• Title/Summary/Keyword: Korea Research Institute of Chemical Technology

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Vasorelaxation Effect of the Flavonoids from the Rhizome Extract of Alpinia offcinarum on Isolated Rat Thoracic Aorta (고량강 추출물로부터 분리된 Flavonoid 화합물의 혈압강하 효과)

  • Kim, Hye-Jin;Yoo, Mi-Young;Kim, Hyun-Ki;Lee, Byung-Ho;Oh, Kwang-Suk;Seo, Ho-Won;Yon, Gyu-Hwan;Gendaram, Odontuya;Kwon, Dae-Young;Kim, Young-Sup;Ryu, Shi-Yong
    • Korean Journal of Pharmacognosy
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    • v.37 no.1 s.144
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    • pp.56-59
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    • 2006

  • The vascular relaxant effets of Alpinia officinarum(Zingiberaceae) were evaluated on isolated thoracic aorta from rats. The methanolic extract of rhizome of Alpinia officinarum caused a concentration-dependent relaxation of rat aortic preparations precontracted with $0.3{\mu}M$ phenylephrine, The intensive investigation of the extract by way of activity-guided fractionation led us to yield three kind of active components, galangin(1), kaempferide(2), and kaempferol(3), which were responsible for the vasodilating property of the extract. Stuctures of the isolated active components were established by chemical and spectroscopic means.

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Synthesis of homovanillic amide derivatives and their analgesic activity

  • Lim, Hee-Jong;Jung, Young-Sik;Ha, Deok-Chan;Seong, Churl-Min;Lee, Jong-Cheol;Choi, Jin-Il;Choi, Seung-Won;Han, Man-So;Lee, Kwang-Sook;Park, No-Sang
    • Archives of Pharmacal Research
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    • v.19 no.3
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    • pp.246-247
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    • 1996

  • In the previous reports (Park et al., 1991, and 1993), we described the synthesis and analgesic effects of various homovanillic amides as analogs of capsaicin. In the study, we tried to enhance the analgesic actvity of capsaicin by structural modification. Our study has been performed in three directions. First, the amide bond of capsaicin was transposed. Second, a phenyl ring was introduced to replace a double bond of capsaicin. Finally, aminoethylation was performed on 4-hydroxy group of capsaicin to improve oral bioavailability. These studies have led to N-(3-phenylpropyl)homovanillic amide 2 which has high analgesic activity. Our continuing efforts in this area have focused on the introduction of various substituents on the phenyl ring of 2 as well as their pharmacological studies. We report herein the synthesis of homovanillic amide derivatives and their analgesic activity.

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