• Title/Summary/Keyword: Know-How

Search Result 1,709, Processing Time 0.027 seconds

Recent Advances in Cellular Senescence, Cancer and Aging

  • Lim, Chang-Su;Judith Campisi
    • Biotechnology and Bioprocess Engineering:BBE
    • /
    • v.6 no.4
    • /
    • pp.231-236
    • /
    • 2001
  • How much do we know about the biology of aging from cell culture studies Most normal somatic cells have a finite potential to divide due to a process termed cellular or replicative senescence. A growing body evidence suggests that senescence evolved to protect higher eu-karyotes, particularly mammals, from developing cancer, We now know that telomere shortening due to the biochemistry of DNA replication, induces replicative senescence in human cells. How-ever in rodent cells, replicative senescence occurs despite very long telomeres. Recent findings suggest that replicative senescence is just the tip of the iceberg of a more general process termed cellular senescence. It appears that cellular senescence is a response to potentially oncogenic in-sults, including oxidative damage. In young orgainsms, growth arrest by cell senescence sup-presses tumor development, but later in life, due to the accumulation of senescent cells which se-cret factors that can disrupt tissues during aging, cellular senescence promotes tumorigenesis. Therefore, antagonistic pleiotropy may explain, if not in whole the apparently paradoxical effects of cellular senescence, though this still remains an open question.

  • PDF

Measures of Effectiveness and Selection Criteria of Technology Development (산업기술도입의 선정기준과 효율측정)

  • Kim, Jae-Ju;Lee, Myeon-Ryang;Jeong, Yeong-Sam
    • Journal of Korean Institute of Industrial Engineers
    • /
    • v.2 no.1
    • /
    • pp.37-44
    • /
    • 1976
  • It is necessary for developing countries to increase their consolidation of domestic technology in order to improve their economy. In order to raise their techniques, they have to try to induce the advanced know-how from other countries in spite of heavy cost. The object of this study is to establish the model on which we base our choice of the proper techniques or plants and give priority to them by using quantified selection criteria. The method in this study has two stages, and the writer has selected 12 factors affecting the decision making for the importation of technology from the industrially advanced countries. First, the lists of valuable know-how for the better development of national industry should be determined, and for the formulation and arrangement of the lists, a council of specialists which uses questionnaires in terms of the Semantic Differential Method, should be organized. Second, for the assignments of priority to the prospective items for importation, the writer has imployed both the Leontief Model and the Disman Model as objective methods and Mottley-Newton method, one of the R&D Project Selection Methods, as a general model. The writer has applied the methods described above to the fields of petrochemical industry in Korea.

  • PDF

A Review on the paradiam of Eyewear Design Concept (안경 design concept의 paradigm에 관한 고찰)

  • Kang, Hyunshik;Jang, Woo-Yeong
    • Journal of Korean Ophthalmic Optics Society
    • /
    • v.9 no.1
    • /
    • pp.189-195
    • /
    • 2004
  • Eyewear must not be judged only by the skill of the designer who created it. For production of successful eyewear, we must always take into account the point of view of the wearer. Because eyewear is above all a means to correct of the visual acuity, it is a medical instrument. Therefore in any case, it should not submit to the dictatorship of fashion designer. The eyewear designer's role may therefore be summarized in following way: to have a subtle sensitivity and inspiration, and originality, know-how to develop a symbiosis between functionality and technical know-how, harmonious production of the design and concept of the human engineering. At present, the way of designing has undergone a big change to enabling us to supply the customer with technical design and rapid prototyping of eyewear with assistance to computer processing such as computer graphic and cad/cam.

  • PDF

A Survey on Job Performance of Dietitians (영양사의 업무수행도 실태조사)

  • 박영희;최봉순
    • Journal of the East Asian Society of Dietary Life
    • /
    • v.5 no.1
    • /
    • pp.29-39
    • /
    • 1995
  • The purpose of this study was to evaluate job performance of dietitians. The survey also examined differences in job performance of dietitians by institutional classicification, types of task, levels of education and job experience. Data was collected form national samples. Results are summarized as follows. 1. By institutional classification, dietitians working in industry showed lowest score(3.0465${\pm}$.4151), which those working in hospital showed highest score(3.2883${\pm}$.4124) in job performance. 2. By types of task, the score of job performance is in order of hygience management(3.3933${\pm}$.4236), business management(3.3183${\pm}$.5435) and education management(2.3132${\pm}$.7551). 3. By educational level, dietitians who graduated universities scored higher than who graduated junior colleges in general. Specifically, the former had high scores in business management(3.4796${\pm}$.4692) and hygiene management, while the latter had high scores in hygiene management(3.3615${\pm}$.440) and business management, as in order. 4. By job experience, job performance increases after-3 year-experience and peaks in over-10 year-experience. 5. For reasons of negligence in specified taskes, 109 of respondents(22.7%) answered "don't know how to perform" and 108 of them(22.5%) answered "lack of human resources." Also, the lower in job experience the more answered "don't know how to perform" as a reason of negligence a their task(34.5% of below-2 year-experience and 24.2% of junior colleges answered to this reason).

  • PDF

Review of Environmental Assessment for Climate Factors in Urban Planning (도시계획에서의 기후요소 평가기법에 관한 고찰)

  • Eum, Jeong-Hee
    • Journal of Environmental Policy
    • /
    • v.11 no.1
    • /
    • pp.27-48
    • /
    • 2012
  • The aim of this paper is to review the environmental assessment of urban climatic factors relating to urban planning in Korea and Germany, and suggest efficient ways to consider climatic factors in the environmental assessment process for urban planning in Korea. For these purposes, current assessment systems concerning urban master plan and urban management plan in Korea were reviewed to know how urban climatic factors are assessed. Furthermore, two German cases of Strategic Environmental Assessment were investigated to know how urban climatic factors are assessed and considered in the urban and regional planning of Germany. Based on the results, efficient ways to consider climatic factors in the environmental assessment for urban planning were suggested from three aspects of factors, methods and available data for climate assessment.

