• Journal of Life Science
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• v.30 no.5
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• pp.483-490
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• 2020

The ubiquitin system uses ligases and deubiquitinases (DUBs) to regulate ubiquitin position on protein substrates and is involved in many biological processes which determine stability, activity, and interaction of the target substrate. DUBs are classified in six groups according to catalytic domain, namely ubiquitin-specific proteases (USPs); ubiquitin C-terminal hydrolases (UCHs); ovarian tumor proteases (OTUs); Machado Joseph Disease proteases (MJDs); motif interacting with Ub (MIU)-containing novel DUB family (MINDY); and Jab1/MPN/MOV34 metalloenzymes (JAMMs). Otubain 1 (OTUB1) is a DUB in the OTU family which possesses both canonical and non-canonical activity and can regulate multiple cellular signaling pathways. In this review, we describe the function of OTUB1 through regulation of its canonical and non-canonical activities in multiple specifically cancer-associated pathways. The canonical activity of OTUB1 inhibits protein ubiquitination by cleaving Lys48 linkages while its non-canonical activity prevents ubiquitin transfer onto target proteins through binding to E2-conjugating enzymes, resulting in the induction of protein deubiquitination. OTUB1 can therefore canonically and non-canonically promote tumor cell proliferation, invasion, and drug resistance through regulating FOXM1, ERα, KRAS, p53, and mTORC1. Moreover, clinical research has demonstrated that OTUB1 overexpresses with high metastasis in many tumor types including breast, ovarian, esophageal squamous, and glioma. Therefore, OTUB1 has been suggested as a diagnosis marker and potential therapeutic target for oncotherapy.

• Journal of the Korean Institute of Landscape Architecture
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• v.43 no.2
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• pp.73-86
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• 2015

This study aimed to identify influencing factors such as job environment, job characteristics, and job competency as they are related to newcomer turnover intentions in the construction of landscape architecture, Korea. The results based on statistical analyses are follows as: The turnover experience of newcomers in the field of landscape architecture construction was 54.5%, about 1.6 times higher than in other fields. The influencing factors among newcomer turnover intentions in the construction of landscape architecture were workload(p<0.01), job suitability, and personal relations(p<0.01), while in job autonomy, work conditions, job competency, job identity, job variety, and job compensation were not statistically significant. This study found that key important factors of dependent variables that conceptually explain the influence of turnover intentions among newcomers differed between the construction of landscape architecture and other fields. The most important factors in turnover intention were workload>personal relationship>job suitability among independent factors. This study implied that efforts for improvement are needed in areas of workload, personal relations, and job suitability to mitigate newcomer turnover intentions so as to establish common and personal goals in the field of landscape architecture construction because turnover intention could lead losses in human resources, time, economy, and psychological health. In conclusion, this study suggested the importance of efforts for human resource management to reduce turnover intentions among newcomers in the field of landscape architecture construction.

• Journal of Navigation and Port Research
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• v.37 no.1
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• pp.91-100
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• 2013

The purpose of this study was to examine the levels of sustainability of marine sport events by types of events and thus to provide fundamental information that helps developing sustainable marine sport events. In order to accomplish such the purpose, this study employed survey methodology with a total of 285 visitors to marine sport events. Questionnaires were developed based on Tripple Bottom Line theory suggested by previous research and validated throughout a panel of experts to check out content validity. Data collected were analyzed using descriptive statistics and ANOVA with Scheffe post hoc tests. Accordingly following findings were derived from current study. First, among 12 positive sustainability variables, marine space improvement had the highest mean score(M=3.82) but creation of jobs had the lowest mean score(M=3.46). Among 11 negative sustainability variables, traffic jab had the highest mean score(M=3.16) but conflict between participants and residents had the lowest mean score(M=2.73). Second, a festival typed marine sport event had the significantly high mean scores in all positive sustainability index including economic sustainability(M=3.79), social sustainability(M=3.84) and environmental sustainability(M=3.80). Third, a business typed marine sport event had the relatively higher mean scores in all negative sustainability index including economic sustainability(M=3.22), social sustainability(M=3.26) and environmental sustainability(M=3.25). In conclusion, these findings suggest that marine sport event organizers concentrate on marine sport event with more sustainability potentials.

