• 대한한의학방제학회지
• /
• 제21권1호
• /
• pp.111-118
• /
• 2013

Objectives : Traditional medicine Oryeong-san (ORS) has been prescribed for a long time to treat light fever, thirst, dysuria, and accompanying edema. However, the acute toxicity and safety were not reported. In this study, we evaluated the potent acute toxicity and safety of ORS. Methods : ICR mice were used to evaluate acute toxicity and safety by oral administration of 0, 500, 1,000, 2,000mg/kg of ORS. Mortality, body weight, and clinical symptoms were observed, and organ weight and blood biochemical parameters were analyzed after necropsy. Results : We found no mortality and no toxic or abnormal clinical symptoms by administration of ORS. Comparing with control group, no significant alterations in organ weight and blood biochemical parameters were observed. Conclusions : ORS recognized as safe and non-toxic medicinal material, and median lethal dose considered to be over 2,000 mg/kg in both male and female ICR mice.

• 동의생리병리학회지
• /
• 제29권3호
• /
• pp.218-222
• /
• 2015

Facial diagnosis based on quantitative facial features has been studied in many Korean medicine fields, especially in Sasang constitutional medicine. By the rapid growing of 3D measuring technology, generic and cheap 3D sensors, such as Microsoft Kinect, is popular in many research fields. In this study, the possibility of using Kinect in facial diagnosis is examined. We introduce the development of facial feature extraction system and verify its accuracy and repeatability of measurement. Furthermore, we compare Sasang constitution diagnosis results between DSLR-based system and the developed Kinect-based system. A Sasang constitution diagnosis algorithm applied in the experiment was previously developed by a huge database containing 2D facial images acquired by DSLR cameras. Interrater reliability analysis result shows almost perfect agreement (Kappa = 0.818) between the two systems. This means that Kinect can be utilized to the diagnosis algorithm, even though it was originally derived from 2D facial image data. We conclude that Kinect can be successfully applicable to practical facial diagnosis.

• Natural Product Sciences
• /
• 제26권1호
• /
• pp.83-89
• /
• 2020

Osteoporosis is a worldwide disease leading to significant economic and societal burdens globally. Osteoporosis is caused by unbalanced bone remodeling between the rate of osteoclast bone resorption and osteoblast bone formation. Acer tegmentosum Maxim (AT) is a traditional herbal medicine containing multiple biological activities such as anti-oxidant and anti-inflammatory purposes. However, its role in osteoporosis has not been fully studied. Therefore, we investigated whether AT has a potent inhibitory effect on osteoporosis and its mechanism through a systemic evaluation in ovariectomized (OVX) mice. OVX mice were orally administrated with the AT at doses of 50, 100, and 200 mg/kg for 10 weeks. Histological images and histomorphometry analyses were performed by H&E and Toluidine blue satin, and the expression levels of receptor activator for nuclear factor-kB ligand (RANKL), nuclear factor of activated T cells cytoplasm 1 (NFATc1), c-Fos, and matrix metalloproteinase 9 (MMP9) related to the osteoclast differentiation were investigated using immunohistochemical analysis. Administration of AT prevented bone loss and the alternations of osteoporotic bone parameters at the distinct regions of the distal femur and spongiosa region in OVX mice. Further, administration of AT increased periosteal bone formation in a dose-dependent manner. Meanwhile, AT inhibited not only the expression of NFATc1 and c-Fos, which are two major regulators of osteoclastogenesis but also reduced bone resorbed encoding expression of MMP9 and RANKL. Our results indicated that administration of AT prevented bone loss and the alternations of osteoporotic bone parameters at the distinct regions of the distal femur and spongiosa region in OVX mice. Also AT has the bone protective effect through the suppression of osteoclast and promotion of osteoblast, suggesting that it could be a preventive and therapeutic candidate for anti-osteoporosis.

• 대한한의학방제학회지
• /
• 제28권2호
• /
• pp.189-198
• /
• 2020

Objectives : This study investigated the liver-protective effects of MJY2018, a Herbal formula, against alcoholic fatty liver disease and anti-oxidative effects. Methods : Its effects were investigated in an alcoholic fatty liver disease model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. MJY2018 (100 and 200 mg/kg bw/day) or silymarin (50 mg/kg bw/day) were orally administered daily in the alcoholic fatty liver disease mice for 16 days. Results : The results indicate that MJY2018 promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels as indicators of liver damage in the serum. Furthermore, MJY2018 reduced accumulation of triglyceride and total cholesterol, increased levels of superoxide dismutase (SOD) and glutathione (GSH) in the livers of the alcoholic fatty liver disease mice model. Additionally, it improved the serum alcohol dehydrogenase (ADH) activity. Conclusions : These results indicate that MJY2018 were effective in improving and protecting oxidative stress and alcoholic liver disease.

