cm/sec), according to each models. In the relationship between the factor of safety and the hydraulic gradient within the upstream slope, it's gradient must be below 0.36~0.43.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.1
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• pp.81-92
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• 2013

The ultimate flexural strength of HSB I-girders, considering the effect of local bucking, was investigated through a series of nonlinear finite element analysis. The girders were selected such that the inelastic local flange buckling or the plastic yielding of compression flanges governs the flexural strength. Both homogeneous sections fabricated from HSB600 or HSB800 steel and hybrid sections with HSB800 flanges and SM570-TMC web were considered. In the FE analysis, the flanges and web were modeled using thin shell elements and initial imperfections and residual stresses were imposed on the FE model. An elasto-plastic strain hardening material was used for steels. After establishing the validity of present FE analysis by comparing FE results with test results published in the literature, the effects of initial imperfection and residual stress on the inelastic flange local buckling behavior were assessed. The ultimate flexural strengths of 60 I-girders with various compression flange slenderness were obtained by FE analysis and compared with those calculated from the KHBDC, AASHTO LRFD and Eurocode 3 provisions. Based on the comparison, the applicability of design equations in these specifications for the flexural strength of I-girder considering flange local buckling was evaluated.

• Clinical and Experimental Reproductive Medicine
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• v.43 no.1
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• pp.9-14
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• 2016

Objective: Autophagy contributes to the clearance and recycling of macromolecules and organelles in response to stress. We previously reported that vitrified mouse oocytes show acute increases in autophagy during warming. Herein, we investigate the potential role of Atg7 in oocyte vitrification by using an oocyte-specific deletion model of the Atg7 gene, a crucial upstream gene in the autophagic pathway. Methods: Oocyte-specific Atg7 deficient mice were generated by crossing Atg7 floxed mice and Zp3-Cre transgenic mice. The oocytes were vitrified-warmed and then subjected to in vitro fertilization and development. The rates of survival, fertilization, and development were assessed in the Atg7 deficient oocytes in comparison with the wildtype oocytes. Light chain 3 (LC3) immunofluorescence staining was performed to determine whether this method effectively evaluates the autophagy status of oocytes. Results: The survival rate of vitrified-warmed $Atg7^{f/f}$;Zp3-Cre ($Atg7^{d/d}$) metaphase II (MII) oocytes was not significantly different from that of the wildtype ($Atg7^{f/f}$) oocytes. Fertilization and development in the $Atg7^{d/d}$ oocytes were significantly lower than the $Atg7^{f/f}$ oocytes, comparable to the $Atg5^{d/d}$ oocytes previously described. Notably, the developmental rate improved slightly in vitrified-warmed $Atg7^{d/d}$ MII oocytes when compared to fresh $Atg7^{d/d}$ oocytes. LC3 immunofluorescence staining showed that this method can be reliably used to assess autophagic activation in oocytes. Conclusion: We confirmed that the LC3-positive signal is nearly absent in $Atg7^{d/d}$ oocytes. While autophagy is induced during the warming process after vitrification of MII oocytes, the Atg7 gene is not essential for survival of vitrified-warmed oocytes. Thus, induction of autophagy during warming of vitrified MII oocytes seems to be a natural response to manage cold or other cellular stresses.

• Journal of dental hygiene science
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• v.17 no.1
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• pp.65-72
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• 2017

Temporomandibular joint (TMJ) pain is characterized by persistent jaw pain associated with dysfunction and tenderness of the temporomandibular muscles and joints. The aim of this study was to investigate whether treatment with red or black ginseng extract helps in the modulation of inflammatory TMJ pain. Male Sprague-Dawley rats weighing 220~260 g were used. The experimental group was subdivided into 4 groups based on the treatment method (n=6, each group): formalin (5%, $30{\mu}l$), formalin after distilled water (vehicle), formalin after red or black ginseng extract (per oral, single or repeated, respectively). To induce TMJ pain, $30{\mu}l$ of formalin was injected into the articular cavity under ether inhalation anesthesia. The number of noxious behavioral responses of scratching the facial region proximal to the injection site was recorded for 9 successive 5-min intervals following formalin injection. Repeated treatment with red or black ginseng extract reduced the nociceptive responses in the second phase (11~45 min). Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor. Both ginsengs significantly down-regulated the increased Nrf2 level compared to the vehicle group. In the test for liver and kidney functions, repeated treatment with red or black ginseng was not different compared to the vehicle group. These results indicate that red and black ginseng extract might be promising analgesic agents in the treatment of inflammatory TMJ pain.

