• Tuberculosis and Respiratory Diseases
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• v.44 no.4
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• pp.871-888
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• 1997

Background : It is now thought that the earliest manifestation of idiopathic pulmonary fibrosis is alveolitis, that is, an accumulation of inflammatory and immune effector cells within alveolar walls and spaces. Inflammatory cells including alveolar macrophages and resident normal pulmonary tissue cells participate through the release of many variable mediators such as inflammatory growth factors and cytokines, which contribute to tissue damage and finally cause chronic pulmonary inflammation and fibrosis. This study was performed to investigate the source and distribution pattern of transforming growth factor-${\beta}_1$(TGF-${\beta}_1$), platelet derived growth factor(PDGF), basic fibroblast growth factor(bFGF), interleukin 1(IL-1), interleukin 6(IL-6), tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and the role of these mediators on bleomycin(BLM)-induced pulmonary injury and fibrosis in rats. Method : Wistar rats were divided into three groups(control group, BLM treated group, BLM and vitamine E treated group). Animals were sacrificed periodically at 1, 2, 3, 4, 5, 7, 14, 21, 28 days after saline or BLM administration. The effects were compared to the results of bronchoalveolar lavage fluid analysis, light microscopic findings, immunohistochemical stains for six different mediators(TGF-${\beta}_1$, PDGF, bFGF, IL-1, IL-6 and TNF-$\alpha$) and mRNA in situ hybridization for TGF-${\beta}_1$. Results : IL-1 and IL-6 are maximally expressed at postbleomycin 1~7th day which are mainly produced by neutrophils and bronchiolar epithelium. It is thought that they induce recruitment of inflammatory cells at the injury site. The expression of IL-1 and IL-6 at the bronchiolar epithelium within 7th day is an indirect evidence of contribution of bronchiolar epithelial cells to promote and maintain the inflammatory and immune responses adjacent to the airways. TNF-$\alpha$ is mainly produced by neutrophils and bronchiolar epithelial cells during 1~5th day, alveolar macrophages during 7~28th day. At the earlier period, TNF-$\alpha$ causes recruitment of inflammatory cells at the injury site and later stimulates pulmonary fibrosis. The main secreting cells of TGF-${\beta}_1$ are alveolar macrophages and bronchiolar epithelium and the target is pulmonary fibroblasts and extracellular matrix. TGF-${\beta}_1$ and PDGF stimulate proliferation of pulmonary fibroblasts and TGF-${\beta}_1$ and bFGF incite the fibroblasts to produce extracellular matrix. The vitamine E and BLM treated group shows few positive cells(p<0.05). Conclusion : After endothelial and epithelial injury, the neutrophils and bronchiolar epithelium secrete IL-1, IL-6, TNF-$\alpha$ which induce infiltration of many neutrophils. It is thought that variable enzymes and $O_2$ radicals released by these neutrophils cause destruction of normal lung architecture and progression of pulmonary fibrosis. At the 7~28th day, TGF-${\beta}_1$, PDGF, bFGF, TNF-$\alpha$ secreted by alveolar macrophages sting pulmonary fibroblasts into proliferating with increased production of extracellular matrix and finally, they make progression of pulmonary fibrosis. TNF-$\alpha$ compares quite important with TGF-${\beta}_1$ to cause pulmonary fibrosis. Vitamine E seems to decrease the extent of BLM induced pulmonary fibrosis.

• Journal of Korean Biological Nursing Science
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• v.2 no.2
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• pp.20-37
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• 2000

