• Korean Journal of Acupuncture
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• v.25 no.2
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• pp.43-55
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• 2008

Objectives : The acupuncture has been in the classic arsenal of Oriental medicine over inflammatory diseases. Its physiological mechanism is not fully understood but being known better everyday. We reviewed several papers to describe current concepts over anti-inflammatory mechanism of acupuncture. Methods : Some computerized literature searches were done using the key words of 'acupuncture' AND 'Anti-inflammatory' in Medline via Pubmed between March 2007 and December 2007. Only rationally-designed studies were picked among practically associated materials. A well-known hypothesis on acupunctural physiology was adapted for integration. Result : 18 studies were selected. 17 studies were laboratory experiment and 1 was a clinical study. Data was classified into some comprehensive categories. Author's opinion was added at the end of each category. Study results supported the hypotheses on acupunctural physiology; Acupuncture has some influences on autonomic nerve system(ANS). And it stimulates several receptors from target cells like macrophage, and finally inhbits cytokines like TNF-${\alpha}$, IL-1${\beta}$ andIL-10 which are inflammation-mediated. Acupuncture increases the opioid releasing therefore relieves inflammation. And acupuncture inhibits cyclooxgenase(COX) but its mechanism is controversial until now. Conclusion : Current concepts over anti-inflammatory mechanism of acupuncture are as follows. Acupucture suppresses inflammation by stimulation of ANS, increasing of opioid releasing and inhibition of COX. But more studies are needed to fully describe the anti-inflammatory effect of acupuncture.

• Journal of the Korean Society for Library and Information Science
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• v.47 no.2
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• pp.265-291
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• 2013

Because of the increased interest in health, medical care, and wellness, the utilization of health-related information resources, especially those found on the Internet, has been rapidly increasing. In addition, despite encountering an increasing number of health and medical-related reference questions in public libraries, public librarians feel limitations in their ability to perform these types of reference services. Therefore, this study proposed the cooperative network system model for vitalizing CHI Services, meaning that all the related agencies, including public libraries, medical libraries, medical institutions, and the health and medical community collaboratively provide consumer health information service. This study presented in detail the key elements of the cooperation model, the subject of cooperation, target sources for cooperation, the content of cooperation, operations of CHI-providing sites, operations and roles of Cooperation Centers, and directions for cooperating with commercial institutions.

• Journal of Korea Multimedia Society
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• v.8 no.4
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• pp.450-460
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• 2005

Today, multimedia information is used on the internet and various social areas by rapid development of computer and communication technology. Therefor, the usage is growing dramatically. Multimedia information analysis system is basically based on text. So, there are many difficult problems like expressing ambiguity of multimedia information, excessive burden of works in appending notes and a lack of objectivity. In this study, we suggest a method which uses color and shape information of multimedia image partitions efficiently analyze a large amount of multimedia information. Partitions use field growth and union method. To extract color information, we use distinctive information which matches with a representative color from converting process from RGB(Red Green Blue) to HSI(Hue Saturation Intensity). Also, we use IMI(Improved Moment Invariants) which target to only outline pixels of an object and execute computing as shape information.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.337-340
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• 2004

The exactly reproduced prosody of a TTS system is one of the key factors that affect the naturalness of synthesized speech. In general, rules about prosody had been gathered either from linguistic knowledge or by analyzing the prosodic information from natural speech. But these could not be perfect and some of them could be incorrect. So we proposed artificial neural network(ANN)s that can be trained to team the prosody of natural speech and generate it. In learning phase, let ANNs learn the pitch and energy contour of center phoneme by applying a string of phonemes in a sentence to ANNs and comparing the output pattern with target pattern and making adjustment in weighting values to get the least mean square error between them. In test phase, the estimation rates were computed. We saw that ANNs could generate the prosody of a sentence.

