• Journal of Soil and Groundwater Environment
• /
• v.7 no.3
• /
• pp.103-114
• /
• 2002

Knowledge of soil water retention characteristic is essential for many problems involving water flow and organic solute transport in unsaturated soils. A physico-empirical approach based on the translation of the particle-size distribution (PSD) into a corresponding water retention curve has been accomplished by others using the concept that the pore-size distribution is directly related to PSD. This approach implies that details of a PSD curve may affect the estimation of water retention characteristic (WRC). To determine whether the WRC estimation using the Arya-Paris model could be affected by the selection of a PSD model, four PSD models with one to four fitting parameters were used. The Jaky model with only one fitting parameter had greater WRC estimation ability than other models with greater number of fitting parameters. The better performance of the Jaky model may be explained by the effect of soil structure in field soils.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2000.11a
• /
• pp.74-82
• /
• 2000

Prostate cancer initially responds and regresses in response to androgen depletion therapy, but most human prostate cancers will eventually recur, and re-grow as an androgen independent tumor. Once these tumors become hormone refractory, they usually are incurable leading to death for the patient. Little is known about the molecular details of how prostate cancer cells regress following androgen ablation and which genes are involved in the androgen independent growth following the development of resistance to therapy. Such knowledge would reveal putative drug targets useful in the rational therapeutic design to prevent therapy resistance and control androgen independent growth. The application of genome scale technologies have permitted new insights into the molecular mechanisms associated with these processes. Specifically, we have applied functional genomics using high density cDNA microarray analysis for parallel gene expression analysis of prostate cancer in an experimental xenograft system during androgen withdrawal therapy, and following therapy resistance, The large amount of expression data generated posed a formidable bioinformatics challenge. A novel template based gene clustering algorithm was developed and applied to the data to discover the genes that respond to androgen ablation. The data show restoration of expression of androgen dependent genes in the recurrent tumors and other signaling genes. Together, the discovered genes appear to be involved in prostate cancer cell growth and therapy resistance in this system. We have also developed and applied tissue microarray (TMA) technology for high throughput molecular analysis of hundreds to thousands of clinical specimens simultaneously. TMA analysis was used for rapid clinical translation of candidate genes discovered by cDNA microarray analysis to determine their clinical utility as diagnostic, prognostic, and therapeutic targets. Finally, we have developed a bioinformatic approach to combine pharmacogenomic data on the efficacy and specificity of various drugs to target the discovered prostate cancer growth associated candidate genes in an attempt to improve current therapeutics.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.3363-3368
• /
• 2013

Background: The burden due to cancers is an emerging public health concern especially in resource-limited countries like Nigeria. The WHO estimates that cancer kills more people than tuberculosis, HIV/AIDS and malaria combined. As people in Nigeria and other developing countries are beginning to survive infectious diseases, there is an observed epidemiologic transition to chronic diseases, such as cancers. In 2008, 75 out of 1,000 Nigerians died of cancer. Despite the rising incidence and public health importance, Nigeria lacks an organized and comprehensive strategy to deal with cancers. Materials and Methods: This article reviewed 30 peer-reviewed manuscripts on cancer care in four countries. It highlights the limitations to cancer care in Nigeria; due to lack of awareness, low health literacy, absence of organized screening programs, inadequate manpower (in terms of quality and quantity) as well as limited treatment options. Results: This review led to the formulation of a proposal for Nigerian National Cancer Policy, mainly drawn from effective strategies used in Canada, Brazil and Kenya. This is a vertical cancer program that is patient-centered with an emphasis on tobacco control and cancer disease screening (similar to Canada and Brazil). Additionally, it emphasizes primary cancer prevention (similar to Kenya). Its horizontal integration with other disease programs like HIV/AIDS will improve affordability in a poor resourced country like Nigeria. Capacity building for health professionals, hub-and-spoke implementation of screening services, as well as investment in effective treatment options and increased research in cancer care are essential. International 'twinning collaborations' between institutions in richer countries and Nigeria will enhance effective knowledge translation and improve the quality of patient care. Conclusions: A national cancer policy must be developed and implemented in Nigeria in order to overcome the present limitations which help contribute to the observed increases in cancer morbidity and mortality rates. Cancer control is feasible in Nigeria if the nation was to consider and employ some of the cost-effective strategies proposed here.

