• Molecules and Cells
• /
• v.27 no.5
• /
• pp.577-582
• /
• 2009

The development of a high-throughput functional genomic screening provides a novel and expeditious approach in identifying critical genes involved in specific biological processes. Here we describe a cell-based cDNA screening system to identify the transcription activators of BiP, an endoplasmic reticulum (ER) chaperone protein. BiP promoter contains the ER stress element which is commonly present in the genes involved in unfolded protein response (UPR) that regulates protein secretion in cells. Therefore, the positive regulators of BiP may also be utilized to improve the recombinant protein production through modulation of UPR. Four BiP activators, including human UDP-glucose:glycoprotein glucosyltransferase 1 (HUGT1), are identified by the cDNA screening. Overexpression of HUGT1 leads to a significant increase in the production of recombinant erythropoietin, interferon ${\gamma}$, and monoclonal antibody in HEK293 cells. Our results demonstrate that the cDNA screening for BiP activators may be effective to identify the novel BiP regulators and HUGT1 may serve as an ideal target gene for improving the recombinant protein production in mammalian cells.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.16 no.1
• /
• pp.144-151
• /
• 2008

The bi-modal vehicle is composed of two car-bodies and three axles. Each axle of the vehicle has an independent suspension and all wheels are steerable. Since the bi-modal vehicle has longer wheelbase than most urban buses, the All-Wheel-Steering(AWS) system is adapted for to ensure safe driving and proper turning radius on a curved road. This paper proposes an AWS control algorithm for stable driving of bi-modal vehicle. Steering angles and directions of each axle of bi-modal vehicle changed according to the driving environment and steering modes. In the case that front and rear axles should be steered in opposite directions is a negative mode, and the other case that the axles should be steered in the same direction is a positive mode. For example, in the positive mode, front and real axles are steered in the same direction, while in the negative mode, they are steered in the opposite direction. A multibody model of the vehicle is used to verify the performance of the steering algorithm and simulation results of 2WS are compared with those of AWS under the same condition.

• Journal of Broadcast Engineering
• /
• v.16 no.2
• /
• pp.190-206
• /
• 2011

We propose an adaptive combination scheme of intra and inter prediction modes, where uni-directional intra prediction, bi-directional intra prediction, and inter prediction method are adaptively selected in an EMB (extended macro block). For each EMB, after all inter blocks have been encoded and decoded, the reconstructed blocks are used as reference data for bi-directional intra prediction of other blocks. Whereas conventional intra coding scheme does not use the right and below side pixels of the current block as reference data, the proposed method uses those for bi-directional intra prediction mode. In this paper, we propose three advanced techniques; (a) filter design for bi-directional prediction, (b) adaptive coding order scheme which increases the chance to use the bi-directional intra prediction mode, (c) modification of syntax to represent coding order. The information for the coding order is informed to the decoder by using the modified syntax structure without adding any additional flag. The simulation results show that the proposed scheme reduces the BD-Rate by 0.5%, on average, compared to KTA.

• Korean Journal of Materials Research
• /
• v.8 no.12
• /
• pp.1110-1114
• /
• 1998

The crystallization behaviors and electrical conductivities of the glasses heat-treated at various times and temperatures in the CuO-Bi$_2$O$_3$-V$_2$O$_{5}$ glass system were investigated. Among glass samples with various compositions, the highest conductivity obtained in the 31CuO-14Bi$_2$O$_3$-55V$_2$O$_{5}$ (mol%) glass sample. The 31CuO-14Bi$_2$O$_3$-55V$_2$O$_{5}$ (mol%) glass sample crystallized by heat treatment at 358$^{\circ}C$ for 8h had 2.67$\times$10$^{-2}$ $\Omega$$^{-1}$ $cm^{-1}$ /, which was much high value as a solid electrolyte. Compared to the glass sample, the heat- treated glass sample was increased in conductivity by an order of 10$^3$-10$^4$due to the formation and growth of BiVO$_4$ and CuVO$_3$crystals.

• Korean Journal of Materials Research
• /
• v.10 no.6
• /
• pp.430-436
• /
• 2000

In this paper, we have studied the effect of constituent ratio NiO, CuO and doped with B-Bi-Zn on proper-ties(microstructure, density, shrinkage, permeability as a function of frequency, etc.) of hexagonal-ferrite for high fre- quency chip-inductor material about several GHz. The permeability were analyzed by impedance analyzer(100 kHz∼ 40 MHz) and network analyzed(30 MHz∼3 GHz). As a result of the characteristics. the B-Bi-Zn glass ceramic was used to lower the sintering temperature for additive as function of frequency from 100kHz to 1.8 GHz showed con-stant tends. The maximum imaginary value of complex permeability was observed near the resonance frequency of 2 GHz.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.44 no.12
• /
• pp.73-78
• /
• 2007

In this paper, the CPW-fed triple-band internal planar monopole antenna which simultaneously meets the three bands such as Cellular, PCS and Wibro is designed. The size of the radiation elements can be reduced to about $\lambda/4$ by designing the CPW-fed monopole antenna and then we can miniaturize the antenna size by meandering the radiation elements. In addition, we design the planar antenna for the slim-type mobile phone. We can obtain the desired antenna properties by controlling the length of each radiation elements. The measured return loss of the antenna is less than -7 dB at the desired bandwidth. And the measured radiation patterns are similar to that of the monopole antenna. The designed antenna has the gains -5.2 dBi. -2 dBi, -0.4 dBi at each resonant frequencies respectively.

