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Investigation of Neuroprotective Effect Using Herb Medicine against Dementia related Brain Damage in Organotypic Hippocampal Slice Culture (뇌해마배양조직을 이용한 치매 뇌손상 모델에 대한 소풍순기원(疏風順氣元)과 황련해독탕(黃連解毒湯) 처방약재의 신경보호효과 연구)

  • Chu, Ching-Nai;Kim, Jong-Woo;Chung, Sun-Yong;Park, Ji-Ho
    • Journal of Oriental Neuropsychiatry
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    • v.21 no.1
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    • pp.43-57
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    • 2010
  • Objectives: This study was designed to assess neuroprotective effects of herb medicine against Alzhheimer's disease related brain damage in organotypic hippocampal slice culture. Methods: We induced dementia related brain damage in organotypic hippocampal slices by $\beta$-amyloid. Those slices were treated with herb medicines - Hwangryeonhaedoktang, Sopungsoongiwon. Using by PI staining, the extents of cell death were assessed. After that, we selected the best effective one among those herb medicines and the major components of that medicine were studied to reveal neuroprotective effects and related proteins by using PI stating. Results: In PI staining, Sopungsoongiwon is the best effective herb medicine between Hwangryeonhaedoktang and Sopungsoongiwon. Notopterygii Rhizoma, Corni Fructus, Areca Catechu, Aurantii Fructus Immaturus, Plantaginis Semen is the best effective one among the components of Sopungsoongiwon. Conclusions: We suggested that purgative effect would be the best effetive medicine on dementia related brain damage between clearing heat and toxic materials.

Anti-oxidative effects of fractionated Pulsatilla koreana $N_{AKAI}$ extracts (백두옹 분획층의 항산화 효과)

  • Cho, Hyun-Jin;Yun, Hyun-Jeong;Yi, Hyo-Seung;Park, Sun-Dong
    • The Korea Journal of Herbology
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    • v.25 no.2
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    • pp.99-106
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    • 2010
  • Objectives : This study was designed to investigate the effects of anti-oxidation of fractionated Pulsatilla koreana $N_{AKAI}$ (PK) extracts. And we examined to determine that a certain fractionated extract has the best anti-oxidative effects between the fractionated PK extracts. Methods : Anti-oxidative effects of fractionated PK extracts was measured by scavenging activities of DPPH, superoxide, nitric oxide (NO) and peroxynitrite radicals. And also scavenging activities of anti-oxidation in lipopolysaccharide (LPS)-treated RAW 264.7 cell was measured. After these examination, we determined a fraction that has best anti-oxidative effects. Results : Fractionated PK extracts inhibited radicals effectively. Also in RAW 264.7 cell, intracellular oxidation has inhibited by PK extracts. In these tests, ethyl acetate (EA) fraction has the best anti-oxidative effects among PK extracts. Conclusions : This results demonstrate that PK extracts exhibit anti-oxidative effects. And EA fraction has the best inhibition effects among the six fractions of PK.

EQUIVALENCE CONSTANTS FOR THE 𝑙p-NORMS AND THE 𝑙q-SYMMETRIC MULTILINEAR OPERATOR NORMS OF VECTORS IN ℂn

  • Kim, Sung Guen
    • Communications of the Korean Mathematical Society
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    • v.35 no.2
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    • pp.565-570
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    • 2020
  • We investigate the best equivalence constants for the 𝑙p-norms and the 𝑙q-symmetric multilinear operator norms of vectors in ℂn which are induced by symmetric n-linear forms. In this paper, we provides estimates which are either best possible or close to best possible.

Variable Selection Based on Mutual Information

  • Huh, Moon-Y.;Choi, Byong-Su
    • Communications for Statistical Applications and Methods
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    • v.16 no.1
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    • pp.143-155
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    • 2009
  • Best subset selection procedure based on mutual information (MI) between a set of explanatory variables and a dependent class variable is suggested. Derivation of multivariate MI is based on normal mixtures. Several types of normal mixtures are proposed. Also a best subset selection algorithm is proposed. Four real data sets are employed to demonstrate the efficiency of the proposals.

Performance evaluation of Multicast in an Integrated Services Packet Network (종합 서비스 패킷망에서의 멀티캐스트의 성능 평가)

  • Lee, Wang-Bong;Kim, Young-Han
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.1
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    • pp.9-19
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    • 1999
  • An increase of the number of the real time applications and the Internet hosts make the Internet architecture changed. Current Internet architecture has some problems to process the real time traffics. To solve these problem, a new Internet architecture is proposed as the Integrated Service model. In the current Internet, as multicast protocols, the QoS multicast and the best-effort multicast have been studied in their separate network environments. But, the Integrated Service Packet Network is a heterogeneous network composed of the QoS delivery domain and the best-effort delivery domain. Thus, those separated multicast protocols have limitations in an ISPN. In this paper, we propose a multicast protocol for the ISPN with the QoS and the best-effort multicasting, and analyze the performance of this protocol. As a result, we find that the packet losses are same for hybrid multicast and best-effort multicast when the bandwidth is sufficient. But, if there exist some background traffics, the hybrid multicast has less packet loss than of the best-effort multicast.