• Journal of Life Science
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• v.28 no.8
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• pp.931-937
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• 2018

Triptolide is a compound found in Tripterygium wilfordii and reported to have an anti-inflammatory and anti-oxidant activities. A previous study shows that the dietary supplementation with triptolide increases resistance to environmental stressors, including oxidative stress, heat shock, and ultraviolet irradiation, and extends lifespan in C. elegans. Here, we investigated the underlying mechanisms involved in the lifespan-extending effect of triptolide. The effect of triptolide on age-related diseases, such as diabetes mellitus and Alzheimer's disease, was also examined using animal disease models. The longevity phenotype conferred by triptolide was not observed in the eat-2 mutant, a well-known genetic model of dietary restriction, while there was an additional lifespan extension with triptolide in age-1 and clk-1 mutants. The long lifespan of age-1 mutant is resulted from a reduced insulin/IGF-1-like signaling and the clk-1 mutant lives longer than wild-type due to dysfunction of mitochondrial electron transport chain reaction. The effect of dietary restriction using bacterial dilution on lifespan also overlapped with that of triptolide. The toxicity of high glucose diet or transgenic human amyloid beta gene was significantly suppressed by the supplementation with triptolide. These findings suggest that triptolide can mimic the effect of dietary restriction on lifespan and onset of age-related diseases. We conclude that triptolide can be a strong candidate for the development of dietary restriction mimetics.

• The Journal of Engineering Geology
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• v.7 no.2
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• pp.101-112
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• 1997

Gravity and electrical resistivity surveys were carried out across the Kwangju fault in the downstream area of the Jangsung Lake, to investigate the location and geometrical feature of the fault. In the resistivity survey, dipole - dipole array method was adopted for 3 survey lines of which length and electrode spacing are 500m and 25m, respectively. Resistivity data are interpreted with aid of computer program "RESIS" which is widely used in resistivity data analysis and two dimensional resistivity profiles are obtained for 3 survey lines. Two large fracture zones relevant to the Kwangju fault are identified in the resistivity profiles. The total of 80 gravity data are observed with the mean spacing of 40 m and the exact leveling is accompanied to obtain more precise gravity anomalies. The subterranean density discontinuities calculated from the inverse method are appeared at the depths of 650rn and 120m. It is considered that the deep discontinuity indicates boundary between Jurassic granites and oveflying Cretaceous tuff formation. while, the shallow discontinuity is interpreted to be a boundary between alluvial deposits and basements. The subsurface geological structure to satisfy the observed Bouguer anomaly is determined from the iterative forward method in which results from existing surface geological informations, the inverse method, and from the resistivity interpretations are employed as an iuitial model. In conclusion, Kwangju fault is appeared to be a high angle normal fault mainly formed in tension stress filed.

• Ecology and Resilient Infrastructure
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• v.3 no.3
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• pp.207-211
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• 2016

This study focuses on the categorization of the phenomenon of vegetative recruitment on riparian channels, so called, the phenomenon from "white river" to "green river", and proposes for the corresponding research direction. According to the literature review and research outputs obtained from the authors' previous research performed in Korea within a limited scope, the necessary and sufficient conditions for the recruitment and retrogression of riparian vegetation may be the mechanical disturbance (riverbed tractive stress), soil moisture (groundwater level, topography, composition of riverbed material, precipitation etc.), period of submergence, extreme weather, and nutrient inflow. In this study, two categories, one for the reduction in spring flood due to the change in spring precipitation pattern in unregulated rivers and the other for the increase in nutrient inflow into streams, both of which were partially proved, have been added in the categorization of the vegetative recruitment and retrogression on the riparian channels. In order to scientifically investigate further the phenomenon of the riparian vegetative recruitment and retrogression and develop the working riparian vegetative models, it is necessary to conduct a systematic nationwide survey on the "white to green" rivers, establishment of the categorization of the vegetation recruitment and retrogression based on the proof of those hypotheses and detailed categorization, development of the working mathematical models for the dynamic riparian vegetative recruitment and retrogression, and adaptive management for the river changes.