  • PDF

Contribution Analysis Using Shape Simplification Method for Casting Structure Shrinkage (주조 구조물 수축공의 형상단순화 기법을 통한 정적하중에 대한 영향도 분석)

  • Kwak, Si-Young;Lim, Chae-Ho;Baek, Jae-Wook
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.33 no.8
    • /
    • pp.807-812
    • /
    • 2009
  • Most structure engineers give the casting components over-estimated factor of safety without any reasonable foundation due to the worries about the unavoidable defects such as shrinkages and porosity in castings; the engineers have little knowledge on the relation between the defect and structural behavior. And the workers in casting field also do not know how to control the defects by manufacturing; they do not know to where the defects move or until how size they reduce the defects. In this study, shrinkage defect was scanned by industrial computerized tomography instrument (CT), and subsequently was modeled to a spheroid primitive for structural analysis. Using these simplified models of shrinkage, we observed the effects of the defect on the results of the structural analysis. A commercial structural analysis code was used to do the analysis works. Considering the conclusions, it is possible to manage the shrinkages effectively in casting process and to design the products with more reliable

An Investigation on the Possibility to Teach Mathematical Principles of Tessellations in Elementary School Mathematics (초등학교에서 테셀레이션의 수학적 원리 지도 가능성 탐색)

  • Baek, Seon-Su;Kim, Won-Kyung
    • The Mathematical Education
    • /
    • v.46 no.1 s.116
    • /
    • pp.81-96
    • /
    • 2007
  • This study was conducted to investigate the possibility of teaching tessellations' mathematical principles in elementary school mathematics. A survey was carried out and the two hours of the instructional experiment were developed for this study triangular tessellation activity and rectangular tessellation activity. Six fifth graders from W elementary school participated voluntarily in the instructional experiment. It was shown from the survey that teachers and students both know what the tessellation is, but they don't know what the mathematical principles really are in the tessellation. This is because they have just done the covering up-activities in class. It was seen from the instructional experiments that even ordinary students were able to understand the mathematical principles of the tessellation if teachers could throw the suitable focusing questions like 'how to move the rectangles making sides equal' and 'how to gather vertexes making angle $360^{\circ}$'. Furthermore, it is desirable to teach the rectangular tessellation prior to the triangular tessellation since the rectangular tessellation is more easy to deal with than the triangular tessellation.

  • PDF

Developing an Art-based Integration Program for the Korean Schools in the United States

  • Jung, Hyunil
    • International Journal of Advanced Culture Technology
    • /
    • v.6 no.1
    • /
    • pp.1-7
    • /
    • 2018
  • The purpose of this study is to develop an art-based integration program for the Korean schools in the United States to improve students' academic performance and nurture the spirit of the young and can enable students taking art classes to better understand social and cultural phenomena influencing their lives. This study integrates with six other subjects that are language art, math, religion, social studies, and Korean history. Art classes are considered the main vehicle for integrating the entire program using a thematic approach. The methodology of this study is based on the literature research and the information of the place, the Korean School of Columbus, is that the school is one of 124 Korean Schools in the Mid-western states and is located in the northern part of Columbus, Ohio. In this study, I developed an art-based integration program to be connected well with other subjects to help students to make sense of them in the complex societies and to help them to obtain the five goals that are included: First, students will understand about a Korean history and culture through making a kite; Second, they will know that a kite can be used as ways of communication with people and God; Third, they will also know how different types of kites respond to the airflow of the wind; Fourth, they will understand an enjoyable and different way of learning about aspects of Fine art, Bible, Language art, Mathematics, Science, History, and Social studies; Lastly, they will learn how important to cooperate with each other.

A Study of Development and Production Technology for Camcoder Iris Assembly (캠코더용 Iris Assembly의 국산화 및 생산 기술 개발)

  • 고종선
    • The Transactions of the Korean Institute of Power Electronics
    • /
    • v.3 no.1
    • /
    • pp.53-60
    • /
    • 1998
  • In this paper, the principle of operation, the part characteristic, characteristic of component movement, analysis are carried out for camcoder iris assembly which is one of the important element component in Video camera large projection TV instrument. And some Know-how for development of element component is also included. The magnetic field circuit for the small and simple structure with low power consumption is introduced and new materials of yoke for small motor system is suggested. Especially, the relation with remained magnetic field and operation duration time is analyzed by experimental results. Some problems of nonlinear torque characteristics included in this system is considered to obtain the simple and low cost structure in domestic production. Furthermore, development procedure is suggested for iris assembly and some methods to reduce the burr with some check points for small precise accessories are explained.

A Development of the Business processing unit for visually-handicapped persons (시각 장애인을 위한 사무 자동화 보조 장치 개발)

  • Kim, Song-Min
    • The Journal of the Korea institute of electronic communication sciences
    • /
    • v.7 no.1
    • /
    • pp.141-147
    • /
    • 2012
  • Blind persons are information alienation class in spite of development of an Information-Communication technology. Need dog's paw of a business automation technology that apply Information-Communication know-how to do these in white-collar job go to work. I wish to develop VI 05 that can improve computer practical use ability by developing integration solution that can analyze know-how that need in transaction of business and overcome this technologically. Because developed VI 05 reserves and handles work that require screen spread, function that convert data of screen including character into voice, accuracy by integration solution that is necessary in transaction of business the process simplificaton make function that need in Secretariat state process such as knowing function have.