• Transactions of the Korean hydrogen and new energy society
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• v.26 no.6
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• pp.560-566
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• 2015

HCCI (Homogeneous Charge Compression Ignition) hydrogen engine has relatively narrower operation range caused by knock occurrence due to the rapid pressure rising by using higher compression ratio. In this study, EGR as one of the countermeasure methods is considered to extend operation range of HCCI hydrogen engine. Also, the effects of hydrogen EGR are compared with the effects of EGR using hydrocarbon fuel. Hydrocarbon EGR is carried out by adding carbon dioxide to exhaust gas of HCCI hydrogen engine. As the results, EGR has positive effects on a HCCI hydrogen engine in reducing rate of pressure rise as same as the other engines used hydrocarbon fuels. However, the effects of hydrogen EGR are better than those of hydrocarbon EGR in decreasing minimum compression ratio and rate of pressure rise. When applying EGR to HCCI hydrogen engine by 20% rate, the rate of pressure rise decreases by 58% and it results in about 48% increase of the operation range in terms of supply energy.

• Korean Business Review
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• v.22 no.1
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• pp.103-123
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• 2009

The uncertainty of international financial market was increased suddenly, since 2008 September 15th Lehman Brothers bankruptcy. In spite of the money market stabilization management of various nations, the stock market of the world was visible the features which slump and sudden rise are insecure. The reliability about dollarization was depreciated suddenly in depression of American money market, and the dollarization was converted with important currency comparison bearish trend. Relates with this, this thesis analyzed press information about the policies which the authorities confronts since global banking crisis after Lehman situation. And it provided various current points. Despite these meanings, this research has several critical points. So this thesis refers the critical points and presets research direction In future.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.12
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• pp.1905-1910
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• 2001

Pressure resonance frequency that is caused in the combustion chamber can be interpreted by acoustic analysis. Until now the pressure resonance has been assumed and calculated to a disc type combustion chamber that neglected the combustion chamber height because the knock occurs near the TDC(top dead center). In this research FEM(finite element method) has been used to calculate the pressure resonance frequency inside the experimental engine combustion. The error of the resonance frequency obtained by FEM has decreased about 50% compared to the calculation of Draper's equation. Due to the asymmetry in the shape of the combustion chamber that was neglected in Draper's equation we could find out that a new resonance frequency could be generated. To match the experimental results, the speed of sound that satisfies Draper's equation is selected 13% higher than the value for pent-roof type combustion chamber.

• Anxiety and mood
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• v.1 no.1
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• pp.25-30
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• 2005

In the 40 years since the first benzodiazepine was brought into clinical use there has been a substantial growth in understanding the molecular basis of action of these drugs and the role of their receptors in anxiety disorders. Benzodiazepine receptors are present throughout the brain with the highest concentration in cortex, and it potentiate and prolong the synaptic action of the inhibitory neurotransmitter GABA. Central benzodiazepine receptors and $GABA_A$ receptors are part of the same macromolecular complex. Abnormalities of these $GABA_A$-benzodiazepine receptors as a result of drug challenge tests and neuroimaging studies may underlie some anxiety disorders. The role of $GABA_A$-benzodiazepine receptors in the action of benzodiazepine and as a factor in anxiety disorder, in both animal and humans including knock-out and knock in technique, may lead to new anxiolytics that have potentially significant therapeutic gains without unwanted side effects.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.293-294
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• 2005

• International Journal of High-Rise Buildings
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• v.11 no.1
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• pp.41-50
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• 2022

The Spiral, a supertall tower at the Hudson Yards Zoning District of NYC is an new iconic commercial office tower. The spiraling terraces throughout the height of the building creates unique outdoor spaces at each level for its occupants while introduces structural challenges unlike common office towers. Innovative structural solutions and an integrated connection design and steel detailing delivery process proved to be a key factor in the success of the project.