• Structural Engineering and Mechanics
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• v.56 no.4
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• pp.569-588
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• 2015

A comprehensive methodology is proposed for design of metallic dampers in seismic retrofit of earthquake-damaged frame structures. It is assumed that the metallic dampers remain elastic and only provide stiffness during frequent earthquake (i.e., earthquake with a 63% probability of exceedance in 50-year service period), while in precautionary earthquake (i.e., earthquake with a 10% probability of exceedance in 50-year service period), the metallic dampers yield before the main frame and dissipate most of the seismic energy to either prevent or minimize structural damages. Therefore by converting multi-story frame to an equivalent single-degree-of-freedom system, the added stiffness provided by metallic dampers is designed to control elastic story drifts within code-based demand under frequent earthquake, and the added damping with the combination of added stiffness influences is obtained to control structural stress within performance-based target under precautionary earthquake. With the equivalent added damping ratio, the expected damping forces provided by metallic dampers can be calculated to carry out the configuration and design of metallic dampers along with supporting braces. Based on a detailed example for retrofit of an earthquake-damaged reinforced concrete frame by using metallic dampers, the proposed design procedure is demonstrated to be simple and practical, which can not only meet current China's design codes but also be used in retrofit design of earthquake-damaged frame with metallic damper for reaching desirable performance objective.

• Reproductive and Developmental Biology
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• v.38 no.2
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• pp.79-84
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• 2014

MicroRNAs (miRNAs) are approximately 22 nucleotides of small noncoding RNAs that control gene expression at the posttranscriptional level through translational inhibition and destabilization of their target mRNAs. The miRNAs are phylogenetically conserved and have been shown to be instrumental in a wide variety of key biological processes including cell cycle regulation, apoptosis, metabolism, imprinting, and differentiation. Recently, a paper has shown that expression of the miRNA-302/367 cluster expressed abundantly in mouse and human embryonic stem cells (ESCs) can directly reprogram mouse and human somatic cells to induced pluripotent stem cells (iPSCs) efficiently in the absence of any of the four factors, Oct4, Sox2, c-Myc, and Klf4. To apply this efficient method to porcine, we analyzed porcine genomic sequence containing predicted porcine miRNA-302/367 cluster through ENSEMBL database, generated a non-replicative episomal vector system including miRNA-302/367 cluster originated from porcine embryonic fibroblasts (PEF), and tried to make porcine iPSCs by transfection of the miRNA-302/367 cluster. Colonies expressing EGFP and forming compact shape were found, but they were not established as iPSC lines. Our data in this study show that pig miRNA-302/367 cluster could not satisfy requirement of PEF reprogramming conditions for pluripotency. To make pig iPSC lines by miRNA, further studies on the role of miRNAs in pluripotency and new trials of transfection with conventional reprogramming factors are needed.

• Current Photovoltaic Research
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• v.2 no.4
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• pp.182-188
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• 2014

For the dissemination of new and renewable energy, Korean government introduced a renewable portfolio standard (RPS) scheme in 2012 after terminating feed-in tariff (FIT) scheme that was introduced in 2004. With the RPS scheme, 64.7% of its own goal (95.7% in PV and 63.3% in non-PV) was achieved in 2012 and 67.2% of that (94.9% in PV, 65% in non-PV) was achieved in 2013. The deployment of PV systems met the goal very well and that of non-PV did not. Recently, Korean government revised the target year of supplying 10% electricity from new and renewable energy from 2022 to 2024 and released a couple of measures on PV area. Recent studies showed that the bankability of a project plays a key role for PV dissemination. Therefore, the dissemination should be assessed from the point of bankability under the RPS scheme and a little adjustment is necessary to achieve the goal. Especially, installing a small size PV (<100 kwp) system needs a minimum REC price or a FIT scheme. In non-PV area, permission process is a common bottleneck and the related regulation should be eased. In addition, to achieve the long term goal, an implementing scenario has to be prepared. Currently, the portion of the waste-gas energy originated from fossil fuel is too large among the new and renewable energy sources and the portion should be lowered or eliminated in the 10% of electricity supply goal. Seoul Metropolitan Government (SMG) has its own FIT scheme for PV dissemination from 2014 SMG and revised the PV tariff from 50 to 100 won/kwh in effective of 2015. It is worth to spread the other provinces.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.8
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• pp.875-881
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• 2014

