• 한국가구학회지
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• 제18권3호
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• pp.234-242
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• 2007

This study purpose is to design the stand-hangers that can be fabricated conveniently and effectly for manufacture and the market situation of Piwoori Furniture. The study scope is from the research to design prototype in a design process. This study explored the development of knock-down hanger which can be easily assembled and be newly oriented to hanger style. The hangers were made into two main parts with lower part composed as legs, drawers, and containers, and with lower part composed as a shelf and hanger-bear As they are emphasized by the function and usefulness, small sized clothing, underwear, and socks can be stored, and a lot of pants and jackets can be hanged by adjusting the height Therefore, it is not difficult for them to be packed, stored, and transported by being easily assembled and disassembled from the adaption of the knock-down system. Furthermore, the hangers made of the natural wood show the quality of texture and appearance.

• Reproductive and Developmental Biology
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• 제32권4호
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• pp.229-235
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• 2008

Silencing of Dicer1 by siRNA did not inhibit development up to the blastocyst stage, but decreased expression of selected transcription factors, including Oct-4, Sox2 and Nanog, suggesting that Dicer1 gene expression is associated with differentiation processes at the blastocyst stage (Cui et al., 2007). In order to get insights into genes which may be linked with microRNA system, we compared gene expression profiles in Gapdh and Dicer1 siRNA-microinjected blastocysts using the Applied Biosystem microarray technology. Our data showed that 397 and 737 out of 16354 genes were up- and down-regulated, respectively, following siRNA microinjection (p<0.05), including 24 up- and 28 down-regulated transcription factors. Identification of genes that are preferentially expressed at particular Dicer1 knock down embryos provides insights into the complex gene regulatory networks that drive differentiation processes in embryos at blastocyst stage.

• Molecules and Cells
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• 제41권5호
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• pp.454-464
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• 2018

Crosstalk between G-protein signaling and glutamatergic transmission within the brain reward circuits is critical for long-term emotional effects (depression and anxiety), cravings, and negative withdrawal symptoms associated with opioid addiction. A previous study showed that Regulator of G-protein signaling 4 (RGS4) may be implicated in opiate action in the nucleus accumbens (NAc). However, the mechanism of the NAc-specific RGS4 actions that induce the behavioral responses to opiates remains largely unknown. The present study used a short hairpin RNA (shRNA)-mediated knock-down of RGS4 in the NAc of the mouse brain to investigate the relationship between the activation of ionotropic glutamate receptors and RGS4 in the NAc during morphine reward. Additionally, the shRNA-mediated RGS4 knock-down was implemented in NAc/striatal primary-cultured neurons to investigate the role that striatal neurons have in the morphine-induced activation of ionotropic glutamate receptors. The results of this study show that the NAc-specific knock-down of RGS4 significantly increased the behaviors associated with morphine and did so by phosphorylation of the GluR1 (Ser831) and NR2A (Tyr1325) glutamate receptors in the NAc. Furthermore, the knock-down of RGS4 enhanced the phosphorylation of the GluR1 and NR2A glutamate receptors in the primary NAc/striatal neurons during spontaneous morphine withdrawal. These findings show a novel molecular mechanism of RGS4 in glutamatergic transmission that underlies the negative symptoms associated with morphine administration.

• 한국가구학회지
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• 제25권4호
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• pp.250-257
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• 2014

In recent years, young customers whose priority are on rationality and practicality of products and set a high value on space usage and storage efficiency have shown larger interest in knocked down furniture, thus its purchase has been on the rise. A baby bed design utilizing knocked down system suggested in this article, allows simple assembly and disassembly, easy transportation, easy movement, and also possible to recycle. Using laminated wood made of Douglas fir, a natural material, a baby bed is designed as knocked down structure. Its prototype is made to suggest easy assembly and disassembly design, which does not require any hardware. If efforts are put on the research of furniture design and its product development, focusing on the applicable usage and strength of knocked down furniture, it can become one of the solutions to the development of currently stagnant domestic furniture industry.

• 통합자연과학논문집
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• 제12권4호
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• pp.142-146
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• 2019

Peroxidasin is a unique member of peroxidase family in that it has extracellular matrix (ECM) motif as well as peroxidase activity. Peroxidasins are involved in consolidation the extracellular matrix during development and in innate immune defense. C. elegans has two functional peroxidasins, PXN-1 and PXN-2, and PXN-2 is known to contribute to innate immune system. However, it is not clear of PXN-1 function in innate immune system. Therefore, this study is focused on the function of PXN-1 and the relationship between PXN-1 and PXN-2 in innate defense system in C. elegans. When pxn-1 was knocked down by RNAi, the worm turned to be more resistant to pathogens, Staphylococcus aureus and Pseudomonas aeruginosa and the enhanced resistance was abolished in pxn-1pxn-2 double knock down. By contrast, pxn-2 knock down showed stronger susceptibility to the pathogens. These results suggest that pxn-2 can contribute the pathogen resistance and pxn-1 can suppress the pathogen resistance. To confirm the idea, overexpression experiments were performed. Overexpression of pxn-1 showed more susceptible to pathogens compared to the control and double overexpression of pxn-1pxn-2 overcame the susceptibility of pxn-1 overexpression to the pathogens. On the other hand, pxn-2 overexpression made the worm more resistant to the pathogens and the resistance was maintained in pxn-1pxn-2 double overexpression. The comparison of the susceptibilities to the bacterial pathogens in above mentioned constructs suggests that PXN-1 suppress the function of PXN-2 in defense against bacterial pathogens in Caenorhabditis elegans.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2000년도 춘계공동학술대회 논문집
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• pp.17-20
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• 2000

