• Journal of Oriental Neuropsychiatry
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• v.21 no.1
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• pp.59-69
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• 2010

Objectives: The study aims to look into how the application of EA(Electro-acupuncture) in the initial step of ischemic brain injury affects the changes in Bax and Caspase-3 expression among forebrain apoptosis. Methods: It caused GI by using common carotid artery occlusion and conducted the test by dividing into the no applied EA group after 6 hours and 12 hours, the LI 4 EA group that applied EA to LI4, and GV 20 EA group that was applied to GV 20. After that, the following results were obtained by comparing Bax and Caspase-3 expression, which were apoptosis-related factors, with its application time through immunohistochemical staining after extracting brain of each group. Results: According to each group's Bax expression by the application time, the order of expression increase after 6 hours is shown to be the no applied EA group, LI 4 group, and GV 20 group. The stimulation after 12 hours was most lowly expressed in the GV 20 group, and the no applied EA group and LI 4 group showed similar level. Conclusions: EA stimulation in the initial step after ischemia seems to affect positively Bax and Caspase-3 expression that are index of forebrain apoptosis.

• Journal of the Korean Applied Science and Technology
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• v.39 no.3
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• pp.442-453
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• 2022

Various animal models have been used to study the efficacy and action mechanisms of human diseases and medicines. Zebrafish (Danio rerio) is increasingly and successfully used as a model in translational research on human diseases. We obtained necessary information from original peer reviewed articles published in scientific 54 journals, such as Pubmed, Google Scholar, Scopus scince their inception until Dec, 2020 using the following terms: zebrafish animal models, herbal medicine, in vivo screening. In this review, we discuss the recent contributions of the various zebrafish disease models to study of herbal medicines. We focused on cancer, eye diseases, vascular diseases, diabetes and its complications, and cosmetic dermatology. We also highlight the molecular action mechanisms of medicines against these disease, demonstrated using zebrafish embryo. Zebrafish can be pivotal in bridging the gap from lab to clinical bedside. It is used as a model to understand human diseases pathogenies with further scope for drug development. Furthermore, zebrafish can reduce rat and mouse animals in biomedical research.

• The Journal of Korean Medical History
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• v.22 no.2
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• pp.99-109
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• 2009

Jejung Sinpyeon (New Edition of Medical Prescriptions) is a medical book that was compiled in order to overcome the shortcomings of Donguibogam (Exemplar of Korean Medicine), to improve and offer prescriptions suitable for new diseases according to the changing times, and simply to publish new medical books. As a result of an analysis of Yakseongga of Jejung Sinpyeon (a book of medicine written by Kang Myeong-gil in 1799, the 23rd year of the reign of King Jeongjo of the Joseon Dynasty), it was found that a total of 303 lines had been quoted from Wan-bing-hui-chun of the Ming Dynasty of China] and Dongeui Susebowon and that 83 lines had been newly inserted by the author. Of the 303 lines, 296 were quoted from Dongeui Susebowon, and only seven from Wan-bing-hui-chun. This means that the author of Jejung Sinpyeon chiefly used Dongeui Susebowon as the source of Yakseongga quoted therein. 275 lines, or 76%, of a total of 386 lines of Yakseongga of Jejung Sinpyeon, have their Korean names marked. Medicinal herbs marked as Chinese herbs number 83 out of 386. Among the 83 herbs named, one belongs to the part newly inserted by the author, while the remaining 82 are quoted from Yakseongga. The foregoing suggests that the author expected that the knowledge could be used by people easily based on an effort to make it localized knowledge, although Yakseongga was compiled based on quotations from Chinese literature. Yakseongga of Jejung Sinpyeon has significant value as the country's first State-compiled book of medicine to contain Yakseongga.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.4
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• pp.1-11
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• 2021

