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An Object-Based Verification Method for Microscale Weather Analysis Module: Application to a Wind Speed Forecasting Model for the Korean Peninsula (미기상해석모듈 출력물의 정확성에 대한 객체기반 검증법: 한반도 풍속예측모형의 정확성 검증에의 응용)

  • Kim, Hea-Jung;Kwak, Hwa-Ryun;Kim, Sang-il;Choi, Young-Jean
    • The Korean Journal of Applied Statistics
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    • v.28 no.6
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    • pp.1275-1288
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    • 2015
  • A microscale weather analysis module (about 1km or less) is a microscale numerical weather prediction model designed for operational forecasting and atmospheric research needs such as radiant energy, thermal energy, and humidity. The accuracy of the module is directly related to the usefulness and quality of real-time microscale weather information service in the metropolitan area. This paper suggests an object based verification method useful for spatio-temporal evaluation of the accuracy of the microscale weather analysis module. The method is a graphical method comprised of three steps that constructs a lattice field of evaluation statistics, merges and identifies objects, and evaluates the accuracy of the module. We develop lattice fields using various evaluation spatio-temporal statistics as well as an efficient object identification algorithm that conducts convolution, masking, and merging operations to the lattice fields. A real data application demonstrates the utility of the verification method.

Blood-neural Barrier: Intercellular Communication at Glio-Vascular Interface

  • Kim, Jeong-Hun;Kim, Jin-Hyoung;Park, Jeong-Ae;Lee, Sae-Won;Kim, Woo-Jean;Yu, Young-Suk;Kim, Kyu-Won
    • BMB Reports
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    • v.39 no.4
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    • pp.339-345
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    • 2006
  • The blood-neural barrier (BNB), including blood-brain barrier (BBB) and blood-retinal barrier (BRB), is an endothelial barrier constructed by an extensive network of endothelial cells, astrocytes and neurons to form functional 'neurovascular units', which has an important role in maintaining a precisely regulated microenvironment for reliable neuronal activity. Although failure of the BNB may be a precipitating event or a consequence, the breakdown of BNB is closely related with the development and progression of CNS diseases. Therefore, BNB is most essential in the regulation of microenvironment of the CNS. The BNB is a selective diffusion barrier characterized by tight junctions between endothelial cells, lack of fenestrations, and specific BNB transporters. The BNB have been shown to be astrocyte dependent, for it is formed by the CNS capillary endothelial cells, surrounded by astrocytic end-foot processes. Given the anatomical associations with endothelial cells, it could be supposed that astrocytes play a role in the development, maintenance, and breakdown of the BNB. Therefore, astrocytes-endothelial cells interaction influences the BNB in both physiological and pathological conditions. If we better understand mutual interactions between astrocytes and endothelial cells, in the near future, we could provide a critical solution to the BNB problems and create new opportunities for future success of treating CNS diseases. Here, we focused astrocyte-endothelial cell interaction in the formation and function of the BNB.

A Study on 'Dangdokyeok' Epidemics in the Early 17C of the Joseon -Focusing on Heojun's 『Byeokyeoksinbang』- (17세기 초 조선에서 유행한 '당독역'에 대한 연구 -허준의 『벽역신방』을 중심으로-)

  • Chough Won Joon;Kim Young Ik;Yeom Kee Bok;Lim Hyo Jong;Jeong Woo Yeal;Jean Byung Hun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.2
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    • pp.311-343
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    • 2004
  • Various aspect of epidemics broke out continually from the middle of Joseon Dynasty due to the famine and drought caused by abnormal climate of the sixteenth century and the war. Thus the Dynasty performed sacrificial rites, isolated the patients and published plenty of medical books related epidemics in order to cure of the patients, and Heojun edited 『Byeokyeoksinbang』 as 'Dangdokyeok' broke out at Gwanbuk(關北) districts in 1613, Heojun explained the cause of Dangdokyeok as meteorology under the feudal conditions, and concluded Simhwa(心火) by fever toxin, Therefore he selected the method of puting out Simhwa by attack of fever toxin. In addition he presented emergency treatment that can maintain the airway by bleeding. To treat Dangdokyeok, Heojun presented lots of prescriptions so as Seungmagalgeuntang(升麻葛根湯), Cheongyeolhaedoksan(淸熱解毒散), Yeongyopaedok-san(連翹敗毒散), Bangpungtongsaongsan(防風通聖散), Jowiseunggitang(調胃升氣湯) and Hwangryeonhaedoktang(黃連解毒湯) etc. And he proposed Samdueum (三豆飮), Realgar(石雄黃) and so on to prevent infection from that. They presume from 120 to 150 years as the period of human adaptation to the first epidemics. Dangdokyeok put a large number of people to death at first, but it wasn't referred at the history any more after Byeokyeoksinbang. So we can say that the treatment of Heojun may be effective. Common cold and dyspeptic cold broke out in our country differently from 'Shanghan(傷寒)' in the China, so we had settled 'pestilence infectious epidemic disease(瘟疫)' while 'epidemic febrile disease(溫病)' of the China. Dangdokyeok of Heojun is similar to 'Scalet fever' belonging to 'virulent heat pathogen(溫毒)', 'newly epidemic febrile disease(新感溫病)'. As a cure of Dangdokyeok, the Korean medicine uses the treatment of removing fever state whereas the western medicine uses the antibiotics to kill the streptococcus. The symptoms of Dangdokyeok are remarkably similar to those of the Scarlatina, so this occupies a high position on the world history of medicine in aspects of the period and details of symptoms. These days we have the problems that the tolerance of antibiotics increases and disease of unknown cause is prevalent. It means the western medicine get to limits. So if we progress epidemiography based on Heojun's medicine, we may contribute to the world history of medicine.

