• Journal of Life Science
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• v.29 no.11
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• pp.1179-1191
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• 2019

Cancer cells undergo the epithelial-mesenchymal transition (EMT) and show unique oncogenic metabolic phenotypes such as the glycolytic switch (Warburg effect) which are important for tumor development and progression. The EMT is a critical process for tumor invasion and metastasis. High-mobility group box 1 (HMGB1) is a chromatin-associated nuclear protein, but it acts as a damage-associated molecular pattern molecule when released from dying cells and immune cells. HMGB1 induces the EMT, as well as invasion and metastasis, thereby contributing to tumor progression. Here, we show that HMGB1 induced the EMT by activating Snail. In addition, the HMGB1/Snail cascade was found induce a glycolytic switch. HMGB1 also suppressed mitochondrial respiration and cytochrome c oxidase (COX) activity by a Snail-dependent reduction in the expression of the COX subunits COXVIIa and COXVIIc. HMGB1 also upregulated the expression of several key glycolytic enzymes, including hexokinase 2 (HK2), phosphofructokinase-2/fructose-2,6-bisphosphatase 2 (PFKFB2), and phosphoglycerate mutase 1 (PGAM1), in a Snail-dependent manner. However, HMGB1 was found to regulate some other glycolytic enzymes including lactate dehydrogenases A and B (LDHA and LDHB), glucose transporter 1 (GLUT1), and monocarboxylate transporters 1 and 4 (MCT1 and 4) in a Snail-independent manner. Transfection with short hairpin RNAs against HK2, PFKFB2, and PGAM1 prevented the HMGB1-induced EMT, indicating that glycolysis is associated with HMGB1-induced EMT. These findings demonstrate that HMGB1 signaling induces the EMT, glycolytic switch, and mitochondrial repression via Snail activation.

• Journal of Nutrition and Health
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• v.53 no.6
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• pp.613-628
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• 2020

Purpose: The purpose of the study was to identify the health anxiety issues of middle-aged women, their health-promoting behavior, and quality of life as well as to examine the relationship between these variables. Methods: The participants were 334 women in Jeonbuk area. Demographic characteristics, the status of health anxiety, health-promoting behavior, and life quality was assessed using a self-administered questionnaire. The data were analyzed using a t-test, analysis of variance, Duncan test, and hierarchical regression analysis with SPSS ver. 24.0. Results: The score for health anxiety was 37.64 points out of a possible score of 60, and the score for health-promoting behavior was 79.18 points out of a possible score of 115. The score for the quality of life was 101.18 points out of a possible score of 150. The health anxiety scores showed significant differences, varying as per body mass index (BMI) (p < 0.05), income (p < 0.05), occupation (p < 0.05), disease (p < 0.05), satisfaction with weight (p < 0.05), and interest in weight control (p < 0.05). The health-promoting behavior showed significant differences according to age (p < 0.01), BMI (p < 0.01), income (p < 0.05), menses (p < 0.05), intake of dietary supplements (p < 0.05), perception of body image (p < 0.05), and satisfaction with weight (p < 0.05). The quality of life showed significant differences according to BMI (p < 0.05), income (p < 0.01), education level (p < 0.05), occupation (p < 0.05), disease (p < 0.05), and satisfaction with weight (p < 0.05). Regression analysis showed that health-promoting behavior was the most influential variable on the quality of life, followed by disease and health anxiety. Conclusion: Based on these results, we conclude that it is necessary to consider educational programs on improving the quality of life of middle-aged women according to the health anxiety levels and health-promoting behavior.

• Economic and Environmental Geology
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• v.54 no.1
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• pp.21-33
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• 2021

The purpose of this study is to determine the order of priority for the use of amendments, matching the optimal amendment to the specific site in Korea. This decision-making process must prioritize the stabilization and economic efficiency of amendment for heavy metals and metalloid based on domestic site contamination scenarios. For this study, total 5 domestic heavy metal contaminated sites were selected based on different pollution scenarios and 13 amendments, which were previously studied as the soil stabilizer. Batch extraction experiments were performed to quantify the stabilization efficiency for 8 heavy metals (including As and Hg) for 5 soil samples, representing 5 different pollution scenarios. For each amendment, the analyses using XRD and XRF to identify their properties, the toxicity characteristics leaching procedure (TCLP) test, and the synthetic precipitation leaching procedure (SPLP) test were also conducted to evaluate the leaching safety in applied site. From results of batch experiments, the amendments showing > 20% extraction lowering efficiency for each heavy metal (metalloid) was selected and the top 5 ranked amendments were determined at different amount of amendment and on different extraction time conditions. For each amendment, the total number of times ranked in the top 5 was counted, prioritizing the feasible amendment for specific domestic contaminated sites in Korea. Mine drainage treatment sludge, iron oxide, calcium oxide, calcium hydroxide, calcite, iron sulfide, biochar showed high extraction decreasing efficiency for heavy metals in descending order. When the economic efficiency for these amendments was analyzed, mine drainage treatment sludge, limestone, steel making slag, calcium oxide, calcium hydroxide were determined as the priority amendment for the Korean field application in descending order.