• Journal of the Korean Institute of Landscape Architecture
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• v.46 no.1
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• pp.106-114
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• 2018

The aim of this study was to empirical understanding on the impact of work environment on the job satisfaction among the landscape architecture workers through conduct survey. The results was found that the affecting factors of environment in landscape architecture workers were work environment, personal relationship, and job compensation on jab satisfaction, but were not affected between workload and job satisfaction (p<0.05). And this implied that personal relationship in job environment factors was critical factor to decide the levels of job satisfaction (${\beta}$ value 0.233) across the landscape architecture workers. The results guessed the factor that workload among the job satisfaction is or is not statistical significant in many research were because it depends on whether the task is passively recognized or positive recognized according to the job recognition situation. The results was guessed the fact that the affecting factors of the workload among the job satisfaction of landscape architecture workers is not statistical significant were because they have their works cut out for them, makes worthwhile if they thinks that were meaningful and feel have been growing capabilities and recognized that there is a social contribution, and feel the great sense of accomplishment of self-development and self-realization nevertheless they have much their's works.

• Journal of the Korean Home Economics Association
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• v.42 no.4
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• pp.55-68
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• 2004

This study investigated differences or similarities of infant rearing practices in Korea, Hong Kong and the United States and in young mothers and grandmothers generations. The silbjects were young mothers(YM) with babies from 2 to 2.5 years and their mothers or mothers-in-law(GM) in Korea(YM=118, GM=118), Hong Kong(YM= 126, GM=78) and the United States(YM= 105, GM= 105). The subjects answered questionnaires on infant rearing practices that were constructed by child study specialists in Korea, Hong Kong and the United States. Statistical analyses were by frequencies, percentages, and $\chi$$^2$ The results of this study were as follows. 1. Kum-Jut was used to announce giving birth to relatives and neighbors only in Korea. Mothers in Korea were more helped in their recovery by their mother or mother-in-law than their husband, but the opposite was the case in Hong Kong and the United States. Most Korean mothers ate special foods after giving birth, but mothers in Hong Kong and the United Slates didn't. Mothers in Korea were more likely to avoid contact with strangers for a given period of time than mothers in Hong Kong and the United States. The babies in Korea were more often named by grandparents than by parents, but most of the babies in Hong Kong and the United States were named by parents. The greater part of babies in Korea didn't have childhood names or nick names, but most babies in Hong Kong and the United States did. 2. Mothers in Korea were more likely to give a banquet, exercise Dol Jab le, share foods with neighbors, and take souvenir pictures on the baby's first birthday than mothers did in Hong Kong and the United States. Most mothers in Korea tended to think that their baby's fiyst birthday was more meaningful than the other birihdays, but most mothers in Hong Kong and the United States didn't. 3. Some differences between young mothers and grandmothers generations in infant rearing practices were found in each culture.

• Korean Journal of Heritage: History & Science
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• v.52 no.1
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• pp.120-147
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• 2019

In this study, we divided the portraits in the reign of King Seonjo into those which were created before and after the Japanese invasion. We then examined various aspect of costumes expressed in the portraits of meritorious vassals. To analyze official uniforms (Heuk-Danryeung), we examined the Samo height; the side wings' type and pattern; the Danryeung pattern; the Mu style; the processing method of lateral lines in Danryeung the rank badge and rank belt, the color of Dabho and Cheolrik, which were undergarment of Danryeung and Heuk-wa. The meritorious vassals' portraits, prior to Imran, were analyzed with a portrait of Han Eung-in, a Gwang-kuk Pyeong-nan meritorious vassals. The Samo was the highest of the Choson dynasties, and the cloud and treasure pattern was identified on the side wings. The Heuk-Danryeung was a dark blue(acheongsaeg) Danryeung of manja-shaped cloud patterns with a large outward wrinkled Mu, and it had a wild goose badge (second rank) and a Sabgeumdae. It did not coincide with the Pumgye(Jaheondaebu) recorded in Gugjo-inmulgo. Reddish Dabho for Dangsang-kwan, green Cheolrik which was undergarment of Danryeung, and Heuk-wa. were identified. After the invasion of Japan, portraits of Hoseong, Seonmu, and Cheong-nan meritorious vassals were analyzed through eighteen portraits, including Lee Hyeon-bok. After the invasion of the Japanese, the height of the Samo's top was much lower and the width of the side wings was wider than before the invasion of Japanese. The Heuk-Danryeung was a dark blue (acheongsaeg) Danryeung of manja-shaped cloud patterns with a stretching backward Mu. Rank badge and rank belts were almost identical with the record, but there were two exceptions (Sin-jab and Kim, Sae-sin). Therefore, it was reaffirmed that the meritorious vassals' portraits were drawn by the Pumgye at the time of appointment. Among the undergarments of Heuk-Danryeung, green Dabho(11), blue Dabho(4), reddish Dabho(3), and blue Cheolrik(10), green Cheolrik(6), reddish Cheolrik(1), and yucheongsaeg Cheolrik(1) were identified, However, it is suggested that the Dabho of Hoseong, Seonmu, and Cheong-nan meritorious vassals should be the reddish Dabho of Dangsang-kwan, which is the same as the previous Imran, and a green Cheolrik.