• Research in Plant Disease
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• v.16 no.3
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• pp.312-315
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• 2010

Pectobacterium carotovorum subsp. carotovorum (Pcc) causes soft rot disease in various plants. Although many studies about Pcc have been going on, little is known yet about the defense genes from plants. To identify defense associated genes in response to Pcc, we screened about 20 thousand Arabidopsis T-DNA knock out lines by inoculation with Pcc. We obtained a line (Atspt1) showing more susceptible symptom compared to WT (Col-0) on 1 day after the inoculation of Pcc on leaves of Arabidopsis with toothpicks. In this study, we optimized the system to select resistant and susceptible lines to Pcc from T-DNA inserted pool of Arabidopsis and expect the system and Atspt1 might be used for molecular breeding to produce resistant vegetables against Pcc.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.525-530
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• 2014

Transient receptor potential vanilloid subtype 1 (TRPV1) was originally found in sensory neurons. Recently, it has been reported that TRPV1 is expressed in salivary gland epithelial cells (SGEC). However, the physiological role of TRPV1 in salivary secretion remains to be elucidated. We found that TRPV1 is expressed in mouse and human submandibular glands (SMG) and HSG cells, originated from human submandibular gland ducts at both mRNA and protein levels. However, capsaicin (CAP), TRPV1 agonist, had little effect on intracellular free calcium concentration ($[Ca^{2+}]_i$) in these cells, although carbachol consistently increased $[Ca^{2+}]_i$. Exposure of cells to high temperature (> $43^{\circ}C$) or acidic bath solution (pH5.4) did not increase $[Ca^{2+}]_i$, either. We further examined the role of TRPV1 in salivary secretion using TRPV1 knock-out mice. There was no significant difference in the pilocarpine (PILO)-induced salivary flow rate between wild-type and TRPV1 knock-out mice. Saliva flow rate also showed insignificant change in the mice treated with PILO plus CAP compared with that in mice treated with PILO alone. Taken together, our results suggest that although TRPV1 is expressed in SGEC, it appears not to play any direct roles in saliva secretion via transcellular pathway.

• Journal of Radiation Protection and Research
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• v.11 no.2
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• pp.139-145
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• 1986

An improved mothod of assessing fuel status by analyzsis of the fission product in the reactor coolant system is proposed. The release mechanism of specific fission products is established for determination of the coefficients in the equations which relate the radioactivities with the amount of defected fuel. Knock-out and migration models are employed in the formulation of the release mechanism. The influence of the tramp uranium is quantified. Sample calculations were made for KNU 1 reactor system using the I-131 and I-133 concentrations in the primary coolant. The estimated number of defected fuel pins in the third and sixth cycles appeared to be $9.34{\pm}1.13\;and\;0.294{\pm}0.092$, respectively.

• BMB Reports
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• v.51 no.10
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• pp.520-525
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• 2018

Cardiovascular diseases arising from atherosclerosis are the leading causes of mortality and morbidity worldwide. Lipid-lowering agents have been developed in order to treat hypercholesterolemia, a major risk factor for atherosclerosis. However, the prevalence of cardiovascular diseases is increasing, indicating a need to identify novel therapeutic targets and develop new treatment agents. Adenosine receptors (ARs) are emerging as therapeutic targets in asthma, rheumatoid arthritis, cancer, ischemia, and inflammatory diseases. This study assessed whether LJ-1888, a selective antagonist for $A_3$ AR, can inhibit the development of atherosclerosis in apolipoprotein E knock-out ($ApoE^{-/-}$) mice who are fed a western diet. Plaque formation was significantly lower in $ApoE^{-/-}$ mice administered LJ-1888 than in mice not administered LJ-1888, without any associated liver damage. LJ-1888 treatment of $ApoE^{-/-}$ mice prevented western diet-induced hypercholesterolemia by markedly reducing low-density lipoprotein cholesterol levels and significantly increasing high-density lipoprotein cholesterol concentrations. Reduced hypercholesterolemia in $ApoE^{-/-}$ mice administered LJ-1888 was associated with the enhanced expression of genes involved in bile acid biosynthesis. These findings indicate that LJ-1888, a selective antagonist for $A_3$ AR, may be a novel candidate for the treatment of atherosclerosis and hypercholesterolemia.