• Genomics & Informatics
• /
• v.21 no.2
• /
• pp.17.1-17.12
• /
• 2023

Coronavirus has left severe health impacts on the human population, globally. Still a significant number of cases are reported daily as no specific medications are available for its effective treatment. The presence of the CD147 receptor (human basigin) on the host cell facilitates the severe acute respiratory disease coronavirus 2 (SARS-CoV-2) infection. Therefore, the drugs that efficiently alter the formation of CD147 and spike protein complex could be the right drug candidate to inhibit the replication of SARS-CoV-2. Hence, an e-Pharmacophore model was developed based on the receptor-ligand cavity of CD147 protein which was further mapped against pre-existing drugs of coronavirus disease treatment. A total of seven drugs were found to be suited as pharmacophores out of 11 drugs screened which was further docked with CD147 protein using CDOCKER of Biovia discovery studio. The active site sphere of the prepared protein was 101.44, 87.84, and 97.17 along with the radius being 15.33 and the root-mean-square deviation value obtained was 0.73 Å. The protein minimization energy was calculated to be -30,328.81547 kcal/mol. The docking results showed ritonavir as the best fit as it demonstrated a higher CDOCKER energy (-57.30) with correspond to CDOCKER interaction energy (-53.38). However, authors further suggest in vitro studies to understand the potential activity of the ritonavir.

• International conference on construction engineering and project management
• /
• 2013.01a
• /
• pp.634-639
• /
• 2013

The aim of the study is to develop the 3D visualization of Building Information Model and integrated 4D model for optimization of resources in the construction project. This study discuss the process of methodology and creation of 4D model of the project and simulate it to monitor the workflow at the site. Different stages of the construction process and activities are generated by using Revit and MS Project. MS project has been used for creation of the schedules and these are linked with the Revit for 3D modeling. The time used as the fourth dimension and 4D model created by using Navisworks Time liner software. Narges shopping center is presented as a case study to realize the actual uses and benefits of Building Information Model (BIM). Narges shopping mall is located in Tehran, Iran. As a part of Hekmat master plan, Narges shopping center is an 11 stores building with a total area of 30000 Sq.m. This shopping and entertainment center is comprised of 150 retails and two multi-use public halls with a capacity of 400 persons each and underground parking with total 400 parking space. The main purpose of architecture was to create an urban public center along with its revolving, spiral like form and an ever changing continuous façade by means of different colors, materials, which is in harmony with the other building of the master plan. The approximate cost of the project is $17 million and duration of the project schedule is 30 months. The developed Building Information Model enabled us to identify the potential collisions or clashes between various structural and architectural systems. 4D model has been used for limiting the interaction between subcontractors installing the different systems so rework could be avoided and productivity maximized. It is also observed that the utility of BIM for construction stimulation and clash detection is the best suitable method. Clash detection before the implementation of work is highly recommended to avoid rework.

• The Journal of Information Systems
• /
• v.32 no.4
• /
• pp.1-28
• /
• 2023

Purpose Recently, organizations have been allocating significant financial resources toward the implementation of new technologies and stringent information security (IS) policies in order to enhance IS. However, the potential for IS threats from internal sources within organizations remains high. This study proposes a mechanism whereby the organization's IS environment (organizational justice) enhances employees' perception of IS value congruence and encourages their voice behavior. Furthermore, this study validates that an individual's susceptibility to interpersonal influence can reinforce the relationship between the aforementioned factors and voice behavior. Design/methodology/approach We utilized AMOS 22.0 and Process 3.1 to validate the research model and hypotheses. The data was gathered from 435 employees employed in South Korean firms that implemented IS policies in their work. Structural equation modeling was employed to examine the relationship between organizational justice, value congruence, and voice behavior, and the interaction effect was confirmed by incorporating model 1 of Process 3.1 for the hypothesis pertaining to susceptibility to interpersonal influence. Findings The findings of this study indicate that organizational justice has a positive impact on voice behavior, which is further enhanced by value congruence. Furthermore, the influence of organizational justice and value congruence on voice behavior is moderated by susceptibility to information influence, while susceptibility to normative influence only moderates the effect of organizational justice. These results provide valuable insights for organizations in developing customized information systems strategies that effectively promote employees' voice behaviors.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.11 no.4
• /
• pp.467-475
• /
• 2023

