Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지
DOI QR코드

DOI QR Code

Spontaneous Peripheral Ameloblastic Odontoma in a Male Sprague-Dawley Rat

  • Received : 2016.11.22
  • Accepted : 2017.02.21
  • Published : 2017.04.15
Download PDF
⟨ Previous Next ⟩

Abstract

Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately $2.5{\times}2.0{\times}2.0cm$, protruded from the ventral area of the right mandible. The nodule was not attached to mandibular bone and was not continuous with the normal teeth. Histopathologically, the tumor was characterized by the simultaneous occurrence of an ameloblastomatous component and composite odontoma-like elements within the same tumor. The epithelial portion formed islands or cords resembling the follicle or plexiform pattern typical of ameloblastoma and was surrounded by mesenchymal tissue. Formation of eosinophilic and basophilic hard tissue matrix (dentin and enamel) resembling odontoma was observed in the center of the tumor. Mitotic figures were rare, and areas of cystic degeneration were present. Immunohistochemically, the epithelial component was positive for cytokeratin AE1/AE3 (CK AE1/AE3), and the mesenchymal component and odontoblast-like cells were positive for vimentin, in the same manner as in normal teeth. On the basis of these findings, the tumor was diagnosed as a peripheral ameloblastic odontoma in an extraosseous mandibular region in a SD rat. In the present study, we report the uncommon spontaneous peripheral ameloblastic odontoma in the SD rat. We also discuss here the morphological characteristics, origin, histochemical, and immunohistochemical features for the diagnosis of this tumor.