• Current Optics and Photonics
• /
• v.1 no.6
• /
• pp.613-617
• /
• 2017

Due to optimal advances such as chromatic performance, durability, low power consumption, high efficiency, long-lifetime, and excellent environmental friendliness, white LEDs (WLEDs) are widely used in vehicle front lighting, backlighting, decorative lighting, street lighting, and even general lighting. In this paper, the remote packaging WLEDs (RP-WLEDs) with bi-layer red-emitting $Sr_2Si_5N_8:Eu^{2+}$ and yellow-emitting YAG:Ce phosphor was proposed and investigated. The simulation results based on the MATLAB software and the commercial software Light Tools indicated that the color rendering index (CRI) of bi-layer phosphor RP-WLEDs had a significant increase. The CRI had a considerable increase from 72 to 94. In conclusion, the results showed that bi-layer red-emitting $Sr_2Si_5N_8:Eu^{2+}$ and yellow-emitting YAG:Ce phosphor could be a prospective approach for manufacturing RP-WLEDs with enhanced optical properties.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2007.06a
• /
• pp.486-487
• /
• 2007

$Bi_2Sr_2Ca_{n-1}Cu_nO_x$(n=0, 1, 2) thin films have been fabricated by co-deposition at an ultra-low growth rate using ion beam sputtering(IBS) method. The growth rates of the films was set in the region from 0.17 to 0.27 nm/min. MgO(100) was used as a substrate. In order to appreciate stable existing region of Bi 2212 phase with temperature and ozone pressure, the substrate temperature was between 655 and $820^{\circ}C$ and the highly condensed ozone gas pressure in vacuum chamber was varied between $2{\times}10^{-6}{\sim}4{\times}10^{-5}$ Torr. Bi 2212 phase appeared in the temperature range of 750 and $795^{\circ}C$ and single phase of Bi 2201 existed in the lower region than $785^{\circ}C$. Whereas, $PO_3$ dependance on structural formation was scarcely observed regardless of the pressure variation.

• The Journal of Traditional Korean Medicine
• /
• v.15 no.1
• /
• pp.1-48
• /
• 2006

Dang, jonghae had written five books on chinese medicine, ${\ulcorner}$Hyeoljeungron${\lrcorner}$ is his most important work. He wanted to correct the fallacies of the theory of Jang(臟) and Bu(腑) by comparing with chinese and western medicine. He distinguished Bi(脾) from Cheomyuk(甛肉) by comparing the spleen with the pancreas. He recognized Stomach as the warehouse of foods, and explained that Bi took charge of digestion actually. Bi charged the function of Transportation(運化) and Blood-govering(統血) in addition to plain digestion, he wrote. Dang, jonghae regarded the metabolism of the human body as the interaction of Gi(氣), Blood (血), Water(水) and Fire(火). And he explained that Bi adjusted them. He classified Syndrome of Blood(血證) into five sorts of syndrome and presented four kinds of treatment. Especially he took a serious view of the treatment connected with Bi and Stomach. He set up the theory of Bi and Stomach(脾胃論) practically on basis of anatomy, but he didn't assorted the physiology and pathology of each organ clearly. However he proved the importance of Bi and Stomach by treating Syndrome of Blood and provided with the foundation of merging chinese and western medicine.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2013.02a
• /
• pp.260-260
• /
• 2013

Multiferroic materials have attracted much attention due to their fascinating fundamental physical properties and technological applications in magnetic/ferroelectric data-storage systems, quantum electromagnets, spintronics, and sensor devices. Among single-phase multiferroic materials, $BiFeO_3 $ is a typical multiferroic material with a room temperature magnetoelectric coupling in view of high magnetic-and ferroelectric-ordering temperatures (Neel temperature $T_N$~647 K and Curie temperature $T_C$~1,103 K). Rare-earth ion substitution at the Bi sties is very interesting, which induces suppressed volatility of Bi ion and improved ferroelectric properties. At the same time, Fe-site substitution with magnetic ions is also attracting, and the enhanced ferromagnetism was reported. In this study, $Bi_{1-x}Dy_xFe_{0.95}Co_{0.05}O_3$ (x=0, 0.05 and 0.1) bulk ceramic compounds were prepared by solid-state reaction and rapid sintering. High-purity $Bi_2O_3$, $Dy_2O_3$, $Fe_2O_3$ and $Co_3O_4$ powders with the stoichiometric proportions were mixed, and calcined at $500^{\circ}C$ or 24 h to produce $Bi_{1-x}Dy_xFe_{0.95}Co_{0.05}O_3$. The samples were immediately put into an oven, which was heated up to $800^{\circ}C$ nd sintered in air for 30 min. The crystalline structure of samples was investigated at room temperature by using a Rigaku Miniflex powder diffractometer. The field-dependent magnetization measurements were performed with a vibrating-sample magnetometer. The electric polarization was measured at room temperature by using a standard ferroelectric tester (RT66B, Radiant Technologies).