• Journal of Science Education
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• v.44 no.3
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• pp.273-288
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• 2020

This study aims to investigate the presentation of the Nature of Science (NOS) in integrated science textbooks of the 2015 revised curriculum. The five integrated science textbooks published by the revised 2015 curriculum were analyzed with the conceptual framework of the four themes of the Nature of Science (NOS) (Lee, 2013) based on scientific literacy. The four themes of the NOS are 1. nature of scientific knowledge (theme I), 2. nature of scientific inquiry (theme II), 3. nature of scientific thinking (theme III), and 4. nature of interactions among science, technology, and society. The reliability of the textbooks analysis was measured between two coders by the Cohen's kappa and resulted in between 0,83 and 0,96, which means the results of analysis was consistent and reliable. The findings were as follows. First, overall theme II, nature of scientific inquiry emphasized on the integrated science textbooks of the 2015 revised curriculum by devoting the contents over 40 % in the all five publishing companies' textbooks. Second, while the theme II, nature of scientific inquiry was emphasized on the textbooks regardless of the publishing companies, other themes of the NOS were emphasized in different portions by the publishing companies. Thus, the focus among other three themes of the NOS was presented differently by the publishing companies except that in theme II, nature of scientific inquiry was most emphasized on integrated science textbooks. Third, the presentation of the NOS was identified similarly across the topics of integrated science textbooks except on topic 4. Environment and Energy. The theme IV, nature of interactions among science, technology, and society was emphasized reasonably only in the topic of Environment and Energy of the textbooks. Finally, the presentation of the NOS in the integrated science textbooks of the 2015 revised curriculum were more balanced among the four themes of the NOS with focus on the scientific inquiry compared to the previous curriculum textbooks.

• Journal of Environmental Impact Assessment
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• v.29 no.6
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• pp.414-429
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• 2020

For the management of rivers, the target water quality is set by establishing the total amount of water pollution and water environment basic plan. For Geumho river T-P has achieved the target water quality, but for BOD, COD, TOC the target water quality of the water environment basic plan has been exceed for the past five years. Therefore, the flow rate for satisfying the target water quality was simulated by analyzing the load, load density, and pollution contribution rate of the Geumho river using BOD, COD, TOC and by utilizing QUAL-MEV a one-dimensional water quality model. According to the analysis of the load, the BOD, COD and TOC all showed the highest levels at the Geumho C point at 9,832.2 kg/day 20,656.6 kg/day, and 15,545.1 kg/day. The load density was highest at 9.47 kg/day/㎢, 37.55 kg/day/㎢, 30.20 kg/day/㎢, and 17.19 kg/day/㎢, 39.14 kg/day/㎢ in Dalseocheon stream during the wet seasons and dry seasons. Pollution contribution rate was highest at about 25 percent for Palgeocheon stream during the wet season and about 50 percent for Dalseocheon stream during the dry season. In addition, the correlation analysis between organic materials showed in the main stream and tributaty of the Geumho river that COD-TOC was 0.8 or higherthan BOD-COD and BOD-TOC in both the wet seasons and dry seasons. And after surveying the total amount of water pollution and the target quality of the water environment basic plan at Geumho C, it was analyzed that an additional flow tate of 14 times and 22 times was needed as of April 2019 (3.46 ㎥/sec).

• Journal of Korean Society of Forest Science
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• v.100 no.3
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• pp.352-358
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• 2011