• 대한한의학회지
• /
• 제40권4호
• /
• pp.41-48
• /
• 2019

Objectives: The objective of this study was to report the general characteristics, satisfaction, and changes before and after treatment to foreign athletes and officials who were received Korean Medicine at the 2019 Chungju World Martial Arts Masterships Korean Medical Clinic. Methods: We investigated age, gender, nationality, type of sports, and, onset through medical records. Besides, we developed the patient satisfaction survey to determine how satisfied the patients were with the treatment they received. The survey included type of injury, location of the injury, cause of injury, Numeric Rating Scale (NRS) before and after treatment, and treatment satisfaction. Result: This study showed that knee and lower leg injuries (S80-S89) were the most frequent injuries in the Korean Medicine(KM) clinic of the 2019 Chungju World Martial Arts Masterships. We provided KM treatments including acupuncture, cupping therapy, Chuna manual therapy, herbal medicine, dressing, and taping. Acupuncture was the most frequently performed and the most satisfactory treatment. The average NRS after treatment significantly decreased, suggesting that KM is effective in controlling pain in sports injuries. The overall satisfaction was also high with KM treatments.

• 대한한방부인과학회지
• /
• 제21권1호
• /
• pp.134-149
• /
• 2008

Purpose: Dysmenorrhea is a common gynecologic condition among reproductive-age women. It consisted with menstrual clamps and other symptoms such as nausea. vomiting, diarrhea, and fatigue. Pain control for this disease mainly through NASIDs. but recently CAM therapies, acupuncture and others for painful menstruation are widely used in western countries. But RCT articles about dysmenorrhea in Korea, are not enough to lead such global research trends. The purpose of this study is to review treatment method and other research tendency about dysmenorrhea in Korean Medicine(KM) related dominant journals. Methods: Searching was done through web site and directly searched dysmenorrhea related articles in journals of Korean medicine Gynecology, published during 1996-2007. Results: Twenty five articles were searched in KM related journals, then two of them were simple case report and ten were paper of clinical trials. But there no RCT or control group-designed study. All of them present positive effect on dysmenorrhea but drop out rates were relatively high. Conclusion: KM therapies including acupuncture and herbal medicine have some beneficial effect to resolve menstrual cramps, but KM therapy related Korean articles don't have strong objective power as a evidence in the viewpoint of EBM. So continuous clinical trials such as RCT and multi center trials are needed.

• 대한한방부인과학회지
• /
• 제35권1호
• /
• pp.12-33
• /
• 2022

Objectives: Since the importance of Korean Medicine (KM) treatment for Poor Ovarian Response (POR) is high, we intend to present appropriate treatment standards and methods by analyzing information on KM knowledge presented in related research papers and literature. Methods: First, research papers dealing with Diminished Ovarian Reserve (DOR) and POR are analyzed. In addition, we analyze and refer to research papers on Premature Ovarian Failure and Premature Menopause, which are closely related to DOR. Results: It is considered that the application of KM treatment alone for DOR should be based on the age that best reflects the ovarian reserve rather than the value of the ovarian reserve-related index centered on Anti-Müllerian Hormine (AMH). Accordingly, as a DOR woman under the age of 38, if normal sexual intercourse is achieved and the spouse factor is excluded, KM treatment, focusing on herbal medicine and acupuncture, can be applied. Conclusions: Korean Medicine treatment for infertility caused by decreased ovarian reserve is expected to be effective. However, research on specific treatments and targets will have to be added.