Effect of specific serum IgG antibody against Streptococcus mutans on the adherence of S. mutans to smooth surface in vitro (특이혈청항체(特異血淸抗體) IgG분획(分劃)이 Streptococcus mutans의 평활면(平滑面) 부착(附着)에 미치는 영향(影響)에 관(關)한 연구(硏究))

  • Lee, Jean-Yong;Choi, Eu-Gene;Ha, Youn-Mun;Kim, Chan-Soo
    • The Journal of the Korean Society for Microbiology
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    • v.17 no.1
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    • pp.75-85
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    • 1982
  • In order to demonstrate the effect of specific serum IgG antibody on the adherence of Streptococcus mutans to smooth surface and the mechanism of effective adherence inhibition by IgG antibody, in the present study authors obtained purified IgG from different immunogen preparations of S. mutans NCTC 10449(serotype c) and observed the effect of each IgG preparation on the adherence of each S. mutans strain cultured in different conditions. In addition, the present study was undertaken to observe the cross-reactivity of IgG and the effect of sucrose concentration on the adherence of S. mutans in vitro non-growth condition. The adherence of S. mutans to glass surface was effectively inhibited by serum IgG antibody. At the same IgG concentrations, anti-2% fructose grown/1N NaCl washed S. mutans NCTC 10449 cell showed greater adherence inhibitory effect to S. mutans strains than anti-2% sucrose grown and anti-S. mutans NCTC 10449 cell wall, and the greater inhibitory effects of IgG preparations were observed in assay using 2% fructose grown S. mutans cell preparations than using 0.1% sucrose grown cell preparations. These results suggest that the more effective adherence inhibition by serum IgG antibody is due to the reaction with S. mutans cell surface antigens rather than glucan and cell-associated glucosyltransferase. The greatest adherence inhibitory effect of IgG to S. mutans strains was observed on homologous NCTC 10449 strain and the inhibition cross-reactivities were observed between serotype c, e, and f strains. More pronounced cross-reactivity of adherence inhibition of IgG to S. mutans was observed in assay using anti-2% fructose grown/1N NaCl washed cell than using other IgG preparations, and observed in assay using 2% fructose grown S. mutans cell preparations than 0.1% sucrose grown cell preparations. It was interested that low, but adequate concentration of reactive IgG antibody significantly increased the adherence ability of S. mutans. This result may be due to the formation of small cell aggregates resulted in a increase in the numbers of organisms which adhered to glass surface. The adherence of S. mutans to glass surface was possible in the absence of glucan-synthetic activity. Low level of sucrose significantly increased the adherence ability of S. mutans to glass surface, but excessive amount of sucrose induced large cell aggregates resulted in a decrease in the numbers of organism which adhered.

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Analysis of Observational Cases Measured by MRR and PARSIVEL Disdrometer for Understanding the Physical Characteristics of Precipitation (강수의 물리적 특성 이해를 위한 MRR 및 PASIVEL 우적계의 관측사례 분석)