The purpose of this study was to investigate the relationships between the differentials in life styles and their effect on the epidermal facial tissue in order to provide a basis for health professionals so that they might better be able to maintain and promote healthy skin care and further delay the premature ageing of the epidermal facial tissue. The subjects consisted of 145 females of various ages who visited skin care room in cerming health promoting behaviors(Park In sook's Profile) and questions on their behavioral practices pertaining to personal skin care were used. The investigation also ess of the four parts of the epidermal facial tissue studied. All data collected wee entered into the SAS program and analyzed for frequency, percentages, the utilized Pusan. The study dates ranged from May 1, 1998 to May 30, 1998. The methods used for this investigation were a questionnaire survey consisting of general objective questions. The questions con a "skin analyzer" to measured levels of moisturizing hydrated, facial oils, and roughnmean, t-test, ANOVA, and Pearson Correlation Coefficients. The results of this study were as follows ; 1. Epidermal facial oil was at its highest levels in the chin area with additional decreasing levels in the forehead and nose regions. The least regions were those of the cheeks. The highest levels of hydration on the other hand started with the forehead followed by the area of the chin, the cheeks and the lowest level of epidermal facial hydration was in the region of the nose. 2. The average score of the performance in the health promoting behaviors variable was 139.51. The variables with the highest degree of the performance were rest and sleeping(35.71). The lowest degree was hiegenic life(23.44). 3. The relationship health promoting behaviors and epidermal condition was not correlated with oil, hydration and roughness of the skin surface. 4. Skin care behavioral characteristics related to epidermal condition were washing style and temperature of washing water. 5. General characteristics related to epidermal condition were occupation, education level, acne and melasma. In conclusion, this study showed that several factors were significant in the behavior of skin care. Clear knowledge of both internal and external factors which affect the epidermal condition will help women to pursue active and appropriate practices in their health behaviors and skin care.

• Korean Chemical Engineering Research
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• v.52 no.5
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• pp.592-602
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• 2014

In the Integrated Gasification Combined Cycle (IGCC), the stability of the gasifier has strong influences on the rest of the plant as it supplies the feed to the rest of the power generation system. In order to ensure a safe and stable operation of the entrained-flow gasifier and for protection of the gasifier wall from the high internal temperature, the solid slag layer thickness should be regulated tightly but its control is hampered by the lack of on-line measurement for it. In this study, a previously published dynamic simulation model of a Shell-type gasifier is reproduced and two different linear model predictive control strategies are simulated and compared for multivariable control of the entrained-flow gasifier. The first approach is to control a measured secondary variable as a surrogate to the unmeasured slag thickness. The control results of this approach depended strongly on the unmeasured disturbance type. In other words, the slag thickness could not be controlled tightly for a certain type of unmeasured disturbance. The second approach is to estimate the unmeasured slag thickness through the Kalman filter and to use the estimate to predict and control the slag thickness directly. Using the second approach, the slag thickness could be controlled well regardless of the type of unmeasured disturbances.

• Journal of Korean society of Dental Hygiene
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• v.11 no.2
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• pp.179-188
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• 2011

Objectives : The study set out to analyze correlations between emotional labor and job stress among dental hygienist, who have direct and lasting relationships with patients in dental clinic, and provide basic data to resolve stressors and manage stress. Methods : A survey was taken among dental hygienists working at dental clinics, and 200 questionnaires were used in analysis. The gathered data were put to Cronbach's alpha with the SPSS WIN12.0 program to test the reliability of the inventories to measure their emotional labor and job stress. In addition, correlation analysis was conducted to examine relations between the items of emotional labor and those of job stress along with regression analysis to examine relations between emotional labor and job stress. Finally, t-test and One-way ANOVA were conducted to test mean differences in the job stress items according to the degrees of emotional labor with the statistical significance level set at 0.05. Results : 1. The measurement tool used in the study recorded 0.7 for all the areas of Cronbach's alpha for internal reliability and thus achieved high reliability. 2. The overall mean of emotional labor was 2.74, which indicates that the dental hygienists had 'average' or higher stress for emotional labor. 3. Emotional labor had statistically significant relations with educational background, place of work, motivation to choose to be a dental hygienist, and religion of their general characteristics. 4. There was statistical significance in relations between general characteristics and job stress according to educational background, position at work, and experience with change of occupation. 5. The correlations between emotional labor and the stress areas were analyzed. As a result, emotional labor was in positive(+) correlations with job demand, lack of job autonomy, relational conflict, job instability, organizational system, and corporate culture. In addition, regression analysis was conducted to test causal relations between emotional labor and job stress. The results indicate that there were positive(+) influences between emotional labor and job stress. Conclusions : The results show that emotional labor can serve as a mediating variable for job stress in dental clinic. Thus both dental clinics and dental hygienists need to have ways to deal with job stress derived from emotional labor in which they are forced to process their emotions according to the dental clinics' demands, properly. The study will hopefully trigger ongoing follow-up researches on the deployment of dental hygienists according to their job characteristics and the situational variables to alleviate the negative results of emotional labor.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2159-2165
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• 2013