Objectives: Nephrotic syndrome is a kidney disorder, which is characterized by proteinuria, edema (swelling), and hyperlipidemia. Maydis Stigma (Corn silk) has been widely used in Asia as a traditional medicine and is known to have a diuretic effect and is used for the treatment of edema and indigestion. Methods: The aim of this study is to investigate the improvement effect of Maydis Stigma in treating nephrotic syndrome induced by puromycin aminonucleoside. Sprague-Dawley rats were intravenously injected with 75 mg/kg/day puromycin aminonucleoside, then treated with either Losartan or 200 mg/kg/day Maydis Stigma for seven days. Results: Maydis Stigma significantly decreased ascites and proteinuria level. Plasma levels of blood urea nitrogen (BUN) and plasma creatinine reduced significantly by Maydis Stigma. In addition, treatment with Maydis Stigma attenuated histological damage. Treatment with Maydis Stigma also restored podocin expression and reduced inflammation markers such as intracellular adhesion molecules (ICAM-1), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor alpha (TNF-α) and high-mobility group box-1 (HMGB1). Conclusions: Maydis Stigma ameliorates kidney injury in nephrotic syndrome rat models. Maydis Stigma exerts a renoprotective effect owing to its anti-inflammatory effects and reductions of ascites and proteinuria. Thus, these results indicate that Maydis Stigma is likely to be a promising agent in the treatment of nephrotic syndrome.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.7-12
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• 2011

Objectives : The purpose of this study is to evaluate the quality of four different kinds of agarwood and analysis chemical constituents by GC-MS. Methods : Four source plants were two of Vietnamese agarwood, Indonesian agarwood and Myanmar agarwood. These plant materials were named sample No. 1-4. The chemical constituents of each agarwood were analysed by GC-MS. Results : GC-MS analysis showed that ${\beta}$-selinene was found in all the samples. The Vietnamese agarwood, Sample 1, and 4 has contained 6.861% and 7.497% of ${\beta}$-selinene and reached the highest level at the retention times 46.245 and 46.274 (min). Sample 2, the Myanmar agarwood has contained 1.608%, the lowest level of ${\beta}$-selinene, and it also has contained about 20% of ${\alpha}-,{\beta}-,{\gamma}$-eudesmol and 4.076% of valerianol. Sample 3, the Indonesian agarwood has contained 9.59% of ${\beta}$-selinene, 9.493% of ${\beta}$-selinene and shown its highest level (more than 19%) at the retention time 43.998 (min). Conclusion : It suggested that ${\beta}$-selinene could be a standard marker to evaluate agarwood by GC-MS analysis.

• Journal of the Korean Society of Food Culture
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• v.31 no.6
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• pp.541-553
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• 2016

Medicinal porridge (藥粥) is made by putting rice or grains into a pot and boiling with water until a semi-liquid texture is obtained. Porridge is digested fast and absorbed by the body. Children or elderly people with weak digestive ability can eat it without difficulty. The authors of this literature focused on utilization of mung bean porridge (Nokdu-juk) based on SeungjeongwonIlgi (承政院日記), which is the daily record of the Royal Secretariat of the Joseon Dynasty from 1623 to 1910. Four cases were found. The first case used mungbean for treating fever diseases (熱症), the second as a meal alternative, the third for wound recovery, and the last case described the culture of the joseon dynasty. According to the actual cases in SeungjeongwonIlgi (承政院日記), mung bean porridge (Nokdu-juk) was actively used to lower fever and strengthen the spleen and stomach. When suffering from the after effects of a malignant tumor or serious liver disease (肝病), an infectious disease, or a serious physical wound, people ate mung bean porridge (Nokdu-juk). It is suggested that mung bean porridge (Nokdu-juk) can be used as an alternative food treatment for the current medical field due to the prevalence of pain-killers and psychotropic drug abuse.

• Journal of Information Management
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• v.40 no.4
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• pp.93-108
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• 2009

In order to achieve the growth of traditional Chinese medicine, the chinese government has annually released "China Statistical Yearbook of Chinese Medicine" to the world since "State Administration of Traditional Chinese Medicine of the People's Republic of China" established in 1988. It is believed that the chinese government intends to secure the early dominance of the global medical market by systematic management of its own medicine infrastructures. Although the statistics of "China Statistical Yearbook of Chinese Medicine" weren't systematically organized at the beginning, it has becoming richer, more systematic, and more standardized in the data construction and system as time has passed. Furthermore, we can take a look at China's effort to take the initiative of oriental medicine by expanding investment in several core areas - medicine resources, operation of medical instruments, service, medicine education, medicine science research, and working expenses. This article will show how china has been trying to develop the chinese medicine, focusing on two parts. One is specific analysis of the book "China Statistical Yearbook of Chinese Medicine". It is divided into analysis of its construction system, the degree of data construction, and its statistical system. The other is analysis of annual changes in areas of medicine resources, operation of medical instruments, service, medicine education, medicine science research, and working expenses.