가전업의 CKD(Complete Knock Down)업무는 해외의 바이어나 현지공장에 가전제품을 구성하는 부품/반제품들을 개별 포장하여 수출하는 물류업무이다. 이러한 CKD 업무는 가격경쟁이 치열한 부분으로 경쟁력 강화를 위해 물류비의 절감이 요구되고 있다. 특히 CKD 업무의 경쟁력 강화를 위해서는 포장품질과 적재율 향상을 위한 포장/적재의 최적화가 이루어져야 하며, 이를 지원하는 Packing Optimization System 의 구축이 절실히 필요하다. 본 논문에서는 가전업 CKD의 업무특징과 업무환경의 변화에 대해 기술하였으며, 환경변화에 대한 대응방법으로 가전업 CKD 업무를 위한 Packing Optimization System 의 주요 기능과 업무 프로세스를 제시하였다. 그리고, 시뮬레이션 방법을 이용한 Packing Optimization system의 구현 사례를 예시하였다.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2007년도 춘계학술대회 논문집
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• pp.110-113
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• 2007

Modernity which is superficial phenomenon set off the mass scale for mass consumption and provide uniformly artificial environment. But natural destruction, environment pollution, resources exhaustion and so on has been caused by this and now ecology is threatened by destruction and damage beyond the limitation and human beings survival is even threatened. Accordingly furniture development for environment preservation considered environment problem is the urgent real situation. Recent paradigm is the concept of Eco-design which is the green design possible to live together in symbiosis, and new types of alternative furniture are needed in Korea as well. 'Furniture for disassembly' is presented as new method for alternative furniture.

• 한국공간정보시스템학회:학술대회논문집
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• 한국공간정보시스템학회 2004년도 춘계 학술발표회 논문집 제1권1호(통권1호)
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• pp.83-88
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• 2004

First author proposed a proportioning method for member sections of a single layer reticulated dome subjected to uniform and non-uniform load without any geometrical initial imperfection, and discussed the validity and effectiveness of the method which was based on linear buckling stress and a knock down factor. However, buckling of a single layer reticulated dome is strongly affected by initial imperfection. It is well known that geometrical initial imperfections reduce the nonlinear buckling capacity of a single layer raticulated dome. Thus, structural engineers may be recommended to reflect the effects of geometrical initial imperfections in proportioning member sections. In this paper, firstly, the presented proportioning method by first author is applied to dome without consideration of any imperfections and the thickness and diameter of each member are determined. Secondly, the load bearing capacities of the proportioned domes are checked with the imperfection, by the inelastic buckling analysis.

• 한국가구학회지
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• 제19권3호
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• pp.193-202
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• 2008

In order to occupy educational furniture market that grows by the day and to meet demands for alternative product for the current market, this study took business features and productivity of Sinil Furniture Co into consideration, and developed computer desk for education by group, which is new among educational furniture. The scope of the study ranges from data research based on design process into creation of prototype. By improving the condition where, despite that electrically-powered computer desk for anti-theft system is high priced, it sees frequent malfunction, the study suggested low-priced, non- electrically-powered anti-theft system which has more solid structure. Furthermore, in order for the user to be more free and comfortable while studying on it, it differentiates from other products by locating PC main body to the back of the monitor and lowering it below the altitude of monitor to prevent it from interfering with studies. We've made the higher board of the desk in a soft curved-shape in order to lessen the stress from studying. And as space for the monitor's lower mount was decreased, we've put the lower mount below the higher board; so that lacking space can be recovered while functioning as anti-theft system. Moreover, we've covered the PC main body with steel cover so that it would add color and formal luxuriousness to the appearance of the desk. Considering ease of mobility and productivity, knock-down system was introduced.

• 한국공간구조학회:학술대회논문집
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• 한국공간구조학회 2008년도 춘계 학술발표회 논문집
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• pp.43-48
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• 2008

본 논문은 유닛 모듈러를 구성하는 주구조체인 각형강관 기둥과 냉간성형 LEB C-형강 보가 볼트 접합된 접합부를 가진 모듈러 건물의 접합부 구조성능 및 시공성을 평가하는 것이 연구의 목적이다. 모듈러 건축의 장점은 공사기간 단축, 경량성, 이동가능성 등으로 볼 수 있다. 반면에 유닛 또는 모듈의 운송비용이 공사비 절감 비용을 반감시킬 수 있고 많은 공장들이 외부 지역에 있으므로 이들을 도심지나 원하는 지역으로 이동하기 위해서는 비용이 추가된다. 그리고 유닛이나 모듈 설치에 크레인 등의 장비 사용으로 인해 시공비용이 증가될 수 있는 단점들이 존재한다. 본 연구에서는 해체조립이 용이한 볼트접합부 구조성능 및 모듈러 건축물의 시공사례를 통하여 공기, 비용 등 측면에서 기존 연구와 비교분석을 진행하고자 한다.