• 대한한방부인과학회지
• /
• 제20권4호
• /
• pp.175-190
• /
• 2007

Purpose: Ovarian cysts are fluid-filled sacs or pockets within or on the surface of an ovary. Most cysts present little or no discomfort and are noncancerous and harmless. So non-surgical treatments with herbal medicine or acupuncture and moxa therapy are important and suitable in this pathology. But there are few RCT articles about ovarian cyst in Korean Medicine(KM) clinical and research field. Methods: To review treatment method and other research tendency about ovarian cyst in journals related with KM and Traditional Chinese Medicine(TCM) through web-searching. Searching was done through web site #http://omis.ksucc.ac.kr# and pub-med(http://www.ncbi.nlm.nih.gov/sites/entrez) with key words #ovarian cyst#, #TCM#, #herb#, #CAM#, and #acupuncture#. Results: Seven articles were searched in journals related with KM, then six of them were simple case report and the other one was about diagnosis for ovarian cyst and another gynecologic disease such as uterine myoma and infertility through the iris diagnosis. And two articles were searched in journals related with TCM, then one of them was simple case report but the other is RCT article. Conclusion: KM and TCM therapies have some beneficial effect to resolve cyst, but objective power as a evidence is weak in the viewpoint of EBM. So continuous clinical trials such as RCT and multi center trials are needed.

• 동의생리병리학회지
• /
• 제16권6호
• /
• pp.1211-1216
• /
• 2002

To evaluate whole-body vibration(WBV) exposure and fatigue-decreased proficiency(FDP) boundary in passenger car driver, several roads in Busan were divided into 3 types by the condition of road surface; Road 1 was partially damaged, Road 2 was normal without damage, and Road 3 was better than Road 2. The results were following: The highest passenger driver's exposures to whole-body vibration acceleration and fatigue-decreased proficiency boundary at 40km/h were 0.108m/s² and about 2099 minutes in Road 2 for xh axis, 0.134m/s² and about 1585 minutes in Road 2 for yh axis, and 0.183m/s² and about 1053 minutes in Road 2 for zh axis, respectively. The highest passenger driver's exposures to whole-body vibration acceleration and fatigue-decreased proficiency boundary at 80km/h were 0.219m/s² and about 830 minutes in Road 3 xh axis, 0.203m/s² and about 918 minutes in Road 3 for yh axis, and 0.622m/s² and about 195 minutes in Road 1 for zh axis, respectively. The highest vector sums of whole-body vibration exposure at 40km/h and 804km/h were 0.328m/s² in Road 2 and 0.730m/s² in Road 1, respectively. The highest crest factors at 40km/h were 4.25 in Road 1 for xh, 4.51 in Road 3 for yh, and 5.81 in Road 2 for zh, respectively. The highest crest factors at 80km/h were 5.57 in Road 1 for xh, 5.60 in Road 2 for yh, and 6.46 in Road 3 for zh, respectively. The highest transmissibilities of whole-body vibration from floor to seat at 40km/h and 80km/h were 0.89 in Road 3 and 0.82 in Road 3 for xh axis, 0.83 in Road 3 and 0.87 in Road 1 and 2 for yh, and 0.80 in Road 2 and 0.92 in Road 1 tor zh axis, respectively. The highest fatigue-decreased proficiency boundaries for whole-body vibration exposure of passenger car driver in floor and seat were 457 minutes in Road 3 and 583 minutes in Road 3 at 40km/h and 159 minutes in Road 2 and 251 minutes in Road 2 at 80km/h, respectively.

• 동의생리병리학회지
• /
• 제35권3호
• /
• pp.104-116
• /
• 2021

In order to reduce the social and economic costs due to the increase in dementia patients, which is a representative senile disease in an aging society, it will be important to prevent dementia and to detect and treat early in high-risk groups. This study reported the results of treatment for the elderly with high risk of dementia and depression who received Korean medicine (KM) treatment in 9 KM clinics. Medical charts were surveyed on 116 patients with high risk of dementia and depression who received KM treatment at 9 KM clinics in Gangseo-gu from September 1, 2020 to December 31, 2020. The majority of the patients were female(76.72%), the average age was 71.66±7.18 years old, and the average education level was 8.96±3.91 years. The average treatment period was 61.47±10.30 days, the average number of treatments was 15.38±1.06 times, and both acupuncture and herbal medicine were administered. After receiving KM treatment, cognitive assessment scores such as MMSE-DS and MoCA-K, depression-related GDSSF-K score, dementia knowledge, attitude, and preventive behavior, blood debilitation scale, and GQOL-D score were improved compared to before. There was no specific adverse reaction except that one patient with elevated AST and ALT levels was observed. This study showed improvement in cognitive function, depression, dementia-related scale, and quality of life in high-risk groups for dementia and depression over 60 years old who received KM treatment. More systematic and large-scale planned clinical studies will be needed.