• Title/Summary/Keyword: Kangwon National University

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Flavonoid Glycosides as Acetylcholinesterase Inhibitors from the Whole Plants of Persicaria thunbergii

  • Kim, Se Young;Park, Jun Young;Park, Pil Sung;Bang, Sang Ho;Lee, Kyung Min;Lee, Yu Ra;Jang, Yong Hyun;Kim, Myong Jo;Chun, Wanjoo;Heo, Moon Young;Kwon, Yongsoo
    • Natural Product Sciences
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    • v.20 no.3
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    • pp.191-195
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    • 2014
  • The n-BuOH soluble fraction of the whole plant of Persicaria thungergii showed acetylcholinesterase inhibitory activity. Four flavonoid glycosides and a flavonoid were isolated from this fraction, and identified as quercitrin (1), luteolin-4'-O-${\beta}$-D-glucopyranoside (2), quercetin (3), quercetin-3-O-glucuronide (4), and isorahmnetin-3-O-glucuronid (5), by chromatographed and spectral data, respectively. All isolated compounds were showed acetylcholinesterase inhibitory activity, with $IC_{50}$ values of 243.1, 10.5, 39.1, 8.2 and $23.2{\mu}M$, respectively.

A Case of Massive Empyema Caused by Streptococcus constellatus and Anaerobic Bacteria for Mental Retardation (정신지체환자에서 발생한 Streptococcus constellatus와 혐기성 균에 의한 거대 농흉 1예)

  • Kim, Kyeong-Hyun;Kim, Se-Hyun;Heo, Jeong-Won;Lee, Sang-Hoon;Han, Seon-Sook;Lee, Seoung-Joon;Kim, Woo-Jin
    • Tuberculosis and Respiratory Diseases
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    • v.71 no.6
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    • pp.476-479
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    • 2011
  • The Streptococcus milleri group, which also includes S. anginosus, S. intermedius and S. constellatus, is found in the oropharynx, upper respiratory tract, gastrointestinal tract, and urogenital tract mucosa. Bacteria in the Streptococcus milleri group are associated with bacteremia and abscess formation. Most of the reports of of Streptococcus milleri group (SMG) infection occur in patients with underlying medical conditions. Predisposing factors that have been associated with S. milleri group empyema include mucosal disturbances (sinusitis, periodontal disease, enteric disease), preceding to pneumonia, thoracic surgery, malignancy, neurological disease, alcohol abuse, and also diabetes mellitus. We report on a 42-year-old man with mental retardation. He who suffered from dyspnea and a fever that he had developed for over 14 days. S. constellatus and anaerobic bacterias (Prevotella buccae and Micromonas micros) were cultured. The patient was treated with the drainage of pleural effusion and clindamycin and levofloxacin.

Regioselective Addition Reactions of the Organoindium Reagents onto α,β-Unsaturated Ketones

  • Lee, Phil-Ho;Kim, Hyun;Lee, Koo-Yeon;Seomoon, Dong;Kim, Sun-Dae;Kim, Hee-Chul;Kim, Hyun-Seok;Lee, Mi-Ae;Shim, Eun-Kyong;Lee, Seok-Ju;Kim, Mi-Sook;Han, Mi-Jeong;Noh, Kwang-Hyun;Sridhar, Madabhushi
    • Bulletin of the Korean Chemical Society
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    • v.25 no.11
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    • pp.1687-1691
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    • 2004
  • Regioselectivity on the reactions of ${\alpha},{\beta}$--enones with organoindium such as in situ generated allylindium and allenylindium was systematically studied in the presence of TMSCl as an additive. Treatment of 2-cyclohexen-1-one, carvone, 2-cyclohepten-1-one, and chalcone with allylindium reagent produced 1,4-addition products in good yields, while 2-cyclopenten-1-one, 2-methyl-2-cyclopenten-1-one, 4,4-dimethylcyclohexen-1-one, 3-nonen-2-one, 4-hexen-3-one, and 4-phenyl-3-buten-2-one afforded 1,2-addition products. Indium reagent derived from indium and propargyl bromide in Grignard type gave addition products in good yields, under which the successive addition of ${\alpha},{\beta}$-enone and TMSCl were necessary. Although organoindium reagent derived from propargyl bromide produced propargylated compound in Grignard type except 2-cyclohepten-1-one, indium reagent obtained from 1-bromo-2-butyne having ${\gamma}$-methyl group gave allenylated product inBarbier type.