• Bulletin of the Korean Chemical Society
• /
• v.33 no.7
• /
• pp.2177-2180
• /
• 2012

New [$^{18}F$]F-fluorination methods using a minimized amount of precursor has been developed by controlling the base concentration. In the first method, pre-conditioning of the anion exchange cartridge with $K_2CO_3$ solution or water was carried out. The trapped [$^{18}F$]fluoride on the cartridge was then eluted by KOMs or KOTf solution. [$^{18}F$]F-Fluorination could be performed without additional base. In the second method, the QMA cartridge was preconditioned with KOMs solutions. Trapped [$^{18}F$]fluoride on the QMA was then eluted with KOMs and additional base, such as KOH, $K_2CO_3$, and $KHCO_3$, was added into the reaction vessel. Method 1 showed a [$^{18}F$]F-incorporation yield of 20.9% for [$^{18}F$]FLT synthesis with 5 mg of precursor. Unlike method 1, a [$^{18}F$]F-incorporation yield of 91.4% was achieved from the same amount of precursor in method 2.

• The Journal of Korean Medical History
• /
• v.25 no.2
• /
• pp.113-120
• /
• 2012

Objective : Academies or societies of Korean Medicine have their journals. Those Journals usually follow guidlines for authors of Journal of KOMS(Korean oriental medical society). However, altough academies or societies of Korean Medicine are branches of KOMS, their guidlines for authors of journal are different form KOMS's. Method : We compared guidlines for authors in academies or societies of Korean Medicine which journals is listed in NRF(National Research Foundation of Korea). Result : They have 78.9% coincidence in guidlines for authors of journal, 68.4% in url adress and 57.9% in both books and chapter. Conclusion : Academies or societies of Korean Medicine might comply with KIOM in guidlines for authors of their journal because they are brabches of KIOM. In addition, these days, scholars try to make journal DB, journal referaence DB, ontology and so on so journals of KIOM and journals of Korean Medicine academies might be agreed especially in guidlines for authors.

• Journal of Korean Medical classics
• /
• v.20 no.4
• /
• pp.1-15
• /
• 2007

Paper Submission and Examination Management System established by Korea Institute of Oriental Medicine(KIOM) provided a momentum for the sub-societies of Korean Oriental Medical Society(KOMS) to standardize the process of publishing a journal of papers. Also, the system helped a researcher to reduce time-consuming and to increase their research efficiency. Korea Institute of Oriental Medicine(KIOM) is planning to optimize this system reflecting the current conditions of KOMS through its steady updates.

• The Journal of Korean Medicine
• /
• v.30 no.1
• /
• pp.1-16
• /
• 2009

Objectives: To study the standard herb prescriptions based on the specific names of the sick and wounded for the application of Eastern Medicine Health Insurance. Methods: We selected 678 herb prescriptions from the eleven Eastern medical books recognized by the Ministry for Health of Korea and then researched the concrete opinions of Korean Oriental Medicine Societies (KOMS) on those herb prescriptions from July 31, 2006 to August 31, 2006. Results and Conclusions: KOMS said that 80 herb prescriptions must be included and 26 herb prescriptions must be excluded. They also said that the proper numbers of the specific names of the sick and wounded for the application of Eastern Herbal Medicine Health Insurance were 20-29 and the proper range of herb prescription change was within 30 percent.