• Journal of Korean Academy of Nursing
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• v.19 no.2
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• pp.212-222
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• 1989

When the head nurse who is pivotal in the nursing service administration of the hospital performs efficiently as a first-line manager, the effectiveness of the nursing unit, which includes the quality of nursing care, the jab satisfaction of staff members, and the cohesiveness of staff members is increased. With this point of view in mind, the researcher carried out a study to determine the actual work (the content of the work, the work process, the role of the head nurse, the activity media, and the purpose of the work) of the head nurse in a university hospital in Korea. In addition, this study was also carried out for the purpose of preparing an ideal model for the work of the head nurse. The research subjects were 39 head nurses. This included all the head nurses in two university hospitals except those who were working in outpatient care, operating rooms, central supply, nursing administration, in-service education and emergency care. Data were collected from September 24th to October 21th, 1987 and April 4th to 12th, 1988. A work activity record on which the head nurse recorded directly in a chronological narrative form, was used as the research instrument. The 234 work activity records, 39 head nurse's continuous recording over 6 days(from Monday to Saturday) were collected and analysed. The results were as follows ; 1. With regard to the work content for the total daily work of the head nurse, 45.2% of the activities were managerial activities but 58.1% of the head nurse' s time was spent in direct patient care. 2. With regard to the work process of the head nurse, specifically the location, the size and membership of groups contacted, the results were as follows : 1) Of the total daily work activities 92.4% were carried out in the nursing unit and this occupied 84.5% of total daily work time. Direct patient care was generally performed on the nursing unit and managerial work was performed in other areas. 2) Of the total daily work activities, 73% was with one or more persons and 51.2% of total daily work time was spent in groups. 3) A total of 51 persons, working in different capacities were contacted. These included 21 persons giving patient care, 19 persons working in nursing unit management, and 7 persons working in human resource management. 3. With regard to the head nurse's role in work activity, 53.3% of total daily work activities involved the informational role, 26.9%, the interpersonal role and 19.9%, the decisional role. With regard to time, 57.7% was spent in the informational role, 23.9%, in the interpersonal role and 18.3%, in the decisional role. When the head nurse performed managerial work, she gave nearly equal emphasis to all three roles when she gave direct patient care the informational role was increased. 4. With regard to the activity media, the number of unscheduled activities accounted for 27.1% of the activities, scheduled activities, 24.3%, desk work activity, 22.1%, rounds, 12.5% and telephone calls, made or received, 14.0%. In daily total work time managerial work related to desk work and scheduled activities were high, ranging from 29.8% to 29.9% but for direct patient care time, scheduled activities and unscheduled activities were high, ranging from 23.6％ to 35.3%. 5. With regard to the purpose of the work performed, 54.4% of the total daily work was concerned with the team and 41.4% was concerned with the agency. The managerial work was concerned mainly with the team and the direct patient care was concerned mainly with the patient. When the frequency of an activity and time were compared no significant difference was found between the days for which the work was recorded for any of the variables : the work content, the work process, the work role, the activity media and purpose of the work. On the basis of this study the following are proposed as an ideal model for head nurse work in Korea : The managerial work should be increased to 70%. The decisional role activities should be increased to 40%. Twenty percent of the work activity should be allocated to agency, community and profession. It is believed that this model for the head nurse's work can contribute to guidelines for job description development. Finally, educational programs, organizational and structural devices, and administrative support are needed for the proper function of the head nurse in this proposed model.