• The Korea Journal of Herbology
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• v.23 no.2
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• pp.1-8
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• 2008

Objectives : The purpose of this study was to evaluate on the antimicrobial effect on the periodontal pathogens and anti-inflammatory effect of Artemisiae Iwayomogii Herba. Artemisiae Iwayomogii Herba has been used for treating as Artemisiae Capilaris Herba in Korea. Methods : Artemisiae Iwayomogii Herba was prepared by extracting medicinal herb with water. We investigated antimicrobial activity by the minimun inhibitory concentration (MIC) test. We also investigated inhibition of IL-$1{\beta}$-induced collagenase-l(MMP-l), stromelysin-1(MMP-3), interleukin-6 gene expression in human gingival fibroblasts. Results : The antimicrobial effect of Artemisiae Iwayomogii Herba was evaluated with MIC against periodontopathogens; Porphyromonas gingivalis 2561, W50, A7A1-28, 9-14K-1, Prevotella intermedia28, and Actinobacillus actinomycetemcomitans Y4, MICs of Artemisiae Iwayomogii Herba were 0.156 mg/ml, 0.625 mg/ml, 0.313 mg/ml, 1.25 mg/ml, 10 mg/ml and 10 mg/ml. The anti-inflammatory effect of Artemisiae Iwayomogii Herba was evaluated with Influence of herbs on the IL-$1{\beta}$-induced expression of MMP-1, MMP-3, interleukin-6, IL-$1{\beta}$ increased MMP-1, MMP-3, interleukin-6 mRNA levels. Artemisiae Iwayomogii Herba significantly inhibited IL-$1{\beta}$-induced MMP-1, MMP-3, interleukin-6 gene expressions in a dose-dependent manner. Conclusions : These results suggested that Artemisiae Iwayomogii Herba might reduce the excessive proteolytic capacity of the gingival fibroblast during inflammation and could be developed a new drug in periodontitis.

• The Journal of Korean Medical History
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• v.28 no.2
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• pp.97-103
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• 2015

The medical information of Lee-Kyukyeong has been considered as one of the cases delivering western medical knowledge, attracting public attention. The medical theories delivered from western countries were very unfamiliar and unique however he knew that e dissection information of East Asia was more detailed compared to the dissection theories of East Asia left in East Asia. And, he made a valuation of the East Asian traditional medical information related to human body in the book. However, the information that he left was mixed with medical books, many written statements and encyclopedias in fashion etc. and many information written by him delivers very unique legends with the confirmation of the information about the human body. Therefore, there are many cases that these information are hard to be discussed at the same level and there are wrong information in therms of 'Fact' and introductions in terms of opposite contetns in the same article. This is originated from the advantages and limits that "OhjuYeonmunJangjeonSango" has, whose author tried to collect the knowledge as much as possible in the same frame under the identical topic. This is the example that shows the climate of the some intellectuals who made an example by accepting all kinds of information and making information of their own. This intelligent climate clearly shows the discordance between medical information suggested by Ohju and the medical reality that Ohju faced. In other words, there were latest information in "Ohju-Yeonmun-Jangjeon-Sango", but had to be sensitive in supply of medicines for Ohju who used to live in the backwoods. Therefore, the medical benefits that he could choose were single - medicine prescription that is closer to conventional medicine and experiential prescription and Yangsaengsoo which medical costs do not occur. These facts imply that the stories about the latest opinion that was in fashion to look at the medical reality in late Chosun Dynasty and detailed research on the daily life that one person faced should be accompanied.

• Journal of Environmental Science International
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• v.17 no.8
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• pp.871-878
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• 2008

In this study, we measured volatile organic compounds in Gimhae city, South Korea. We selected twenty site and measured volatile organic compounds in ambient air by passive sampler when at sampling intervals of two month from April to December 2005. Passive sampler was exposed for fifteen day in ambient air. And samples were analyzed by GC/FID for volatile organic compounds. The results of each measured functional zone, mean concentration of each compound measured were generally higher the industrial complex area and traffic pollution area than residental area. Each area showed similar pattern for the observation period. concentration of measured each compound were the following order: winter > fall > spring > summer.