• Journal of Korean Academy of Nursing
• /
• v.43 no.2
• /
• pp.145-153
• /
• 2013

Purpose: The purpose of this manuscript is to discuss the need for use of evidence based practice (EBP) in LTC, the current use of evidence in long term care facilities and what we know about adoption of the use of EBP in LTC. Methods: Literature review and reporting of findings from the M-TRAIN study that was a quasi-experimental design to test the effectiveness of an intervention to increase the use of EBPs for urinary incontinence and pain in 48 LTC facilities. Results: Barriers to adopting EBPs include lack of available time, lack of access to current research literature, limited critical appraisal skills, excessive literature to review, non-receptive organizational culture, limited resources, and limited decision-making authority of staff to implement change. Strategies to promote adoption of EBP include the commitment of management; the culture of the home; leadership; staff knowledge, time, and reward; and facility size, complexity, the extent that members are involved outside the facility, NH chain membership, and high level of private pay residents. Findings from the M-TRAIN add, stability of nurse leader and congruency between the leaders perception of their leadership and the staff's perception of the leadership. Conclusion: There is clear evidence of the need and the benefits to residents of LTC and to the health care system yet adoption of EBP continues to be slow and sporadic. There is also evidence for the process of establishing best evidence and many resources to find the available EBPs. The urgent need now is finding ways to best get the EBPs implemented in LTC. There is growing evidence about best methods to do this but continued research is needed. Clearly, residents in LTC deserve the best care possible and EBPs represent an important vehicle by which to do this.

• Journal of Korean Medical classics
• /
• v.33 no.2
• /
• pp.61-76
• /
• 2020

Objectives : To study the pediatric contents in the 『Maijing』, the most comprehensive compilation of pulse theory. Methods : First, the original meaning was understood comprehensively through careful translation of the original text. Next, the original texts from which 『Maijing』 quoted certain verses were traced. Then, contents of 『Maijing』 were analyzed through comparison with contents from later period texts such as 『Beijiqianjinyaofang』, 『Zhubingyuanhoulun』, 『Xiaoeryaozhengzhijue』, 『Zhengzhizhunsheng』. Results : The study of pediatric contents of Wangshuhe's 『Maijing·Chapter9·Determining Pediatric Diseases 9th』 revealed that he set the standards of 'normal pulse' in terms of number of pulsation and pulse xiang[脈象] differently for children compared to adults. He summarized the most common disease patterns to be wind epilepsy[風癎], indigestion of breast milk[乳不消], and fright seizure[客忤氣], and described the pulses that reflected these conditions's physical characteristics. He also described the pulse and symptom patterns of 'growth fever[變蒸]' and 'heat in bone part[骨間有熱]' based on his observation, which contents were quoted and developed in 『Zhubingyuanhoulun』 and 『Xiaoeryaozhengzhijue』. For other miscellaneous pediatric conditions, he quoted prior texts such as 『Lingshu』 while adding words or making modifications to better reflect characteristics of children based on his observations in clinical pediatrics. Conclusions : It is concluded that 『Maijing·Chapter9·Determining Pediatric Diseases 9th』 not only describes pulse diagnostics but reflects in its contents pediatric theories and clinical knowledge of the Jin(晉)period, which affected pediatrics development of following periods.

• The KIPS Transactions:PartB
• /
• v.10B no.2
• /
• pp.219-228
• /
• 2003

This paper presents an efficient construction method of determination rules of thematic roles from syntactic relations in Korean language processing. This process is one of the main core of semantic analysis and an important issue to be solved in natural language processing. It is problematic to describe rules for determining thematic roles by only using general linguistic knowledge and experience, since the final result may be different according to the subjective views of researchers, and it is impossible to construct rules to cover all cases. However, our method is objective and efficient by considering large corpora, which contain practical osages of Korean language, and case frames in the Sejong Electronic Lexicon of Korean, which is being developed by dozens of Korean linguistic researchers. To determine thematic roles more correctly, our system uses syntactic relations, semantic classes, morpheme information, position of double subject. Especially by using semantic classes, we can increase the applicability of the rules.

