• 한국전자거래학회지
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• 제16권2호
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• pp.39-71
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• 2011

최근 정보기술이 발전함에 따라 전자거래가 증가되고, 시스템의 분산화가 빠르게 진행되면서 상호운용성의 중요성에 대한 공감대가 형성되고 있다. 그러나 적용분야와 이해관계자의 관점에 따라 상호운용성의 정의가 상이하여 특정 시스템에 요구되는 상호운용성의 수준이나 평가 방법에 관한 공감대는 여전히 부족한 실정이다. 예를 들어 국방 분야에서는 동일한 업무를 하는 관계 기관별로도 상이한 정의를 사용하며 상호운용성의 실질적인 시험평가는 정의와는 다소 무관하게 정보교환 능력 수준의 저차원적인 평가만을 수행한다. 본 연구에서는 다양한 상호운용성 정의를 수집하여 그 정의의 구성요소를 추출하고, 이들을 데이터 마이닝의 연관성 규칙 탐사 방법을 이용하여 새로운 상호운용성 정의를 제시한다. 이 정의를 기준으로 한국군에서 사용 중인 정의들과 비교 분석한다. 본 연구에서는 장바구니 분석 기법을 이용하여 민간 및 국방 분야의 상호운용성 정의 구성요소의 연관성을 찾아, 가장 일반적이고 범용적인 정의를 도출하였다. 이 결과는 상호운용성에 대한 정의와 수준 및 평가항목 등에 대한 다양한 이해당사자들의 합의를 도출하는 데에 도움을 줄 것으로 기대한다.

• 대한안전경영과학회지
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• 제15권1호
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• pp.11-19
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• 2013

In modern systems design and development, one of the key issues is considered to be related with how to reflect faithfully the stakeholder requirements including customer requirements therein, thereby successfully implementing the system functions derived from the requirements. On the other hand, the issue of safety management is also becoming greatly important these days, particularly in the operational phase of the systems under development. An approach to safety management can be based on the use of the failure mode effect and analysis (FMEA), which has been a core method adopted in automotive industry to reduce the potential failure. The fact that a successful development of cars needs to consider both the complexity and failure throughout the whole life cycle calls for the necessity of applying the systems engineering (SE) process. To meet such a need, in this paper a method of FMEA is developed based on the SE concept. To do so, a process model is derived first in order to identify the required activities that must be satisfied in automotive design while reducing the possibility of failure. Specifically, the stakeholder requirements were analyzed first to derive a set of functions, which subsequentially leads to the task of identifying necessary HW/SW components. Then the derived functions were allocated to appropriate HW/SW components. During this design process, the traceability between the functions and HW/SW components were generated. The traceability can play a key role when FMEA is performed to predict the potential failure that can be described with the routes from the components through the linked functions. As a case study, the developed process model has been applied in a project carried out in practice. The results turned out to demonstrate the usefulness of the approach.

• Journal of Ginseng Research
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• 제44권4호
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• pp.580-592
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• 2020

Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people's physical vitality and is also a non-organ-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms. Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng. Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cell-mediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2. Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.

• Asian-Australasian Journal of Animal Sciences
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• 제19권5호
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• pp.632-637
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• 2006

Oviduct-specific glycoprotein 1 (OVGP1) is implicated in playing a role in fertilization and early embryo development. In this study, we have obtained the sequence of intron 9 of OVGP1 gene in swine. Comparative sequencing of Meishan (a native Chinese breed) and Large White pig breeds revealed an A/T substitution at position 943. A PCR-EcoRI-RFLP assay was developed to detect this mutation. Polymorphism analysis in Qingping animals showed that pigs with BB genotype had lower number of piglets born alive (NBA) in multiple parities than pigs with AA (p<0.05) and AB genotype (p<0.01). In Large $White{\times}Meishan$ ($LW{\times}M$) $F_2$ offspring, the weight of both ovaries (OW) of the BB genotype was significantly lighter than that of AB (p = 0.05) and AA (p<0.01) genotypes. Analysis of the data also revealed that the mutation locus affected these two traits mostly by additive effects. These studies indicated that the polymorphism was associated with NBA and OW in two distinct populations and further investigations in more purebreds or crossbreds are needed to confirm these results.

