• Journal of Korean Medical classics
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• v.28 no.4
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• pp.121-137
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• 2015

Objectives : To investigate the progress, characteristics, and reasons of CV12 moxibustion that King Sukjong of Joseon Dynasty had experienced 31 years since 1684. Methods : This study mainly extracted the records and related records about CV12 moxibustion of King Sukjong and relevant records from Seungjeongwon Ilgi, and analyzed them. Aside from that, medical books wrote at that time and relevant records were additionally investigated. Results : King Sukjong cauterized CV12 or other CV12 related acupoints with moxa 21 years out of his 31 years from 1684 to 1714. The cautery period was usually between late January and mid February. He had 100 pieces of moxa for cautery. On the last day of his moxibustion, he cauterized ST36 with moxa. The moxibustion process consisted of the following steps: suggestion or requirement of moxibustion, decision of date and time, and moxa cautery. In 1684, the reason why King Sukjong cauterized CV12 with moxa was to treat his joint pain and nauseous symptoms. The effect can be found in Donguibogam, many other Korean medical books, and other general books at that time. In 1685, he began to cauterize CV12 with moxa to prevent diseases. Since then, most moxa cautery on CV12 had been performed in the same context. Conclusions : For 21 years, King Sukjong repeatedly cauterized CV12 with moxa. The moxa therapy was conducted to prevent diseases mostly. And King Sukjong had a lot of interest in the therapy. For the reasons, the therapy had repeatedly been performed so long.

• Korean Journal of Acupuncture
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• v.35 no.4
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• pp.210-225
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• 2018

Objective : This research is aimed to compare the three sets of Dongin(K-1, K-2, K-3) to Chosun and Chinese acupuncture bronze men, and through literature review of acupuncture points and meridians to see how acupuncture of Chosun affected the Japan's acupuncture bronze men. Methods : Using 3D scanning, we compared the location of acupoints by the proportional bone measurement method of the three sets of Dongin to those of Chosun and China. We also compared the meridians and acupuncture points of the three sets of Dongin to Doningyosodo. Results : Dongin K-1 and K-2 have all the unique characteristics of ChimGuemDongIn. Their heads were made about 30% larger than the location of points by the proportional bone measurement method and their necks were shortened to get the right proportion. Their gender was not specified. Their hands were sticking forward, and knees were slightly bent, and the arms and legs were carefully crafted to record acupuncture points. Dongin K-1 and K-2 marked the meridians and acupuncture points according to Doningyosodo. In particular, BL39 in Dongin K-1 and K-2 has been marked as in ChimGeumDongIn, which is considered to have come from DongUiBoGam. These characteristics do not exist in Chinese acupuncture bronze men. The location of points by the proportional bone measurement method was marked on the right side of the Dongin K-3, while the eight extra meridians were marked on the left side. Conclusions : In summary, Dongin K-1 and K-2 indicate the Japanese history of acupuncture which may have influenced from Chosun.

• Journal of Korean Medical classics
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• v.37 no.3
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• pp.1-9
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• 2024

Objectives : This study aims to clarify the interpretation of the verse "jinyinhuabohetangxia(金銀花薄荷湯下)" in Zhouxuehai(周學海)'s corrective commentary in the Xiaoeryaozhenzhijue(小兒藥證直訣), by examining traditional pediatric texts in relation to the verse. Methods : For each of the three possible interpretations of the instructive phrase for taking herbal formulas-Lonicera flower with peppermint(金銀花+薄荷), gold and silver with peppermint(金銀+薄荷), and gold coin peppermint(金錢薄荷)-applications of these herbs in the various pediatric books were analyzed to determine the most appropriate interpretation. Results & Conclusions : The formulary composition of Liangjingwan(凉驚丸) and Wusewan(五色丸) seems to sufficiently target the pathology of pediatric convulsion(驚癎) and heart malnutrition(心疳). Furthermore, it seems unnecessary to add Lonicera flower(金銀花) to the gastrointestinal fragility(脾胃虛弱) of the malnourished(疳). Some of the herbal formulas in the pediatrics chapter of the Zhengzhizhunsheng(證治准繩) include Lonicera flower(金銀花) to treat only carbuncles(癰腫, 腫毒), while other books do not include it in their formulas. On the other hand, instructions to take water boiled with gold and silver appear in many texts, including the Xiaoeryaozhenzhijue(小兒藥證直訣), and sometimes include gold leaf(金箔) directly in the formula. Descriptions of gold and silver pots with instructions on how to make herbal formulas were found as well, which supports what Zhouxuehai(周學海) commented on the Xiaoeryaozhenzhijue(小兒藥證直訣). Although gold coin peppermint(金錢薄荷) is currently used as Lianqiancao(連錢草) in China, it was difficult to verify its identity as Jinqianbohe(金錢薄荷), which seems to have been recognized as a type of mint in the past. No reported anticonvulsant studies of Lonicera flower(金銀花), gold and silver(金銀), and Lianqiancao(連錢草) were found. Peppermint(薄荷) was ubiquitous in instructions for taking herbal formulas treating pediatric convulsions. Therefore, the instruction to take water boiled with gold and silver, or to take the herbal medicine in water boiled in a gold and silver pot, rather than using Lonicera flower(金銀花), could be considered as an interpretation closer to the original author's intent.