To ensure the safety of the pipeline against large deformation of the pipeline during lowering construction, the analysis for pipeline becomes emphasized. The FE analysis has a lower efficiency at calculating time, while it could be obtained high accuracy. In this paper, a reasonable analytical model for analysis of pipeline is proposed during lowering-in. This analytical model is partitioned considering the geometrical characteristics and modeled as two parameters Beam On Elastic Foundation and Euler-Bernoulli beam considering the boundary condition. This takes into account the pipeline-soil interaction and the axial forces acting on the pipeline. Previous model can only be applied to standardized conditions, whereas the proposed model defined as Segmented Pipeline Model can be considered for the majority of construction conditions occurred during lowering-in. In addition, minimized assumptions and segmented elements lead to improve the convenience and applicability of modeling. Nevertheless, the model shows accurate results compared to the FE model. Accordingly, it is expected that it will be used efficiently for configuration management as well as safety assessment of pipeline during lowering-in.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.18 no.6
• /
• pp.1197-1206
• /
• 2023

To assess the risk level of a public restroom implemented in virtual reality, we sought to evaluate the spatial elements present in the restroom. To provide the theoretical foundation for the evaluation subjects and criteria, we introduced prior research that proposed a checklist to entance the safety of public restroom. To set up evaluation criteria, we analyzed and established based on the theories of Paul J. Brantingham and Patricia L. Brantingham, focusing on the interaction between space and criminals. Ronald V. Clarke's "Routine Activity Theory" was also introduced and incorporated into the evaluation approach. We analyzed based on the correlation between the criminal, user, and spatial elements of the public restroom in terms of the criminal's actions, the spatial relevance to crime, and user exposure during use. Using these criteria, we developed an algorithm to evaluate th spatial elements of public restroom. Based on this, we created an application, demonstrating the feasibility of developing on evaluation tool.

• Steel and Composite Structures
• /
• v.50 no.3
• /
• pp.265-280
• /
• 2024

The collapse behavior observed in single-story beam-column assembly (SSBCA) do not accurately represent the actual overall stress characteristic of multi-story frame structure (MSFS) under column loss scenario owing to ignoring the interaction action among different stories, leading to a disconnection between the anti-collapse behaviors of "components" and "overall structures", that is, the anti-collapse performance of frame structures with two different structural scales has not yet formed a combined force. This paper conducts a numerical and theoretical study to explore the difference of the collapse behaviors of the SSBCA and MSFS, and further to reveal the internal force relationships and boundary constraints at beam ends of models SSBCA and MSFS. Based on the previous experimental tests, the corresponding refined numerical simulation models were established and verified, and comparative analysis on the resistant-collapse performance was carried out, based on the validated modeling methods with considering the actual boundary constraints, and the results illustrates that the collapse behaviors of the SSBCA and MSFS is not a simple multiple relationship. Through numerical simulation and theoretical analysis, the development laws of internal force in each story beam under different boundary constraints was clarified, and the coupling relationship between the bending moment at the most unfavorable section and axial force in the composite beam of different stories of multi story frames with weld cover-plated flange connections was obtained. In addition, considering the effect of the yield performance of adjacent columns on the anti-collapse bearing capacities of the SSBCA and MSFS during the large deformation stages, the calculation formula for the equivalent axial stiffness at the beam ends of each story were provided.

