• Toxicological Research
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• v.28 no.4
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• pp.225-233
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• 2012

The present study was carried out to examine the toxicity and target organs of oral cholera vaccine (OCV) after repeated oral administration in Sprague-Dawley rats for 6 weeks (3 administrations, once every 2 weeks). OCV is an inactivated oral cholera vaccine that contains Vibrio cholerae and confers protection against cholera caused by V. cholera serogroups O1 (Inaba and Ogawa serotypes) and O139 (strain 4260B). The animals were orally administered either OCV placebo (negative control) or OCV at a dose equivalent to 240 times the anticipated human dose. Throughout the administration period, no significant change was detected in clinical signs, body weight, food or water consumption, urinalysis results, hematological and clinical biochemistry test results, organ weights, necropsy, or histopathological examination results. Minor changes were found in hematological and clinical biochemistry tests; however, these changes were within normal ranges. The above results suggest that oral administration of OCV in rats did not induce any toxicologically meaningful changes, and the target organs could not be determined. This study was conducted in accordance with the guidelines established by Good Laboratory Practice (2009-183, KFDA, December 22, 2009) and the OECD Principles of Good Laboratory Practice (1997).

• Toxicological Research
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• v.33 no.2
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• pp.141-147
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• 2017

Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately $2.5{\times}2.0{\times}2.0cm$, protruded from the ventral area of the right mandible. The nodule was not attached to mandibular bone and was not continuous with the normal teeth. Histopathologically, the tumor was characterized by the simultaneous occurrence of an ameloblastomatous component and composite odontoma-like elements within the same tumor. The epithelial portion formed islands or cords resembling the follicle or plexiform pattern typical of ameloblastoma and was surrounded by mesenchymal tissue. Formation of eosinophilic and basophilic hard tissue matrix (dentin and enamel) resembling odontoma was observed in the center of the tumor. Mitotic figures were rare, and areas of cystic degeneration were present. Immunohistochemically, the epithelial component was positive for cytokeratin AE1/AE3 (CK AE1/AE3), and the mesenchymal component and odontoblast-like cells were positive for vimentin, in the same manner as in normal teeth. On the basis of these findings, the tumor was diagnosed as a peripheral ameloblastic odontoma in an extraosseous mandibular region in a SD rat. In the present study, we report the uncommon spontaneous peripheral ameloblastic odontoma in the SD rat. We also discuss here the morphological characteristics, origin, histochemical, and immunohistochemical features for the diagnosis of this tumor.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.8
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• pp.1292-1296
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• 2007

To investigate the gel properties of surimi-like materials (SLM) made from pig heart (PH), psoas major muscle (PM) and semimembranosus muscle (SM) of pigs, the three muscles were diced, chopped and washed with 25 mM sodium phosphate buffer (pH 7.0) to extract myofibrillar protein. SLM from SM had significantly (p<0.05) higher moisture content and lower crude protein content compared with PH and PM samples. The cooked SLM from PH was darker than that from PM and SM. Gel from PH had significantly (p<0.05) lower L* and hue values, and higher b* and chroma values compared to gels from PM and SM. The cooked SLM from PH had poor water-holding capacity (WHC) resulting in higher cooking loss. SDS-PAGE showed that the bands of myosin and tropomyosin/troponin had reduced staining intensity in the PH sample, and some unidentified bands that were not in PM and SM samples were observed in PH samples.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3460-3467
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• 2013

The In this paper, we have made numerical experiments to compare 2D image reconstruction algorithm of earth model by electrical resistance tomograpy (ERT). Gauss-Newton, simultaneous iterative reconstruction technieque (SIRT) and truncated least squares (TLS) approaches for Wenner and Schlumberger electrode arrays are presented for the solution of the ERT image reconstruction. Computer simulations show that the Gauss-Newton and TLS approach in ERT are proper for 2D image reconstruction of an earth model.