Cancer registries help to establish and maintain cancer incidence reporting system, serve as a resource for investigation of cancer and its causes, and provide information for planning and evaluation of preventive and control programs. However, their wider role in directly enhancing oncology drug access has not been fully explored. We examined the value of cancer registries in oncology drug access in the Asia-Pacific region on three levels: (1) specific registry variable types; (2) macroscopic strategies on the national level; and (3) a regional cancer registry network. Using literature search and proceedings from an expert forum, this paper covers recent cancer registry developments in eight economies in the Asia-Pacific region - Australia, China, Hong Kong, Malaysia, Singapore, South Korea, Taiwan, and Thailand - and the ways they can contribute to oncology drug access. Specific registry variables relating to demographics, tumor characteristics, initial treatment plans, prognostic markers, risk factors, and mortality help to anticipate drug needs, identify high-priority research area and design access programs. On a national level, linking registry data with clinical, drug safety, financial, or drug utilization databases allows analyses of associations between utilization and outcomes. Concurrent efforts should also be channeled into developing and implementing data integrity and stewardship policies, and providing clear avenues to make data available. Less mature registry systems can employ modeling techniques and ad-hoc surveys while increasing coverage. Beyond local settings, a cancer registry network for the Asia-Pacific region would offer cross-learning and research opportunities that can exert leverage through the experiences and capabilities of a highly diverse region.

• Journal of Distribution Science
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• v.17 no.10
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• pp.93-105
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• 2019

Purpose - First, empirical research will reveal how personal creativity affects the knowledge sharing and innovation behaviors of organizational members. Second, self-management competency will be verified to explain the causal relationship between independent and dependent variables as a mediating variable and to reduce the time interval. Research design, data, and methodology - There are two major research models. First, personal creativity (professionalism, emotional intelligence, internal motivation) has a positive impact on knowledge sharing (creation of knowledge, organization of knowledge, use of knowledge) and innovation behavior (deriving ideas, implementing ideas, promoting ideas). Second, self-management competency (intellectual capacity, emotional capacity, personality capacity) plays a mediating role. In addition to descriptive statistics and correlation analysis, Cronbach's α was calculated for 259 workers in the retail industry. In addition, confirmatory factor analysis was performed using the AMOS 24.0 program, and the influence on the measurement model was analyzed to verify the structural equation model. Results - First, personal creativity had a positive effect on knowledge sharing and innovation behavior. In other words, it was confirmed that the decision-making process accompanied by individual creativity can create an atmosphere of knowledge sharing and continue to innovate. Second, personal creativity had a positive effect on self-management competency, and self-management competency had a positive effect on knowledge sharing and innovation behavior. Third, self-management competency was found to partially mediate the influence of personal creativity on knowledge sharing and innovation behavior. Conclusions - First, it is important for managers to recognize the value of creative talents who can be a fundamental source of organizational success and competitive advantage, and to attract talented people. Second, managers should be able to develop decision-making processes to develop potential creativity and encourage creative ideas, opinions, or solutions when organizing the work environment of their members. Third, managers should promote the sharing and integration of new knowledge that underlies the creative views and attitudes of teams and organizational members. Unlike previous studies, which emphasize the role of the work environment in which creative behaviors are promoted, this study shows that creativity of individual members, itself, is an important determinant of knowledge sharing and innovation behavior.

• Journal of Preventive Medicine and Public Health
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• v.36 no.4
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• pp.390-398
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• 2003

Objectives : To evaluate the degree of adolescent internet addiction, and investigate its relationship to the general characteristics, internet environments, and contents, especially the stress measured by the psychosocial wellbeing index-short form(PWI-SF). Methods : The data was obtained from self-administered questionnaires from 886 11th grade urban area students. The questionnaires consisted of general characteristics, internet user's environments, frequencies by internet contents, internet addiction test and PWI-SF. Results : The possible rate of internet use at home was 95.1%, and the area of most internet use was the home. The frequencies of internet game and porno site use were higher in males, with web searching and community uses higher in females. The total mean of internet addiction score was 56.8, and was higher for male than for female students. From multiple regression, as analyzed by the internet addiction score as a dependent variable, on-line friends, internet use times, years of internet use, frequencies of internet game, & porno site use, and PWI-SF scores were significant in male. Internet use times, the frequencies of internet game, chatting, community use, and PWI-SF score were significant in female. Four PWI-SF subscales(social role & self reliability, depression, general health & vitality, and sleep disturbance & anxiety) and internet addiction were significantly correlated in both male and female students, with depression having the most correlation. Conclusion : The results of this study suggest that intervention should be provided to prevent internal addiction, especially for coping with stress in Korean teenage students.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.5
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• pp.447-453
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• 2010

