Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Acute Toxicity Study on Oryeong-san in Mice

오령산 열수추출물의 단회투여 급성독성 연구

  • Park, Hwayong (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Hwang, Youn-Hwan (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Ha, Jeong-Ho (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Jung, Kiyoun (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Ma, Jin Yeul (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine)
  • 박화용 (한국한의학연구원 한의신약연구그룹) ;
  • 황윤환 (한국한의학연구원 한의신약연구그룹) ;
  • 하정호 (한국한의학연구원 한의신약연구그룹) ;
  • 정기연 (한국한의학연구원 한의신약연구그룹) ;
  • 마진열 (한국한의학연구원 한의신약연구그룹)
  • Received : 2013.01.23
  • Accepted : 2013.02.14
  • Published : 2013.06.30
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Abstract

Objectives : Traditional medicine Oryeong-san (ORS) has been prescribed for a long time to treat light fever, thirst, dysuria, and accompanying edema. However, the acute toxicity and safety were not reported. In this study, we evaluated the potent acute toxicity and safety of ORS. Methods : ICR mice were used to evaluate acute toxicity and safety by oral administration of 0, 500, 1,000, 2,000mg/kg of ORS. Mortality, body weight, and clinical symptoms were observed, and organ weight and blood biochemical parameters were analyzed after necropsy. Results : We found no mortality and no toxic or abnormal clinical symptoms by administration of ORS. Comparing with control group, no significant alterations in organ weight and blood biochemical parameters were observed. Conclusions : ORS recognized as safe and non-toxic medicinal material, and median lethal dose considered to be over 2,000 mg/kg in both male and female ICR mice.

Keywords

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