• Journal of Acupuncture Research
• /
• v.23 no.6
• /
• pp.239-254
• /
• 2006

The 3rd Japan-Korea Workshop on Acupuncture and EBM was held at Kanazawa on June $16^{th}$. From Korea team, 4 papers were presented. Dr. Hahn introduced a new approach of data analysis on series of n-of-1 trials using the Bayesian statistics. It offered important information for the future n-of-1 trials. Dr. Park clearly demonstrated the significance of various sham devices proposed and stressed the importance of research questions when we choose the control intervention in RCT. Dr. Lee reported the results of survey in Korean Medical Doctors (KMD) for their point selection and techniques to the distal and local points. Dr. Kim presented the results of face to face survey on the KMD with 28 items for acupuncture treatment on the knee OA. Finally, a draft of protocol was introduced by Dr. Kim. The title was "multi-center, a randomized, single blinded, two arms, parallel-group study to compare the effectiveness and safety of 'individualized acupuncture' and 'standardized minimal acupuncture' in Korean and Japanese patients with knee osteoarthritis (Phase IV)". From Japan team, 7 speakers presented their comments and proposals on the protocol. Dr. Takahashi introduced several issues regarding n-of-1 trials and pointed out the importance of obtaining generalizability from n-of-1 trials. Dr. Shichidou pointed the importance of research design, selection of outcome measures and reduction of biases. Dr. Itoh presented the results of point selection for the knee OA based on the literature survey. Dr. Sumiya introduced several differences between KMD and Japanese acupuncturists based on the questionnaire used in KMD survey. Dr. Furuya demonstrated a result of press tack needle and its sham device on shoulder stiffness. Dr. Yamashita introduced the results of literature survey regarding adverse events occurred by acupuncture on knee OA. Dr.Tsukayama stressed the importance of responsibility of Institutional Review Board (IRB) for the conduction of clinical trials. After several issues were discussed, the need of continued meeting for final protocol development was agreed, then the workshop was closed.

• The Journal of Korean Medicine
• /
• v.32 no.5
• /
• pp.66-77
• /
• 2011

Objectives: This study aimed to make preliminary data through the bibliometric analysis of journals registered by national research foundations of Korea for the improvement of traditional Korean medical (TKM) journals. Methods: We collected 4,396 articles from the OASIS database, which is composed of articles published by TKM societies and institutes. First, we analyzed the 'authors by year', 'average authors per article', 'articles by institute' and 'authors by institute' to get the author-related conditions. Second, we analyzed the 'reference type', 'cited times', 'IF with self citation' and 'IF without self citation' to get the citation condition. Results: First, we found that the journal order of total authors was KAOOMP (2362), KOMS (1189), and KAMS (967), and of average authors per article was KAMS (5.29), KOIMS (5.25), and KOMS (4.75). Second, we learned that the journal order of occupied article ratio by high rank institutes was SCMS (92.4%), MAS (90.03%), and KOPS (87.22%) and of occupied author ratio by high rank institutes was KOPMS (96.55%), MAS (95.19%), and SCMS (93.85%). Third, we analyzed the most highly cited reference type by journals and we found that OMCS was books, SCMS was oriental medical journals and the other 10 journals were not oriental medical journals. Finally, we observed that the journal order of self citation ratio was SCMS (16.79%), KMAS (11.77%), and OOGS (11.67%) and also that the IF order was KAMS (0.675), OOGS (0.546), and KAOH (0.430). Conclusions: Through this study we found that TKM research leans too much toward on oriental medical universities, so we insist that TKM R&D institutes must be expanded. We also found that the self citation ratio was high in TKM journals, so the ratio must be decreased to improve the quality of the TKM journals.

• The Journal of Korean Medicine
• /
• v.33 no.3
• /
• pp.120-132
• /
• 2012

Objectives: This study aimed to analyze the current status of treatments and patients with interstitial cystitis, and then map out a strategy for development of generalized-treatments for interstitial cystitis in Traditional Korean Medicine. Methods: We selected research paper from various databases such as PubMed, Google, KStudy, KoreanTK, OIM, and KOMS. Also, to understand current tendencies of medical cost related with interstitial cystitis, we requested Health Insurance Review and Assessment Service clinical data from 2007 to 2011. Results: It was reported that treatment of interstitial cystitis using Traditional Korean Medicine was effective. However, patients of this usually visit a Western medical center rather than seek Traditional Korean Medicine. To take charge of clinical fields related with interstitial cystitis by Traditional Korean Medicine, we need more research and experiments of interstitial cystitis using Traditional Korean Medicine, and we must make a standardized protocol. Conclusions: Various studies related with interstitial cystitis using Traditional Korean Medicine will have to be undertaken. We expect that Traditional Korean Medicine will play a role in treatment of interstitial cystitis.

