• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.1059-1063
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• 2012

Objective: Angiogenesis represents a key element in the pathogenesis of malignancy. There are no robust data on prognostic factors for overall survival (OS) in patients with metastatic colorectal cancer treated with vascular endothelial growth factor (VEGF)-targeted therapy. The present study was conducted to establish a prognostic model for patients using an oxaliplatin-based or irinotecan-based chemotherapy plus bevacizumab in metastatic colorectal cancer. Methods: Baseline characteristics and outcomes on 170 patients treated with FOLFIRI or XELOX plus anti-VEGF therapy-naive metastatic colorectal cancer were collected from three Turkey cancer centers. Cox proportional hazards regression was used to identify independent prognostic factors for OS. Results: The median OS for the whole cohort was 19 months (95% CI, 14.3 to 23.6 months). Three of the seven adverse prognostic factors according to the Anatolian Society of Medical Oncology (ASMO) were independent predictors of short survival: serum lactate dehydrogenase (LDH) greater than the upper limit of normal (ULN; p<0.001); neutrophils greater than the ULN (p<0.0014); and progression free survival (PFS) less than 6 months (p =0.001). Conclusion: Serum LDH and neutrophil levels were the main prognostic factors in predicting survival, followed by PFS. This model validates incorporation of components of the ASMO model into patient care and clinical trials that use VEGF-targeting agents.

• 동의생리병리학회지
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• 제24권3호
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• pp.519-524
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• 2010

This clinical study was done to examine comparison the prevalence of metabolic syndrome and obesity index between patients with silent lacunar infarction and normal controls. We compared the components of metabolic syndrome and obesity index between patients silent lacunar infarction(n=62) and normal controls(n=72). The analysis of the data was done by Frequency Analysis, two sample t-test, Chi-square Test. Hypertension and diabetes mellitus was significantly higher in patients of silent lacunar infarctions. Body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome were higher significantly in patients of silent lacunar infarctions than normal controls. Although statistically insignificant, waist circumference showed relatively higher in patients of silent lacunar infarction. This result emphasizes the importance of managing that hypertension, diabetes, body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome in silent lacunar infarction.

• 대한한방내과학회지
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• 제26권1호
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• pp.221-228
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• 2005

The intent of this study is to investigate whether two oriental medical prescriptions named haengsotang(HST) and gami-palmihwan(GPMH) significantly effect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells, Confluent HTSE cells were metabolically radiolabeled with $^3H-glucosamine$ for 24 hrs and chased for 30 min in the presence of HST or GPMH to assess the effect of each agent on $^3H-mucin$ release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of HST and GPMH on contractility of isolated tracheal smooth muscle were investigated. The results are consistant with the following assertions: (1) HST significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity; (2) GPMH did not effect mucin release without cytotoxicity; (3) HST and GPMH did not effect contractility of isolated tracheal smooth muscle. These results suggest a need for further investigation of HST and its components, for its potential in oriental medicine prescriptions and novel agents that effectively regulate (inhibit) mucin secretion from airway goblet cells.

• Tuberculosis and Respiratory Diseases
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• 제51권5호
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• pp.482-487
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• 2001

저자들은 연하곤란, 호흡곤란, 상복부동통으로 내원한 44세 남자에서 좌측 흉수를 발견하고 흉수 천자와 흉부 및 복부 전산화 단층촬영을 시행하여 종격동올 침범한 췌장성 가성낭종을 진단하고 외과적 시술 없이 총정맥 영양공급과 소마토스타틴 투여등 내과적 치료로 호전된 종격동 췌장성 가성낭종 1례를 경험하였기에 보고하는 바이다.

• 한국조리학회지
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• 제21권5호
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• pp.192-203
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• 2015

내부 마케팅은 서비스의 질과 고객 만족을 높이기 위한 방법으로 사용되어 왔다. 그러나, 내부 마케팅의 정의와 그 적용은 연구자에 따라 다르게 사용되어 왔다. 따라서, 본 연구의 목적은 외식 산업에서 사용 가능한 내부 마케팅 요소를 개발하는 것이다. 본 연구는 웹 설문지를 통하여 405개의 자료를 최종분석에 사용하였다. 기존 연구 논문을 바탕으로 다섯 개의 내부 마케팅 요소(비전, 개발, 보상, 동기 부여, 사내 커뮤니케이션)가 채택되었고, 자료 분석, 결과 다섯 개의 내부 마케팅 요소는 직원의 직업 만족도를 향상시키는 데 큰 영향을 미침을 알 수 있었다.

• 한국화재소방학회논문지
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• 제30권2호
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• pp.87-91
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• 2016

최근 우리나라의 인구구조가 표주박형태의 고령화 사회로 변화함에 따라 급사의 원인이 되는 심장질환의 발생이 고령이 될수록 증가하고 있다. 심정지나 호흡이 정지된 환자에게 사용되는 인공호흡기중 전 세계적으로 보급되고 있는 공급되는 산소의 압력만으로 자동으로 작동되는 휴대용 인공호흡기의 필요성이 증가하고 있다. 이러한 휴대용 인공호흡기의 구성품 및 인공호흡기에 중요시되는 성능요구사항에 따른 시험방법을 제시하고 그에 따른 인공호흡기 내부감압셋팅 변화조건에 따른 최적 성능요구조건에 적합한 내부 감압조건을 찾고자 한다.