Field Cage plots ($1m{\times}1m{\times}1m$) were established (7 units) to find the lowest limit time about the tending of red pine forest (Pinus densiflora) which can no longer be used as a habitat by Monochamus alternatus, vector insect of pine wilt disease at the experimental forest of the southern forest research center of the Korea forest research institute in February in 2010. Thinning slashes (length, 1 m; diameter, 5~10 cm) tended at the different times were put in cages, and 4~6 couples of adult M. alternatus were put into each the cage in June. Presence or absence the larval entrance holes and larval were determined in November in 2010. Incase of the combination 24, 18, 12 and 6-month-old thinning slashes from thinning times to the time of adult emergence inside a single cage, larval entrance holes were found in the 6-month-old and 12-month-old thinning slashes but larvae were found only in the 6-month-old thinning slashes (treatment 1). In case of the combination 24, 18, 15 and 12-month-old thinning slashes inside a single cage, larval entrance holes were found in the 15-month-old and 12-month-old thinning slashes but larvae were found only in the 12-month-old (treatment 2). When 24, 18, 15, 12 and 6-month-old thinning slashes with treated dry and humid condition were put separately inside each cage, larval entrance holes were found in the 18, 15, 12, 6-month-old thinning slashes without the relation of the dry and humid conditions. But larvae were found in the 15, 12, 6-month-old thinning slashes in the dry conditions and only in the 6-month-old thinning slashes in the humid conditions. Results indicated the lowest limit time which can no longer be used as a habitat by M. alternatus is before 24 month from the time of adult emergence.

• The Journal of Korean Philosophical History
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• no.52
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• pp.131-155
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• 2017

While the lecture activities in Simwonsa, Ganjae Jeon Wu(1841~1922) has established a "law of lecture activities" which was an ritual between a teacher and pupil, between the couple. Through this way he expected to recover the former ritual, even within their own school. In 1884 he built a "law of Sidong school", meaning to build a large object, elementary scholarship will serve as the rules of conduct, and argued that human nature mainly served to the core in the course of study. Ganjae in Mungyeong area was also discussing studies with Song Byeong-hwa(1852~1916) and received correspondence with scholars in areas related to Mungyeong. They were Kim Jae-kyung(1841~1926) and Park Se-hwa (1834~1910). Ganjae had also some big national events on the sojourn time in Mungyeong. In 1882 there were army incident, in 1884 there were a command of the government that people must pull on western clothes. Ganjae did not follow the command of the government. Someone asked "Can we not follow the command of the government?" Ganjae replied "We have a right to resist to the illegal command of the government. There were also 1884's Gapsin-coup, Ganjae saw that we must defend the country by rejecting foreign power and keeping our rituals. Given the above, the timing that Ganjae lectured in Mungyeong personally was a time that provided a clue to establish his core ideas. Nationally it was a time that must defend the country from foreign nations. Ganjae had faith that for keeping the country we must keep firmly our own rituals.

• 한국사회정책
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• v.24 no.1
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• pp.33-66
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• 2017

Based on the premise that the systematic career process of workers in the general labor market was one of core elements of successful achievements and their establishment both at the individual and organizational level, this study set out to conduct empirical analysis of factors influencing the subjective career success of disabled workers in competitive employment at the multi-dimensional levels of individuals and organizations(corporations) and thus provide practical implications for the career management directionality of their successful vocational life with data based on practical and statistical accuracy. For those purposes, the investigator administered a structured questionnaire to 126 disabled workers at 48 companies in Seoul, Gyeonggi, Chungcheong, and Gangwon and collected data about the individual and organizational characteristics. Then the influential factors were analyzed with the multilevel analysis technique by taking into consideration the organizational effects. The analysis results show that organizational characteristics explained 32.1% of total variance of subjective career success, which confirms practical implications for the importance of organizational variables and the legitimacy of applying the multilevel model. The significant influential factors include the degree of disability, desire for growth, self-initiating career attitude and value-oriented career attitude at the individual level and the provision of disability-related convenience, career support, personnel support, and interpersonal support at the organizational level. The latter turned out to have significant moderating effects on the influences of subjective career success on the characteristic variables at the individual level. Those findings call for plans to increase subjective career success through the activation of individual factors based on organizational effects. The study thus proposed and discussed integrated individual-corporate practice strategies including setting up a convenience support system by reflecting the disability characteristics, applying a worker support program, establishing a frontier career development support system, and providing assistance for a human network.

• The Journal of Korean Philosophical History
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• no.42
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• pp.71-103
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• 2014