• Korean Journal of Microbiology
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• v.50 no.1
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• pp.15-21
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• 2014

The promoting effect of Pseudomonas sp. P7014 on the mycelia growth of Pleurotus eryngii was investigated. An ethyl acetate fraction (F5) from the culture supernatant of the bacteria was confirmed to contain the growth promoting compound (GPC). The GPC was identified to be indole acetic acid (IAA) by TLC, HPLC, MS/MS, and NMR analyses. P. eryngii mycelia grew rapidly both on PDA and in PDB after the treatment of GPC. The promoting concentration of GPC was as low as 1.0 nM. Tryptophan, the aminated form of IAA, was confirmed to be the precursor of IAA. These results suggested that bacterial secreted compound was IAA and plays an important role in promoting growth of mushroom mycelia.

• The Korea Journal of Herbology
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• v.20 no.4
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• pp.1-10
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• 2005

Objectives : We investigated the anti-aging effect on skin with the extract of the needles of red pine, Pinus densiflora. Methods : We measured various effects related to skin such as the anti-oxidant effect, the protection against ultraviolet (UV) irradiation, the inhibition of reactive oxygen species (ROS) generation, the induction of heat shock protein 70 (HSP70), the reduction of matrix metalloproteinase-2 (MMP-2) synthesis and senescent cell. Results : The results were as follows : The extract of the needles of red pine (RP) had the potent anti-oxidant effect and the ROS scavenging effect. Also RP preserved the systemic anti-oxidant enzyme system (superoxide dismutase and catalase) from UVB irradiation. RP protected the cell membrane from the damages induced by UVB irradiation. RP induced HSP70, a mediator of resistance to UVB irradiation. RP reduced the synthesis of MMP-2 induced by UVB irradiation. And RP inhibited the amount of senescent-associated (SA) ${\beta}-galactosidase$ staining, as a marker of replicative senescence. Conclusions : The results of our study indicate that the extract of the needles of red pine, Pinus densiflora, has anti-aging effects on skin.

• Applied Microscopy
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• v.31 no.2
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• pp.167-173
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• 2001

This study, the ultrastructure of radial glial cells in the fetuses (the 60th, 90th, 105th 120th of gestation) and neonate brains of korean native goat were investigated by immunohistochemical method and transmisson electron microscopy. 1. In the 60th day of gestation, mitochondria and many glycogen body were observed in the radial glial cells. 2. In the 90th day of gestation, mitochondria, many glycogen body and rough endoplasmic reticulum were observed. 3. In the 95th day of gestation, Golgi's apparatus was found. 4. In the 120th day of gestation, Endfeets of radial glial cell attached vessel wall were observed.

• Journal of Korean Medical classics
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• v.26 no.3
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• pp.75-84
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• 2013

Objective : This study considered the annual cyclical rituals related to medicine in an effort to look into the general medical conditions in the late Joseon Dynasty. Method : This study selected Uibanghappyeon 'Wolhaeng' as its research material in that it reflects the medical conditions at that time as a writing in the late Joseon Dynasty, and it's a record about annual cyclical rituals included in a medical book. The annual cyclical rituals are possible to analyze from various angles, but this study perceives the fundamental elements forming the annual rituals as (1) the time when a ritual was held (2) purpose, (3) method, and analyzed the calendaric rituals by dividing them according to the three elements. Result : There appear 97 sorts of annual rituals period in all according to their contents in Uibanghappyeon 'Wolhaeng.' (1) the case of directly suggesting a specific day like May 5 was found to be the most with 46 cases on the basis of the character of the implemented time, followed by the part (16 cases) with the sexagenary cycle like the Day of the Ox. (2) From the aspect of the purpose, the case of aiming at preventing diseases was found to be the most with 24 cases, and the case of expressing 'having to do like that' without any clear reason, or 'that would be better' was found to be the third-most 19 cases. In a broad sense, should these two be perceived as disease prevention, these statistics accounted for a half of the whole with 43 cases. Meanwhile, the style of rituals whose purpose was disease treatment(22 times) was to make a medicine on a specific day. Among the 22 sorts related to disease treatment, 16 sorts were the custom of making medicine on a designated day. (3) When classified from the aspect of methods, they can be divided into pharmaceutical preparations(23 cases), specific behavior(20cases), taboo(19 cases), taking medicine(15 cases), fasting(11 cases) and external medical treatment(9 cases), etc. This shows a comparatively even distribution rather than the case of dividing the annual rituals into a period or purpose. Conclusion : Medicine is the knowledge for preventing and treating diseases. However, the medical science and medical treatment of a traditional society show not a little difference from what we feel. The research on the annual cyclical rituals related to medicine is expected to be helpful to our perception of such a difference.

