Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prognostic Factors for Overall Survival in Patients With Metastatic Colorectal Carcinoma Treated With Vascular Endothelial Growth Factor-Targeting Agents

  • Cetin, Bulent (Department of internal Medicine, Gazi University Faculty of Medicine) ;
  • Kaplan, Mehmet Ali (Department of internal Medicine, Dicle University Faculty of Medicine) ;
  • Berk, Veli (Department of internal Medicine, Division of Medical Oncology, Erciyes University Faculty of Medicine) ;
  • Ozturk, Selcuk Cemil (Department of internal Medicine, Dicle University Faculty of Medicine) ;
  • Benekli, Mustafa (Department of internal Medicine, Gazi University Faculty of Medicine) ;
  • Isikdogan, Abdurrahman (Department of internal Medicine, Dicle University Faculty of Medicine) ;
  • Ozkan, Metin (Department of internal Medicine, Division of Medical Oncology, Erciyes University Faculty of Medicine) ;
  • Coskun, Ugur (Department of internal Medicine, Gazi University Faculty of Medicine) ;
  • Buyukberber, Suleyman (Department of internal Medicine, Gazi University Faculty of Medicine)
  • Published : 2012.03.31
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Abstract

Objective: Angiogenesis represents a key element in the pathogenesis of malignancy. There are no robust data on prognostic factors for overall survival (OS) in patients with metastatic colorectal cancer treated with vascular endothelial growth factor (VEGF)-targeted therapy. The present study was conducted to establish a prognostic model for patients using an oxaliplatin-based or irinotecan-based chemotherapy plus bevacizumab in metastatic colorectal cancer. Methods: Baseline characteristics and outcomes on 170 patients treated with FOLFIRI or XELOX plus anti-VEGF therapy-naive metastatic colorectal cancer were collected from three Turkey cancer centers. Cox proportional hazards regression was used to identify independent prognostic factors for OS. Results: The median OS for the whole cohort was 19 months (95% CI, 14.3 to 23.6 months). Three of the seven adverse prognostic factors according to the Anatolian Society of Medical Oncology (ASMO) were independent predictors of short survival: serum lactate dehydrogenase (LDH) greater than the upper limit of normal (ULN; p<0.001); neutrophils greater than the ULN (p<0.0014); and progression free survival (PFS) less than 6 months (p =0.001). Conclusion: Serum LDH and neutrophil levels were the main prognostic factors in predicting survival, followed by PFS. This model validates incorporation of components of the ASMO model into patient care and clinical trials that use VEGF-targeting agents.