Park Se-dang (朴世堂, 1629-1703) is a figure rebuked as a "disturbing enemy of the Confucian canon" (斯文亂賊), having composed the Namhwagyeong Joohaesanbo (南華經註解刪補), the sole commentary on every chapter of the Zhuangzi (莊子) in Joseon Dynasty. This article purports to articulate the significance of Park Se-dang's composition of the Namhwagyeong Joohaesanbo within Joseon Dynasty in the 17th century, through the comparison between him and Zhu Xi (朱熹, 1130-1200), the founder of Neo-Confucianism, the mainstream ideology of Joseon Dynasty, in their recognition of the Zhuangzi. Since Neo-Confucianism attained an absolute status as the canonical doctrine in Joseon Dynasty, the other thoughts, including the thoughts of the Laozi and the Zhuangzi, could not be discussed without their relationship with it. Park Se-dang's recognition of the Zhuangzi does not deviate far from Zhu Xi's recognition of it. While his composition of the Namhwagyeong Joohaesanbo might be said to have inherited and deepened Zhu Xi's recognition, it can also be seen as an attempt to escape from Neo-Confucianism in some aspects. Due to this complication, when the faction of the Noron (老論, a faction separated from the Seoin in the Joseon Dynasty, the hard-liners) rebuked him as a "disturbing enemy of the Confucian canon," they did not mention neither his Shinjoo Dodeokgyeong (新註道德經, New Commentary on the Laozi) nor his Namhwagyeong Joohaesanbo. In his Namhwagyeong Joohaesanbo, Park Se-dang does not think that the Zhuangzi is in diametrical opposition to Confucian thoughts. Firstly, he emphasizes that Zhuangzi faces the actual world with ultimately positive concern, though from a critical perspective. Secondly, he seeks common grounds between the thoughts of Zhuangzi and Confucians, proving that Zhuangzi emphasizes human relationships between father and son or between king and subject. Thirdly, he illuminates Zhuangzi's theory of human nature from a new perspective in order to reestablish Confucian theory of human nature. Fourthly, he attempts to apply Zhuangzi's thoughts in order to overcome contemporary consumptive political feuds, including the splits of political factions or the disputes about ritual proprieties (禮訟論爭). Park Se-dang's composition of Shinjoo Dodeokgyeong and Namhwagyeong Joohaesanbo was a complementary measure for Confucianism, his proper mainstay being Confucianism. He attempted to escape, not from Confucianism itself, but from the absolutism of Neo-Confucianism. In the 17th century Joseon Dynasty, when Neo-Confucianism was becoming dogmatized and absolutized as a canonical doctrine and a dominant ideology, Park Se-dang's composition of Namhwagyeong Joohaesanbo was a very innovative attempt, which shows that he established himself as a pioneer to escape Neo-Confucianism, having consolidated his own unique and progressive academic province, differentiating himself from traditional Confucian scholars in his objective.

• (The)Study of the Eastern Classic
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• no.72
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• pp.157-183
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• 2018

The purpose of this study was to investigate the existence aspects of the Hyangri class in Imsilhyeon, Jeolla Province in the latter half of Joseon based on Woonsuyeonbangseonsaengan, which provides lists of Hyangris in Imsilhyeon from the fourth year(1724) of King Gyeongjong's reign to the early 20th century. It contained the names of total 704 Hyangris, who included 119 Kims, 103 Eoms, 103 Jins, 87 Parks, 86 Muns, 66 Lees, 31 Baeks, 27 Hwangs, and 17 Taes. In addition, there were 12 more family names that produced fewer than ten Hyangris. Based on the share of representative family names among the Hyangris of the area, it is estimated that the dominant family names were Kim, Eom, Jin, Park, Mun, and Lee. Another interesting aspect is that the Jeon and Yang families produced no Hyangris in the 19th century, whereas the Hwang family produced 5% of Hyangris in the century with the Jin family accounting for 10% or more. These findings show that little changes were consistent within the community of Hyangris despite the fact that a couple of families were dominant. The family clans of the family names were checked in Nosogyean, which records that they were the Kim family of Gyeongju, Eom family of Yeongwol, Jin family of Namwon, Park family of Hamyang, Mun family of Nampyeong, and Lee family of Gyeongju. The study then examined the family names of 76 Hojangs that were recorded to hold the Hojang title in Woonsuyeonbangseonsaengan to see whether the family names that produced higher-level Hyangris were the same as the ones above. There was an overall agreement between the family names that produced a lot of Hojangs and those that produced the most Hyangris, but there were differences according to the periods. Six family names produced Hojangs in similar percentage in the 18th century, and only three family names, which were the Jin family of Namwon(13), Mun family of Nampyeong(9), and Eom family of Yeongwol(6), produced more than ten Hojangs in the 19th century. Other noteworthy changes in the 19th century include the rapidly rising frequency of Hojangs serving the term twice or more compared with the 18th century and the concentration of Hojangs on certain family names. These findings indicate that six family names coexisted in the active production of Hyangris in the community of Hyangris in Imsilhyeon in the latter half of Joseon, that there were changes to the family names of higher-level Hyangris internally according to the periods, and that a shift happened toward the leadership of certain family names in the society of Hyangris.