• The Journal of the Korea Contents Association
• /
• v.8 no.11
• /
• pp.404-411
• /
• 2008

The purpose of this study is to suggest the effects of schema activation on reading comprehension. The subject of a sample survey was a 36 student experimental group and a 32 student control group, total 68 students at third grade class of C Middle School in Gwangju. Students ability to read English in the two groups were almost the same through, which was shown by pre-test administered before the beginning of the experiment. As a pre-reading activity, the experimental group was showed the pictures and vocabularies related to the text before reading. The other control group did Grammar Translation Method about text. The data needed for this study was obtained by the questionnaires with 25 questions about the English reading. The data analyzing method was t-test through the statistics program SPSS 12.0. The result of this study is as follows : First, the experimental group got a more meaningful score than the control group at the test. Second, pre-reading activities for providing prior knowledge of the text were affected by the student's English proficiency, peculiarly more effective on low level student than advanced level. Studying English reading through schema activation led the students to be present in classes with interests, so the experimental group showed more academic accomplishments than the control group.

• Journal of Educational Research in Mathematics
• /
• v.14 no.1
• /
• pp.39-69
• /
• 2004

This paper investigates the teaching and learning of Linear function relating functional contexts and suggests the improved methods of representation-shift through this analysis. The methods emphasize the link between students' preacquired knowledge of mathematical representations and the way of using those. This methods are explanatory teaching, teaching and teaming based on modelling perspectives or tasks (interpretation, prediction, translation and scaling). We categorize the 8th grade middle school students' errors on the linear function relating real contexts and make a comparative study of the error-remedial effects and the teaching and teaming methods. We present the results of a study in which representation-shift methods based on modelling perspectives and tasks are more effective in terms of flexible connection of representations and error remediation. Also, We describe how students used modelling perspective-taking to explain and justify their conceptual models, to assess the quality of their models and to make connection to other mathematical representation during the problem solving focusing on the students' self-diagnosis.

• The Journal of Korean Medical History
• /
• v.16 no.2
• /
• pp.105-140
• /
• 2003

1. "Eonhaegukupbang(諺解救急方)" is a medical book that was published and edited by Naeuiwon(內醫院) under the king's command in the Joseon Dynasty in 1607. 2. It includes the contents but doesn't a preface and an epilogue. And several medical treatments and herb medicines of diseases from emergency are noted in the original text of "Eonhaegukupbang(諺解救急方)". The book is composed of two volume and 181 pages. 3. A number of cultural properties and medical books were lost and all people of the nation were suffered from poverty and diseases during Japanese invasion of Korea in 1592. Then some books of Korean translation of Chinese classics were edited under the king's command with the intention of recompiling the lost books and easy application of medical knowledge for the people. 4. "Eonhaegukupbang(諺解救急方)" admit several books and notes the reference books at the beginning or the end. This book has 37 kinds of reference books, and those are "Boncho(本草)", "Uihakgangmok(醫學綱目)", "Uihakimmun(醫學入門)", "Deukhyobang(得效方)", "Uihakjeongjeon(醫學正傳)", "Dan-gyebang(丹溪方)" and so on in the main. 5. "Gugupbang(救急方)"(in the Sejo Dynasty) is similar to "Eonhaegukupbang(諺解救急方)" in aspect of helping the people with convenient contents. But it is a point of difference that the composition and contents of "Eonhaegukupbang(諺解救急方)" are more centering about the medical prescriptions than those of "Gukupbang(救急方)". 6. "Eonhaegukupbang(諺解救急方)" is very similar to the "Gukupmun救急門" in the "Donguibogam(東醫寶鑑)" in the contents and construction of the list. "Eonhaegukupbang(諺解救急方)" was published during the writing of "Donguibogam(東醫寶鑑)", so it has a deep meaning that "Eonhaegukupbang(諺解救急方)" is a condensed version of easy application for the civilian by regulating already established section. 7. It seems that "Eonhaegukupbang(諺解救急方)" has continuous influences in the part of emergency in the "Donguibogam(東醫寶鑑)"

• Journal of Astronomy and Space Sciences
• /
• v.23 no.1
• /
• pp.71-90
• /
• 2006

This study is about , which constitutes Honcheonui(an armillary sphere) put of $\ulcorner$Uigijipseol$\lrcorner$ (Volume I) together with and -dealt with earlier than this subject. The study's construction on the text of is organized into 15 categories, including installation, observations, instructions for use, astronomical theories and formulas, etc. This study provides easy-to-understand illustrations of the figures shown in the original and contains detailed descriptions of the related calculation procedures. In the 'Instructions for Use of Honcheonui' discussed here, the readers are introduced to astronomical computation systems, mainly based on spherical trigonometry and proportional methods. The section also provides systematic and detailed reviews of astronomical theories and calculation procedures, allowing you to assess the level of astronomy knowledge at that time.