• The Journal of Korean Medicine
• /
• v.30 no.5
• /
• pp.127-136
• /
• 2009

Objective: This study aimed to analyze the current status of treatments and patients with diabetic peripheral neuropathy, and then map out of a strategy for development of generalized-treatments for diabetic peripheral neuropathy in Traditional Korean Medicine. Methods: We selected research materials from various databases such as PubMed, Google, KStudy, KoreanTK, OIM, KOMS and books. Also, to understand current tendencies of medical examination and treatment related with diabetic peripheral neuropathy, we requested Health Insurance Review and Assessment Service clinical data from 2003 to 2007. Results: It is reported that the incidence of diabetic peripheral neuropathy is increasing in an aging society. The medical fees of National Health Insurance related with diabetic peripheral neuropathy show a year-on-year increase. There are no particularly effective therapies for diabetic peripheral neuropathy in Western medicine, and in some papers, it was reported that treatment of diabetic peripheral neuropathy using Traditional Korean Medicine was effective. However, patients usually visit on Western medical center rather than seek Traditional Korean Medicine. To take charge of clinical fields related with diabetic peripheral neuropathy by Traditional Korean Medicine, we need more studies and experiments of diabetic peripheral neuropathy using Traditional Korean Medicine and should make a standardized protocol. Conclusion: Various studies related with diabetic peripheral neuropathy using Traditional Korean Medicine will have to be undertaken hereafter. We expect that Traditional Korean Medicine will play a vital role in treating of diabetic peripheral neuropathy.

• The Journal of Korean Medicine
• /
• v.30 no.4
• /
• pp.28-36
• /
• 2009

Objectives: Fatigue is a prevalent symptom encompassing both acute and chronic manifestations. Most fatigue symptoms can be cured by taking a rest or removing underlying causes. However, chronic fatigue is frequently problematic due to its duration and effect on quality of life. There are no particularly effective therapies for chronic fatigue of unknown causes, and patients in Korea usually visit an Oriental clinic. This study aimed to analyze the current status of treatments and patients with chronic fatigue, and then map out of a strategy for development of generalized-treatments for chronic fatigue in Oriental Medicine. Methods: Clinical information related to chronic fatigue was selected from various different databases such as PubMed, KoreaMed, KStudy, DBPIA, OIM, and KOMS. Also, to understand current tendency of medical examination and treatment related with chronic fatigue, we requested Health Insurance Review & Assessment Service for clinical datum from 2003 to 2007. Results: The medical fees of National Health Insurance related with fatigue show an explosive year-on-year increase. On the other hand, it has been decreasing annually in the western medical fields. To take charge of clinical fields related with chronic fatigue by Oriental Medicine, we should make a unified diagnostic system. Then, we should also make standard evaluation tools and develop herbal drugs according to this unified diagnostic system. Conclusions: Fatigue-related symptoms will be a main target of Oriental medicine in the future. We expect that various studies related with chronic fatigue will be undertaken hereafter.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.24 no.4
• /
• pp.105-113
• /
• 2011

Objectives: To examine the current status of clinical research in oriental medicine, and to assess 'risk of bias'(ROB) of randomized clinical trials(RCTs) in oriental medicine in Korea. Methods: Special committee for EBM, KOMS(Korean Oriental Medicine Society) reviewed 17 journals related to oriental medicine in Korea (from the first issue to May 2010), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 2, 2010), and PubMed (1966 to May 2010). Then we selected eligible RCTs in terms of oriental medicine, and assessed 'risk of bias'. Results: We reviewed 12,653 articles from the 17 journals, and 41 articles from CENTRAL and PubMed. After non-clinical articles were excluded, 1,004 articles were left. Among them, the number of eligible studies in terms of oriental medicine was 306. In these eligible studies, 130 were RCTs. Of RCTs, 69 were on acupuncture, 25 on herbal medicine. The proportion of 'unclear' is high in the criteria of 'Allocation concealment', 'Blinding of participants and personnel', 'Blinding of outcome assessment' and 'Other bias'. On the other hand, 'low' has high in the criteria of 'Incomplete outcome data' and 'Selective reporting'. Conclusions: Risk of bias on oriental medicine is unclear in terms of 'allocation concealment' and 'blinding'. For high-quality research in oriental medicine, further research should be needed on randomization and blinding in the RCTs.