The hemifacial microsomia is characterized by variable underdevelopment of the craniofacial skeleton, external ear, and facial soft tissues. So, patients with hemifacial microsomia have an occlusal plane canting and malocclusion with facial asymmetry. Distraction osteogenesis (DO) with an intraoral or extraoral device is a technique using tension to generate new bone with gradual bone movement and remodeling. DO has especially been used to correct craniofacial deformities such as a hemifacial microsomia, facial asymmetry, and mandible defect that could not adequately be treated by conventional reconstruction with osteotomies. It has a significant advantage to lengthen soft and hard tissue of underdeveloped site without bone graft and a few complication such as nerve injury or muscle contracture. A 13-years old girl visited our clinic for the chief complaint of facial asymmetry. She had a left hypoplastic maxilla and mandible, occlusal plane canting and malocclusion. We diagnosed hemifacial microsomia and lanned DO to lengthen the affected side. Le Fort I osteotomy, left mandibular ramus and symphysis osteotomy were performed. The internal distraction devices fixed with screw on maxillary and mandibular ramus osteotomy sites. External devices were adapted to lower jaw for DO on symphysis osteotomy site and to upper jaw for rapid maxillary expansion (RME). At 7days after surgery, distraction was started at the rate of 1mm per day for 13days, and after 4months consolidation periods, distraction devices were removed. Simultaneous multiple maxillo-mandibular distraction osteogenesis with RME resulted in a satisfactory success in correcting facial asymmetry as well as occlusal plane canting for our hemifacial microsomia.

• The Korean Journal of Financial Management
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• v.25 no.2
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• pp.33-68
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• 2008

The purpose of this paper is to test the market timing hypothesis and impact of macro economic variables on capital structure choice as well as the traditional static trade-off and pecking order theories of capital structure in a integrated framework. Through a two stage test of target capital structure and capital structure choice, none of theories was consistently supported, but most of them were partly supported. In the first stage analysis of target ratio, coefficients of firm-specific variables generally supported the predictions of pecking order theory rather than those of the static trade-off theory. However, the result of the second stage test on capital structure choice supported the hypothesis of the static trade-off theory, which claims that firms usually set and pursue the target leverage ratio. Further, the result of the seconde stage shows that a simple pecking oder theory does not hold because firms with deficit of internal fund tend to issue bonds rather than stocks to raise outside fund. Also, the result indicates that the market timing hypothesis holds because firms with over-valued stocks tend to issue stocks rather than bonds. However, contrary to Korajczyk and Levy(2003), the impact of macro economic variables such as term or credit spreads on capital structure choice was negligible, and the impact of macro economic and market timing hypothesis variables were not greater in financially unconstrained firms as Korajczyk and Levy(2003) suggested.

• Korean Journal of Health Education and Promotion
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• v.22 no.2
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• pp.155-171
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• 2005

Objectives: The purpose of this study is to find out how well the primary school students are practicing the health promotion behaviors and the factors relating their health promotion behavior. Methods: This study was carried out by using questionnaires with 1,215 students attending at a 6th grade, 16 primary schools which arranged the school health teachers in Kyoungpook, Chilkok Gun from the 21th through 22th of December 2004. Among them, 1,189 were included in final analysis. The collected data was analyzed through frequency, percentage mean and standard deviation, multiple regression. Results: According to the data from multiple regression of analysis which has the health promotion behavior practice as a subordinate variable, in male students' case the degree of health promotion behavior practice becomes high in proportion to their parents' interest in health, to their perceived self efficacy, and in case of the barriers of the health promotion behavior practice. As to the female students, their health behavior practice becomes high in proportion to their parents' interest in health. It also becomes high in proportion to the perceived health status, the understanding of the importance of the health, internal health locus of control in personality, the perceived self efficacy and the perceived benefit of the health promotion behavior. But in case of the barriers of the health promotion behavior, it was the same as the male students' case. Conclusions: As the results of study, it showed that the knowledge to importance of health, the self efficacy, the knowledge of benefit of health promotion behaviors and the health concern to the children of the parents were related to health promotion behaviors of the primary school students. So, through the systematic development of health education program, we induced to desirable direction for the changeable factors of actions to health promotion for the health, and through the connective guidelines between the School and the Home, we have to adapt to effective health promotion program for the health management of the young boys and girls.