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Receding Horizon Next-Best-View Planner Based Voronoi-Biased 3D Multi-Robot Exploration Algorithm (Receding Horizon Next-Best-View 계획법 기반의 보로노이 편향 3차원 군집 로봇 탐사 알고리즘)

  • Lee, Jaeho;Lee, Chaeju;Jung, Woochang;Song, Soohwan;Jo, Sungho
    • Proceedings of the Korea Information Processing Society Conference
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    • 2016.10a
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    • pp.579-580
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    • 2016
  • 본 연구에서는 군집 로봇 체계에서 next-best-view(NBV)의 결정과 경로 계획(path planning)을 동시에 수행하는 효율적인 3차원 탐사 알고리즘을 제안한다. NBV 결정 및 경로 계획을 동시에 수행하는 단일 로봇 탐사 알고리즘에는 최근에 제안된 RH-NBVP[1]가 있다. 우리는 각 로봇에게 효율적으로 탐사 영역을 분배하는 Voronoi-biased multi-RRTs(VB-MRRTs)를 제시하며, 이를 통해 군집 로봇 체계에 RH-NBVP를 적용한다. 제시한 VB-MRRTs가 공간을 얼마나 점유하는지 분석하였으며, 3차원 시뮬레이션 상의 군집 로봇 체계에서 VB-MRRTs가 적용된 RH-NBVP의 탐사율 향상을 확인하였다.

Future Change Using the CMIP5 MME and Best Models: I. Near and Long Term Future Change of Temperature and Precipitation over East Asia (CMIP5 MME와 Best 모델의 비교를 통해 살펴본 미래전망: I. 동아시아 기온과 강수의 단기 및 장기 미래전망)

  • Moon, Hyejin;Kim, Byeong-Hee;Oh, Hyoeun;Lee, June-Yi;Ha, Kyung-Ja
    • Atmosphere
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    • v.24 no.3
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    • pp.403-417
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    • 2014
  • Future changes in seasonal mean temperature and precipitation over East Asia under anthropogenic global warming are investigated by comparing the historical run for 1979~2005 and the Representative Concentration Pathway (RCP) 4.5 run for 2006~2100 with 20 coupled models which participated in the phase five of Coupled Model Inter-comparison Project (CMIP5). Although an increase in future temperature over the East Asian monsoon region has been commonly accepted, the prediction of future precipitation under global warming still has considerable uncertainties with a large inter-model spread. Thus, we select best five models, based on the evaluation of models' performance in present climate for boreal summer and winter seasons, to reduce uncertainties in future projection. Overall, the CMIP5 models better simulate climatological temperature and precipitation over East Asia than the phase 3 of CMIP and the five best models' multi-model ensemble (B5MME) has better performance than all 20 models' multi-model ensemble (MME). Under anthropogenic global warming, significant increases are expected in both temperature and land-ocean thermal contrast over the entire East Asia region during both seasons for near and long term future. The contrast of future precipitation in winter between land and ocean will decrease over East Asia whereas that in summer particularly over the Korean Peninsula, associated with the Changma, will increase. Taking into account model validation and uncertainty estimation, this study has made an effort on providing a more reliable range of future change for temperature and precipitation particularly over the Korean Peninsula than previous studies.

The study of sawdust cultivation and the characteristics of mycelial growth of Pholiota nameko (맛버섯균의 균배양 특성 및 톱밥재배 기술에 관한 연구)

  • Kim, Hong-Kyu;Kim, Yong-Kyun;Seo, Gwan-Seuk;Oh, Se-Hyeon;Kim, Hong-Gi
    • Journal of Mushroom
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    • v.4 no.2
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    • pp.62-67
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    • 2006
  • Pholiota nameko is one of the four major profitable mushrooms along with oak mushroom, winter mushroom, and oyster mushroom. It contains abundant proteins, carbohydrates, organic acids and vitamins. Its unique taste and flavor as well as its nutritional features make it widely favoured. Mushroom complete medium was the optimal medium for mycelial growth of Pholiota nameko. The optimal temperature and pH for the mycelial growth were $25^{\circ}C$ and 5.0, respectively. The best carbon sources for mycelial growth were glucose and mannose, and the best nitrogen sources were yeast extract, peptone, asparagine, etc. The 8:2 ratio mix of oak sawdust and wheat bran was the best for the bottle cultivation. The best mushroom was yielded after 30 days incubation. The best yield was produced with 850g of medium weight in a PP bag and bottle.

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Best practices for GridFTP service in WAN (WAN 상에서의 GridFTP 최적화 구축)

  • Choi, Youn-Keun;Kim, Sung Jun;Sung, Jin Woo;Lee, Sang Dong
    • Proceedings of the Korea Contents Association Conference
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    • 2007.11a
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    • pp.527-529
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    • 2007
  • We build the striped and parallel gridftp server on WAN and test to find the best parameters for high performance. Also we check the various problems about gridftp service as production level and propose a best configuration for real service environment.

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