Keywords

References

  1. Kramer, I.R.H., Pindborg, J.J. and Shear, M. (1992) World Health Organization (International histological classification of tumours). Histological typing of odontogenic tumours (2nd edition), Springer-Verlag Heidelberg, New York.
  2. Burrough, E.R., Myers, R.K. and Whitley, E.M. (2010) Spontaneous odontoameloblastoma in a female Sprague Dawley rat. J. Vet. Diagn. Invest., 22, 998-1001. https://doi.org/10.1177/104063871002200628
  3. Mosqueda-Taylor, A., Carlos-Bregni, R., Ramirez-Amador, V., Palma-Guzman, J.M., Esquivel-Bonilla, D. and Hernandez- Rojase, L.A. (2002) Odontoameloblastoma. Clinic-pathologic study of three cases and critical review of the literature. Oral Oncol., 38, 800-805. https://doi.org/10.1016/S1368-8375(02)00046-5
  4. Weber, K. (2007) Induced and spontaneous lesions in teeth of laboratory animals. J. Toxicol. Pathol., 20, 203-213. https://doi.org/10.1293/tox.20.203
  5. Nold, J.B., Powers, B.E., Eden, E.L. and McChesney, A.E. (1984) Ameloblastic odontoma in a dog. J. Am. Vet. Med. Assoc., 185, 996-998.
  6. Quigley, P.J. and Leedale, A.H. (1983) Tumors involving bone in the domestic cat: A review of fifty-eight cases. Vet. Pathol., 20, 670-686. https://doi.org/10.1177/030098588302000603
  7. Chalmers, G.A. and Shacklady, E.T. (1991) Ameloblastic odontoma in a calf. Can. Vet. J., 32, 365-366.
  8. Dubielzig, R.R. and Griffith, J.W. (1982) An odontoameloblastoma in an adult sheep. Vet. Pathol., 19, 318-320. https://doi.org/10.1177/030098588201900310
  9. Step, D.L., Ritchey, J.W., Drost, W.T. and Bahr, R.J. (2003) Ameloblastic odontoma in the mandible of a llama. Can. Vet. J., 44, 824-827.
  10. Davis, J.A., Banks, R.E. and Young, D. (1988) Ameloblsatic odontoma in a cynomolgus monkey (Macaca fascicularis). Lab. Anim. Sci., 38, 312-315.
  11. Yanai, T., Masegi, T., Tomita, A., Kudo, T., Yamazoe, K., Iwasaki, T., Kimura, N., Katou, A., Kotera, S. and Ueda, K. (1995) Odontoameloblastoma in a Japanese Monkey (Macaca fuscata). Vet. Pathol., 32, 57-59. https://doi.org/10.1177/030098589503200108
  12. Fitzgerald, J.E. (1987) Ameloblastic odontoma in the Wistar rat. Toxicol. Pathol., 15, 479-481. https://doi.org/10.1177/019262338701500414
  13. Wang, H., Terashi, S. and Fukunishi, R. (1975) Ameloblastic odontoma in rats induce by N-butylnitrosourea. Gan, 66, 319-321.
  14. Stanley, H.R.J. and Krogh, H.W. (1959) Peripheral ameloblastoma: Report of a case. Oral Surg. Oral Med. Oral Pathol., 12, 760-765. https://doi.org/10.1016/0030-4220(59)90124-0
  15. Wettan, H.L., Patella, P.A. and Freedman, P.D. (2001) Peripheral ameloblastoma: review of the literature and report of recurrence as severe dysplasia. J. Oral Maxillofac. Surg., 59, 811-815. https://doi.org/10.1053/joms.2001.24302
  16. Pekiner, F.N., Ozbayrak, S., Sener, B.C., Olgac, V. and Sinanoglu, A. (2007) Peripheral ameloblastoma: a case report. Dentomaxillofac. Radiol., 36, 183-186. https://doi.org/10.1259/dmfr/26369051
  17. Kishino, M., Murakami, S., Yuki, M., Iida, S., Ogawa, Y., Kogo, M. and Toyosawa, S. (2007) A immunohistochemical study of the peripheral ameloblastoma. Oral. Dis., 13, 575-580. https://doi.org/10.1111/j.1601-0825.2006.01340.x
  18. Kuijpers, M.H., van de Kooij, A.J. and Slootweg, P.J. (1996) Review article. The rat incisor in toxicologic patholody. Toxicol. Pathol., 24, 346-360. https://doi.org/10.1177/019262339602400311
  19. Karim, A.C. and Eddy, E.L. (1984) A light and electron microscopic study of osteodentin formation in the rat incisor after adriamycin administration. Am. J. Anat., 169, 207-219. https://doi.org/10.1002/aja.1001690208
  20. Ueki, H., Sumi, A., Takaishi, H., Ito, H., Oyamada, T. and Yoshikawa, H. (2004) Malignant ameloblastic fibro-odontoma in a dog. Vet. Pathol., 41, 183-185. https://doi.org/10.1354/vp.41-2-183
  21. Stoica, G. and Koestner, A. (1984) Diverse spectrum of tumors in male Sparague-Dawley rats following single high doses of N-ethyl-N-nitrosourea (ENU). Am. J. Pathol., 116, 319-326.
  22. Gardner, D.G. (1992) An orderly approach to the study of odontoenic tumours in animals. J. Comp. Pathol., 107, 427-438. https://doi.org/10.1016/0021-9975(92)90016-N
  23. Isomura, E.T., Okura, M., Ishimoto, S., Yamada, C., Ono, Y., Kishino, M. and Kogo, M. (2009) Case report of extragingival peripheral ameloblastoma in buccal mucosa. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 108, 577-579. https://doi.org/10.1016/j.tripleo.2009.06.023
  24. Rajesh, B.C., Vinayakumar, A.R., Mathai, J., Valsaladevi, S. and Nair, P.P. (1998) Peripheral ameloblastoma involving tongue-A rare case. Indian. J. Otolaryngol. Head Neck Surg., 50, 387-389. https://doi.org/10.1007/BF03000696
  25. Ramnarayan, K., Nayak, R.G. and Kavalam, A.G. (1985) Peripheral ameloblastoma. Int. J. Oral Surg., 14, 300-301. https://doi.org/10.1016/S0300-9785(85)80044-2
  26. Beena, V.T., Choudhary, K., Heera, R., Rajeev, R., Sivakumar, R. and Vidhyadharan, K. (2012) Peripheral ameloblastoma: A case report and review of literature. Case Rep. Dent., 2012, 571509.
  27. Ida-Yonemochi, H., Ishibashi, O., Sakai, H. and Saku, T. (2004) Recruitment of osteoclasts in the mandible of osteopetrotic (op/op) mice. Eur. J. Oral. Sci., 112, 148-155. https://doi.org/10.1111/j.0909-8836.2004.00109.x
  28. Gorlin, R.J. and Meskin, L.H. (1963) Odontogenic tumors in man and animals: pathologic classification and clinical behavior- A review. Ann. N. Y. Acad. Sci., 108, 722-771.
  29. Hertz, J. (1952) Adamantinoma; histo-pathologic and prognostic studies. Acta Chir. Scand., 102, 405-432.

Cited by

  1. Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig vol.30, pp.5, 2018, https://doi.org/10.1177/1040638718794784