Keywords

References

  1. Burzykowski T, Molenberghs G, Buyse M (2001). Validation of surrogate endpoints in multiple randomized clinical trials with failure-time endpoints. J Roy Stat Soc C Appl Stat, 50, 405-22. https://doi.org/10.1111/1467-9876.00244
  2. Buyse M, Burzykowski T, Carroll K, et al (2007). Progressionfree survival is a surrogate for survival in advanced colorectal cancer. J Clin Oncol, 25, 5218-24. https://doi.org/10.1200/JCO.2007.11.8836
  3. Burzykowski T, Buyse M, Piccart-Gebhart MJ, et al (2008). Evaluation of tumor response, disease control, progressionfree survival, and time to progression as potential surrogate endpoints in metastatic breast cancer. J Clin Oncol, 26, 1987-92. https://doi.org/10.1200/JCO.2007.10.8407
  4. Coiffier B, Gisselbrecht C, Vose JM, et al (1991). Prognostic factors in aggressive malignant lymphomas. Description and validation of prognostic index that could identify patients requiring a more intensive therapy. J Clin Oncol, 9, 211-19. https://doi.org/10.1200/JCO.1991.9.2.211
  5. Collette L, Burzykowski T, Carroll KJ, et al (2005). Is prostatespecific antigen a valid surrogate end point for survival in hormonally treated patients with metastatic prostate cancer? J Clin Oncol, 23, 6139-48. https://doi.org/10.1200/JCO.2005.08.156
  6. de Gramont A, Figer A, Seymour M, et al (2000). Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer. J Clin Oncol, 18, 2938-47. https://doi.org/10.1200/JCO.2000.18.16.2938
  7. Dimopoulos MA, Barlogie B, Smith TL, et al (1991). High serum lactate dehydrogenase level as a marker for drug resistance and short survival in multiple myeloma. Ann Intern Med, 115, 931-35. https://doi.org/10.7326/0003-4819-115-12-931
  8. Donskov F, von der Maase H (2006). Impact of immune parameters on long-term survival in metastatic renal cell carcinoma. J Clin Oncol, 24, 1997-05. https://doi.org/10.1200/JCO.2005.03.9594
  9. Ferrara N, Hillan KJ, Gerber HP, et al (2004). Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov, 3, 391. https://doi.org/10.1038/nrd1381
  10. Ferrara N (2004). Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev, 25, 581-?. https://doi.org/10.1210/er.2003-0027
  11. Grothey A, Hedrick EE, Mass RD, et al (2008). Responseindependent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107. J Clin Oncol, 26, 183-89. https://doi.org/10.1200/JCO.2007.13.8099
  12. Hecht JR, Trarbach T, Jaeger E (2005). A randomized, doubleblind, placebo-controlled, phase III study in patients with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5- fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1). J Clin Oncol, 23, 16S (abstr LBA3).
  13. Heng DY, Xie W, Regan MM, et al (2009). Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factortargeted agents:results from a large, multicenter study. J Clin Oncol, 27, 5794-99. https://doi.org/10.1200/JCO.2008.21.4809
  14. Hollen CW, Henthorn J, Koziol JA, et al (1992). Serum interleukin-6 levels in patients with thrombocytosis. Leuk Lymphoma, 8, 235-41. https://doi.org/10.3109/10428199209054910
  15. Kemeny N, Braun DW Jr (1983). Prognostic factors in advanced colorectal carcinoma. Importance of lactic dehydrogenase level, performance status, and white blood cell count. Am J Med, 74, 786-94. https://doi.org/10.1016/0002-9343(83)91066-5
  16. Kerbel RS, Kamen BA (2004). The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer, 4, 423-?. https://doi.org/10.1038/nrc1369
  17. Mancuso P, Colleoni M, Calleri A, et al (2006). Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy. Blood, 108, 452-?. https://doi.org/10.1182/blood-2005-11-4570
  18. Nisman B, Barak V, Hubert A, et al (2003). Prognostic factors for survival in metastatic breast cancer during first line paclitaxel chemotherapy. Anticancer Res, 23, 1939-42.
  19. Saltz L, Cox JV, Blanke C, et al (2000). Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med, 343, 905-14. https://doi.org/10.1056/NEJM200009283431302
  20. Suppiah R, Shaheen PE, Elson P, et al (2006). Thrombocytosis as a prognostic factor for survival in patients with metastatic renal cell carcinoma. Cancer, 107, 1793-00. https://doi.org/10.1002/cncr.22237
  21. Tas F, Aykan F, Alici S, et al (2001). Prognostic factors in pancreatic carcinoma: serum LDH levels predict survival in metastatic disease. Am J Clin Oncol, 24, 547-50. https://doi.org/10.1097/00000421-200112000-00003
  22. Tas F, Aydiner A, Demir C, et al (2001). Serum lactate dehydrogenase levels at presentation predict outcome of patients with limited-stage small-cell lung cancer. Am J Clin Oncol, 24, 376-78. https://doi.org/10.1097/00000421-200108000-00013
  23. Tournigand C, Andre T, Achille E, et al (2004). FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol, 22, 229-37. https://doi.org/10.1200/JCO.2004.05.113
  24. Tournigand C, Cervantes A, Figer A, et al (2006). OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer-a GERCOR study. J Clin Oncol, 24, 394-00. https://doi.org/10.1200/JCO.2005.03.0106

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