The redundancy resolution of the seven DOF (Degree of Freedom) upper limb exoskeleton is key to the synchronous motion between a robot and a human user. According to the seven DOF human arm model, positioning and orientating the wrist can be completed by multiple arm configurations that results in the non-unique solution to the inverse kinematics. This paper presents analysis on the kinematic and dynamic aspect of the human arm movement and its effect on the redundancy resolution of the seven DOF human arm model. The redundancy of the arm is expressed mathematically by defining the swivel angle. The final form of swivel angle can be represented as a linear combination of two different swivel angles achieved by optimizing two cost functions based on kinematic and dynamic criteria. The kinematic criterion is to maximize the projection of the longest principal axis of the manipulability ellipsoid of the human arm on the vector connecting the wrist and the virtual target on the head region. The dynamic criterion is to minimize the mechanical work done in the joint space for each of two consecutive points along the task space trajectory. The contribution of each criterion on the redundancy was verified by the post processing of experimental data collected with a motion capture system. Results indicate that the bimodal redundancy resolution approach improved the accuracy of the predicted swivel angle. Statistical testing of the dynamic constraint contribution shows that under moderate speeds and no load, the dynamic component of the human arm is not dominant, and it is enough to resolve the redundancy without dynamic constraint for the realtime application.

• Journal of Plant Biotechnology
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• v.34 no.2
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• pp.145-152
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• 2007

Lactoferrin is an 80-kDa iron-binding glycoprotein known to exert many biological activities, such as facilitating iron absorption and having antimicrobial and anti-inflammatory effects. Rice can be a useful target for edible food plants to introduce human lactoferrin, because it has lower allergenicity and is likely to be safer than microorganisms or transgenic animals. A cDNA fragment encoding human lactoferrin (HLF) driven by the maize polyubiquitin promoter, along with herbicide resistance gene (bar) driven by CaMV 35S promoter, was introduced into rice (Oryza sativa L. cv. Dong Jin) using the Agrobacterium -mediated transformation system. Putative transformants were initially selected on the medium containing bialaphos. The stable integration of the bar and HLF genes into transgenic rice plants was further confirmed through polymerase chain reaction (PCR) and Southern blot analyses. The expression of the full length HLF protein from various tissues such as grains and young leaves of transgenic rice was verified by Western blot analysis. Analysis of progeny also demonstrated that introduced genes were stably inherited to the next generation at the Mendelian fashion.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.915-921
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• 2013

Background: Hepatocellular carcinoma is one of the leading causes of mortalities worldwide. The search for new therapeutic targets is of utmost importance for improved treatment. Altered expression of HDAC1 in hepatocellular carcinoma (HCC) and its requirement for liver formation in zebrafish, suggest that it may regulate key events in liver carcinogenesis and organogenesis. However, molecular mechanisms of HDAC1 action in liver carcinogenesis are largely unknown. The present study was conducted to identify HDAC1 interacting proteins in HepG2 cells using modified SH-double-affinity purification coupled with liquid mass spectrophotemetery. Materials and Methods: HepG2 cells were transfected with a construct containing HDAC1 with a C-terminal strepIII-HA tag as bait. Bait proteins were confirmed to be expressed in HepG2 cells by western blotting and purified by double affinity columns and protein complexes for analysis on a Thermo LTQ Orbitrap XL using a C18 nano flow ESI liquid chromatography system. Results: There were 27 proteins which showed novel interactions with HDAC1 identified only in this study, while 14 were among the established interactors. Various subunits of T complex proteins (TCP1) and prefoldin proteins (PFDN) were identified as interacting partners that showed high affinity with HDAC1 in HepG2 cells. Conclusions: The double affinity purification method adopted in this study was very successful in terms of specificity and reproducibility. The novel HDAC1 complex identified in this study could be better therapeutic target for treatment of hepatocellular carcinoma.