• 패션비즈니스
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• 제18권1호
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• pp.37-49
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• 2014

By investigating structural relationships between personal image and self-efficacy, this experimental study purposes to suggest a direction and the meaning of effective education on personal image. Based on scholars' studies on personal image and self-efficacy, this study extracts a revised questionnaire on personal image. The experimental study proved the relationship between the variables of personal image and self-efficacy by using personal image questionnaires which are extracted from the literature study. For this purpose, we have conducted a questionnaire survey including 234 students from women's university in Seoul. The results of this study are as follows. First, for cognitions on personal image, which are components of the internal image, both the visual image and social image impacting on self-efficacy have a significant efficacy in the self-regulation factor. Second, the satisfaction rates of the components for personal image impacting all the factors of self-efficacy showed a significant effect. Third, the significant results are being obtained from the analysis of differences in self-efficacy according to the levels of satisfaction rates on internal image and social image, which are expected to have effects on the self-efficacy between the groups for all factors. However, according to the analysis of differences in self-efficacy in relation to the levels of satisfaction for visual images, only the self-confidence factor in the self-efficacy is different between the groups.

• Smart Structures and Systems
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• 제13권1호
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• pp.1-24
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• 2014

The present study deals with two dimensional electro-elastic analysis of a functionally graded piezoelectric (FGP) cylinder under internal pressure. Energy method and first order shear deformation theory (FSDT) are employed for this purpose. All mechanical and electrical properties except Poisson ratio are considered as a power function along the radial direction. The cylinder is subjected to uniform internal pressure. By supposing two dimensional displacement and electric potential fields along the radial and axial direction, the governing differential equations can be derived in terms of unknown electrical and mechanical functions. Homogeneous solution can be obtained by imposing the appropriate mechanical and electrical boundary conditions. This proposed solution has capability to solve the cylinder structure with arbitrary boundary conditions. The previous solutions have been proposed for the problem with simple boundary conditions (simply supported cylinder) by using the routine functions such as trigonometric functions. The axial distribution of the axial displacement, radial displacement and electric potential of the cylinder can be presented as the important results of this paper for various non homogeneous indexes. This paper evaluates the effect of a local support on the distribution of mechanical and electrical components. This investigation indicates that a support has important influence on the distribution of mechanical and electrical components rather than a cylinder with ignoring the effect of the supports. Obtained results using present method at regions that are adequate far from two ends of the cylinder can be compared with previous results (plane elasticity and one dimensional first order shear deformation theories).

• 한국산업정보학회논문지
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• 제26권6호
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• pp.11-16
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• 2021

본 논문에서는 자동차 배선에 사용되는 커넥터의 조립 불량 상태를 식별하는 품질 검사 시스템을 개발하였다. 방수용 커넥터는 방수를 위하여 내부 Seal을 필수적으로 삽입하여야 하는데 생산 과정에서 누락되거나 이중 삽입되는 경우가 있다. 이를 구분하기 위하여 포토센서와 터치스위치를 사용하여 자동화 검사 지그를 설계하였다. 기존 육안검사의 경우 5인이 하루 8시간 검사하였을 때 6,400개의 커넥터를 검사하였으나 개발된 검사 지그를 사용할 때는 20,000개를 검사하므로 기존의 육안 검사와 비교하여 생산성이 크게 향상되었다.

• Journal of Ginseng Research
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• 제21권3호
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• pp.174-186
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• 1997

In this study, rat hepatocytes known to have active carbohydrate metabolism were obtained by using the liver perfusion technique to examine the hypoglycemic action of red ginseng saponin components [ginsenoside (mixture, $Rb_1$, and $Rg_1$)] and incubated in two different media-one containing insulin and glucagon (control group), and the other containing glucagon only, The specific activities of some regulatory enzymes such as glucokinase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glucose 6-phosphatase, in main pathways which were directly related to the glucose metabolism were compared between these two kinds of hepatocytes cultured in two different media. The effects of red ginseng saponin components [ginsenoside (mixture, $Rb_1$, and $Rg_1$)] under the concentration of $10^3$~$10^6$% on these enzymes In hepatocytes were also investigated, when they were added to these two media. The results were as follows. The specific activity of enzymes such as glucokinase, glucose 6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase related to glucose-consuming pathways of insulin-deficient group was much less than control one, however, their decreased activity was recovered after the addition of ginseng components at all range of concentrations. The increased specific activity of these on - zymes was shown by the addition of ginseng components to the control group. On the other hand, the specific activity of glucose 6-phosphatase related to glucose-producing pathway of insulin-deficient group was much higher than control one, but their Increased activity was decreased after the addition of ginseng components at all range of concentrations. The same results were obtained after the addition of ginseng components to the control group. These results suggest that the red ginseng saponin components might better diabetic hyperglycemia by regulating the activity of enzymes related to glucose metabolism directly and/or Indirectly though more detailed studies were needed.