• Journal of Microbiology and Biotechnology
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• 제14권1호
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• pp.116-120
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• 2004

The medicinal properties of Ganoderma lucidum have been recognized in China for many centuries. Active pharmaceutical components include triterpenes. To elucidate the molecular regulation of triterpene biosynthesis in this mushroom, a 57-base pair DNA fragment encoding the fourth conserved domain SQ-4 (SMGLFLQKTNIIRDYNEDL) of squalene synthase was synthesized and cloned into the expression vector pET-32a(＋). The recombinant fusion protein induced by IPTG (isopropyl-$\beta$-D-thiogalactopyranoside) was overexpressed in the Escherichia coli. Using the purified recombinant fusion protein of 20.9 kDa, a specific polyclonal antibody was obtained from immunized rabbit. Expression of squalene synthase at different development stages of Ganoderma lucidum was analyzed.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1571-1578
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• 2013

Cancer is a leading cause of death worldwide. Recently, the demand for more effective and safer therapeutic agents for the chemoprevention of human cancer has increased. As a white rot fungus, Inonotus obliquus is valued as an edible and medicinal resource. Chemical investigations have shown that I. obliquus produces a diverse range of secondary metabolites, including phenolic compounds, melanins, and lanostane-type triterpenoids. Among these are active components for antioxidant, antitumoral, and antiviral activities and for improving human immunity against infection of pathogenic microbes. Importantly, their anticancer activities have become a hot recently, but with relatively little knowledge of their modes of action. Some compounds extracted from I. obliquus arrest cancer cells in the G0/G1 phase and then induce cell apoptosis or differentiation, whereas some examples directly participate in the cell apoptosis pathway. In other cases, polysaccharides from I. obliquus can indirectly be involved in anticancer processes mainly via stimulating the immune system. Furthermore, the antioxidative ability of I. obliquus extracts can prevent generation of cancer cells. In this review, we highlight recent findings regarding mechanisms underlying the anticancer influence of I. obliquus, to provide a comprehensive landscape view of the actions of this mushroom in preventing cancer.

• Journal of Power Electronics
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• 제17권5호
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• pp.1308-1316
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• 2017

The distributed maximum power point tracking (DMPPT) concept is widely adopted in photovoltaic systems to avoid mismatch loss. However, the high cost and complexity of DMPPT hinder its further promotion in practice. Based on the concept of DMPPT, this paper presents an integrated submodule level half-bridge stack structure along with an optimal current point tracking (OCPT) control algorithm. In this full power processing integrated solution, the number of power switches and passive components is greatly reduced. On the other hand, only one current sensor and its related AD unit are needed to perform the ideal maximum power generation for all of the PV submodules in any irradiance case. The proposal can totally eliminate different small-scaled mismatch effects in real-word condition and the true maximum power point of each PV submodule can be achieved. As a result, the ideal maximum power output of the whole PV system can be achieved. Compared with current solutions, the proposal further develops the integration level of submodule DMPPT solutions with a lower cost and a smaller size. Moreover, the individual MPPT tracking for all of the submodules are guaranteed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제2권5호
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• pp.265-277
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• 2008

In spite of previous common assumptions about the incompatibility of public key cryptography (PKC) schemes with wireless sensor networks (WSNs), recent works have shown that they can be utilized for such networks in some manner. The major challenge of employing a PKC-based scheme in a wireless sensor network is posed by the resource limitations of the tiny sensors. Considering this sensor feature, in this paper we propose an efficient PKC-based security architecture with relatively lower resource requirements than those of previously proposed PKC schemes for WSN. In addition, our scheme aims to provide robust security in the network. Our security architecture comprises two basic components; a key handshaking scheme based on simple, linear operations and the derivation of a decryption key by a receiver node. Our architecture enables node-to-base-station and node-to-node secure communications. Analysis and simulation results show that our proposed architecture ensures a good level of security for network communications, and can be effectively implemented with the limited computational, memory, and energy budgets of current-generation sensor nodes.

• Wind and Structures
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• 제30권4호
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• pp.405-421
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• 2020

Quayside container cranes are important delivery machineries located in the most frontiers of container terminals, where strong wind attacks happen occasionally. Since the previous researches on quayside container cranes mainly focused on the mean wind load and static response characteristics, the fluctuating wind load and dynamic response characteristics require further investigations. In the present study, the aerodynamic wind loads on quayside container cranes were obtained from wind tunnel tests. The probabilistic and spectral models of the fluctuating aerodynamic loads were established. Then the joint probabilistic distributions of dynamic wind-induced responses were derived theoretically based on a series of Gaussian and independent assumption of resonant components. Finally, the results were validated by time domain analysis using wind tunnel data. It is concluded that the assumptions are acceptable. And the presented approach can estimate peak dynamic sliding force, overturning moments and leg uplifts of quayside container cranes effectively and efficiently.

• Journal of Magnetics
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• 제22권1호
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• pp.49-54
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• 2017

The significant reduction of the image quality caused by the magnetic field of samples is a major problem affecting the application of SEM (scanning electron microscopy) in the analysis of electronic devices. The main reason for this is that the electron trajectory is deflected by the Lorentz force. The usual solution to this problem is degaussing the sample at high temperatures. However, due to the poor heat resistance of some electronic components, it is imperative to find a method that can reduce the impact of magnetic field on the image quality and is straightforward and easy to operate without destroying the sample. In this paper, the influence of different magnetic field directions on the imaging quality was discussed by combining the experiment and software simulation. The principle of the method was studied, and the best observation direction was obtained.