• Journal of IKEEE
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• v.22 no.1
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• pp.149-155
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• 2018

In this paper, we used ET(Electrical Tomography) for earth resistivity image reconstruction of vertical multi layer underground model. The earth resistivity is analyzed generally as the parallel multi-layer model, however possibly there happens vertical layer model. Here to find the best electrode array in case of vertical layer underground model, Wenner, Schlumberger, and Dipole-dipole electrode arrays, which are well known electrode arrays used in ET, have been tested. And Gauss-Newton algorithm is used in ET inversion. RMS error analysis shows that Wenner electrode array is best in imaging.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.860-867
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• 2015

This paper presents a control method for energy cost saving in the water reuse pumping system. An optimize horizon switching strategy is proposed to implement an pump control. And Particle Swarm Optimization (PSO) algorithm is used to solve optimal problems in each time step. Energy costs are calculated for electricity on both TOU in the light, heavy, and maximum load time period and peak charges. The control method in water reuse pumping systems is determined to reduce the TOU cost. The simulation results show a energy cost saving for water reuse pumping systems.

• Journal of Microbiology and Biotechnology
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• v.4 no.3
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• pp.195-199
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• 1994

Immunostimulation effects of the cell wall components isolated from Lactobacillus plantarum were investigated by studying the macrophage s tumorcidal activity, splenocyte proliferation, anticomplementary activity and the inhibition of peritoneal tumor cell growth measured with ICR mice inoculated with sarcoma 180. The immunopotentiating cell wall components were a complex of peptidoglycan and exopolysaccharides. The tumorcidal activity of macrophage against Yacl and B16 tumor cells was enhanced when the cell wall components were added into the macrophage s culture medium. They also stimulated splenocytes to proliferate up to the same level as when the concanavalin A was added into the splenocyte's culture medium. The complementary activity was inhibited by 50% when the cell wall components were incubated with the sheep red blood cells treated with hemolysin and guinea pig complement. This result confirmed that the cell wall components had an antitumor effect, because the anticomplementary activity is usually accompanied by an antitumor activity at the same time. This fact was confirmed again by the inhibition of the growth of sarcoma 180 when the cell wall components were injected intraperitoneally into ICR mice inoculated with sarcoma 180. As a result, it is concluded that the cell wall components isolated from Lactobacillus plantarum had multifunctional immunostimulation effects in vitro and in vivo.

• Journal of Sensor Science and Technology
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• v.7 no.5
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• pp.334-341
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• 1998

In this paper, we present a new interpolation scheme for image enhancement using nonlinear operator. In general, interpolation techniques are based on linear operators which are essentially lowpass filters, hence, they tend to blur fine details in the original image. In our approach, the operator itself balances the strength of its sharpening and noise suppressing components according to the properties of the input image data.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7451-7458
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• 2014

In this paper, the system modeling and multi-agent control algorithm in isolated wind hybrid power systems are proposed. The multi-agent control is a new type of the hybrid control method that is made up of wind turbine, diesel generator, battery, and dumpload. Fourteen different modes of operations of the wind hybrid power system are performed by wind speed changes and the SOC of battery. Simulation results show that the efficient operations under various wind variations in isolated wind hybrid power systems can be obtained using proposed algorithms.

• Proceedings of the Korean Information Science Society Conference
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• 2007.06d
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• pp.229-233
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• 2007

VoIP(Voice over Internet Protocol)란 음성 데이터를 IP 데이터그램 방식으로 기존 인터넷망을 통해 전달해 주는 기술을 말한다. 기존 인터넷망을 이용하여 음성 데이터를 전달해 줌으로써 기존의 음성 전화 서비스에서 사용되던 회선비용을 크게 절감할 수 있다는 점은 VoIP의 장점 중 하나이다. 그런데 VoIP를 기존의 인터넷망에 그대로 적용하기에는 VoIP에서 사용되는 프로토콜의 특성으로 인해 어려움이 따르게 된다. 즉, 기존의 인터넷망에서 사용되고 있는 방화벽과 NAT(Network Address Translator)장비는 보안을 위해서는 필수적인 요소들 이지만, VoIP의 통신 입장에서는 음성 데이터의 원활한 통신을 방해하는 요소로 작용을 하게 된다. 이러한 문제는 VoIP 통신에 사용되는 시그널링 프로토콜인 H.323과 SIP 프로토콜의 연결 설정과 데이터 전송에 사용되는 동작 방식이 방화벽과 NAT장비의 기능에 충돌하는 점 때문에 발생하게 된다. 따라서 기존의 인터넷망을 그대로 사용하면서 VoIP의 통신이 원활하게 이루어지도록 하기 위해서는 이러한 문제의 해결이 반드시 이루어져야 한다. 본 논문에서는 기존에 Firewall/NAT Traversal 문제 해결을 위해 연구되던 기법들에 대해 살펴보고, 새로운 구조를 제시한다.