  • Cha, Joo-Wan;Chang, Ki-Ho;Oh, Sung-Nam;Choi, Young-Jean;Jeong, Jin-Yim;Jung, Jae-Won;Yang, Ha-Young;Bae, Jin-Young;Kang, Sun-Young
    • Atmosphere
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    • v.20 no.1
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    • pp.37-47
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    • 2010
  • The methods measuring the precipitation drop size distribution(hereafter referred to as DSD) at Cloud Physics Observation System (CPOS) in Daegwallyeong are to use PARSIVEL (PARticle SIze and VELocity) disdrometer (hereafter referred to as PARSIVEL) and Micro Rain Radar (hereafter referred to as MRR). First of all, PARSIVEL and MRR give good correlation coefficients between their rain rates and those of rain gage: $R^2=0.93$ and 0.91, respectively. For the DSD, the rain rates are classified in 3 categories (Category 1: rr (Rain Rate) ${\leq}0.5\;mm\;h^{-1}$, Category 2: $0.5\;mm\;h^-1$ < rr < $4.0\;mm\;h^{-1}$, Category 3: rr ${\geq}4\;mm\;h^{-1}$). The shapes of PARSIVEL and MRR DSD are relatively most similar in category 2. In addition, we retrieve the vertical rain rate and liquid water content from MRR under melting layer, calculated by Cha et al's method, in Daegwallyeong ($37^{\circ}41{\prime}N$, $128^{\circ}45^{\prime}E$, 843 m ASL, mountain area) and Haenam ($34^{\circ}33^{\prime}N$, $126^{\circ}34^{\prime}E$, 4.6 m ASL, coast area). The vertical variations of rain rate and liquid water content in Daegwallyeong are smaller than those in Haenam. We think that this different vertical rain rate characteristic for both sites is due to the vertical different cloud type (convective and stratiform cloud seem dominant at Haenam and Daegwallyeong, respectively). This suggests that the statistical precipitation DSD model, for the application of weather radar and numerical simulation of precipitation processes, be considered differently for the region, which will be performed in near future.

A Study on Ontology of Digital Photo Image Focused on a Simulacre Concept of Deleuze & Baudrillard (디지털 사진 이미지의 존재론에 관한 연구 -들뢰즈와 보드리야르의 시뮬라크르 개념을 중심으로)

  • Gwon, Oh-sang
    • Cartoon and Animation Studies
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    • s.51
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    • pp.391-411
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    • 2018
  • The purpose of this thesis is to examine ontology of digital photo image based on a Simulacre concept of Gilles Deleuze & Jean Baudrillard. Traditionally, analog image follows the logic of reproduction with a similarity with original target. Therefore, visual reality of analog image is illuminated, interpreted, and described in a subjective viewpoint, but does not deviate from the interpreted reality. However, digital image does not exist physically but exists as information that is made of mathematical data, a digital algorithm. This digital image is that newness of every reproduction, that is, essence of subject 'once existing there' does not exist anymore, and does not instruct or reproduce an outside target. Therefore, digital image does not have the similarity and does not keep the index instruction ability anymore. It means that this digital image is converted into a virtual area, and this is not reproduction of already existing but display of not existing yet. This not-being of digital image changes understanding of reality, existence, and imagination. Now, dividing it into reality and imagination itself is meaningless, and this does not make digital image with technical improvement but is a new image that is basically completely different from existing image. Eventually, digital image of the day passes step to visualize an existent target, nonexistent things have been visualized, and reality operates virtually. It means that digital image does not reproduce our reality but reproduces other reality realistically. In other words, it is a virtual reproduction producing an image that is not related to a target, that is to say Simulacre. In the virtually simulated world, reality has an infinite possibility, and it is not a picture of the past and present and has a possibility as the infinite virtual that is not fixed, is infinitely mutable, and is not actualized yet.

Design of the Active Optical Compensation Movements for Image Stabilization of Small Satellite (소형 위성 영상안정화를 위한 능동형 광학 보정장치 설계)

  • Hwang, Jai Hyuk;Yang, Ji Youn;Park, Jean Ho;Jo, Jeong Bin;Kang, Myoung Soo;Bae, Jae Sung
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.43 no.5
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    • pp.472-478
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    • 2015
  • This paper describes the design of the active optical compensation movements(at focal plane, secondary mirror) for the image stabilization of a small satellite camera. The movements can correct optical misalignment on-line and directly compensate vibration disturbances in the focal plane. Since the devices are installed inside the space camera, it has an remarkable advantage to deal with the structural deformation of a space camera effectively. In this paper, the requirements of the active optical compensation movements for 1m GSD small satellite camera have been analyzed. Based on the established requirements, the design of the active compensation movements have been conducted. The designed active optical compensation system can control 5 axes movements independently to compensate micro-vibration disturbances in the focal plane and to refocus the optical misaligned satellite camera.