• Nuclear Engineering and Technology
• /
• v.56 no.3
• /
• pp.973-979
• /
• 2024

In the framework of the Generation IV research and development project, in which the French Commission of Alternative and Atomic Energies (CEA) is involved, a main objective for the design of Sodium-cooled Fast Reactor (SFR) is to meet the safety goals for severe accidents. Among the severe ones, the Unprotected Transient OverPower (UTOP) accidents can lead very quickly to a global melting of the core. UTOP accidents can be considered either as slow during a Control Rod Withdrawal (CRW) or as fast. The paper focuses on fast UTOP accidents, which occur in a few milliseconds, and three different scenarios are considered: rupture of the core support plate, uncontrolled passage of a gas bubble inside the core and core mechanical distortion such as a core flowering/compaction during an earthquake. Several levels and rates of reactivity insertions are also considered and the thermal-mechanical behavior of an ASTRID fuel pin from the ASTRID CFV core is simulated with the GERMINAL code. Two types of fuel pins are simulated, inner and outer core pins, and three different burn-up are considered. Moreover, the feedback from the CABRI programs on these type of transients is used in order to evaluate the failure mechanism in terms of kinetics of energy injection and fuel melting. The CABRI experiments complete the analysis made with GERMINAL calculations and have shown that three dominant mechanisms can be considered as responsible for pin failure or onset of pin degradation during ULOF/UTOP accident: molten cavity pressure loading, fuel-cladding mechanical interaction (FCMI) and fuel break-up. The study is one of the first step in fast UTOP accidents modelling with GERMINAL and it has shown that the code can already succeed in modelling these type of scenarios up to the sodium boiling point. The modeling of the radial propagation of the melting front, validated by comparison with CABRI tests, is already very efficient.

• International Journal of Stem Cells
• /
• v.16 no.3
• /
• pp.269-280
• /
• 2023

Background and Objectives: The colonic epithelial layer is a complex structure consisting of multiple cell types that regulate various aspects of colonic physiology, yet the mechanisms underlying epithelial cell differentiation during development remain unclear. Organoids have emerged as a promising model for investigating organogenesis, but achieving organ-like cell configurations within colonic organoids is challenging. Here, we investigated the biological significance of peripheral neurons in the formation of colonic organoids. Methods and Results: Colonic organoids were co-cultured with human embryonic stem cell (hESC)-derived peripheral neurons, resulting in the morphological maturation of columnar epithelial cells, as well as the presence of enterochromaffin cells. Substance P released from immature peripheral neurons played a critical role in the development of colonic epithelial cells. These findings highlight the vital role of inter-organ interactions in organoid development and provide insights into colonic epithelial cell differentiation mechanisms. Conclusions: Our results suggest that the peripheral nervous system may have a significant role in the development of colonic epithelial cells, which could have important implications for future studies of organogenesis and disease modeling.

• Journal of Industrial Convergence
• /
• v.22 no.3
• /
• pp.27-37
• /
• 2024

The purpose of this study was to analyze the impact of community characteristics of induced participants on values, attitudes, and behaviors (VAB) and intention to continue participation. Convenience sampling (n=192) was used to sample the research subjects, and confirmatory factor analysis, correlation analysis, and structural equation modeling were conducted using SPSS 26.0 and AMOS 26.0. The results of this study are as follows. 1) Among the community attributes of the participants, reputation, enjoyment, interaction, and social connection had a significant impact. 2) Value-Attitude-Behavior (VAB) was found to have a significant hierarchical impact. 3) Behavioral intention was found to have a significant effect on continuation intention. Through this, the Judo community needs to build a participant-centered organizational culture that can create positive value in order to increase participants' participation in Judo.

• Advanced Industrial SCIence
• /
• v.3 no.3
• /
• pp.1-7
• /
• 2024

The purpose of this study is to investigate how supply chain digital transformation affects corporate performance by building supply chain agility and innovation capabilities based on the resource-based view (RBV) theory. The model was verified using structural equation modeling based on a data set of 271 domestic companies, and mediation and moderation analyzes were performed to test the research hypotheses. The study found a positive correlation between supply chain digital transformation and corporate performance that is fully mediated by both supply chain agility and innovation capability, with the potential for the interaction between supply chain agility and innovation capability to have adverse consequences for corporate performance. This study is expected to advance our understanding on the antecedents of corporate performance by integrating supply chain digital transformation and the mediating mechanisms of supply chain agility and innovation capabilities that serve as a conduit between supply chain digital transformation and RBV-based corporate performance.