• 생물정신의학
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• 제19권3호
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• pp.134-139
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• 2012

Objectives : Proinflammatory process has been implicated as an underlying mechanism of bipolar disorder and schizophrenia. Previous studies have suggested a possible role of lymphotoxin alpha (LTA) gene in the development of schizophrenia and have prompted further investigation in bipolar patients. Association of the LTA +252A/G polymorphism with susceptibility to bipolar I disorder itself as well as with vulnerability among a subset of psychotic bipolar patients were tested. Methods : DNA extraction was done by a standard method and genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 114 Korean patients with bipolar I disorder and 202 healthy controls. SPSS v18.0 was used for statistical analysis. Comparisons of the genotype and allele distributions in LTA +252A/G polymorphism were made using a chi-square test. The genotype and allele associations were also evaluated using odds ratio (OR) and 95% confidence interval (CI). Statistical significance was accepted when p was < 0.05. Results : No significant association was found between the LTA +252A/G polymorphism and bipolar disorder. However, LTA +252G allele was present with significantly higher frequency among bipolar patients with psychotic features compared to those without (${\chi}^2$ = 4.69, p = 0.034, OR = 2.495, 95% CI = 1.069-5.827). Conclusion : The results suggest that the allele LTA +252G of the polymorphism may be associated with the psychotic subset of bipolar disorder but not with bipolar I disorder itself. Adequately powered subsequent studies should be conducted.

• Environmental Engineering Research
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• 제8권5호
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• pp.252-258
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• 2003

• 한국통신학회:학술대회논문집
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• 한국통신학회 2004년도 추계종합학술대회 논문 초록집
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• pp.252-252
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• 2004

• Journal of Radiation Protection and Research
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• 제38권4호
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• pp.172-178
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• 2013

본 연구에서는 미래 파이로 시설에서의 핵물질 계량 연구를 위하여 개발하고 있는 통합비파괴측정장치(Unified Non-Destructive Assay, UNDA)의 중성자 검출 효율을 MCNPX 코드를 이용하여 평가하였다. 검출 효율 평가는 두 개의 다른 설계안의 UNDA에 대하여 수행되었으며, $^{252}Cf$ 중성자 발생 선원 위치에 따른 검출 효율 평가와 감손우라늄의 용기 두께 및 위치에 따른 검출 효율 평가를 수행하였다. $^{252}Cf$ 중성자 선원의 위치에 따른 UNDA의 검출 효율 결과는 6.83%부터 13.35%까지 분포로 나타났으며, $^{252}Cf$ 선원이 장치 내부의 상단에 위치할수록 검출 효율은 증가 후 감소하는 경향을 나타냈고, 선원이 외각에 위치될수록 효율이 증가하는 경향을 보였다. 감손우라늄 용기의 두께 및 위치에 따른 검출 효율 평가에서는 용기 두께가 증가할수록 검출 효율은 낮아지는 경향을 보이며, 용기 위치가 장치 상부에 위치될수록 효율은 감소하고, 외각에 위치할수록 효율은 증가하였다. 검출 효율은 $^{252}Cf$ 선원의 경우보다 약간 높게 나타났다(10.31~13.61%). 또한, 장치 상단에 고밀도 폴리에틸렌 덮개가 있는 설계안이 덮개가 없는 설계안 보다 평균적으로 약 2% 정도 중성자 검출 효율이 높은 것으로 평가되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1949-1952
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• 2012

Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations. Conclusion: Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2007년도 The 1st International Symposium on Advanced Magnetic Materials
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• pp.252.2-252.2
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• 2007

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2007년도 The 1st International Symposium on Advanced Magnetic Materials
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• pp.252.1-252.1
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• 2007

• Animal cells and systems
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• 제11권2호
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• pp.205-213
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• 2007

Nek6 belongs to NIMA1 (never in mitosis, gene A) related kinase, which was originally identified in Aspergillus nidulans as a serine/threonine kinase critical for cell cycle progression. We noticed that the putative SUMOylation site is localized on the $K^{252}$ residue in $^{251}FKsD^{254}$ of Nek6, based on the consensus sequence ${\Phi}KxE$; where ${\Phi}$ represents L, I, V or F and x is any amino acid. We observed that the Nek6 SUMO mutant (K252R) has decreased protein kinase activity, nuclear speckle localization and protein stability, compared with that of the Nek6 wild type. However, the Nek6 SUMO mutant increased the cell survival rate of COS-1 cells as determined by FACS analysis. Therefore, our data suggest that SUMOylation on the $K^{252}$ residue of Nek6 is required for its normal functions, such as proper nuclear localization, kinase activity and protein stability, to control cell cycle.

• Journal of Radiation Protection and Research
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• 제18권2호
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• pp.71-79
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• 1993

중성자 측정장비 교정을 위한 표준중성자장을 제작하기 위하여 순수멕스월분포(kt=1.42MeV)로부터 $^{252}Cf$ 자발핵분열 중성자선원의 밀봉이 교정인자에 미치는 영향을 고찰하였다. SR-Cf-100과 SR-Cf-1273 밀봉모형을 실제 제작조건으로 하여 MCNP 코드를 사용하여 몬테카를로 모의를 수행하여, 비등방성교정인자와 선속밀도-대-선량당량 환산인자를 산정하였고, 다른 연구결과와 비교하였다. 결과로서, $FI({\theta}=90^{\circ})$는 1.061(통계오차 : ${\pm}0.2%$), $H/{\Phi}$는 $333.9(pSv\;cm^2)$ (통계오차 : ${\pm}0.5%$)인 것으로 산정되었다. 이 환산인자$(H/{\Phi})$의 값은 ISO 8529의 권고보다 1.8%가 작은 것인데, 이것은 한국원자력연구소의 비감속 $^{252}Cf$중성자선원의 스펙트럼이 ISO의 것보다 약간 더 연화하다는 물리적 의미를 갖는다.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1996년도 한국생물과학협회 국제학술대회
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• pp.252.1-252
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• 1996

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