The Relation of Body Mass Index to Dietary Intake and Blood Lipid Levels in Korean Adults

  • Jean, Rim;Kim, Chin-Ock;Kang, Soon-Ah;Wee, Hio-Jung
    • Nutritional Sciences
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    • v.1 no.1
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    • pp.70-76
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    • 1998
  • This study was designed to investigate the relationship between body mass index (BMI) and dietary intake, and the relationship between BMI and plasma lipid levels in Korean adults. This study was conducted from January 1 to December 31 of 1997. It consisted of 3781 subjects (men 2402, women : 1379) with the majority between the ages of 40 and 59. The dietary assessment was based upon a twenty-four-hour food record. Subjects were classified into one of four reference BMI groups : underweight ($\leq 20 kg/m^2$), normal (20.1-25.0 kg/$m^2$), overweight (25.1-30.0 kg/$m^2$), and obese (>30 kg/$m^2$). The biochemical assessment included measurements of plasma total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglyceride (TG), lipoprotein (a), and plasminogen activator inhibitor-1 (PAI-1). The BMI study showed that 60.5% of the men measured were normal and 32.6% of the men were overweight and/or obese subjects. Sixty-four percent of the women were normal and 20.3% of the women measured were overweight and/o. obese subjects. With respect to the daily energy intake of the men and women subjects, the levels of daily energy intake appeared to increase as values of BMI increased. Men of the overweight group had significantly higher protein, fat and cholesterol intake than those of the normal or the underweight groups. The alcohol intake of the men in the overweight group was also significantly higher than that of the men in the underweight group. With respect to percent energy intake of macronutrients, there was no significant difference between the four BMI groups and percent energy intake for all the subjects in the study. The ratio of percent energy intake of carbohydrates : protein : fat : alcohol of the normal women group was 62 : 17 : 20 : 1, respectively. Women apparently had a higher intake of carbohydrates than men (52 : 17 : 19 : 10). With respect to the levels of plasma TC, LDL-C, TG, and HDL-C, the levels of plasma TC, LDL-C and TC appeared to increase as the values of BMI increased, while the level of HDL-C appeared to decrease as values of BMI increased. Levels of lipoprotein (a) appeared to be inversely related to the values of BMI, and levels of PAI-1 appeared to increase as values of BMI increased. The results of this study demonstrate that there is a relationship between dietary intake and BMI, and that there is a relationship between BMI and blood lipids levels.

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Study of the Image Design Components of Urban Landscape Media Facade (도시경관 미디어파사드의 영상디자인 구성요소 연구)

  • Yu, Jung-Sun;Chung, Jean-Hun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.11
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    • pp.6478-6483
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    • 2014
  • Media facades project images on the external walls of a building as a screen. Such facades can recover the cultural emotions of users tired of a high level of market competition in urban spaces and develop into urban aesthetics and be reinterpreted as an image design as the city becomes a topic as well as the target projected. From a cultural perspective, the artistic possibility and strengthening of publicness of media facades are discussed. One of the considerations is that it should be the medium communicating with the building or surrounding of the projected target. Urban landscape media facades, such as 2014 Gwanghwamun media facade, 2014 Sejong Center for the Performing Arts media facade and 2013 Namsan media facade were compared and analyzed. As a result, four types of image design components could be derived such as motifs, concepts, stories and projection types. Media facade, which is establishing itself as a new technological genre beyond canvas and theater screens, should contain messages, themes and technological advances as a higher level of the urban symbolic art form in the future. This paper derived the components of image design through the comparative analysis of symbolic urban landscape media facade.

Differentiated Thyroid Carcinoma Risk Factors in French Polynesia

  • Xhaard, Constance;Ren, Yan;Clero, Enora;Maillard, Stephane;Brindel, Pauline;Rachedi, Frederique;Boissin, Jean-Louis;Sebbag, Joseph;Shan, Larrys;Bost-Bezeaud, Frederique;Petitdidier, Patrick;Drozdovitch, Vladimir;Doyon, Francoise;Rubino, Carole;de Vathaire, Florent
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2675-2680
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    • 2014
  • Background: To investigate differentiated thyroid cancer risk factors in natives of French Polynesia is of interest because of the very high incidence of this cancer in the archipelago. Materials and Methods: To assess the role of various potential risk factors of thyroid cancer in the natives of French Polynesia we performed a case-control study. The study included almost all the French Polynesians diagnosed with differentiated thyroid carcinoma between 1981 and 2003 (n=229) and 373 French Polynesian control individuals from the general population without cancer. Results: Thyroid radiation dose received from nuclear fallout before the age of 15, a personal history of neck or/and head medical irradiation, obesity, tallness, large number of children, an artificial menopause, a familial history of thyroid cancer, a low dietary iodine intake, and having a spring as the main source of drinking water were found to be significant risk factors. No roles of smoking habits, alcohol consumption, iodine containing drugs, and exposure to pesticides were evidenced. Conclusions: Except for smoking, differentiated thyroid carcinoma risk factors in natives of French Polynesia are similar to those in other populations. Our finding on the role of having a spring as a drinking water origin is coherent with some other studies and could be due to geological factors.