• YAKHAK HOEJI
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• v.51 no.1
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• pp.68-74
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• 2007

Scutellaria Radix, the dried roots of Scutellaria baicalensis Georgi (Labiatae), has been used in oriental traditional medicine for treatment of fever urine disorder, diarrhea, inflammation. Present study was carried out for the gastroprotective effect of chrysin, baicalein, baicalin, wogonin from Scutellaria baicalensis. This reports evaluated antioxidant effect, antibacterial activity against Helicobacter pylori and HCI-ethanol-induced gastric lesion in rats and showed the significant effectiveness. It may be regarded that the antigastritic effects and antibacterial activity of baicalin, baicalein from Scutellaria baicalensis are originated from acid-neutralizing capacity, free radical scavenging effects and the antibacterial activity against Helicobacter pylori.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.490-495
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• 2020

Background: Ginsenoside Rk1, a saponin component isolated from heat-processed Panax ginseng Meyer, has been implicated in the regulation of antitumor and anti-inflammatory activities. Although our previous studies have demonstrated that ginsenoside Rg3 significantly attenuated the activation of NMDA receptors (NMDARs) in hippocampal neurons, the effects of ginsenosides Rg5 and Rk1, which are derived from heat-mediated dehydration of ginsenoside Rg3, on neuronal NMDARs have not yet been elucidated. Methods: We examined the regulation of NMDARs by ginsenosides Rg5 and Rk1 in cultured rat hippocampal neurons using fura-2-based calcium imaging and whole-cell patch-clamp recordings. Results: The results from our investigation showed that ginsenosides Rg3 and Rg5 inhibited NMDARs with similar potencies. However, ginsenoside Rk1 inhibited NMDARs most effectively among the five compounds (Rg3, Rg5, Rk1, Rg5/Rk1 mixture, and protopanaxadiol) tested in cultured hippocampal neurons. Its inhibition is independent of the NMDA- and glycine-binding sites, and its action seems to involve in an interaction with the polyamine-binding site of the NMDAR channel complex. Conclusion: Taken together, our results suggest that ginsenoside Rk1 might be a novel component contributable to the development of ginseng-based therapeutic treatments for neurodegenerative diseases.

• The Korea Journal of Herbology
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• v.30 no.3
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• pp.63-68
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• 2015

Objectives : We applied the term weighting method used in the field of data search to quantify relevancy between symptoms and medicinal herbs, and, based on this, we aim to introduce a method of visualizing the characteristics of medicinal herbs. Methods ： We proposed HF-IFF, an adaptation of TF-IDF, which is a term weighting measurement method adapted in the field of data search. Using this method, we deduced relevancy between symptoms and medicinal herbs In Cheongkangeuigam that was published in 1984 by organizing the medical theory of Cheongkang, Kim Younghoon, and visualized this as a graph in order to compare the characteristics of medicinal herbs used for different symptoms. Results ： HF-IFF is the product of HF and IFF, where HF is the frequency of the relevant medicinal herb for a set of symptoms, and IFF is the inverse of the number of formulations (FF) containing that herb. A total of 251 types of medicinal herb are used in Cheongkangeuigam, and 1538 formulations are classified according to 67 types of symptom. The overall mean for HF-IFF was 0.491, with a maximum of 4.566 and a minimum of 0.013. Conclusions ： In spite of several limitations, we were able to use HF-IFF to measure relevancy between symptoms and medicinal herbs, with formulations as an intermediate. We were able to use the quantified results to visually express the characteristics of the herbs used for symptoms by bubble chart and word-cloud from HF-IFF.