The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Renoprotective Effect of Maydis Stigma on Puromycin Aminonucleoside-induced Nephrotic Syndrome

Puromycin Aminonucleoside에 의해 유도된 신증후군에 대한 옥미수(玉米鬚)의 보호효과

  • Yoon, Jung-Joo (Dept. of Phygiology, College of Korean Medicin) ;
  • Kho, Min-Chol (Hanbang Cardio-Renal Syndrome Research Center) ;
  • Han, Byung-Hyuk (Dept. of Phygiology, College of Korean Medicin) ;
  • Kim, Hye-Yoom (Dept. of Phygiology, College of Korean Medicin) ;
  • Ahn, You-Mee (Clinical Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Yun-Jung (Dept. of Phygiology, College of Korean Medicin) ;
  • Lee, Ho-Sub (Dept. of Phygiology, College of Korean Medicin) ;
  • Kang, Dae-Gill (Dept. of Phygiology, College of Korean Medicin)
  • 윤정주 (원광대학교 한의과대학 생리학교실) ;
  • 고민철 (원광대학교 한방심신증후군연구센터) ;
  • 한병혁 (원광대학교 한의과대학 생리학교실) ;
  • 김혜윰 (원광대학교 한의과대학 생리학교실) ;
  • 안유미 (한국한의학연구원 한의과학연구부) ;
  • 이윤정 (원광대학교 한의과대학 생리학교실) ;
  • 이호섭 (원광대학교 한의과대학 생리학교실) ;
  • 강대길 (원광대학교 한의과대학 생리학교실)
  • Received : 2021.09.03
  • Accepted : 2021.11.26
  • Published : 2021.11.26
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Abstract

Objectives: Nephrotic syndrome is a kidney disorder, which is characterized by proteinuria, edema (swelling), and hyperlipidemia. Maydis Stigma (Corn silk) has been widely used in Asia as a traditional medicine and is known to have a diuretic effect and is used for the treatment of edema and indigestion. Methods: The aim of this study is to investigate the improvement effect of Maydis Stigma in treating nephrotic syndrome induced by puromycin aminonucleoside. Sprague-Dawley rats were intravenously injected with 75 mg/kg/day puromycin aminonucleoside, then treated with either Losartan or 200 mg/kg/day Maydis Stigma for seven days. Results: Maydis Stigma significantly decreased ascites and proteinuria level. Plasma levels of blood urea nitrogen (BUN) and plasma creatinine reduced significantly by Maydis Stigma. In addition, treatment with Maydis Stigma attenuated histological damage. Treatment with Maydis Stigma also restored podocin expression and reduced inflammation markers such as intracellular adhesion molecules (ICAM-1), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor alpha (TNF-α) and high-mobility group box-1 (HMGB1). Conclusions: Maydis Stigma ameliorates kidney injury in nephrotic syndrome rat models. Maydis Stigma exerts a renoprotective effect owing to its anti-inflammatory effects and reductions of ascites and proteinuria. Thus, these results indicate that Maydis Stigma is likely to be a promising agent in the treatment of nephrotic syndrome.

Keywords

Acknowledgement

본 논문의 연구는 원광대학교(2020)의 지원을 받아 수행되었으며 이에 감사드립니다.

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